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  1. Article: The impact of COVID-19 on the male genital tract: a qualitative literature review of sexual transmission and fertility implications.

    Verrienti, Pierangelo / Cito, Gianmartin / Di Maida, Fabrizio / Tellini, Riccardo / Cocci, Andrea / Minervini, Andrea / Natali, Alessandro

    Clinical and experimental reproductive medicine

    2022  Volume 49, Issue 1, Page(s) 9–15

    Abstract: The angiotensin-converting enzyme 2 receptor (ACE2) appears to be widely expressed in cells in the testes, predominantly in spermatogonia, Sertoli cells, and Leydig cells, and its co-expression with transmembrane protease serine 2 (TMPRSS2) is essential ... ...

    Abstract The angiotensin-converting enzyme 2 receptor (ACE2) appears to be widely expressed in cells in the testes, predominantly in spermatogonia, Sertoli cells, and Leydig cells, and its co-expression with transmembrane protease serine 2 (TMPRSS2) is essential for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For this reason, the male reproductive system could be considered a potential target for SARS-CoV-2, as well as a possible reservoir of infection. However, to date, there is very little evidence about the presence of SARS-CoV-2 in semen and testicular samples. The aim of this paper was to review the current evidence regarding the impact of SARS-CoV-2 on male fertility and sexual health, with a particular focus on reproductive hormones, the presence of the virus in seminal fluid and testis, and its impact on fertility parameters. We found very limited evidence reporting the presence of SARS-CoV-2 in semen and testicular samples, and the impact of SARS-CoV-2 on reproductive hormones and fertility parameters is unclear. The quality of the examined studies was poor due to the small sample size and several selection biases, precluding definitive conclusions. Hence, future well-designed prospective studies are needed to assess the real impact of SARS-CoV-2 on male reproductive function.
    Language English
    Publishing date 2022-02-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2653899-4
    ISSN 2233-8241 ; 2233-8233
    ISSN (online) 2233-8241
    ISSN 2233-8233
    DOI 10.5653/cerm.2021.04511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurogenic Sexual Dysfunction Treatment: A Systematic Review.

    Del Popolo, Giulio / Cito, Gianmartin / Gemma, Luca / Natali, Alessandro

    European urology focus

    2019  Volume 6, Issue 5, Page(s) 868–876

    Abstract: Context: The genesis of neurogenic sexual dysfunction (NSD) can be central, peripheral, or both. The correct stratification of the level of sexual dysfunction allows the clinician to choose the best type of treatment, in order to reduce sexual ... ...

    Abstract Context: The genesis of neurogenic sexual dysfunction (NSD) can be central, peripheral, or both. The correct stratification of the level of sexual dysfunction allows the clinician to choose the best type of treatment, in order to reduce sexual complaints.
    Objective: The aim of our review is to focus on the management of NSD due to central nervous system disorders and peripheral neuropathy.
    Evidence acquisition: A systematic review of the English-language literature was completed until July 2019 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The following terms were included: [(neurogenic sexual dysfunction) OR neurogenic erectile dysfunction)] AND (treatment OR management). An Excel file was created respecting the following criteria: participants, interventions, comparators, outcomes, and study design (PICOS).
    Evidence synthesis: Overall, from 505 identified records, 52 full-text articles were assessed for eligibility. Finally, 46 original researches were included in quantitative analysis.
    Conclusions: The phosphodiesterase type 5 inhibitors sildenafil, tadalafil, and vardenafil were proved to be effective and safe in first-line therapy of erectile dysfunction caused by neurogenic disorders. In addition, intracavernous injections of prostaglandin E1, papaverine, or phentolamine and vacuum systems have been a mainstay of second-line treatment for NSD, extremely successful in the spinal cord injury population. Surgical therapy via penile prosthesis implantation remains a viable alternative as a third-line approach and may also be utilised to assist men with bladder management, despite higher complication rates of infections. Despite poor evidence, a better understanding of female sexual dysfunction due to neurological complaints is needed, in order to find more efficacious therapies for intercourse and orgasmic phase. Further prospective studies are required to better clarify the more successful treatment in improving sexual function and quality of life of these patients.
    Patient summary: Management of neurogenic sexual dysfunction includes phosphodiesterase type 5 inhibitors, intracavernous injections/vacuum devices, and penile prosthesis implantation. Female sexual dysfunction due to neurological disease needs to be better investigated.
    MeSH term(s) Central Nervous System Diseases/complications ; Female ; Humans ; Male ; Peripheral Nervous System Diseases/complications ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/therapy
    Language English
    Publishing date 2019-12-24
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2019.12.002
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  3. Article: Paternal Behaviors in the Era of COVID-19.

    Cito, Gianmartin / Micelli, Elisabetta / Cocci, Andrea / Polloni, Gaia / Coccia, Maria Elisabetta / Carini, Marco / Minervini, Andrea / Natali, Alessandro

    The world journal of men's health

    2020  Volume 38, Issue 3, Page(s) 251–253

    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.200071
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  4. Article ; Online: Desire for parenthood at the time of COVID-19 pandemic: an insight into the Italian situation.

    Micelli, Elisabetta / Cito, Gianmartin / Cocci, Andrea / Polloni, Gaia / Russo, Giorgio Ivan / Minervini, Andrea / Carini, Marco / Natali, Alessandro / Coccia, Maria Elisabetta

    Journal of psychosomatic obstetrics and gynaecology

    2020  Volume 41, Issue 3, Page(s) 183–190

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Adult ; Betacoronavirus ; Birth Rate/trends ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Decision Making ; Female ; Forecasting ; Humans ; Life Style ; Male ; Pandemics ; Parenting/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Quality of Life ; Reproduction ; Reproductive Behavior/psychology ; SARS-CoV-2 ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 604816-x
    ISSN 1743-8942 ; 0167-482X
    ISSN (online) 1743-8942
    ISSN 0167-482X
    DOI 10.1080/0167482X.2020.1759545
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  5. Article ; Online: An assessment of new sperm tests for male infertility.

    Natali, Alessandro / Turek, Paul J

    Urology

    2011  Volume 77, Issue 5, Page(s) 1027–1034

    Abstract: The routine semen analysis, although used for more than 50 years, fails to accurately distinguish between fertile and infertile men. As a consequence, many tests of sperm function (TSF) have been developed. This review discusses both older and newer ... ...

    Abstract The routine semen analysis, although used for more than 50 years, fails to accurately distinguish between fertile and infertile men. As a consequence, many tests of sperm function (TSF) have been developed. This review discusses both older and newer diagnostic TSF. It outlines the principles underlying each assay and reviews aggregate clinical data to determine its current relevance and utility. It concludes that the relevance of many older TSF is questionable, with the wide acceptance of intracytoplasmic sperm injection (ICSI). Newer TSF have the potential to deliver more clinically relevant information but require more extensive study to better understand their predictive role in the ICSI era.
    MeSH term(s) Humans ; Infertility, Male/diagnosis ; Male ; Semen Analysis/methods ; Spermatozoa/ultrastructure
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2010.10.005
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  6. Article: Sperm retrieval by conventional testicular sperm extraction for assisted reproduction in patients with Zinner syndrome.

    Cito, Gianmartin / Gemma, Luca / Giachini, Claudia / Micelli, Elisabetta / Cocci, Andrea / Fucci, Rossella / Picone, Rita / Sforza, Simone / Nesi, Gabriella / Santi, Raffaella / Minervini, Andrea / Masieri, Lorenzo / Carini, Marco / Coccia, Maria Elisabetta / Natali, Alessandro

    Clinical and experimental reproductive medicine

    2021  Volume 48, Issue 1, Page(s) 85–90

    Abstract: We present data from three Caucasian men with Zinner syndrome who attended our center for the treatment of primary couple's infertility. Each patient was scheduled for conventional testicular sperm extraction (cTESE) and cryopreservation. Sperm analysis ... ...

    Abstract We present data from three Caucasian men with Zinner syndrome who attended our center for the treatment of primary couple's infertility. Each patient was scheduled for conventional testicular sperm extraction (cTESE) and cryopreservation. Sperm analysis confirmed absolute azoospermia. Patient 1 had right and left testis volumes of 24 mL and 23 mL, respectively; left seminal vesicle (SV) agenesis, severe right SV hypotrophy with right renal agenesis. Follicle-stimulating hormone (FSH) was 3.2 IU/L. Patient 2 exhibited right and left testis volumes of 18 mL and 16 mL, respectively; a left SV cyst of 32 × 28 mm, ipsilateral kidney absence, and right SV agenesis. FSH was 2.8 IU/L. Patient 3 showed a testicular volume of 10 mL bilaterally, a 65 × 46 mm left SV cyst, right SV enlargement, and left kidney agenesis. FSH was 32.0 IU/L. Sperm retrieval was successful in all patients. Nevertheless, cTESE should be performed on the day of oocyte retrieval.
    Language English
    Publishing date 2021-01-25
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2653899-4
    ISSN 2233-8241 ; 2233-8233
    ISSN (online) 2233-8241
    ISSN 2233-8233
    DOI 10.5653/cerm.2020.03769
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  7. Article ; Online: Complications of self-circumcision: a case report and proposal.

    Natali, Alessandro / Rossetti, Mario Alberto

    The journal of sexual medicine

    2008  Volume 5, Issue 12, Page(s) 2970–2972

    Abstract: Introduction: Male circumcision is a common surgical technique that has been performed worldwide for thousands of years for medical, social, cultural, and religious reasons. It is usually conducted in childhood in a clinical setting, but the practice of ...

    Abstract Introduction: Male circumcision is a common surgical technique that has been performed worldwide for thousands of years for medical, social, cultural, and religious reasons. It is usually conducted in childhood in a clinical setting, but the practice of adult self-circumcision has led to a market for nonmedically approved self-circumcision devices that can be purchased via the Internet.
    Aims: The aims of this report are to report the case of a 30-year-old white man who suffered complications after trying to perform a self-circumcision with a nonmedically approved device purchased via the Internet, and to propose that urologists should take the lead in investigating the problem of male self-circumcision.
    Methods: This case report documents the presentation and treatment of an attempted self-circumcision.
    Results: The attempted self-circumcision was carried out without local anaesthetic and resulted in an incision in the foreskin. The patient presented with uncontrollable local bleeding 2 days after carrying out the procedure. Although questioned as to why he had attempted self-circumcision, the patient was reluctant and/or unable to explain his reasons. Daily local wound care and topical antibiotics resulted in complete wound healing after 2 months, and a clinical clamp circumcision was conducted to treat the remaining severe phimosis.
    Conclusion: Data on the prevalence and outcomes associated with the use of self-circumcision devices are few. The clinicians who treat the complications are best placed to collect data on self-circumcision and should publish case studies. Eventually there may be sufficient understanding of the sector of the population at risk from this practice to educate those likely to attempt self-circumcision, and enough evidence of harm for controls to be placed on the sale of these nonmedically approved devices via the Internet.
    MeSH term(s) Adult ; Circumcision, Male/adverse effects ; Circumcision, Male/instrumentation ; Edema/etiology ; Humans ; Internet ; Male ; Penile Diseases/etiology ; Phimosis/surgery ; Postoperative Complications/etiology ; Postoperative Hemorrhage/etiology ; Reoperation ; Self Care/adverse effects ; Self Care/instrumentation ; Self-Injurious Behavior/complications ; Surgical Instruments
    Language English
    Publishing date 2008-12
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1111/j.1743-6109.2008.00858.x
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  8. Article ; Online: Sperm morphology: What implications on the assisted reproductive outcomes?

    Cito, Gianmartin / Picone, Rita / Fucci, Rossella / Giachini, Claudia / Micelli, Elisabetta / Cocci, Andrea / Falcone, Patrizia / Minervini, Andrea / Carini, Marco / Natali, Alessandro / Coccia, Maria E

    Andrology

    2020  Volume 8, Issue 6, Page(s) 1867–1874

    Abstract: Objective: To evaluate the impact of sperm morphology (SM) on laboratory and pregnancy outcomes in conventional intracytoplasmic sperm injection (c-ICSI) cycles, using the egg donation model to minimize female confounding variables.: Materials and ... ...

    Abstract Objective: To evaluate the impact of sperm morphology (SM) on laboratory and pregnancy outcomes in conventional intracytoplasmic sperm injection (c-ICSI) cycles, using the egg donation model to minimize female confounding variables.
    Materials and methods: We retrospectively collected data of oocyte donation cycles from October 2016 to February 2020. Median seminal parameters, total (1-2-3PN) fertilization rate (FR), 2PN FR, cleavage rate (CR), implantation rate (IR), pregnancy rate (PR), miscarriage rate (MR), and live birth rate (LBR) were collected. The study population was divided into three groups: Group 1 with SM < 4%, Group 2 with SM between 4% and 6%, and Group 3 with SM > 6%.
    Results: Of 741 fresh ICSI cycles and 4507 warmed oocytes were included. Male age was 46.0 (31.0-72.0) years, and recipients' age was 44.0 (29.0-54.0) years. Normal SM was 5.0% (1.0%-15.0%). Male age was negatively correlated with normal SM (P = .002; Rho -0.113). Oocyte survival rate was 83.3% (16.7%-100.0%). Total FR was 75.0% (11.1%-100.0%), 2PN FR was 66.7% (11.1%-100.0%) %, and CR was 100% (0.0%-100%). Comparing samples with SM > 6% and those with SM < 4%, 2PN FR was significantly higher in the first group (P = .04). No significant associations were found among groups in terms of CR. IR was 27.7%, resulting significantly higher when normal SM was > 6% (P < .01). Clinical PR was 36.0%, MR was 23.9%, and LBR was 25.9%. PR and LBR were significantly higher in samples with normal SM > 6%, compared to other groups (P = .02 and P < .01, respectively).
    Conclusions: Although c-ICSI technique allows the embryologist to select the best quality spermatozoa, male factor plays a key role in achieving successful assisted reproductive outcomes. Normal SM has been shown to have implications not only for laboratory outcomes, in terms of fertilization, but also for clinical findings, as regards implantation, pregnancy, and live birth.
    MeSH term(s) Adult ; Aged ; Embryo Implantation/physiology ; Female ; Fertilization/physiology ; Fertilization in Vitro/methods ; Humans ; Male ; Middle Aged ; Oocyte Donation ; Oocytes/physiology ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Retrospective Studies ; Semen Analysis ; Sperm Injections, Intracytoplasmic/methods ; Spermatozoa/physiology ; Young Adult
    Language English
    Publishing date 2020-08-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.12883
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    Zs.A 6983: Show issues Location:
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  9. Article ; Online: Reproductive Outcomes in Infertile Men With Spinal Cord Injury (SCI): A Retrospective Case-Control Analysis.

    Cito, Gianmartin / Picone, Rita / Fucci, Rossella / Del Popolo, Giulio / Cocci, Andrea / Gemma, Luca / Lombardi, Giuseppe / Minervini, Andrea / Carini, Marco / Natali, Alessandro / Coccia, Maria Elisabetta

    Urology

    2020  Volume 141, Page(s) 82–88

    Abstract: Objective: To evaluate semen characteristics and reproductive outcomes after assisted ejaculation methods with fresh in vitro fertilization/intracytoplasmic sperm injection cycles in patients suffering from spinal cord injury (SCI), compared to controls, ...

    Abstract Objective: To evaluate semen characteristics and reproductive outcomes after assisted ejaculation methods with fresh in vitro fertilization/intracytoplasmic sperm injection cycles in patients suffering from spinal cord injury (SCI), compared to controls, affected by idiopathic male infertility (non-SCI group).
    Methods: SCI patients first underwent penile vibratory stimulation. Men "non-responders" to penile vibratory stimulation underwent electroejaculation. Third, testicular sperm aspiration was proposed.
    Results: This retrospective monocenter case-control study included 193 couples: 53 couples in SCI group and 140 couples in non-SCI group. Overall, 210 fresh in vitro fertilization/intracytoplasmic sperm injection cycles were performed. Median semen volume of SCI was significantly lower, compared to non-SCI (1.5 mL vs 3.1 mL; P < .01). Median sperm concentration/mL and total sperm count was considerably higher in SCI. Mean sperm progressive motility was significantly lower in SCI (5.0% vs 35.0%; P < .01). Normal fertilization rate was significantly lower in SCI (46.0% vs 71.0%; P < .01). Total fertilization rate was 50.0% and 75%, respectively, in SCI and non-SCI groups. A trend toward higher pregnancy rates per cycle was found in non-SCI (31.4% vs 21.4%), or in the live birth rate, which was 27.1% and 20.0%, respectively. No significant differences were found in pregnancy, miscarriage, and live birth rates per cycle, between the 2 groups.
    Conclusion: The assisted ejaculation methods in SCI proved to be efficacious and safe to obtain viable sperm for assisted reproductive technologies. Overall, pregnancy and live birth rates were similar to non-SCI patients. Thus, SCI men have the same opportunity to father biological children, compared to men without SCI.
    MeSH term(s) Adult ; Case-Control Studies ; Ejaculation ; Female ; Fertilization in Vitro/methods ; Fertilization in Vitro/statistics & numerical data ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/etiology ; Infertility, Male/therapy ; Italy/epidemiology ; Male ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy Rate ; Retrospective Studies ; Semen Analysis/methods ; Semen Analysis/statistics & numerical data ; Sperm Count/methods ; Sperm Injections, Intracytoplasmic/methods ; Sperm Injections, Intracytoplasmic/statistics & numerical data ; Sperm Motility ; Sperm Retrieval ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/epidemiology
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2020.03.043
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  10. Article ; Online: Primary penile Kaposi's sarcoma in HIV-seronegative patient: a case report and literature review.

    Cito, Gianmartin / Di Costanzo, Roberto / Morselli, Simone / Cocci, Andrea / Santi, Raffaella / Nesi, Gabriella / Natali, Alessandro / Minervini, Andrea / Carini, Marco / Travaglini, Fabrizio

    International braz j urol : official journal of the Brazilian Society of Urology

    2020  Volume 46, Issue 5, Page(s) 825–842

    MeSH term(s) HIV Infections/complications ; Humans ; Male ; Penile Neoplasms/etiology ; Sarcoma, Kaposi/etiology
    Language English
    Publishing date 2020-07-09
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2020.05.03
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