LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 90

Search options

  1. Article ; Online: Traumatic appendicitis is probably not real: an illustrative analysis of coincidental occurrences in nature.

    Naumann, David N / Barker, Tom

    Trauma surgery & acute care open

    2023  Volume 8, Issue 1, Page(s) e001093

    Abstract: There have been sporadic case reports describing 'traumatic appendicitis' (acute appendicitis occurring following injury) for almost a hundred years. Although this might seem to be an interesting and rare diagnosis for the journal reader, both ... ...

    Abstract There have been sporadic case reports describing 'traumatic appendicitis' (acute appendicitis occurring following injury) for almost a hundred years. Although this might seem to be an interesting and rare diagnosis for the journal reader, both appendicitis and trauma are very common, and their occurrence together may only give the illusion of causality. Indeed, such a diagnosis may not even exist. We provide an illustration of the statistical phenomenon of coincidental occurrences in nature using a computer simulation of traumatic appendicitis in the UK population. In our simulation, there are enough cases of traumatic appendicitis every 2 years to 3 years to account for the entire global literature on the topic. We suggest that unless there is a credible pathological process reported with demonstrable causality, further case reports of traumatic appendicitis need to have robust justification.
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Editorial
    ISSN 2397-5776
    ISSN (online) 2397-5776
    DOI 10.1136/tsaco-2023-001093
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Addressing biases in alcohol testing for trauma patients: what is the solution?

    Cubas, Vanessa / Naumann, David N

    Emergency medicine journal : EMJ

    2023  Volume 40, Issue 11, Page(s) 742–743

    MeSH term(s) Humans ; Ethanol ; Alcoholism ; Bias ; Substance-Related Disorders
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2023-213419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Face of a king: battlefield penetrating trauma to the midface in 1403 and a surgeon who changed the course of history.

    Naumann, David N / Anderson, J R

    BMJ military health

    2021  Volume 168, Issue 3, Page(s) 237–238

    MeSH term(s) Humans ; Surgeons ; Wounds, Penetrating/surgery
    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2021-001968
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Oligometastatic deposits of prostate cancer found within the sigmoid pericolic fat that was resected for colonic adenocarcinoma: a case report.

    Naumann, David N / Hejmadi, Rahul K / Richardson, Jonathan J R

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 221

    Abstract: Background: Prostate cancer may rarely metastasize to the colon and colonic lymph nodes, and local treatment of oligometastatic deposits may improve oncological outcomes. Immunohistochemical stains are used to determine the most likely source of ... ...

    Abstract Background: Prostate cancer may rarely metastasize to the colon and colonic lymph nodes, and local treatment of oligometastatic deposits may improve oncological outcomes. Immunohistochemical stains are used to determine the most likely source of metastatic deposits when they are seen within surgical specimens. The aim of this case report is to illustrate how such techniques were used to identify unexpected prostatic metastases within the pericolic fat of a sigmoid colon resection specimen following elective curative surgery for colorectal cancer. To our knowledge, this is the first report of complete excision of oligometastatic deposits of prostate cancer found incidentally within the specimen of another cancer.
    Case report: An 89-year-old Caucasian man underwent sigmoid colectomy for an obstructing colorectal cancer in the sigmoid colon with some mesenteric lymphadenopathy. He had previously received radical radiotherapy for prostate cancer 10 years earlier. When the specimen was examined by the histopathologist, it was noted that the pericolic fat adjacent to the colorectal adenocarcinoma contained some metastatic deposits. Positive immunohistochemical staining for prostate-specific antigen and prostate-specific acid phosphatase with negative staining for CDX2 and CK20 revealed these to be prostatic metastases rather than colonic. Since these were completely excised, and there were no other metastases, this represented a serendipitous, curative excision of oligometastatic deposits of an additional cancer to the one that was being treated.
    Conclusions: This case illustrates how immunohistochemical staining may be used to distinguish the source of metastatic deposits based on the likelihood of primary tumor from a careful and thorough patient history.
    MeSH term(s) Adenocarcinoma/pathology ; Aged, 80 and over ; Carcinoma/surgery ; Colectomy ; Colon, Sigmoid/pathology ; Colon, Sigmoid/surgery ; Colonic Neoplasms/surgery ; Humans ; Male ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery
    Language English
    Publishing date 2022-06-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03441-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Circulating Tumour Cells as Prognostic Biomarkers in Colorectal Cancer: A Systematic Review.

    Veyrune, Léa / Naumann, David N / Christou, Niki

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: Despite therapeutic advances, colorectal cancer (CRC) is still one of the deadliest cancers, partly due to local recurrence and metastatic disease. Tumour cells that spread by gaining access to peripheral blood are called circulating tumour cells (CTCs). ...

    Abstract Despite therapeutic advances, colorectal cancer (CRC) is still one of the deadliest cancers, partly due to local recurrence and metastatic disease. Tumour cells that spread by gaining access to peripheral blood are called circulating tumour cells (CTCs). These may be present before there are any clinical signs, but can be detected within blood samples. CTCs from patients with CRC may be isolated in a laboratory for characterization and multiple analyses. In this review, we focus on the prognostic potential of CTCs detection, by evaluating the reported progress and applications of such analyses. Our search found 77 relevant studies that reported CTC detection in CRC. Both cell count and features were reported as promising prognosis biomarkers. Since CTCs are rare and can lose their differentiation, new tools are being developed to improve detection. CTCs may have potential as prognostic biomarkers for CRC in terms of survival prediction, anticipating chemotherapy resistance, and surgical planning. CTCs are not yet used in clinical practice, and further investigations are required in order to better frame their practical value.
    MeSH term(s) Cell Count ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/therapy ; Humans ; Neoplastic Cells, Circulating ; Prognosis
    Language English
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22083437
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: War surgery and transfusion in makeshift hospitals in beleaguered cities.

    Naumann, David N / Robinson, Michael W / Bowley, Douglas M / Nott, David

    Lancet (London, England)

    2022  Volume 399, Issue 10332, Page(s) 1299–1301

    MeSH term(s) Blood Transfusion ; Cities ; Hospitals ; Humans
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00525-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Defence Healthcare Engagement: A UK Military Perspective to Improve Healthcare Leadership and Quality of Care Overseas.

    Tallowin, Simon / Naumann, David N / Bowley, Douglas M

    Journal of healthcare leadership

    2021  Volume 13, Page(s) 27–34

    Abstract: Defence Healthcare Engagement (DHE) describes the use of military medical capabilities to achieve health effects overseas through enduring partnerships. It forms a key part of a wider strategy of Defence Engagement that utilises defence assets and ... ...

    Abstract Defence Healthcare Engagement (DHE) describes the use of military medical capabilities to achieve health effects overseas through enduring partnerships. It forms a key part of a wider strategy of Defence Engagement that utilises defence assets and activities, short of combat operations, to achieve influence. UK Defence Medical Services have significant recent DHE experience from conflict and stabilisation operations (e.g. Iraq and Afghanistan), health crises (e.g. Ebola epidemic in Sierra Leone), and as part of a long-term partnership with the Pakistan Armed Forces. Taking a historical perspective, this article describes the evolution of DHE from ad hoc rural health camps in the 1950s, to a modern integrated, multi-sector approach based on partnerships with local actors and close civil-military cooperation. It explores the evidence from recent UK experiences, highlighting the decisive contributions that military forces can make to healthcare leadership and quality of care overseas, particularly when conflict and health crisis outstrips the capacity of local healthcare providers to respond. Lessons identified include the need for long-term engagement with partners and the requirement for DHE activities to be closely coordinated with humanitarian agencies and local providers to prevent adverse effects on the local health economy and ensure a sustainable transition to civilian oversight.
    Language English
    Publishing date 2021-01-29
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2587466-4
    ISSN 1179-3201 ; 1179-3201
    ISSN (online) 1179-3201
    ISSN 1179-3201
    DOI 10.2147/JHL.S224906
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Anogenital injury following sexual assault and consensual sexual intercourse: a systematic review and meta-analysis.

    Naumann, David N / Morris, Louise / Bowley, Douglas M / Appleyard, Tracy-Louise / Cumming, Julie / Wardle, Deborah

    EClinicalMedicine

    2023  Volume 65, Page(s) 102266

    Abstract: Background: Sexual violence is a grave human rights violation and a serious global public health challenge. Rates of reporting of sexual violence and subsequent passage of cases through the criminal justice system are poor all over the world. The ... ...

    Abstract Background: Sexual violence is a grave human rights violation and a serious global public health challenge. Rates of reporting of sexual violence and subsequent passage of cases through the criminal justice system are poor all over the world. The presence or absence of anogenital injury following sexual assault may influence survivors in their willingness to report a crime, and law enforcement officers and jurors in their decision making regarding the laying of charges and/or conviction of offenders. The aim of this systematic review was to compare rates of identification of anogenital injury (AGI) in women following sexual assault and consensual sexual intercourse using the same examination techniques.
    Methods: In this systematic review and meta-analysis, Medline, Embase and Google Scholar were searched for relevant studies (in any language, with no age or sex criteria) published between February 25, 1993, and February 25, 2023, that directly compared AGI between individuals after either sexual assault or consensual sexual intercourse. Abstracts, conference proceedings, and case reports were excluded. The primary outcome of interest was any form of detected AGI. The Mantel-Haenszel method was used for meta-analysis using random effects modelling to determine the risk ratio (RR) of AGI between sexual assault and consensual sexual intercourse. Quality assessment was undertaken using the Newcastle-Ottawa scale tool. The
    Findings: We included 10 studies, accounting for 3165 study participants. All participants were female. AGI was detected in 901 (48%) of 1874 participants following sexual assault and 394 (31%) of 1291 participants following consensual sexual intercourse. Meta-analysis of all included studies demonstrated that the presence of AGI was significantly more likely for participants following sexual assault than consensual sexual intercourse (RR 1.59 (95% CI 1.21, 2.09);
    Interpretation: Although AGI was significantly more likely to be detected after sexual assault than consensual sexual intercourse, more than half of survivors of sexual assault have no detectable injuries. The presence of AGI, therefore, does not prove there has been sexual violence and absence of injury does not refute that sexual assault has occurred.
    Funding: The University of Birmingham.
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102266
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Engagement with a youth violence intervention programme is associated with lower re-attendance after violent injury: A UK major trauma network observational study.

    Dickson, Edward A / Blackburn, Lauren / Duffy, Miriam / Naumann, David N / Brooks, Adam

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0292836

    Abstract: The hospital based Redthread Youth Violence Intervention Programme (YVIP) utilises experienced youth workers to support 11-24 year olds following an episode of violent injury, assault or exploitation who present to the Emergency Department (ED) at the ... ...

    Abstract The hospital based Redthread Youth Violence Intervention Programme (YVIP) utilises experienced youth workers to support 11-24 year olds following an episode of violent injury, assault or exploitation who present to the Emergency Department (ED) at the East Midlands Major Trauma Centre (MTC), Nottingham, UK. The YVIP aims to promote personal change with the aim of reducing the incidence of further similar events. We conducted a retrospective, observational, cohort study to examine the association between engagement with the YVIP and re-attendance rates to the ED following a referral to Redthread. We also examined factors associated with engagement with the full YVIP. We found that 573 eligible individuals were referred to the YVIP over two years. Assault with body parts 34.9% (n = 200) or a bladed object 29.8% (n = 171) were the commonest reason for referral. A prior event rate ratio (PERR) analysis was used to compare rates of attendance between those who did and did not engage with the full YVIP. Engagement was associated with a reduction in re-attendances of 51% compared to those who did not engage (PERR 0.49 [95% 0.28-0.64]). A previous attendance to the ED by an individual positively predicted engagement. (OR 2.82 [95% CI 1.07-7.42], P = 0.035). A weekend attendance (OR 0.26 [0.15-0.44], P<0.001) and a phone call approach (OR 0.25 [0.14-0.47], P = 0.001), rather than a face-to-face approach by a Redthread worker, negatively impacted engagement. In conclusion, assaults with or without a weapon contributed to a significant proportion of attendances among this age group. The Redthread YVIP was associated with reduced rates of re-attendance to the East Midlands MTC among young persons who engaged with the full programme.
    MeSH term(s) Humans ; Adolescent ; Retrospective Studies ; Cohort Studies ; Violence/prevention & control ; Emergency Service, Hospital ; United Kingdom/epidemiology
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292836
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Could resuscitation be based on microcirculation data? No.

    Naumann, David N / Lima, Alexandre

    Intensive care medicine

    2018  Volume 44, Issue 6, Page(s) 947–949

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Microcirculation/physiology ; Middle Aged ; Practice Guidelines as Topic ; Resuscitation/methods ; Shock, Hemorrhagic/diagnosis ; Shock, Hemorrhagic/therapy
    Language English
    Publishing date 2018-05-07
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-018-5095-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top