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  1. AU="Nattmann, Phillip"
  2. AU="Assefa, Samuel"
  3. AU="McMahon, Teagan"
  4. AU="Radojičić Zoran"
  5. AU="Muwu Xu"
  6. AU="Sacchi, Diana"
  7. AU="Romain Berraud-Pache"
  8. AU=Johnson Paul D R
  9. AU="Sarigül-Yildirim, Figen"
  10. AU=Chang Yu-Ting
  11. AU="Xu, Ivana"
  12. AU="Linde, Lauren"
  13. AU="Brewer, Katlyn K"
  14. AU="Prow, Natalie A"
  15. AU=Venkatesan Arun
  16. AU="Russcher, H."
  17. AU="Chambino, Beatriz"
  18. AU="L'Abbé, Ericka N."
  19. AU=Moore Stephen M.
  20. AU="Gabriel, Berteșteanu Șerban Vifor" AU="Gabriel, Berteșteanu Șerban Vifor"
  21. AU="Gallo, Eduado"
  22. AU="Yurchenko, Maria"
  23. AU="Fabiana Giber"
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  25. AU="Gutierrez, M. N"
  26. AU=Zhuo Jia L.
  27. AU=Miller Mark A
  28. AU="Dąbrowski, Leszek"
  29. AU="Röltgen, Katharina"
  30. AU="Tumanov, Alexey"
  31. AU="Berns, Lauren"
  32. AU="Elena A. Deshevaya"
  33. AU=Zhang Ruijuan
  34. AU="Mueller, Luke"
  35. AU=Barzon Luisa
  36. AU="Karunakaran, Denuja"
  37. AU="Figueroa-Rivera, Ivonne M"
  38. AU="Blackburn, Fran"
  39. AU="Lee, Hee-Kyung"
  40. AU=Kinoshita J H
  41. AU="Hernesniemi, Juha"
  42. AU="Evans, Matthew L"
  43. AU=Payne Thomas
  44. AU="Brown, Dexter"

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  1. Buch ; Online ; Dissertation / Habilitation: Effekte einer früh-sequenziellen dualen Kombinationstherapie auf die pulmonale Hämodynamik und Risikostratifizierung bei Patienten mit neu diagnostizierter pulmonal arterieller Hypertonie

    Nattmann, Phillip Verfasser] / [Rosenkranz, Stephan [Gutachter] / Stehle, Robert [Gutachter]

    2022  

    Verfasserangabe Phillip Nattmann ; Gutachter: Stephan Rosenkranz, Robert Stehle
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitäts- und Stadtbibliothek Köln
    Erscheinungsort Köln
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  2. Artikel ; Online: Impact of rapid sequential combination therapy on distinct haemodynamic measures in newly diagnosed pulmonary arterial hypertension.

    Kramer, Tilmann / Nattmann, Phillip / Gerhardt, Felix / Stafiej, Patrycja / Dumitrescu, Daniel / Ten Freyhaus, Henrik / Wißmüller, Max / Hohmann, Christopher / Baldus, Stephan / Rosenkranz, Stephan

    ESC heart failure

    2024  Band 11, Heft 3, Seite(n) 1540–1552

    Abstract: Aims: In pulmonary arterial hypertension (PAH), upfront combination therapy with ERA and PDE5i is associated with a reduction in morbidity and mortality events and improves standard haemodynamics, but data remain limited. Aims of this study were (i) to ... ...

    Abstract Aims: In pulmonary arterial hypertension (PAH), upfront combination therapy with ERA and PDE5i is associated with a reduction in morbidity and mortality events and improves standard haemodynamics, but data remain limited. Aims of this study were (i) to capture detailed haemodynamic effects of rapid sequential dual combination therapy in patients with newly diagnosed PAH; (ii) to monitor the impact of treatment initiation on clinical variables and patients' risk status, and (iii) to compare the treatment effect in patients with 'classical PAH' and 'PAH with co-morbidities'.
    Methods: Fifty patients (median age 57 [42-71] years, 66% female) with newly diagnosed PAH (76% idiopathic) were treated with a PD5i/sGC-S or ERA, followed by addition of the respective other drug class within 4 weeks. All patients underwent repeat right heart catheterization (RHC) during early follow-up.
    Results: At early repeat RHC (7 ± 2 months), there were substantial reductions in mean pulmonary artery pressure (mPAP: 52.2 ± 13.5 to 39.0 ± 10.6 mmHg; -25.3%), and pulmonary vascular resistance (PVR: 12.1 ± 5.7 to 5.8 ± 3.1 WU; -52.1%), and an increase in cardiac index (2.1 ± 0.4 to 2.7 ± 0.7 mL/min/m
    Conclusions: Rapid sequential combination therapy with PDE5i/sGC-S and ERA substantially ameliorates cardiopulmonary haemodynamics at early follow-up in patients without, and to a lesser extent, with cardiovascular co-morbidities. This occurs in line with improvements of clinical parameters and risk status.
    Mesh-Begriff(e) Humans ; Female ; Male ; Middle Aged ; Hemodynamics/physiology ; Hemodynamics/drug effects ; Aged ; Drug Therapy, Combination ; Adult ; Phosphodiesterase 5 Inhibitors/administration & dosage ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/diagnosis ; Follow-Up Studies ; Treatment Outcome ; Cardiac Catheterization/methods ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Vascular Resistance ; Time Factors ; Endothelin Receptor Antagonists/administration & dosage
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14611
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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