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  1. AU="Natalie Krahmer"
  2. AU="do Amaral, Diego Serrasol"
  3. AU=David Aldana P.
  4. AU="Hawkins, W"
  5. AU="Elaheh Allahyari"
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  38. AU="Amjad, Muhammad"
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  42. AU="Carlile, Catherine R"
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  1. Artikel ; Online: Catching Lipid Droplet Contacts by Proteomics

    Natalie Krahmer / Matthias Mann

    Contact, Vol

    2019  Band 2

    Abstract: Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how ... ...

    Abstract Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.
    Schlagwörter Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

    Konxhe Kulaj / Alexandra Harger / Michaela Bauer / Özüm S. Caliskan / Tilak Kumar Gupta / Dapi Menglin Chiang / Edward Milbank / Josefine Reber / Angelos Karlas / Petra Kotzbeck / David N. Sailer / Francesco Volta / Dominik Lutter / Sneha Prakash / Juliane Merl-Pham / Vasilis Ntziachristos / Hans Hauner / Michael W. Pfaffl / Matthias H. Tschöp /
    Timo D. Müller / Stefanie M. Hauck / Benjamin D. Engel / Jantje M. Gerdes / Paul T. Pfluger / Natalie Krahmer / Kerstin Stemmer

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of ...

    Abstract Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of insulinotropic proteins from adipose tissue to β-cells.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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