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  1. Article ; Online: A personalized approach for tumour biopsy in hepatocellular carcinoma.

    Ronot, Maxime / Nault, Jean-Charles

    JHEP reports : innovation in hepatology

    2023  Volume 6, Issue 4, Page(s) 100979

    Language English
    Publishing date 2023-12-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Portal hypertension and hepatocellular carcinoma: Navigating uncharted waters.

    Sidali, Sabrina / Nault, Jean-Charles

    United European gastroenterology journal

    2022  Volume 10, Issue 1, Page(s) 8–9

    MeSH term(s) Carcinoma, Hepatocellular/diagnosis ; Humans ; Hypertension, Portal/diagnosis ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genetics of Hepatocellular Carcinoma: From Tumor to Circulating DNA.

    Campani, Claudia / Zucman-Rossi, Jessica / Nault, Jean-Charles

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies and is one of the major causes of cancer-related death. Over the last 15 years, the molecular landscape of HCC has been deciphered, with the identification of the main driver ...

    Abstract Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies and is one of the major causes of cancer-related death. Over the last 15 years, the molecular landscape of HCC has been deciphered, with the identification of the main driver genes of liver carcinogenesis that belong to six major biological pathways, such as telomere maintenance, Wnt/b-catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and MAP kinase. The combination of genetic and transcriptomic data composed various HCC subclasses strongly related to risk factors, pathological features and prognosis. However, translation into clinical practice is not achieved, mainly because the most frequently mutated genes are undruggable. Moreover, the results derived from the analysis of a single tissue sample may not adequately catch the intra- and intertumor heterogeneity. The analysis of circulating tumor DNA (ctDNA) is broadly developed in other types of cancer for early diagnosis, prognosis and monitoring under systemic treatment in order to identify primary and secondary mechanisms of resistance. The aim of this review is to describe recent data about the HCC molecular landscape and to discuss how ctDNA could be used in the future for HCC detection and management.
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Systemic treatment of hepatocellular carcinoma: the times they are a-changin'.

    Campani, Claudia / Nault, Jean-Charles

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 6, Page(s) 893–895

    Language English
    Publishing date 2021-12-22
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator.

    Nault, Jean-Charles

    Gastroenterology

    2017  Volume 152, Issue 5, Page(s) 941–943

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2017.02.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 572: Show issues

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  6. Article ; Online: The end of almost 10 years of negative RCTs in advanced hepatocellular carcinoma.

    Nault, Jean-Charles

    Lancet (London, England)

    2017  Volume 389, Issue 10064, Page(s) 4–6

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms
    Language English
    Publishing date 2017--07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(16)32480-1
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  7. Article ; Online: Advances in molecular classification and precision oncology in hepatocellular carcinoma.

    Rebouissou, Sandra / Nault, Jean-Charles

    Journal of hepatology

    2020  Volume 72, Issue 2, Page(s) 215–229

    Abstract: Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential accumulation of multiple genomic and epigenomic alterations resulting from Darwinian selection. Genes from various signalling pathways such as telomere maintenance, Wnt/β- ... ...

    Abstract Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential accumulation of multiple genomic and epigenomic alterations resulting from Darwinian selection. Genes from various signalling pathways such as telomere maintenance, Wnt/β-catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and MAP kinase are frequently mutated in HCC. Several subclasses of HCC have been identified based on transcriptomic dysregulation and genetic alterations that are closely related to risk factors, pathological features and prognosis. Undoubtedly, integration of data obtained from both preclinical models and human studies can help to accelerate the identification of robust predictive biomarkers of response to targeted biotherapy and immunotherapy. The aim of this review is to describe the main advances in HCC in terms of molecular biology and to discuss how this knowledge could be used in clinical practice in the future.
    MeSH term(s) Animals ; Biomarkers, Tumor/blood ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/classification ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Disease Progression ; Genetic Predisposition to Disease ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Liver Cirrhosis/complications ; Liver Neoplasms/classification ; Liver Neoplasms/etiology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Molecular Targeted Therapy/methods ; Mutation ; Polymorphism, Single Nucleotide ; Precision Medicine/methods ; Transcriptome ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-01-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2019.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Biomarkers for Hepatobiliary Cancers.

    Nault, Jean-Charles / Villanueva, Augusto

    Hepatology (Baltimore, Md.)

    2020  Volume 73 Suppl 1, Page(s) 115–127

    Abstract: The clinical management of primary liver cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) has significantly changed in the last 3 years. The introduction of systemic therapies, including immune-based therapies and biomarker- ... ...

    Abstract The clinical management of primary liver cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) has significantly changed in the last 3 years. The introduction of systemic therapies, including immune-based therapies and biomarker-driven therapies, has significantly improved survival, particularly in patients at advanced stages of disease. Survival is still poor, and projections from the World Health Organization underscore the need to improve outcomes in these patients. Biomarkers have emerged as powerful tools for the diagnosis, prognosis, and prediction of treatment responses to improve patient stratification and maximize clinical benefits. Recent advances in understanding the molecular alterations of HCC have not yet translated into biomarkers. Some reasons for the lack of progress are the absence of druggable mutations in the majority of liver cancers and the significant heterogeneity of the disease. In contrast, several therapeutic targets have been identified in CCA, and biomarker-driven therapies are currently under evaluation in phase 2/3 clinical trials. Here, we summarize the status on biomarker development for HCC and CCA.
    MeSH term(s) Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/genetics ; Biomarkers, Tumor ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/genetics ; Early Detection of Cancer ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31175
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma.

    Allaire, Manon / Nault, Jean Charles

    Hepatobiliary surgery and nutrition

    2019  Volume 8, Issue 1, Page(s) 53–55

    Language English
    Publishing date 2019-03-01
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2018.10.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Personalised dosimetry for SIRT: new standard or bridge to surgical resection?

    Ronot, Maxime / Levy, Vincent / Nault, Jean-Charles

    The lancet. Gastroenterology & hepatology

    2021  Volume 6, Issue 3, Page(s) 161

    MeSH term(s) Brachytherapy ; Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Reference Standards ; Sirtuins
    Chemical Substances Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2021-02-01
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(20)30393-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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