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  1. Article ; Online: Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system

    Nathan McDannold / Yongzhi Zhang / Jeffrey G. Supko / Chanikarn Power / Tao Sun / Natalia Vykhodtseva / Alexandra J. Golby / David A. Reardon

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 19

    Abstract: Abstract We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated enhanced delivery of irinotecan chemotherapy to the brain and a rat glioma ... ...

    Abstract Abstract We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated enhanced delivery of irinotecan chemotherapy to the brain and a rat glioma model. Animals received three weekly sessions of FUS, FUS and 10 mg/kg irinotecan, or irinotecan alone. In each session, four volumetric sonications targeted 36 locations in one hemisphere. With feedback control based on recordings of acoustic emissions, 98% of the sonication targets (1045/1071) reached a pre-defined level of acoustic emission, while the probability of wideband emission (a signature for inertial cavitation) was than 1%. BBB disruption, evaluated by mapping the R1 relaxation rate after administration of an MRI contrast agent, was significantly higher in the sonicated hemisphere (P < 0.01). Histological evaluation found minimal tissue effects. Irinotecan concentrations in the brain were significantly higher (P < 0.001) with BBB disruption, but SN-38 was only detected in <50% of the samples and only with an excessive irinotecan dose. Irinotecan with BBB disruption did not impede tumor growth or increase survival. Overall these results demonstrate safe and controlled BBB disruption with a low-frequency clinical TcMRgFUS device. While irinotecan delivery to the brain was not neurotoxic, it did not improve outcomes in the F98 glioma model.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.

    Muna Aryal / Krisztina Fischer / Caroline Gentile / Salvatore Gitto / Yong-Zhi Zhang / Nathan McDannold

    PLoS ONE, Vol 12, Iss 1, p e

    2017  Volume 0166061

    Abstract: Many blood-borne substances attempting to pass through the luminal membrane of brain endothelial cells are acted upon by a variety of metabolizing enzymes or are actively expelled back into the capillary lumen by embedded efflux transporters, such as ... ...

    Abstract Many blood-borne substances attempting to pass through the luminal membrane of brain endothelial cells are acted upon by a variety of metabolizing enzymes or are actively expelled back into the capillary lumen by embedded efflux transporters, such as Permeability-glycoprotein (Pgp). Overexpression of this protein has also been linked to multidrug resistance in cancer cells. Previous studies have shown that focused ultrasound (FUS), when combined with a microbubble agent, has ability to temporarily disrupt blood-brain barrier (BBBD). In this work, we investigated whether modulation of Pgp expression is part of the FUS-induced effects. We found that ultrasound can temporarily suppress Pgp expression. When BBBD was produced at 0.55 MPa, Pgp was suppressed up to 48 hours and restored by 72 hours. At 0.81 MPa, suppression can last 72 hours or longer. These findings support the idea that microbubble-enhanced FUS disrupts the functional components of the BBB through suppression of drug efflux.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.

    Muna Aryal / Krisztina Fischer / Caroline Gentile / Salvatore Gitto / Yong-Zhi Zhang / Nathan McDannold

    PLoS ONE, Vol 12, Iss 1, p e

    2017  Volume 0166061

    Abstract: Many blood-borne substances attempting to pass through the luminal membrane of brain endothelial cells are acted upon by a variety of metabolizing enzymes or are actively expelled back into the capillary lumen by embedded efflux transporters, such as ... ...

    Abstract Many blood-borne substances attempting to pass through the luminal membrane of brain endothelial cells are acted upon by a variety of metabolizing enzymes or are actively expelled back into the capillary lumen by embedded efflux transporters, such as Permeability-glycoprotein (Pgp). Overexpression of this protein has also been linked to multidrug resistance in cancer cells. Previous studies have shown that focused ultrasound (FUS), when combined with a microbubble agent, has ability to temporarily disrupt blood-brain barrier (BBBD). In this work, we investigated whether modulation of Pgp expression is part of the FUS-induced effects. We found that ultrasound can temporarily suppress Pgp expression. When BBBD was produced at 0.55 MPa, Pgp was suppressed up to 48 hours and restored by 72 hours. At 0.81 MPa, suppression can last 72 hours or longer. These findings support the idea that microbubble-enhanced FUS disrupts the functional components of the BBB through suppression of drug efflux.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

    Park, Juyoung / Muna Aryal / Natalia Vykhodtseva / Nathan McDannold / Yong-Zhi Zhang

    Journal of Controlled Release. 2016,

    2016  

    Abstract: Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as ... ...

    Abstract Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate the relationship between these changes and the resulting concentration of the chemotherapy agent doxorubicin (DOX). 9L gliosarcoma cells were implanted in both hemispheres in male rats. At day 10–12 after implantation, FUS-induced BTB disruption using 690kHz ultrasound and Definity microbubbles was performed in one of the tumors and in a normal brain region in each animal. After FUS, DOX was administered at a dose of 5.67mg/kg. The resulting DOX concentration was measured via fluorometry at 1 or 24h after FUS. The transfer coefficient Ktrans describing extravasation of the MRI contrast agent Gd-DTPA was significantly increased in both the sonicated tumors and in the normal brain tissue (P<0.001) between the two DCE-MRI acquisitions obtained before and after FUS, while no significant difference was found in the controls (non-sonicated tumor/normal brain tissue). DOX concentrations were also significantly larger than controls in both the sonicated tumors and in the normal tissue volumes at 1 and 24h after sonication. The DOX concentrations were significantly larger (P<0.01) in the control tumors harvested 1h after FUS than in those harvested at 24h, when the tumor concentrations were not significantly different than in the non-sonicated normal brain. In contrast, there was no significant difference in the DOX concentrations between the tumors harvested at 1 and 24h after FUS or in the concentrations measured in the brain at these time points. The transfer coefficient Ktrans for Gd-DTPA and the drug concentrations showed a good linear correlation (R2=0.56). Overall, these data suggest that FUS and microbubbles can not only increase DOX delivery across the BBB and BTB, but that it is retained in the tissue at significantly enhanced levels for at least 24h. Such enhanced retention may increase the potency of this chemotherapy agent and allow for reduced systemic doses. Furthermore, MRI-based estimates of Gd-DTPA transport across these barriers might be useful to estimate local DOX concentrations in the tumor and in the surrounding normal tissue.
    Keywords administered dose ; blood-brain barrier ; brain ; doxorubicin ; drug therapy ; fluorometry ; magnetic resonance imaging ; males ; microbubbles ; models ; neoplasms ; permeability ; rats
    Language English
    Size p. .
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2016.10.011
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring.

    Costas D Arvanitis / Margaret S Livingstone / Natalia Vykhodtseva / Nathan McDannold

    PLoS ONE, Vol 7, Iss 9, p e

    2012  Volume 45783

    Abstract: The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major issue has been a lack of control ... ...

    Abstract The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major issue has been a lack of control over the procedure to ensure both safe and effective treatment. Here, we evaluated the use of passively-recorded acoustic emissions as a means to achieve this control. An acoustic emissions monitoring system was constructed and integrated into a clinical transcranial MRI-guided focused ultrasound system. Recordings were analyzed using a spectroscopic method that isolates the acoustic emissions caused by the microbubbles during sonication. This analysis characterized and quantified harmonic oscillations that occur when the BBB is disrupted, and broadband emissions that occur when tissue damage occurs. After validating the system's performance in pilot studies that explored a wide range of exposure levels, the measurements were used to control the ultrasound exposure level during transcranial sonications at 104 volumes over 22 weekly sessions in four macaques. We found that increasing the exposure level until a large harmonic emissions signal was observed was an effective means to ensure BBB disruption without broadband emissions. We had a success rate of 96% in inducing BBB disruption as measured by in contrast-enhanced MRI, and we detected broadband emissions in less than 0.2% of the applied bursts. The magnitude of the harmonic emissions signals was significantly (P<0.001) larger for sonications where BBB disruption was detected, and it correlated with BBB permeabilization as indicated by the magnitude of the MRI signal enhancement after MRI contrast administration (R(2) = 0.78). Overall, the results indicate that harmonic emissions can be a used to control focused ultrasound-induced BBB disruption. These results are promising for clinical translation of this technology.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: 5th International Symposium on Focused Ultrasound

    Menashe Zaaroor / Alon Sinai / Dorit Goldsher / Ayelet Eran / Maria Nassar / Ilana Schlesinger / Jonathon Parker / Vinod Ravikumar / Pejman Ghanouni / Sherman Stein / Casey Halpern / Vibhor Krishna / Amelia Hargrove / Punit Agrawal / Barbara Changizi / Eric Bourekas / Michael Knopp / Ali Rezai / Brian Mead /
    Namho Kim / Panagiotis Mastorakos / Jung Soo Suk / Wilson Miller / Alexander Klibanov / Justin Hanes / Richard Price / Shutao Wang / Oluyemi Olumolade / Tara Kugelman / Vernice Jackson-Lewis / Maria Eleni (Marilena) Karakatsani / Yang Han / Serge Przedborski / Elisa Konofagou / Kullervo Hynynen / Isabelle Aubert / Gerhard Leinenga / Rebecca Nisbet / Robert Hatch / Anneke Van der Jeugd / Harrison Evans / Jürgen Götz / Ann Van der Jeugd / Paul Fishman / Paul Yarowsky / Victor Frenkel / Shen Wei-Bin / Ben Nguyen / Carlos Sierra Sanchez / Camilo Acosta / Cherry Chen / Shih-Ying Wu / Muna Aryal / Iason T. Papademetriou / Yong-Zhi Zhang / Chanikarn Power / Nathan McDannold / Tyrone Porter / Zsofia Kovacs / Saejeong Kim / Neekita Jikaria / Farhan Qureshi / Michele Bresler / Joseph Frank / Henrik Odéen / George Chiou / John Snell / Nick Todd / Bruno Madore / Dennis Parker / Kim Butts Pauly / Mike Marx / Sumeeth Jonathan / William Grissom / Costas Arvanitis / Gregory Clement / Joshua de Bever / Allison Payne / Douglas Christensen / Guillaume Maimbourg / Mathieu David Santin / Alexandre Houdouin / Stéphane Lehericy / Mickael Tanter / Jean Francois Aubry / Christian Federau / Beat Werner / Dong-Guk Paeng / Zhiyuan Xu / Anders Quigg / Matt Eames / Changzhu Jin / Ashli Everstine / Jason Sheehan / M. Beatriz Lopes / Neal Kassell / James Drake / Karl Price / Lior Lustgarten / Vivian Sin / Charles Mougenot / Elizabeth Donner / Emily Tam / Mojgan Hodaie / Adam Waspe / Thomas Looi / Samuel Pichardo / Wonhye Lee / Yong An Chung / Yujin Jung / In-Uk Song / Seung-Schik Yoo / Hyun-Chul Kim / Jong-Hwan Lee / Charles Caskey / Wolf Zinke / Josh Cosman / Jillian Shuman / Jeffrey Schall / Christian Aurup / Hong Chen / Hermes Kamimura / Antonio Carneiro / Tao Sun / Navid Nazai / Sam Patz / Margaret Livingstone / Todd Mainprize / Yuexi Huang / Ryan Alkins / Martin Chapman / James Perry / Nir Lipsman / Allison Bethune / Arjun Sahgal / Maureen Trudeau / Hao-Li Liu / Po-Hung Hsu / Kuo-Chen Wei / Jonathan Sutton / Phillip Alexander / Eric Miller / Thiele Kobus / Alexandre Carpentier / Michael Canney / Alexandre Vignot / Kevin Beccaria / Delphine Leclercq / Cyril Lafon / Jean Yves Chapelon / Khe Hoang-Xuan / Jean-Yves Delattre / Ahmed Idbaih / David Moore / Alexis Xu / Paul Schmitt / Jessica Foley / Jonathan Sukovich / Charles Cain / Aditya Pandey / Neeraj Chaudhary / Sandra Camelo-Piragua / Steven Allen / Jon Cannata / Dejan Teofilovic / Jim Bertolina / Timothy Hall / Zhen Xu / Julien Grondin / Vincent Ferrera / Gail ter Haar / Petros Mouratidis / Elizabeth Repasky / Kelsie Timbie / Lena Badr / Benjamin Campbell / John McMichael / Andrew Buckner / Jessica Prince / Aaron Stevens / Timothy Bullock / Karin Skalina / Chandan Guha / Franco Orsi / Guido Bonomo / Paolo Della Vigna / Giovanni Mauri / Gianluca Varano / George Schade / Yak-Nam Wang / Venu Pillarisetty / Joo Ha Hwang / Vera Khokhlova / Michael Bailey / Tatiana Khokhlova / Ilya Sinilshchikov / Petr Yuldashev / Yulia Andriyakhina / Wayne Kreider / Adam Maxwell / Oleg Sapozhnikov / Ari Partanen / Jonathan Lundt / Tobias Preusser / Sabrina Haase / Mario Bezzi / Jürgen Jenne / Thomas Langø / Massimo Midiri / Michael Mueller / Giora Sat / Christine Tanner / Stephan Zangos / Matthias Guenther / Andreas Melzer / Arianna Menciassi / Selene Tognarelli / Andrea Cafarelli / Alessandro Diodato / Gastone Ciuti / Sven Rothluebbers / Julia Schwaab / Jan Strehlow / Senay Mihcin / Steffen Tretbar / Thomas Payen / Carmine Palermo / Steve Sastra / Kenneth Olive / Matthew Adams / Vasant Salgaonkar / Serena Scott / Graham Sommer / Chris Diederich / Joan Vidal-Jove / Eloi Perich / Antonio Ruiz / Manuela Velat / David Melodelima / Aurelien Dupre / Jeremy Vincenot / Chen Yao / David Perol / Michel Rivoire / Samantha Tucci / Lisa Mahakian / Brett Fite / Elizabeth Ingham / Sarah Tam / Chang-il Hwang / David Tuveson / Katherine Ferrara / Stephen Scionti / Lili Chen / Dusica Cvetkovic / Xiaoming Chen / Roohi Gupta / Bin Wang / Charlie Ma / Kenneth Bader / Kevin Haworth / Christy Holland / Narendra Sanghvi / Roy Carlson / Wohsing Chen / Christian Chaussy / Stefan Thueroff / Claudio Cesana / Carlo Bellorofonte / Qingguo Wang / Han Wang / Shengping Wang / Junhai Zhang / Alberto Bazzocchi / Alessandro Napoli / Robert Staruch / Chenchen Bing / Sumbul Shaikh / Joris Nofiele / Debra Szczepanski / Michelle Wodzak Staruch / Noelle Williams / Theodore Laetsch / Rajiv Chopra / Jarrett Rosenberg / Rachelle Bitton / Suzanne LeBlang / Joshua Meyer / Mark Hurwitz / Pavel Yarmolenko / Haydar Celik / Avinash Eranki / Viktoriya Beskin / Domiciano Santos / Janish Patel / Matthew Oetgen / AeRang Kim / Peter Kim / Karun Sharma / Alexander Chisholm / Dionne Aleman / Roberto Scipione / Michael Temple / Joao Guilherme Amaral / Ruby Endre / Maria Lamberti-Pasculli / Joost de Ruiter / Fiona Campbell / Jennifer Stimec / Samit Gupta / Manoj Singh / Sevan Hopyan / Gregory Czarnota / David Brenin / Carrie Rochman / Roussanka Kovatcheva / Jordan Vlahov / Katja Zaletel / Julian Stoinov / Matthew Bucknor / Viola Rieke / Jenny Shim / Korgun Koral / Brian Lang / Carlos Wong / Heather Lam / Alexander Shinkov / Jim Hu / Xi Zhang / Jonathan Macoskey / Kimberly Ives / Gabe Owens / Hitinder Gurm / Jiaqi Shi / Matthew Pizzuto / Christopher Dillon / Ivy Christofferson / Elaine Hilas / Jill Shea / Paul Greillier / Bénédicte Ankou / Francis Bessière / Ali Zorgani / Mathieu Pioche / Wojciech Kwiecinski / Julie Magat / Sandrine Melot-Dusseau / Romain Lacoste / Bruno Quesson / Mathieu Pernot / Stefan Catheline / Philippe Chevalier / Fabrice Marquet / Pierre Bour / Fanny Vaillant / Sana Amraoui / Rémi Dubois / Philippe Ritter / Michel Haïssaguerre / Mélèze Hocini / Olivier Bernus / Pamela Tebebi / Scott Burks / Blerta Milo / Michael Gertner / Jimin Zhang / Andrew Wong / Yu Liu / Azadeh Kheirolomoom / Jai Seo / Katherine Watson / Hua Zhang / Josquin Foiret / Alexander Borowsky / Doudou Xu / Maya Thanou / Miguell Centelles / Mike Wright / Maral Amrahli / Po-Wah So / Wladyslaw Gedroyc / Esther Kneepkens / Edwin Heijman / Jochen Keupp / Steffen Weiss / Klaas Nicolay / Holger Grüll / Matthew Nagle / Anastasia V. Nikolaeva / Marina E. Terzi / Sergey A. Tsysar / Bryan Cunitz / Pierre Mourad / Matthew Downs / Georgiana Yang / Qi Wang / Johnny Chen / Justin Farry / Adam Dixon / Zhongmin Du / Ali Dhanaliwala / John Hossack / Ashish Ranjan / Danny Maples / Rachel Wardlow / Jerry Malayer / Akhilesh Ramachandran / Hirofumi Namba / Motohiro Kawasaki / Masashi Izumi / Katsuhito Kiyasu / Ryuichi Takemasa / Masahiko Ikeuchi / Takahiro Ushida / Calum Crake / Satya V. V. N. Kothapalli / Wan Leighton / Zhaorui Wang / H. Michael Gach / William Straube / Michael Altman / Young-sun Kim / Hyo Keun Lim / Hyunchul Rhim / Johanna van Breugel / Manon Braat / Chrit Moonen / Maurice van den Bosch / Mario Ries / Cristina Marrocchio / Susan Dababou / Jae Young Lee / Hyun Hoon Chung / Soo Yeon Kang / Kook Jin Kang / Keon Ho Son / Dandan Zhang / Juan Plata / Peter Jones / Aurea Pascal-Tenorio / Donna Bouley / Aaron Bond / Robert Dallapiazza / Diane Huss / Amy Warren / Scott Sperling / Ryder Gwinn / Binit Shah / W. Jeff Elias / Colleen Curley / Ying Zhang / Karina Negron / Roger Abounader / Gesthimani Samiotaki / Tsang-Wei Tu / Georgios Papadakis / Dima Hammoud / Matthew Silvestrini / Frank Wolfram / Daniel Güllmar / Juergen Reichenbach / Denis Hofmann / Joachim Böttcher / Harald Schubert / Thomas G. Lesser / Scott Almquist / Francisco Camarena / Sergio Jiménez-Gambín / Noé Jiménez / Jin Woo Chang / Vandiver Chaplin / Rebekah Griesenauer / Michael Miga / Nicholas Ellens / Raag Airan / Alfredo Quinones-Hinojosa / Keyvan Farahani / Xue Feng / Samuel Fielden / Li Zhao / Max Wintermark / Craig Meyer / Sijia Guo / Xin Lu / Jiachen Zhuo / Su Xu / Rao Gullapalli / Dheeraj Gandhi / Omer Brokman / Hongchae Baek / Hyungmin Kim / Steven Leung / Taylor Webb / Natalia Vykhodtseva / Thai-Son Nguyen / Chang Kyu Park / Sang Man Park / Na Young Jung / Min Soo Kim / Won Seok Chang / Hyun Ho Jung / Michael Plaksin / Yoni Weissler / Shy Shoham / Eitan Kimmel / Pavel B. Rosnitskiy / Steve Krupa / Eilon Hazan / Omer Naor / Yoav Levy / Noam Maimon / Inbar Brosh / Itamar Kahn / Jessica Cahill / Elodie Constanciel Colas / Adrian Wydra / Roman Maev / Amirah Aly / Ozge Sesenoglu-Laird / Linas Padegimas / Mark Cooper / Barbara Waszczak / Seruz Tehrani / Craig Slingluff / James Larner / Kumari Andarawewa / Eugene Ozhinsky / Rutwik Shah / Roland Krug / Roel Deckers / Sabine Linn / Britt Suelmann / Arjen Witkamp / Paul Vaessen / Paul van Diest / Lambertus W. Bartels / Clemens Bos / Nicolas Borys / Gert Storm / Elsken Van der Wall / Navid Farr / Moez Alnazeer / Prateek Katti / Bradford Wood / Alexis Farrer / Cyril Ferrer / Baudouin Denis de Senneville / Marijn van Stralen / Jingfei Liu / J. Kent Leach / Stephan Zidowitz / Hsin-Lun Lee / Fang-Chi Hsu / Chia-Chun Kuo / Shiu-Chen Jeng / Tung-Ho Chen / Nai-Yi Yang / Jeng-Fong Chiou / Yi-tzu Kao / Chia-Hsin Pan / Jing-Fu Wu / Yi-Chieh Tsai / Sara Johnson / Dawei Li / Ye He / Ioannis Karakitsios / Michael Schwenke / Daniel Demedts / Xu Xiao / Ian Cavin / Emilee Minalga / Robb Merrill / Rock Hadley / Pascal Ramaekers / Martijn de Greef / Kian Shahriari / Mohammad Hossein Parvizi / Kiana Asadnia / Marzieh Chamanara / Seyed Kamran Kamrava / Hamid Reza Chabok / Ruben Stein / Sébastien Muller / Jeremy Tan / Cornel Zachiu / Hans-Peter Erasmus / Glen Van Arsdell / Lee Benson / Kee W. Jang / Mary Angstadt / Bobbi Lewis / Hailey McLean / Martijn Hoogenboom / Dylan Eikelenboom / Martijn den Brok / Pieter Wesseling / Arend Heerschap / Jurgen Fütterer / Gosse Adema / Kevin Wang / Pei Zhong / Joyce Joy / Helen McLeod / Harry Kim / Matthew Lewis / Arda Ozilgen / Peter Zahos / Dezba Coughlin / Xinyan Tang / Jeff Lotz / Kathleen Jedruszczuk / Amitabh Gulati / Stephen Solomon / Elena Kaye / John Mugler / Gaetano Barbato / Gian Luca Scoarughi / Cristiano Corso / Alessandro Gorgone / Ilaria Giuseppina Migliore / Zachary Larrabee / Arik Hananel / Jean-Francois Aubry / Ayele Negussie / Emmanuel Wilson / Reza Seifabadi / Hyungwon Moon / Jeeun Kang / Changbeom Sim / Jin Ho Chang / Hyuncheol Kim / Hak Jong Lee / Noboru Sasaki / Mitsuyoshi Takiguchi / Lukas Sebeke / Xi Luo / Bram de Jager / Maurice Heemels / Christopher Abraham / Laura Curiel / Rémi Berriet / Margit Janát-Amsbury / Joseph Corea / Patrick Peiyong Ye / Ana Clauda Arias / Micheal Lustig / Bryant Svedin

    Journal of Therapeutic Ultrasound, Vol 4, Iss S1, Pp 1-

    2016  Volume 113

    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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