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  1. AU="Natividad Benito"
  2. AU=Gzsi Andrs
  3. AU="Yong Soo Choi"
  4. AU="Koçer, Serdar"
  5. AU="Qiu, Shuang"
  6. AU="Quarta, Raffaella"
  7. AU="Samuel Fernández-Carnero"
  8. AU="Kastner, Brigitte"
  9. AU=Robins Harlan
  10. AU="Sundaram, Baskaran"
  11. AU=Whitby R L D
  12. AU="Michel M. Santos"
  13. AU=Chong Yong-Yeow
  14. AU="Posca-Maina, Marcela"
  15. AU="Trupin, Laura"
  16. AU="Bezerra, Antônio Diego M."
  17. AU="Xiao-hua Lin"
  18. AU="Ksenia Zaytseva" AU="Ksenia Zaytseva"
  19. AU="Michael N Alexis"
  20. AU="Rivero-Moreno, Yeisson"
  21. AU="Köllmann, Nienke"
  22. AU="Maveddat, Ashley"
  23. AU=Boerrigter Guido
  24. AU=Wajant H
  25. AU=Marsboom Glenn
  26. AU="Xuwei, Tao"
  27. AU="Matias, Ricardo"
  28. AU="Daly, Brian P."
  29. AU="Bissaro, Maicol"
  30. AU="Mateo, Mathieu"
  31. AU="Yousra Aouinati"
  32. AU=Butros Linda
  33. AU=CASTORENA-GONZALEZ JORGE A.
  34. AU=Grtsch Bettina
  35. AU="José M. Ramada"
  36. AU="Parashar, Prashant"

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  1. Artikel ; Online: Acute Bacterial Meningitis in Healthy Adult Patients

    Virginia Pomar / Natividad Benito / Pol Duch / Marc Colomé / Alba Rivera / Pere Domingo

    Journal of Clinical Medicine, Vol 12, Iss 3624, p

    A Prospective Cohort Study

    2023  Band 3624

    Abstract: Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in ... ...

    Abstract Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in patients without comorbidities. Patients and methods: Single-center, prospective observational cohort study of 328 adults with BM hospitalized in a tertiary university hospital in Barcelona (Spain). We compared the features of infections diagnosed in 1982–2000 and 2001–2019. The main outcome measure was in-hospital mortality. Results: The median age of the patients increased from 37 to 45 years. Meningococcal meningitis significantly diminished (56% versus 31%, p < 0.000) whereas listerial meningitis increased (1.2% versus 8%, p = 0.004). Systemic complications were more common in the second period, although mortality did not vary significantly between periods (10.4% versus 9.2%). However, after adjusting for relevant variables, infection in the second period was associated with lower risk death. Conclusions: Adult patients without underlying comorbidities that developed BM in recent years were older and more likely to have pneumococcal or listerial infections and systemic complications. In-hospital death was less likely in the second period, after adjusting for risk factors of mortality.
    Schlagwörter spontaneous meningitis ; bacterial meningitis ; cerebrospinal fluid analysis ; healthy patient ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Pulmonary Thrombosis or Embolism in a Large Cohort of Hospitalized Patients With Covid-19

    Natividad Benito / David Filella / Jose Mateo / Ana M. Fortuna / Juan E. Gutierrez-Alliende / Nerea Hernandez / Ana M. Gimenez / Virginia Pomar / Ivan Castellvi / Hector Corominas / Jordi Casademont / Pere Domingo

    Frontiers in Medicine, Vol

    2020  Band 7

    Abstract: Objective: We set out to analyze the incidence and predictive factors of pulmonary embolism (PE) in hospitalized patients with Covid-19.Methods: We prospectively collected data from all consecutive patients with laboratory-confirmed Covid-19 admitted to ... ...

    Abstract Objective: We set out to analyze the incidence and predictive factors of pulmonary embolism (PE) in hospitalized patients with Covid-19.Methods: We prospectively collected data from all consecutive patients with laboratory-confirmed Covid-19 admitted to the Hospital de la Santa Creu i Sant Pau, a university hospital in Barcelona, between March 9 and April 15, 2020. Patients with suspected PE, according to standardized guidelines, underwent CT pulmonary angiography (CTPA).Results: A total of 1,275 patients with Covid-19 were admitted to hospital. CTPA was performed on 76 inpatients, and a diagnosis of PE was made in 32 (2.6% [95%CI 1.7–3.5%]). Patients with PE were older, and they exhibited lower PaO2:FiO2 ratios and higher levels of D-dimer and C-reactive protein (CRP). They more often required admission to ICU and mechanical ventilation, and they often had longer hospital stays, although in-hospital mortality was no greater than in patients without PE. High CRP and D-dimer levels at admission (≥150 mg/L and ≥1,000 ng/ml, respectively) and a peak D-dimer ≥6,000 ng/ml during hospital stay were independent factors associated with PE. Prophylactic low molecular weight heparin did not appear to prevent PE. Increased CRP levels correlated with increased D-dimer levels and both correlated with a lower PaO2:FiO2.Conclusions: The 2.6% incidence of PE in Covid-19 hospitalized patients is clearly high. Higher doses of thromboprophylaxis may be required to prevent PE, particularly in patients at increased risk, such as those with high levels of CRP and D-dimer at admission. These findings should be validated in future studies.
    Schlagwörter COVID-19 ; pulmonary thrombosis ; pulmonary embolism (MeSH) ; thromboprophylaxis ; anticoagulant (MeSH) ; thromboinflammation ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Krebs von den Lungen-6 glycoprotein circulating levels are not useful as prognostic marker in COVID-19 pneumonia

    Ivan Castellví / Diego Castillo / Hèctor Corominas / Anaís Mariscal / Sandra Orozco / Natividad Benito / Virginia Pomar / Andrés Baucells / Isabel Mur / David de la Rosa-Carrillo / David Lobo / Ana Milena Millan / Nerea Hernández de Sosa / David Filella / Laia Matas / Laura Martínez-Martínez / Cándido Juarez / Jordi Casademont / Pere Domingo

    Frontiers in Medicine, Vol

    A large prospective cohort study

    2022  Band 9

    Abstract: Coronavirus disease 2019 (COVID-19) has rapidly expanded worldwide. Currently, there are no biomarkers to predict respiratory worsening in patients with mild to moderate COVID-19 pneumonia. Small studies explored the use of Krebs von de Lungen-6 ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has rapidly expanded worldwide. Currently, there are no biomarkers to predict respiratory worsening in patients with mild to moderate COVID-19 pneumonia. Small studies explored the use of Krebs von de Lungen-6 circulating serum levels (sKL-6) as a prognostic biomarker of the worsening of COVID-19 pneumonia. We aimed at a large study to determine the prognostic value of sKL-6 in predicting evolving trends in COVID-19. We prospectively analyzed the characteristics of 836 patients with COVID-19 with mild lung disease on admission. sKL-6 was obtained in all patients at least at baseline and compared among patients with or without respiratory worsening. The receiver operating characteristic curve was used to find the optimal cutoff level. A total of 159 (19%) patients developed respiratory worsening during hospitalization. Baseline sKL-6 levels were not higher in patients who had respiratory worsening (median {IQR} 315.5 {209–469} vs. 306 {214–423} U/ml p = 0.38). The last sKL-6 and the change between baseline and last sKL-6 were higher in the respiratory worsening group (p = 0.02 and p < 0.0001, respectively). The best sKL-6 cutoff point for respiratory worsening was 497 U/ml (area under the curve 0.52; 23% sensitivity and 85% specificity). sKL-6 was not found to be an independent predictor of respiratory worsening. A conditional inference tree (CTREE) was not useful to discriminate patients at risk of worsening. We found that sKL-6 had a low sensibility to predict respiratory worsening in patients with mild-moderate COVID-19 pneumonia and may not be of use to assess the risk of present respiratory worsening in inpatients with COVID-19 pneumonia.
    Schlagwörter COVID-19 ; Krebs von den Lungen-6 (KL-6) ; pneumonia ; biomarker ; predictor ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Validation of a colistin plasma concentration breakpoint as a predictor of nephrotoxicity in patients treated with colistin methanesulfonate

    Horcajada, Juan P / Beatriz Mirelis / Carmina Martí / Concepción Segura / Erika Esteve / Jordi Cuquet / Luisa Sorlí / Milagro Montero / Natividad Benito / Nuria Campillo / Pau Garro / Santiago Grau / Sonia Luque / Virginia Pomar

    International journal of antimicrobial agents. 2016 Dec., v. 48, no. 6

    2016  

    Abstract: Nephrotoxicity limits the effective use of colistin for the treatment of multidrug-resistant Gram-negative bacteria (MDR-GNB) infections. We previously defined a steady-state colistin plasma concentration (Css) of 2.42 mg/L that predicted nephrotoxicity ... ...

    Abstract Nephrotoxicity limits the effective use of colistin for the treatment of multidrug-resistant Gram-negative bacteria (MDR-GNB) infections. We previously defined a steady-state colistin plasma concentration (Css) of 2.42 mg/L that predicted nephrotoxicity at end of treatment (EOT). The objective of this study was to validate this breakpoint in a prospective cohort. This was a multicentre, prospective, observational study conducted at three hospitals with a cohort of patients treated for MDR-GNB infection with colistin methanesulfonate from September 2011 until January 2015. Nephrotoxicity was evaluated at Day 7 and at EOT using the RIFLE criteria. Css values were measured and analysed using HPLC. Taking the previously defined breakpoint for colistin concentration as a criterion, patients were divided into two groups (Css, ≤2.42 mg/L vs. >2.42 mg/L). Sixty-four patients were included. Seven patients (10.9%) had a Css > 2.42 mg/L and were compared with the remaining patients. Bivariate analysis showed that patients with a Css > 2.42 mg/L were older and had a significantly higher incidence of nephrotoxicity at Day 7 and EOT. Although not statistically significant, nephrotoxicity occurred earlier in these patients (6.2 days vs. 9.2 days in patients with lower Css; P = 0.091). Multivariate analysis of nephrotoxicity showed that Css > 2.42 mg/L was the only predictive factor. Nephrotoxicity was more frequent and occurred earlier in patients with colistin plasma concentrations higher than the previously defined breakpoint (2.42 mg/L). Colistin therapeutic drug monitoring should be routinely considered to avoid reaching this toxicity threshold and potential clinical consequences.
    Schlagwörter bivariate analysis ; colistin ; drugs ; Gram-negative bacteria ; high performance liquid chromatography ; hospitals ; monitoring ; multiple drug resistance ; nephrotoxicity ; observational studies ; patients
    Sprache Englisch
    Erscheinungsverlauf 2016-12
    Umfang p. 725-727.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2016.08.020
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: The Impact of Surgical Strategy and Rifampin on Treatment Outcome in Cutibacterium Periprosthetic Joint Infections.

    Kusejko, Katharina / Auñón, Álvaro / Jost, Bernhard / Natividad, Benito / Strahm, Carol / Thurnheer, Christine / Pablo-Marcos, Daniel / Slama, Dorsaf / Scanferla, Giulia / Uckay, Ilker / Waldmann, Isabelle / Esteban, Jaime / Lora-Tamayo, Jaime / Clauss, Martin / Fernandez-Sampedro, Marta / Wouthuyzen-Bakker, Marjan / Ferrari, Matteo Carlo / Gassmann, Natalie / Sendi, Parham /
    Jent, Philipp / Morand, Philippe C / Vijayvargiya, Prakhar / Trebše, Rihard / Patel, Robin / Kouyos, Roger D / Corvec, Stéphane / Kramer, Tobias Siegfried / Stadelmann, Vincent A / Achermann, Yvonne

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Band 72, Heft 12, Seite(n) e1064–e1073

    Abstract: Background: Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These infections are often treated with β-lactams or clindamycin as monotherapy, or in combination with rifampin. Clinical evidence supporting the value of ... ...

    Abstract Background: Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These infections are often treated with β-lactams or clindamycin as monotherapy, or in combination with rifampin. Clinical evidence supporting the value of adding rifampin for treatment of Cutibacterium PJI is lacking.
    Methods: In this multicenter retrospective study, we evaluated patients with Cutibacterium PJI and a minimal follow-up of 12 months. The primary endpoint was clinical success, defined by the absence of infection relapse or new infection. We used Fisher's exact tests and Cox proportional hazards models to analyze the effect of rifampin and other factors on clinical success after PJI.
    Results: We included 187 patients (72.2% male, median age 67 years) with a median follow-up of 36 months. The surgical intervention was a 2-stage exchange in 95 (50.8%), 1-stage exchange in 51 (27.3%), debridement and implant retention (DAIR) in 34 (18.2%), and explantation without reimplantation in 7 (3.7%) patients. Rifampin was included in the antibiotic regimen in 81 (43.3%) cases. Infection relapse occurred in 28 (15.0%), and new infection in 13 (7.0%) cases. In the time-to-event analysis, DAIR (adjusted hazard ratio [HR] = 2.15, P = .03) and antibiotic treatment over 6 weeks (adjusted HR = 0.29, P = .0002) significantly influenced treatment failure. We observed a tentative evidence for a beneficial effect of adding rifampin to the antibiotic treatment-though not statistically significant for treatment failure (adjusted HR = 0.5, P = .07) and not for relapses (adjusted HR = 0.5, P = .10).
    Conclusions: We conclude that a rifampin combination is not markedly superior in Cutibacterium PJI, but a dedicated prospective multicenter study is needed.
    Mesh-Begriff(e) Aged ; Anti-Bacterial Agents/therapeutic use ; Debridement ; Female ; Humans ; Male ; Prospective Studies ; Prosthesis-Related Infections/drug therapy ; Retrospective Studies ; Rifampin/therapeutic use ; Treatment Outcome
    Chemische Substanzen Anti-Bacterial Agents ; Rifampin (VJT6J7R4TR)
    Sprache Englisch
    Erscheinungsdatum 2020-12-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1839
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Short- versus long-duration levofloxacin plus rifampicin for acute staphylococcal prosthetic joint infection managed with implant retention: a randomised clinical trial

    Lora-Tamayo, Jaime / Alex Soriano / Alfredo Jover-Sáenz / Antonio Ramos / Carles Pigrau / Enrique Sandoval / Gorane Euba / Javier Ariza / Javier Cobo / José Antonio Iribarren / Josu Mirena Baraia-Etxaburu / Juan Pablo Horcajada / Julián Palomino / Luis Falgueras / Mar Sánchez-Somolinos / María Dolores del Toro / Marta Fernández-Sampedro / Melchor Riera / Natividad Benito

    International journal of antimicrobial agents. 2016 Sept., v. 48, no. 3

    2016  

    Abstract: Levofloxacin plus rifampicin (L+R) is the treatment of choice for acute staphylococcal prosthetic joint infection (PJI) managed with debridement and implant retention (DAIR). Long courses have been empirically recommended, but some studies have suggested ...

    Abstract Levofloxacin plus rifampicin (L+R) is the treatment of choice for acute staphylococcal prosthetic joint infection (PJI) managed with debridement and implant retention (DAIR). Long courses have been empirically recommended, but some studies have suggested that shorter treatments could be as effective. Our aim was to prove that a short treatment schedule was non-inferior to the standard long schedule. An open-label, multicentre, randomised clinical trial (RCT) was performed. Patients with an early post-surgical or haematogenous staphylococcal PJI, managed with DAIR and initiated on L+R were randomised to receive 8 weeks of treatment (short schedule) versus a long schedule (3 months or 6 months for hip or knee prostheses, respectively). The primary endpoint was cure rate. From 175 eligible patients, 63 were included (52% women; median age, 72 years): 33 patients (52%) received the long schedule and 30 (48%) received the short schedule. There were no differences between the two groups except for a higher rate of polymicrobial infection in the long-schedule group (27% vs. 7%; P = 0.031). Median follow-up was 540 days. In the intention-to-treat analysis, cure rates were 58% and 73% in patients receiving the long and short schedules, respectively (difference −15.7%, 95% CI −39.2% to 7.8%). Forty-four patients (70%) were evaluable per-protocol: cure rates were 95.0% and 91.7% for the long and short schedules, respectively (difference 3.3%, 95% CI −11.7% to 18.3%). This is the first RCT suggesting that 8 weeks of L+R could be non-inferior to longer standard treatments for acute staphylococcal PJI managed with DAIR.
    Schlagwörter debridement ; hips ; levofloxacin ; patients ; prostheses ; randomized clinical trials ; rifampicin ; women
    Sprache Englisch
    Erscheinungsverlauf 2016-09
    Umfang p. 310-316.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2016.05.021
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms

    Natividad Benito / Isabel Mur / Alba Ribera / Alex Soriano / Dolors Rodríguez-Pardo / Luisa Sorlí / Javier Cobo / Marta Fernández-Sampedro / María Dolores del Toro / Laura Guío / Julia Praena / Alberto Bahamonde / Melchor Riera / Jaime Esteban / Josu Mirena Baraia-Etxaburu / Jesús Martínez-Alvarez / Alfredo Jover-Sáenz / Carlos Dueñas / Antonio Ramos /
    Beatriz Sobrino / Gorane Euba / Laura Morata / Carles Pigrau / Juan P. Horcajada / Pere Coll / Xavier Crusi / Javier Ariza / on behalf of the REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections/GEIO (Group for the Study of Osteoarticular Infections), SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiolo

    Journal of Clinical Medicine, Vol 8, Iss 5, p

    2019  Band 673

    Abstract: The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)—including multidrug-resistant organisms (MDRO)—by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative ... ...

    Abstract The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)—including multidrug-resistant organisms (MDRO)—by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama’s scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and “positive intraoperative cultures” (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2–3 months, 4–12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms ( S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
    Schlagwörter prosthetic joint infections ; microbial etiology ; classification schemes for prosthetic joint infections ; antimicrobial empirical treatment ; multidrug-resistant organisms ; Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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