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  1. Article ; Online: Kinetic Intricacies of the Light Emission and Antiradical Influence of Exogenous Bioantioxidants Transformation Products in the Chemiluminescence Bioantioxidant Assay.

    Naumov, Vladimir V / Trofimov, Aleksei V / Fedorova, Galina F / Yablonskaya, Olga I / Vasil'ev, Rostislav F

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: The subject matter of the reported work refers to studying the interactions followed by the excited-state generation, which are chemical models of oxidative processes leading to a weak light emission emerging from living cells, and to explore the ... ...

    Abstract The subject matter of the reported work refers to studying the interactions followed by the excited-state generation, which are chemical models of oxidative processes leading to a weak light emission emerging from living cells, and to explore the possibilities of using them as tools for evaluating the activity of oxygen-metabolism modulators, most prominently, natural bioantioxidants of biomedical value in particular. Methodologically, major attention is paid to analyzing the shapes of the time profiles of the light emission derived from a model sensory system in the presence of lipid samples of vegetable and animal (fish) origin rich in bioantioxidants. As a result, a modified reaction mechanism involving 12 elementary steps is proposed to rationalize the light-emission kinetics in the presence of natural bioantioxidants. We conclude that free radicals formed from bioantioxidants and their dimerization products contribute significantly to the general antiradical activity of lipid samples, which should be taken into account in developing efficient bioantioxidant assays for biomedical applications and while establishing the mechanisms of bioantioxidant effects on metabolic processes in vivo.
    MeSH term(s) Animals ; Luminescence ; Oxidation-Reduction ; Free Radicals ; Luminescent Measurements ; Lipids
    Chemical Substances Free Radicals ; Lipids
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Updating the Chemiluminescence Oxygen-Aftereffect Method for Determining the Rate Constant of the Peroxy-Radical Self-Reaction: Oxidation of Cyclohexene.

    Fedorova, Galina F / Lapina, Viktoryia A / Menshov, Valery A / Naumov, Vladimir V / Trofimov, Aleksei V / Tsaplev, Yury B / Vasil'ev, Rostislav F / Yablonskaya, Olga I

    Photochemistry and photobiology

    2018  Volume 95, Issue 3, Page(s) 780–786

    Abstract: Updating the facile chemiluminescence oxygen-aftereffect method, most suitable for determining the rate constant ( ... ...

    Abstract Updating the facile chemiluminescence oxygen-aftereffect method, most suitable for determining the rate constant (k
    Language English
    Publishing date 2018-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antioxidant potential of curcumin-related compounds studied by chemiluminescence kinetics, chain-breaking efficiencies, scavenging activity (ORAC) and DFT calculations.

    Slavova-Kazakova, Adriana K / Angelova, Silvia E / Veprintsev, Timur L / Denev, Petko / Fabbri, Davide / Dettori, Maria Antonietta / Kratchanova, Maria / Naumov, Vladimir V / Trofimov, Aleksei V / Vasil'ev, Rostislav F / Delogu, Giovanna / Kancheva, Vessela D

    Beilstein journal of organic chemistry

    2015  Volume 11, Page(s) 1398–1411

    Abstract: This study compares the ability to scavenge different peroxyl radicals and to act as chain-breaking antioxidants of monomers related to curcumin (1): dehydrozingerone (2), zingerone (3), (2Z,5E)-ethyl 2-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-4-oxohexa-2,5- ...

    Abstract This study compares the ability to scavenge different peroxyl radicals and to act as chain-breaking antioxidants of monomers related to curcumin (1): dehydrozingerone (2), zingerone (3), (2Z,5E)-ethyl 2-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-4-oxohexa-2,5-dienoate (4), ferulic acid (5) and their corresponding C 2-symmetric dimers 6-9. Four models were applied: model 1 - chemiluminescence (CL) of a hydrocarbon substrate used for determination of the rate constants (k A) of the reactions of the antioxidants with peroxyl radicals; model 2 - lipid autoxidation (lipidAO) used for assessing the chain-breaking antioxidant efficiency and reactivity; model 3 - oxygen radical absorbance capacity (ORAC), which yields the activity against peroxyl radicals generated by an azoinitiator; model 4 - density functional theory (DFT) calculations at UB3LYP/6-31+G(d,p) level, applied to explain the structure-activity relationship. Dimers showed 2-2.5-fold higher values of k A than their monomers. Model 2 gives information about the effects of the side chains and revealed much higher antioxidant activity for monomers and dimers with α,β-unsaturated side chains. Curcumin and 6 in fact are dimers of the same monomer 2. We conclude that the type of linkage between the two "halves" by which the molecule is made up does not exert influence on the antioxidant efficiency and reactivity of these two dimers. The dimers and the monomers demonstrated higher activity than Trolox (10) in aqueous medium (model 3). A comparison of the studied compounds with DL-α-tocopherol (11), Trolox and curcumin is made. All dimers are characterized through lower bond dissociation enthalpies (BDEs) than their monomers (model 4), which qualitatively supports the experimental results.
    Language English
    Publishing date 2015-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.11.151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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