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Book ; Thesis: Zyklusabhängige Expression des Transkriptionsfaktors Hand2 im humanen Endometrium und dessen Korrelation zu epithelialer Proliferation und Steroidhormonrezeptor-Expression

Naumann, Lisanne

2020

Author's details	vorgelegt von Lisanne Naumann
Language	German
Size	122 Seiten, Illustrationen, Diagramme
Publishing place	Aachen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2020
Note	Deutsche und englische Zusammenfassung
HBZ-ID	HT020366352
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Psychedelic Microdosing

Naumann, Linus

SuchtMagazin ; 1377110-3 ; 1422-2221 ; 46 ; 2020 ; 3 ; 22

Hintergründe, Motive und Risiken

2020

Publishing date	2020-06-01
Publisher	Infodrog
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving multidisciplinary management of patients living with obesity: The evaluation of seated bioimpedance measures and relationship to functional performance following targeted intervention.

Ryan, Elizabeth / MacLaughlin, Helen / Hay, Robin / Cawte, Andrea / Naumann, Leonie / Woodruff, Gemma / Cottrell, Michelle / Window, Peter

Clinical obesity

2024 , Page(s) e12655

Abstract: Management of obesity requires a multidisciplinary approach including physical activity interventions, which have significant impacts on overall health outcomes. Greater levels of lean muscle mass are significantly associated with improved health and ... ...

Abstract	Management of obesity requires a multidisciplinary approach including physical activity interventions, which have significant impacts on overall health outcomes. Greater levels of lean muscle mass are significantly associated with improved health and reduced risk of comorbidities and should be preserved where possible when undertaking rapid weight loss. This article reports on the physical and functional outcomes achieved during a 12-week intensive multidisciplinary intervention targeting obesity and evaluates correlations between body composition and functional outcomes. We additionally aimed to investigate the test-retest reliability and levels of agreement in body composition measurements using bioimpedance spectroscopy between seated and standing positions. Of the 35 participants included in analysis, significant differences were observed between baseline and post-intervention measures. These included weight loss of 12.6 kg, waist circumference reduction of 10.5 cm, fat mass reduction by 2.9%, muscle mass increase by 1.6%, 54.5 m improvement in the 6-minute walk test and 3.8 rep improvement in the 30-second sit-to-stand test. No significant correlations were observed between physical and functional outcome measures. Excellent test re-test reliability was observed in bioimpedance spectroscopy seated measurements (ICC >.9). Significant differences were observed between seated and standing bioimpedance spectroscopy measurements, however they are regarded as small differences in a clinical setting.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12655
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Article ; Online: Augmented region of interest for untargeted metabolomics mass spectrometry (AriumMS) of multi-platform-based CE-MS and LC-MS data.

Naumann, Lukas / Haun, Adrian / Höchsmann, Alisa / Mohr, Michael / Novák, Martin / Flottmann, Dirk / Neusüß, Christian

Analytical and bioanalytical chemistry

2023 Volume 415, Issue 16, Page(s) 3137–3154

Abstract: In mass spectrometry (MS)-based metabolomics, there is a great need to combine different analytical separation techniques to cover metabolites of different polarities and apply appropriate multi-platform data processing. Here, we introduce AriumMS ( ... ...

Abstract	In mass spectrometry (MS)-based metabolomics, there is a great need to combine different analytical separation techniques to cover metabolites of different polarities and apply appropriate multi-platform data processing. Here, we introduce AriumMS (augmented region of interest for untargeted metabolomics mass spectrometry) as a reliable toolbox for multi-platform metabolomics. AriumMS offers augmented data analysis of several separation techniques utilizing a region-of-interest algorithm. To demonstrate the capabilities of AriumMS, five datasets were combined. This includes three newly developed capillary electrophoresis (CE)-Orbitrap MS methods using the recently introduced nanoCEasy CE-MS interface and two hydrophilic interaction liquid chromatography (HILIC)-Orbitrap MS methods. AriumMS provides a novel mid-level data fusion approach for multi-platform data analysis to simplify and speed up multi-platform data processing and evaluation. The key feature of AriumMS lies in the optimized data processing strategy, including parallel processing of datasets and flexible parameterization for processing of individual separation methods with different peak characteristics. As a case study, Saccharomyces cerevisiae (yeast) was treated with a growth inhibitor, and AriumMS successfully differentiated the metabolome based on the augmented multi-platform CE-MS and HILIC-MS investigation. As a result, AriumMS is proposed as a powerful tool to improve the accuracy and selectivity of metabolome analysis through the integration of several HILIC-MS/CE-MS techniques.
MeSH term(s)	Chromatography, Liquid/methods ; Tandem Mass Spectrometry ; Metabolomics/methods ; Metabolome ; Electrophoresis, Capillary/methods
Language	English
Publishing date	2023-05-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-023-04715-6
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Article ; Online: Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation.

Klingler, Florian / Schlossbauer, Patrick / Naumann, Lukas / Handrick, René / Hesse, Friedemann / Neusüß, Christian / Otte, Kerstin

Biotechnology and bioengineering

2023 Volume 121, Issue 4, Page(s) 1355–1365

Abstract: N-linked glycosylation is one of the most important post-translational modifications of monoclonal antibodies (mAbs) and is considered to be a critical quality attribute (CQA), as the glycan composition often has immunomodulatory effects. Since terminal ... ...

Abstract	N-linked glycosylation is one of the most important post-translational modifications of monoclonal antibodies (mAbs) and is considered to be a critical quality attribute (CQA), as the glycan composition often has immunomodulatory effects. Since terminal galactose residues of mAbs can affect antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytolysis (CDC) activation, serum half-life, and antiviral activity it has to be monitored, controlled and modulated to ensure therapeutic effects. The ability of small noncoding microRNAs (miRNAs) to modulate glycosylation in Chinese hamster ovary (CHO) production cells was recently reported establishing miRNAs as engineering tools for modulation of protein glycosylation. In this study, we report the characterization and validation of miRNAs as engineering tools for increased (mmu-miR-452-5p, mmu-miR-193b-3p) or decreased (mmu-miR-7646-5p, mmu-miR-7243-3p, mmu-miR-1668, mmu-let-7c-1-3p, mmu-miR-7665-3p, mmu-miR-6403) degree of galactosylation. Furthermore, the biological mode of action regulating gene expression of the galactosylation pathway was characterized as well as their influence on bioprocess-related parameters. Most important, stable plasmid-based overexpression of these miRNAs represents a versatile tool for engineering N-linked galactosylation to achieve favorable phenotypes in cell lines for biopharmaceutical production.
MeSH term(s)	Animals ; Cricetinae ; MicroRNAs/genetics ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; CHO Cells ; Cricetulus ; Glycosylation
Chemical Substances	MicroRNAs ; Antibodies, Monoclonal
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.28616
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Article ; Online: Evaluating telehealth for the education and monitoring of lymphoedema and shoulder dysfunction after breast cancer surgery.

Naumann, Leonie / Reul-Hirche, Hildegard / Comans, Tracy / Burns, Clare L / Paratz, Jenny / Cottrell, Michelle

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 4, Page(s) 239

Abstract: Purpose: The primary aim of this study was to compare the attendance rates at a group lymphoedema education and same-day individual surveillance appointment between telehealth (TH) and in-person (IP) care for participants following breast cancer (BC) ... ...

Abstract	Purpose: The primary aim of this study was to compare the attendance rates at a group lymphoedema education and same-day individual surveillance appointment between telehealth (TH) and in-person (IP) care for participants following breast cancer (BC) surgery. Secondary aims included evaluating participant satisfaction and costs between the two service models, while also determining the extent of technical issues and clinician satisfaction towards TH. Methods: Participants following axillary lymph node dissection surgery attended a group lymphoedema education and same-day 1:1 monitoring session via their preferred mode (TH or IP). Attendance rates, satisfaction and costs were recorded for both cohorts, and technical disruption and clinician satisfaction for the TH cohort. Results: Fifty-five individuals participated. All 28 participants who nominated the IP intervention attended, while 22/27 who nominated the TH intervention attended an appointment. Overall reported participant experience was positive with no significant differences between cohorts. All TH appointments were successfully completed. Clinicians reported high satisfaction for delivery of education (median = 4[IQR 4-5]) and individual assessment (median = 4[IQR 3-4]) via TH. Median attendance costs per participant were Australian $39.68 (Q1-Q3 $28.52-$68.64) for TH and Australian $154.26 (Q1-Q3 $81.89-$251.48) for the IP cohort. Conclusion: Telehealth-delivered lymphoedema education and assessment for individuals following BC surgery was associated with favourable satisfaction, cost savings and minimal technical issues despite lower attendance than IP care. This study contributes to the growing evidence for TH and its potential applicability to other populations where risk for cancer-related lymphoedema exists.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Shoulder/pathology ; Australia ; Lymphedema/etiology ; Telemedicine
Language	English
Publishing date	2023-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07693-8
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Conference proceedings: Bridging the data gap on vaccination coverage in Germany: Analysis of data on standard vaccinations, results from the German prevention index

Naumann, Laura / Witte, Julian / Greiner, Wolfgang

2022 , Page(s) Abstr. 187

Event/congress	67. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 13. Jahreskongress der Technologie- und Methodenplattform für die vernetzte medizinische Forschung e.V. (TMF); sine loco [digital]; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2022
Keywords	Medizin, Gesundheit ; prevention ; vaccination ; Germany
Publishing date	2022-08-19
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22gmds136
Database	German Medical Science

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Book ; Thesis: Understanding and assessing worrying - Analyzing relevant psychopathological mechanisms relevant for generalized anxiety disorder across the lifespan

Naumann, Lena

2015

Abstract: The aim of the two presented studies was to evaluate the factor structure and psychometric properties of the newly developed German Metacognitions Questionnaire for children (MKF-K, Study 1) and the translated German Cognitive Avoidance Questionnaire ( ... ...

Title translation	Besorgnis verstehen und messen - Eine Analyse relevanter psychopathologischer Mechanismen, die für generalisierte Angststörung über die Lebensspanne hinweg relevant sind
Abstract	The aim of the two presented studies was to evaluate the factor structure and psychometric properties of the newly developed German Metacognitions Questionnaire for children (MKF-K, Study 1) and the translated German Cognitive Avoidance Questionnaire (CAQ-D, Study 2) for adults. Further, the relevance of both constructs for pathological worrying and other psychopathologically relevant conditions was evaluated. The factor structure of both instruments was examined using explanatory and confirmatory factor analyses. Construct validity was assessed by correlation coefficients with related constructs and hierarchical regression analyses predicting worry and anxiety in a children's sample (Study 1) consisting of 972 participants aged 7-14 years and positive and negative metacognitions, as well as worry and depressive symptoms in an adult sample (Study 2) consisting of 397 participants (mean age 24 years). In addition to psychometric analyses, age effects of metacognitions and the transdiagnostic value of cognitive avoidance were considered. Participants in Study 1 completed the German versions of the Penn State Worry Questionnaire for Children (PSKJ) and Spence Children Anxiety Scale (SCAS-D) in addition to the MKF-K. Participants in Study 2 completed the German versions of the Penn State Worry Questionnaire (PSWQ), Metacognition Questionnaire (MKF-30), Beck Depression Inventory (BDI-V), Response Style Questionnaire (RSQ-D), and the CAQ-D. The fit indices of the factor structure of both measures indicate moderate to good model fits. Results confirm good psychometric properties in general. Both constructs contributed significantly to the prediction of worrying and anxiety independent of the developmental status (Study 1), and negative metacognitions, worrying, and depressive symptoms (Study 2), even after controlling for demographic variables and related constructs. It is concluded that the German MKF-K serves as a reliable and valid instrument for the assessment of different metacognitive beliefs in childhood and the CAQ-D for cognitive avoidance strategies in adulthood. Metacognitions and cognitive avoidance are relevant constructs to at least two highly relevant psychopathological conditions (anxiety and depression) across the lifespan. The studies provide further support for the validity of both constructs for persistent recurring and intrusive thoughts. Furthermore, metacognitions and cognitive avoidance are important transdiagnostic risk factors.
Keywords	Angst ; Anxiety ; Avoidance ; Factor Structure ; Faktorenstruktur ; Fragebögen ; Generalisierte Angststörung ; Generalized Anxiety Disorder ; Intrusive Gedanken ; Intrusive Thoughts ; Metacognition ; Metakognition ; Questionnaires ; Symptome ; Symptoms ; Test Validity ; Testvalidität ; Vermeidung
Language	English
Size	120 pp., 9 pp. Anhang
Publisher	Universität, Humanwissenschaftliche Fakultät
Publishing place	Köln
Document type	Book ; Thesis
Note	Elektronische Publikation im Internet
Database	PSYNDEX

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Article: High‐throughput glycosylation analysis of intact monoclonal antibodies by mass spectrometry coupled with capillary electrophoresis and liquid chromatography

Naumann, Lukas / Schlossbauer, Patrick / Klingler, Florian / Hesse, Friedemann / Otte, Kerstin / Neusüß, Christian

Journal of separation science. 2022 June, v. 45, no. 12

2022

Abstract: The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of biopharmaceutical drugs. High throughput screening approaches for antibody glycoform analysis are required in various stages of process optimization. Here, we ... ...

Abstract	The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of biopharmaceutical drugs. High throughput screening approaches for antibody glycoform analysis are required in various stages of process optimization. Here, we present high throughput screening suitable mass spectrometry‐based workflows for the analysis of intact antibody glycosylation out of cell supernatants. Capillary electrophoresis and liquid chromatography were coupled with quadrupole time‐of‐flight mass spectrometry or Orbitrap mass spectrometry. Both separation methods offer fast separation (10–15 min) and the capability to prevent the separated cell supernatant matrix to enter the mass spectrometry by post‐separation valving. Both mass spectrometry instruments provide comparable results and both are sufficient to determine the glycosylation pattern of the five major glycoforms of the measured antibodies. However, the Orbitrap yields higher sensitivity of 25 μg/mL (CE‐nanoCEasy‐Orbitrap mass spectrometry) and 5 μg/mL (liquid chromatography‐Orbitrap mass spectrometry). Data processing was optimized for a faster processing and easier detection of low abundant glycoforms based on averaged charge‐deconvoluted mass spectra. This approach combines a non‐target glycoform analysis while yielding the same glycosylation pattern as the traditional approach based on extracted ion traces. The presented methods enable the high throughput screening of the glycosylation pattern of antibodies down to low μg/mL‐range out of cell supernatant without any sample preparation.
Keywords	biopharmaceuticals ; capillary electrophoresis ; glycosylation ; liquid chromatography ; mass spectrometry ; quality control ; separation
Language	English
Dates of publication	2022-06
Size	p. 2034-2044.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100865
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Article ; Online: High-throughput glycosylation analysis of intact monoclonal antibodies by mass spectrometry coupled with capillary electrophoresis and liquid chromatography.

Naumann, Lukas / Schlossbauer, Patrick / Klingler, Florian / Hesse, Friedemann / Otte, Kerstin / Neusüß, Christian

Journal of separation science

2022 Volume 45, Issue 12, Page(s) 2034–2044

Abstract	The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of biopharmaceutical drugs. High throughput screening approaches for antibody glycoform analysis are required in various stages of process optimization. Here, we present high throughput screening suitable mass spectrometry-based workflows for the analysis of intact antibody glycosylation out of cell supernatants. Capillary electrophoresis and liquid chromatography were coupled with quadrupole time-of-flight mass spectrometry or Orbitrap mass spectrometry. Both separation methods offer fast separation (10-15 min) and the capability to prevent the separated cell supernatant matrix to enter the mass spectrometry by post-separation valving. Both mass spectrometry instruments provide comparable results and both are sufficient to determine the glycosylation pattern of the five major glycoforms of the measured antibodies. However, the Orbitrap yields higher sensitivity of 25 μg/mL (CE-nanoCEasy-Orbitrap mass spectrometry) and 5 μg/mL (liquid chromatography-Orbitrap mass spectrometry). Data processing was optimized for a faster processing and easier detection of low abundant glycoforms based on averaged charge-deconvoluted mass spectra. This approach combines a non-target glycoform analysis while yielding the same glycosylation pattern as the traditional approach based on extracted ion traces. The presented methods enable the high throughput screening of the glycosylation pattern of antibodies down to low μg/mL-range out of cell supernatant without any sample preparation.
MeSH term(s)	Antibodies, Monoclonal/chemistry ; Chromatography, Liquid ; Electrophoresis, Capillary/methods ; Glycosylation ; Mass Spectrometry/methods
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2022-01-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100865
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