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  1. Article: Gastric conduit reconstruction after esophagectomy with right gastroepiploic artery absence: a case report.

    Charalampous, C / Kofopoulos-Lymperis, E / Pikouli, A / Lykoudis, P / Pararas, N / Papaconstantinou, D / Nastos, C / Myoteri, D / Dellaportas, D

    Journal of surgical case reports

    2023  Volume 2023, Issue 8, Page(s) rjad474

    Abstract: Gastric conduit reconstruction is the standard choice after esophagectomy. Conduit's vascular supply is of primary importance mainly based on right gastroepiploic vessels. A 57-year-old male with absent right gastroepiploic artery, due to a duodenal ... ...

    Abstract Gastric conduit reconstruction is the standard choice after esophagectomy. Conduit's vascular supply is of primary importance mainly based on right gastroepiploic vessels. A 57-year-old male with absent right gastroepiploic artery, due to a duodenal bleeding ulcer treated with gastroduodenal artery ligation 10 years ago, was treated for gastroesophageal cancer and required esophagectomy. Surgical merits of this troublesome scenario are highlighted. Previous surgical history is highly important for patients requiring complex surgery as esophagectomy. The use of the stomach as conduit after esophagectomy is always the primary option; however vascular supply of it should not be compromised. Variations are rare and careful planning may overcome obstacles as in this case.
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Spontaneous Splenic Rupture due to Metastatic Pancreatic Cancer.

    Politis, D / Myoteri, D / Bourou, M / Nastos, C / Papaconstantinou, I / Dellaportas, D

    Case reports in surgery

    2021  Volume 2021, Page(s) 9918154

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2021-09-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2657697-1
    ISSN 2090-6919 ; 2090-6900
    ISSN (online) 2090-6919
    ISSN 2090-6900
    DOI 10.1155/2021/9918154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report.

    Paspala, Anna / Papakonstantinou, Dimitrios / Pikoulis, Emmanouil / Tomos, Periklis / Nastos, Constantinos

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31294

    Abstract: Bone metastases from thyroid cancer are mainly rare, while sternal metastases are extremely uncommon. Bone metastases might be either synchronous or metachronous to primary thyroid cancer. A 60-year-old male patient presented to our department with a ... ...

    Abstract Bone metastases from thyroid cancer are mainly rare, while sternal metastases are extremely uncommon. Bone metastases might be either synchronous or metachronous to primary thyroid cancer. A 60-year-old male patient presented to our department with a painful, fixed and firm sternal mass. Preoperative imaging studies, such as neck ultrasound (US) and computed tomography (CT) of the chest, revealed a 6.5 cm nodule of the right thyroid lobe with high-risk malignancy characteristics and a massive metastatic mass of the anterior mediastinal, which was extended from the sternal notch to the third
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31294
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  4. Article ; Online: Anesthetic management of a patient with type 1 neurofibromatosis and an occult pheochromocytoma: a case report.

    Theodosopoulou, Polyxeni / Nastos, Constantinos / Paraskeva, Anteia

    Brazilian journal of anesthesiology (Elsevier)

    2021  Volume 73, Issue 5, Page(s) 695–698

    Abstract: Neurofibromatosis type 1 is a complex genetic disorder affecting multiple organ systems. Cardiovascular manifestations include hypertension, often associated with concomitant pheochromocytoma. We present a hypertensive crisis during induction of ... ...

    Abstract Neurofibromatosis type 1 is a complex genetic disorder affecting multiple organ systems. Cardiovascular manifestations include hypertension, often associated with concomitant pheochromocytoma. We present a hypertensive crisis during induction of anesthesia in a patient with neurofibromatosis type 1, scheduled for abdominal myomectomy, which revealed an undiagnosed pheochromocytoma. The case highlights the importance of assessing all patients with neurofibromatosis type 1 for pheochromocytoma, because if it is left undiagnosed, it can be disastrous in the setting of anesthesia and surgery.
    Language English
    Publishing date 2021-04-02
    Publishing country Brazil
    Document type Case Reports
    ISSN 2352-2291
    ISSN (online) 2352-2291
    DOI 10.1016/j.bjane.2021.02.045
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  5. Article ; Online: The Role of the Glycemic Index and Glycemic Load in the Dietary Approach of Gestational Diabetes Mellitus.

    Mavroeidi, Ioanna / Manta, Aspasia / Asimakopoulou, Athina / Syrigos, Alexandros / Paschou, Stavroula A / Vlachaki, Efthimia / Nastos, Constantinos / Kalantaridou, Sophia / Peppa, Melpomeni

    Nutrients

    2024  Volume 16, Issue 3

    Abstract: Gestational diabetes mellitus (GDM) is a common metabolic disorder that often develops during pregnancy, characterized by glucose intolerance and insulin resistance (IR). To ensure the well-being of both the mother and the fetus, the body undergoes ... ...

    Abstract Gestational diabetes mellitus (GDM) is a common metabolic disorder that often develops during pregnancy, characterized by glucose intolerance and insulin resistance (IR). To ensure the well-being of both the mother and the fetus, the body undergoes multiple metabolic and immunological changes that result in peripheral IR and, under certain hereditary or acquired abnormalities, GDM in predisposed women. The adverse short- and long-term effects of GDM impact both the mother and the fetus. Nutrition seems to play an important role to prevent GDM or improve its evolution. An emphasis has been given to the proportion of carbohydrates (CHO) relative to protein and lipids, as well as dietary patterns, in GDM. The effects of CHO on postprandial glucose concentrations are reflected in the glycemic index (GI) and glycemic load (GL). Diets rich in GI and GL may induce or exacerbate IR, whereas diets low in GI and GL appear to enhance insulin sensitivity and improve glycemic control. These positive outcomes may be attributed to direct interactions with insulin and glucose homeostasis or indirect effects through improved body composition and weight management. This comprehensive narrative review aims to explore the significance of nutrition, with a focus on the critical evaluation of GI and GL in the dietary management of women with GDM.
    MeSH term(s) Pregnancy ; Female ; Humans ; Diabetes, Gestational/prevention & control ; Glycemic Index ; Glycemic Load ; Diet ; Insulin Resistance ; Insulin ; Glucose ; Blood Glucose/metabolism ; Dietary Carbohydrates
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2) ; Blood Glucose ; Dietary Carbohydrates
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16030399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dietary Approach of Patients with Hormone-Related Cancer Based on the Glycemic Index and Glycemic Load Estimates.

    Peppa, Melpomeni / Manta, Aspasia / Mavroeidi, Ioanna / Nastos, Constantinos / Pikoulis, Emmanouil / Syrigos, Konstantinos / Bamias, Aristotelis

    Nutrients

    2023  Volume 15, Issue 17

    Abstract: Hormone-related cancers, namely breast, endometrial, cervical, prostate, testicular, and thyroid, constitute a specific group of cancers dependent on hormone levels that play an essential role in cancer growth. In addition to the traditional risk factors, ...

    Abstract Hormone-related cancers, namely breast, endometrial, cervical, prostate, testicular, and thyroid, constitute a specific group of cancers dependent on hormone levels that play an essential role in cancer growth. In addition to the traditional risk factors, diet seems to be an important environmental factor that partially explains the steadily increased prevalence of this group of cancer. The composition of food, the dietary patterns, the endocrine-disrupting chemicals, and the way of food processing and preparation related to dietary advanced glycation end-product formation are all related to cancer. However, it remains unclear which specific dietary components mediate this relationship. Carbohydrates seem to be a risk factor for cancer in general and hormone-related cancers, in particular, with a difference between simple and complex carbohydrates. Glycemic index and glycemic load estimates reflect the effect of dietary carbohydrates on postprandial glucose concentrations. Several studies have investigated the relationship between the dietary glycemic index and glycemic load estimates with the natural course of cancer and, more specifically, hormone-related cancers. High glycemic index and glycemic load diets are associated with cancer development and worse prognosis, partially explained by the adverse effects on insulin metabolism, causing hyperinsulinemia and insulin resistance, and also by inflammation and oxidative stress induction. Herein, we review the existing data on the effect of diets focusing on the glycemic index and glycemic load estimates on hormone-related cancers.
    MeSH term(s) Male ; Humans ; Glycemic Index ; Glycemic Load ; Diet/adverse effects ; Neoplasms ; Dietary Carbohydrates/adverse effects
    Chemical Substances Dietary Carbohydrates
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15173810
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  7. Article ; Online: Robotic-assisted parathyroidectomy and short-term outcomes: a systematic review of the literature.

    Paspala, A / Spartalis, E / Nastos, C / Tsourouflis, G / Dimitroulis, D / Pikoulis, E / Nikiteas, N

    Journal of robotic surgery

    2020  Volume 14, Issue 6, Page(s) 821–827

    Abstract: Minimal invasive techniques in endocrine surgery were lately adopted by surgical teams due to significant complications related to inadequate operative space and high risk of injuring crucial surrounding structures, such as vessels and nerves. Over the ... ...

    Abstract Minimal invasive techniques in endocrine surgery were lately adopted by surgical teams due to significant complications related to inadequate operative space and high risk of injuring crucial surrounding structures, such as vessels and nerves. Over the last years, technological improvements introduced robotic systems and approaches in endocrine surgery. Several case reports and series have described the safety and efficacy of these procedures such as robotic thyroidectomy and robotic parathyroidectomy. In the current review, we included 15 studies which described robotic-assisted parathyroidectomy for cervical parathyroid adenoma, in patients diagnosed with primary hyperparathyroidism or secondary hyperparathyroidism. No significant negative short-term outcomes were observed, in terms of postoperative complications, such as temporary or permanent injury of RLN, postoperative hypoparathyroidism and blood loss. The cosmetic result was, definitely, superior in comparison to conventional open parathyroidectomy. Despite the fact that RAP is an effective and curative method for patients with PHPT or secondary hyperparathyroidism, there are no available randomized clinical trials to establish this modern procedure as a gold-standard treatment strategy for these patients.
    MeSH term(s) Adenoma/surgery ; Female ; Humans ; Hyperparathyroidism, Primary/surgery ; Hyperparathyroidism, Secondary/surgery ; Male ; Parathyroid Neoplasms/surgery ; Parathyroidectomy/methods ; Robotic Surgical Procedures/methods ; Treatment Outcome
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-020-01119-x
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  8. Article: Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review.

    Papaconstantinou, Dimitrios / Pararas, Nikolaos / Pikouli, Anastasia / Nastos, Constantinos / Charalampopoulos, Anestis / Dellaportas, Dionysios / Bagias, George / Pikoulis, Emmanouil

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Liver resection for colorectal liver metastases (CRLM) is widely considered the treatment with the highest curative potential. However, not all patients derive the same oncological benefit, underlining the need for better patient stratification and ... ...

    Abstract Liver resection for colorectal liver metastases (CRLM) is widely considered the treatment with the highest curative potential. However, not all patients derive the same oncological benefit, underlining the need for better patient stratification and treatment allocation. In this context, we performed a systematic review of the literature to determine the role of RAS status in selecting the optimal surgical strategy. Evidence comparing anatomical with non-anatomical resections depending on RAS mutational status was scarce and conflicting, with two studies reporting superiority in mutated RAS (mutRAS) patients and two studies reporting equivalent outcomes. The rate of incomplete microscopic resection (R1) was found to be increased among mutRAS patients, possibly due to higher micrometastatic spread lateral to the primary lesion. The impact of R1 resection margins was evaluated separately for mutRAS and wild-type patients in three studies, of which, two indicated an additive detriment to long-term survival in the former group. In the current era of precision surgery, RAS status can be utilized to predict the efficacy of liver resection in the treatment of CRLM, avoiding a potentially morbid operation in patients with adverse tumor profiles.
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072083
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  9. Article: Changes in Cardiovascular and Renal Biomarkers Associated with SGLT2 Inhibitors Treatment in Patients with Type 2 Diabetes Mellitus.

    Peppa, Melpomeni / Manta, Aspasia / Mavroeidi, Ioanna / Asimakopoulou, Athina / Syrigos, Alexandros / Nastos, Constantinos / Pikoulis, Emmanouil / Kollias, Anastasios

    Pharmaceutics

    2023  Volume 15, Issue 11

    Abstract: Type 2 diabetes mellitus is a major health problem worldwide with a steadily increasing prevalence reaching epidemic proportions. The major concern is the increased morbidity and mortality due to diabetic complications. Traditional but also ... ...

    Abstract Type 2 diabetes mellitus is a major health problem worldwide with a steadily increasing prevalence reaching epidemic proportions. The major concern is the increased morbidity and mortality due to diabetic complications. Traditional but also nontraditional risk factors have been proposed to explain the pathogenesis of type 2 diabetes mellitus and its complications. Hyperglycemia has been considered an important risk factor, and the strict glycemic control can have a positive impact on microangiopathy but not macroangiopathy and its related morbidity and mortality. Thus, the therapeutic algorithm has shifted focus from a glucose-centered approach to a strategy that now emphasizes target-organ protection. Sodium-glucose transporter 2 inhibitors is an extremely important class of antidiabetic medications that, in addition to their glucose lowering effect, also exhibit cardio- and renoprotective effects. Various established and novel biomarkers have been described, reflecting kidney and cardiovascular function. In this review, we investigated the changes in established but also novel biomarkers of kidney, heart and vascular function associated with sodium-glucose transporter 2 inhibitors treatment in patients with type 2 diabetes mellitus.
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15112526
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  10. Article ; Online: Experiential student study groups: perspectives on medical education in the post-COVID-19 period.

    Lazari, Evgenia Charikleia / Mylonas, Charalampos C / Thomopoulou, Georgia Eleni / Manou, Evangelia / Nastos, Constantinos / Kavantzas, Nikolaos / Pikoulis, Emmanouil / Lazaris, Andreas C

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 42

    Abstract: Background: Undergraduate medical curricula often fail to integrate experiential learning methodologies. Thus, a pilot series of interactive pathology lessons was designed and implemented in an attempt to promote experiential learning.: Methods: ... ...

    Abstract Background: Undergraduate medical curricula often fail to integrate experiential learning methodologies. Thus, a pilot series of interactive pathology lessons was designed and implemented in an attempt to promote experiential learning.
    Methods: Thirty pre-graduate medical students voluntarily participated in the interactive study groups at the First Department of Pathology of the National and Kapodistrian University of Athens, Medical School. A questionnaire was designed to investigate the satisfaction of students regarding their participation in pathology study groups and to identify the characteristics that shape students' perceptions of the foundations of medical education. Descriptive statistics (mean values) were used to describe the students' evaluations of the pathology study groups, and thematic analysis was conducted to investigate the data collected using open-ended questions.
    Results: Interactions with the professor and the option of co-observing the slides using dual-view optical microscopes and virtual slides were each evaluated as "Excellent" by ≅ 95% of the students. Four overarching themes were identified regarding the core characteristics of medical education according to the students' perspectives: 1) educational background in medical education, 2) interaction with educators in medical education, 3) educational material in medical education and 4) assessment in medical education.
    Conclusions: The high rates of acceptance of the pathology study groups reflect the desire and need for active learning methodologies to be implemented in modern medical education. Nearly all the students mentioned the need for practical skill acquisition, the integration of theory into practice and ethics in medical education. The success of these optional pathology study groups highlights the need for similar modalities to be incorporated into the main medical education curriculum.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Education, Medical ; Curriculum ; Problem-Based Learning ; Students, Medical ; Education, Medical, Undergraduate/methods
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04006-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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