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  1. Article ; Online: Gout

    Sergei V. Guliaev / Natalia V. Chebotareva / Sergey V. Moiseev

    Терапевтический архив, Vol 94, Iss 12, Pp 1438-

    from Hippocrates till the modern time

    2023  Volume 1441

    Abstract: Gout (podagra) is one of the most ancient articular diseases. Its accurate mechanisms and causes were delineated only during the last century. Major historical investigatory steps are described in relation to causality and pathogenesis of the disease ... ...

    Abstract Gout (podagra) is one of the most ancient articular diseases. Its accurate mechanisms and causes were delineated only during the last century. Major historical investigatory steps are described in relation to causality and pathogenesis of the disease from Hippocrates ages till the modern time. The newest genetic and epidemiologic aspects of the disease are presented in this article.
    Keywords gout ; podagra ; hyperuricemia ; historical review ; uric acid ; purines ; Medicine ; R
    Language Russian
    Publishing date 2023-01-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Diagnostic and treatment difficulties in kidney damage in the patient with generalized sarcoidosis during COVID-19. Case report

    Marina V. Lebedeva / Natalia V. Chebotareva / Vladimir D. Beketov

    Терапевтический архив, Vol 94, Iss 6, Pp 769-

    2022  Volume 771

    Abstract: The presented clinical observation reflects the difficulties of differential diagnosis of progressive kidney damage in a patient with sarcoidosis who has undergone a new coronavirus infection. The differential circle included interstitial nephritis as an ...

    Abstract The presented clinical observation reflects the difficulties of differential diagnosis of progressive kidney damage in a patient with sarcoidosis who has undergone a new coronavirus infection. The differential circle included interstitial nephritis as an exacerbation of the underlying disease, acute drug-induced kidney injury, acute glomerulonephritis. Nephrobiopsy confirmed the diagnosis of acute sarcoid tubulointerstitial nephritis with acute tubular necrosis. Timely administration of corticosteroids led to the control of the sarcoidosis process, restoration of kidney function.
    Keywords sarcoidosis tubulo-interstitial nephritis ; generalized sarcoidosis ; new coronavirus infection ; Medicine ; R
    Language Russian
    Publishing date 2022-08-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Rehberg–Tareev test in assessing the glomerular filtration rate

    Irina N. Bobkova / Elena S. Kamyshova / Natalia V. Chebotareva

    Терапевтический архив, Vol 93, Iss 10, Pp 1246-

    2021  Volume 1248

    Abstract: The history of glomerular filtration rate assessment is presented, an important step of which was the glomerular filtration rate evaluation by the endogenous creatinine clearance (known as the RehbergTareev test). The article highlights the diagnostic ... ...

    Abstract The history of glomerular filtration rate assessment is presented, an important step of which was the glomerular filtration rate evaluation by the endogenous creatinine clearance (known as the RehbergTareev test). The article highlights the diagnostic value of the RehbergTareev test and its place among modern methods for assessing glomerular filtration rate.
    Keywords poul b. rehberg ; evgeniy m. tareev ; endogenous creatinine clearance ; glomerular filtration rate ; Medicine ; R
    Language Russian
    Publishing date 2021-10-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Renal lesions in rheumatoid arthritis

    Natalia V Chebotareva / Sergey V Guliaev / Tatiana V Androsova / Sergey V Moiseev

    Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 2, Pp 588-

    Variants and risk factors

    2021  Volume 589

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Urinary biomarkers of kidney injury in patients treated with anti-VEGF drugs

    Katerina S. Grechukhina / Natalia V. Chebotareva / Liudmila G. Zhukova / Tatiana V. Androsova / Vladimir V. Karpov / Tatiana N. Krasnova

    Терапевтический архив, Vol 94, Iss 6, Pp 725-

    2022  Volume 730

    Abstract: Background. Antiangiogenic drugs are widely used in oncological practice and are aimed at inhibiting angiogenesis. Despite the high antitumor efficacy, their use may be limited by nephrotoxicity, and therefore the search for early biomarkers of kidney ... ...

    Abstract Background. Antiangiogenic drugs are widely used in oncological practice and are aimed at inhibiting angiogenesis. Despite the high antitumor efficacy, their use may be limited by nephrotoxicity, and therefore the search for early biomarkers of kidney damage remains relevant, which will preserve a favorable safety profile of therapy. Aim. To determine urinary biomarkers of tubular and podocyte damage in patients receiving treatment with antiangiogenic drugs. Materials and methods. The study included patients (n=50) who received intravenous anti-VEGF drugs (aflibercept, bevacizumab, ramucirumab) in various chemotherapy regimens. Concentrations of tubular damage markers KIM-1 (Kidney Injury Molecule-1) and NGAL (Neutrophil Gelatinase-Associated Lipocalin), hypoxia marker HIF-1 (Hypoxia-Inducible Factor 1-alpha) in urine samples were determined by enzyme-linked immunosorbent assay (ELISA) before treatment, and during 8 weeks of treatment. To assess the risk factors for kidney damage, a logistic regression analysis was performed with the inclusion of the main clinical and laboratory parameters. Results. A decrease in the calculated GFR of CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Formula) of less than 60 ml/min per 1.73 m2 at week 8 of treatment was noted in 42% of patients. An increase in NGAL, KIM-1, HIF-1 and nephrin in urine during the first two weeks of therapy predicted the development of renal damage by the 8th week of follow-up. When constructing ROC-curves, the high sensitivity and specificity of these urinary indicators as prognostic markers were established. Among the clinical and laboratory indicators, independent unfavorable prognostic factors of nephrotoxicity were an initial decrease in eGFR, a history of hypertension, an increase in the concentration of KIM-1 and HIF-1 in urine during the first two weeks of therapy. Conclusion. The predictors of renal damage in the treatment with antiangiogenic drugs were previously an increase in NGAL, KIM-1 and HIF-1 in urine during the first two ...
    Keywords kidney injury ; antiangiogenic therapy ; thrombotic microangiopathy ; early biomarkers ; kim-1 ; ngal ; hif-1α ; Medicine ; R
    Subject code 610 ; 616
    Language Russian
    Publishing date 2022-08-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Methotrexate-induced lung damage in a patient with rheumatoid arthritis

    Liubov A. Ponomareva / Daria V. Gurova / Elena N. Popova / Natalia V. Chebotareva / Inna B. Bondarenko / Sergey V. Moiseev

    Терапевтический архив, Vol 93, Iss 3, Pp 295-

    2021  Volume 299

    Abstract: We herein report a case of interstitial lung disease secondary to the use of methotrexate in a patient with rheumatoid arthritis. Differential diagnosis between pneumonitis caused by methotrexate in patients treated with basic methotrexate therapy and ... ...

    Abstract We herein report a case of interstitial lung disease secondary to the use of methotrexate in a patient with rheumatoid arthritis. Differential diagnosis between pneumonitis caused by methotrexate in patients treated with basic methotrexate therapy and interstitial pulmonary disease associated with rheumatoid arthritis is based on the clinical examination and instrumental data. The main condition for favorable clinical outcome in all drug-induced lung disease is drug withdrawal, what was proven in our report.
    Keywords methotrexate ; rheumatoid arthritis ; pulmonary fibrosis ; drug-induced lung disease ; Medicine ; R
    Language Russian
    Publishing date 2021-03-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Risk factors of kidney injury in patients with COVID-19

    Anastasia A. Shchepalina / Natalia V. Chebotareva / Aram A. Kitbalian / Pavel P. Potapov / Anna A. Nartova / Larisa A. Akulkina / Mikhail Yu. Brovko / Victoria I. Sholomova / Sergey V. Moiseev

    Терапевтический архив, Vol 94, Iss 6, Pp 743-

    2022  Volume 747

    Abstract: Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19. Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The ... ...

    Abstract Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19. Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The diagnosis was established on the basis of the positive SARS-CoV-2 swab test and/or typical radiologic findings on CT scans. Results. AKI complicated the clinical course in 92 (29.21%) cases. The independent risk factors of AKI were female sex, underline chronic kidney disease and the highest level of C-reactive protein during hospitalization. In the general group of patients were 41 (13%) lethal cases, in the group with AKI 32 (34.8%). Compared with those without AKI, patients with AKI had 4.065 (95% confidence interval 2.154 to 7.671) times the odds of death. Respiratory support, the highest serum creatinine and glucose levels appeared to be the risk factors of death among patients with AKI in the multivariable Cox regression. Conclusion. The clinical course of COVID-19 was complicated by AKI in 29% cases. The independent risk factors of AKI in patients with COVID-19 are underline chronic kidney disease, circulatory disorder and the highest level of C-reactive protein during hospitalization.
    Keywords covid-19 ; acute kidney injury ; risk factors ; Medicine ; R
    Subject code 610 ; 616
    Language Russian
    Publishing date 2022-08-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Evaluation of hemostasis disorders using the thrombodynamic test in patients with chronic glomerulonephritis with nephrotic syndrome

    Angelina S. Berns / Egor N. Sovetnikov / Natalia V. Chebotareva / Svetlana A. Berns / Alena D. Solonkina / Sergei V. Guliaev / Valentina V. Kraeva / Sergey V. Moiseev

    Терапевтический архив, Vol 94, Iss 6, Pp 738-

    2022  Volume 742

    Abstract: Background. Nephrotic syndrome (NS) is accompanied by a risk of thrombotic complications due to hypercoagulability. Routine laboratory tests are not sensitive enough to detect these disorders, and therefore the use of integral coagulation tests, ... ...

    Abstract Background. Nephrotic syndrome (NS) is accompanied by a risk of thrombotic complications due to hypercoagulability. Routine laboratory tests are not sensitive enough to detect these disorders, and therefore the use of integral coagulation tests, including a new thrombodynamic test (TT) in patients with NS, is of high relevance. Aim. Using a TT to determine hemostasis disorders in patients with chronic glomerulonephritis (CGN) with NS. Materials and methods. The study included 49 patients with CGN, mean age 37 years, of which 25 (51%) women and 24 (49%) men. Of all the examined patients, 20 (40.8%) of people had NS, 29 (59.2%) had no NS. The process of clot formation was assessed by TT. Results. According to TT, 30% (6/20) of patients with NS and 13.7% (4/29) of patients without NS have hypercoagulation with changes in parameters that go beyond the reference values. In patients with NS, an increase in clot density (D), clot formation rate (V) and clot size (CS) was found, especially when albumin decreased below 25 g/l. Negative correlations were found between the levels of albumin, creatinine and clot density (D), which reflects the level of hyperfibrinogenemia, the rate of clot formation (V) and the integral index of coagulation (CS). The results indicate mainly the activation of the plasma hemostasis due to the internal coagulation pathway. However, the correlation of Tlag (delay time for the onset of clot formation after contact of blood plasma with the insert-activator) with serum cholesterol levels may also indicate activation of the extrinsic coagulation pathway. Conclusion. In CGN patients with NS, activation of the plasma hemostasis is noted, as evidenced by an increase in the rate of formation (V) and size of the clot (CS) after 30 minutes, as well as the density of the formed clot (D).
    Keywords nephrotic syndrome ; blood coagulation disorders ; thrombodynamics ; hypoalbuminemia ; Medicine ; R
    Subject code 610
    Language Russian
    Publishing date 2022-08-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Successful treatment of a rare variant of mesangioproliferative glomerulonephritis with IgM deposits with Cyclosporin A

    Daria V. Gurova / Natalia V. Chebotareva / Anatoliy A. Vinogradov / Ekaterina V. Stavrovskaya / Lidia V. Lysenko

    Терапевтический архив, Vol 92, Iss 6, Pp 73-

    2020  Volume 75

    Abstract: We present a case with a rare variant of glomerulonephritis, IgM nephropathy, which occurs mainly with nephrotic syndrome. The clinical features of this variant of kidney damage are characterized; the pathogenetic and the transformation of this form of ... ...

    Abstract We present a case with a rare variant of glomerulonephritis, IgM nephropathy, which occurs mainly with nephrotic syndrome. The clinical features of this variant of kidney damage are characterized; the pathogenetic and the transformation of this form of nephritis into focal segmental glomerulosclerosis are discussed. The development of severe nephrotic syndrome at the beginning of the disease, the formation of secondary steroid resistance have confirmed this hypothesis and have justified the treatment with cyclosporin A aimed at the recovery of the function of the podocyte with remission of nephritis.
    Keywords igm nephropathy ; nephrotic syndrome ; focal segmental glomerulosclerosis ; cyclosporin ; Medicine ; R
    Language Russian
    Publishing date 2020-07-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Low serum Klotho level as a predictor of calcification of the heart and blood vessels in patients with CKD stages 2–5D

    Ludmila Yu. Milovanova / Lidia V. Lysenko (Kozlovskaya) / Svetlana Yu. Milovanova / Marina V. Taranova / Vasiliy V. Kozlov / Vladimir A. Reshetnikov / Marina V. Lebedeva / Tatyana V. Androsova / Daria O. Zubacheva / Natalia V. Chebotareva

    Терапевтический архив, Vol 92, Iss 6, Pp 37-

    2020  Volume 45

    Abstract: Cardiovascular calcification (CVC) makes a significant contribution to the manifestation of cardiovascular complications in patients with chronic kidney disease. Early CVC markers are currently being actively studied to optimize cardio-renoprotective ... ...

    Abstract Cardiovascular calcification (CVC) makes a significant contribution to the manifestation of cardiovascular complications in patients with chronic kidney disease. Early CVC markers are currently being actively studied to optimize cardio-renoprotective strategies. We performed a prospective comparative analysis of the following factors: FGF-23, a-Klotho, sclecrostin, phosphate, parathyroid hormone, the estimated glomerular filtration rate (eGFR), central systolic pressure as an independent determinant of CVC. Materials and methods. The study included 131 patients with chronic kidney disease 25D st. Serum levels of FGF-23, Klotho, and sclerostin were evaluated using the ELISA method. Vascular augmentation (stiffness) indices, central arterial pressure (using the SphygmoCor device), calcification of heart valves and the degree of aortic calcification (aortic radiography) were also investigated. The observation period was 2 years. Results. According to the Spearman correlation analysis, the percent of calcification increase and the change in Klotho level are most related. According to ROC analysis, a decrease in serum levels of Klotho by 50 units or more is a significant predictor of an increase in aortic calcification of 50% or more with a sensitivity of 86% and a specificity of 77%. Using logistic regression analysis, it was found that a serum Klotho level 632 pg/L predicts an eGFR below a median level of 48 ml/min/1.73 m2 with a sensitivity of 85.5% and a specificity of 78.5%. Wherein OR 17.477 (CI 95% 8.04637.962; p0.001). Conclusion. The factor most associated with CVC is Klotho. Decreased serum level of Klotho is a predictor of aortic calcification. In addition, the initial serum level of Klotho is a predictor of eGFR after 2 years.
    Keywords chronic kidney disease ; fibroblast growth factor 23 ; klotho ; sclerostin ; cardiovascular calcification ; heart remodeling ; Medicine ; R
    Subject code 616
    Language Russian
    Publishing date 2020-07-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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