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Article: A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers in Patients with Diabetic Macular Edema in Different Stages of Diabetic Retinopathy.

Naveen, Prithvi / Sahu, Vijaya / Pathak, Madhumallika

Clinical ophthalmology (Auckland, N.Z.)

2022 Volume 16, Page(s) 3129–3134

Abstract: Purpose: To compare which imaging and biochemical biomarkers are associated with different stages of diabetic retinopathy (DR) in type 2 diabetes mellitus patients with diabetic macular edema (DME).: Patients and methods: It was a cross-sectional, ... ...

Abstract	Purpose: To compare which imaging and biochemical biomarkers are associated with different stages of diabetic retinopathy (DR) in type 2 diabetes mellitus patients with diabetic macular edema (DME). Patients and methods: It was a cross-sectional, observational study that included 100 patients of DME with different stages of DR. Patients were divided into two groups: Group A - DME with non-proliferative diabetic retinopathy (NPDR) and Group B - DME with proliferative diabetic retinopathy (PDR). Group A was further subdivided into three subgroups: A (1) - DME with mild NPDR, A (2) - DME with moderate NPDR, and A (3) - DME with severe NPDR. The primary outcome measure was the association of imaging and biochemical biomarkers with different stages of DR in patients with DME. Results: Out of 100 patients, Group A (1) had 1, Group A (2) 44, Group A (3) 29, and group: B had 29 patients. As Group A (1) had only one patient, we did not include it in the calculation. The overall mean age of the study population was 54.84+9.87 years, with a male preponderance (76%). The HbA1c levels, serum triglyceride level, serum cholesterol level, and microalbuminuria level showed no significant association with different stages of DR (P>0.05). Still, we found high serum urea levels (p=0.027) in Group B patients. The optical coherence tomography (OCT)-based imaging biomarkers - central subfield thickness (CST), cystoid macular edema (CME), subretinal fluid (SRF), and hyperreflective foci (HRF) - showed no significant association with various stages of DR. The presence of diffuse retinal thickness (DRT) (p=0.04) and the epiretinal membrane (ERM) (p=0.04) showed significant association with Group B patients. Conclusion: The essential biochemical biomarkers such as serum urea levels and DRT and ERM may be considered an important imaging biomarker for the advanced stage of DR.
Language	English
Publishing date	2022-09-23
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S377956
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Article ; Online: Acid-Mediated Kidney Injury Across the Spectrum of Metabolic Acidosis.

Ravikumar, Naveen P G / Pao, Alan C / Raphael, Kalani L

Advances in chronic kidney disease

2022 Volume 29, Issue 4, Page(s) 406–415

Abstract: Metabolic acidosis affects about 15% of patients with chronic kidney disease. As kidney function declines, the kidneys progressively fail to eliminate acid, primarily reflected by a decrease in ammonium and titratable acid excretion. Several studies have ...

Abstract	Metabolic acidosis affects about 15% of patients with chronic kidney disease. As kidney function declines, the kidneys progressively fail to eliminate acid, primarily reflected by a decrease in ammonium and titratable acid excretion. Several studies have shown that the net acid load remains unchanged in patients with reduced kidney function; the ensuing acid accumulation can precede overt metabolic acidosis, and thus, indicators of urinary acid or potential base excretion, such as ammonium and citrate, may serve as early signals of impending metabolic acidosis. Acid retention, with or without overt metabolic acidosis, initiates compensatory responses that can promote tubulointerstitial fibrosis via intrarenal complement activation and upregulation of endothelin-1, angiotensin II, and aldosterone pathways. The net effect is a cycle between acid accumulation and kidney injury. Results from small- to medium-sized interventional trials suggest that interrupting this cycle through base administration can prevent further kidney injury. While these findings inform current clinical practice guidelines, large-scale clinical trials are still necessary to prove that base therapy can limit chronic kidney disease progression or associated adverse events.
MeSH term(s)	Acidosis/etiology ; Aldosterone ; Ammonium Compounds ; Angiotensin II ; Citrates ; Endothelin-1 ; Humans ; Kidney ; Renal Insufficiency, Chronic/etiology
Chemical Substances	Ammonium Compounds ; Citrates ; Endothelin-1 ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB)
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1548-5609 ; 1548-5595
ISSN (online)	1548-5609
ISSN	1548-5595
DOI	10.1053/j.ackd.2022.04.009
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Article ; Online: A Novel Intelligent Hybrid Optimized Analytics and Streaming Engine for Medical Big Data.

Thilagaraj, M / Dwarakanath, B / Pandimurugan, V / Naveen, P / Hema, M S / Hariharasitaraman, S / Arunkumar, N / Govindan, Petchinathan

publication RETRACTED

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 7120983

Abstract: Medical data processing is exponentially increasing day by day due to the frequent demand for many applications. Healthcare data is one such field, which is dynamically growing day by day. In today's scenario, an enormous amount of sensing devices and ... ...

Abstract	Medical data processing is exponentially increasing day by day due to the frequent demand for many applications. Healthcare data is one such field, which is dynamically growing day by day. In today's scenario, an enormous amount of sensing devices and data collection units have been employed to generate and collect medical data all over the world. These healthcare devices will result in big real-time data streams. Hence, healthcare-based big data analytics and monitoring have gained hawk-eye importance but needs improvisation. Recently, machine and deep learning algorithms have gained importance to analyze huge amounts of medical data, extract the information, and even predict the future insights of diseases and also cope with the huge volume of data. But applying the learning models to handle big/medical data streams remains to be a challenge among the researchers. This paper proposes the novel deep learning electronic record search engine algorithm (ERSEA) along with firefly optimized long short-term memory (LSTM) model for better data analytics and monitoring. The experimentations have been carried out using Apache Spark using the different medical respiratory data. Finally, the proposed framework results are contrasted with existing models. It shows the accuracy, sensitivity, and specificity like 94%, 93.5%, and 94% for less than 5 GB dataset, and also, more than 5 GB it provides 94%, 92%, and 93% to prove the extraordinary performance of the proposed framework.
MeSH term(s)	Algorithms ; Big Data ; Delivery of Health Care ; Forecasting ; Humans
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/7120983
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Article: An Unusual Case of Candida kefyr Fungemia in an Immunocompromised Patient.

Jyothi, Lakshmi / Reddy, Naveen P / Naaz, Shazia

Cureus

2021 Volume 13, Issue 3, Page(s) e14138

Abstract: An immunocompromised patient with a known history of cerebrovascular accident (CVA) with right-sided hemiparesis of long duration, type 2 diabetes mellitus, and hypertension presented with signs of rhabdomyolysis and later acute kidney injury (AKI). He ... ...

Abstract	An immunocompromised patient with a known history of cerebrovascular accident (CVA) with right-sided hemiparesis of long duration, type 2 diabetes mellitus, and hypertension presented with signs of rhabdomyolysis and later acute kidney injury (AKI). He subsequently developed Guillain Barre syndrome. Initially, hemodialysis was followed by plasmapheresis. After hemodialysis, the patient presented with multiple episodes of vomiting and weakness of all limbs. A culture showed growth of
Language	English
Publishing date	2021-03-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14138
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Article ; Online: A standardized extract of

Sudeep, Heggar Venkataramana / Gouthamchandra, Kuluvar / Ramanaiah, Illuri / Raj, Amritha / Naveen, Puttaswamy / Shyamprasad, Kodimule

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1211–1221

Abstract: Context: Preparations of : Objective: In this study, : Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of : Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS!# ...

Abstract	Context: Preparations of Objective: In this study, Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS Conclusion: Our results strongly support SEP extract with 4% chicoric acid as a functional ingredient for immunomodulation.
MeSH term(s)	Mice ; Male ; Animals ; Echinacea/chemistry ; Nitric Oxide ; Cytokines ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Macrophages ; Immunosuppression Therapy ; Immunity
Chemical Substances	chicoric acid (S4YY3V8YHD) ; Nitric Oxide (31C4KY9ESH) ; Cytokines ; Plant Extracts
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2244000
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Article ; Online: Mortality and its determinants after an outbreak of post COVID-19 associated rhino-orbito-cerebral mucormycosis in Central India.

Nagarkar, Nitin M / Sahu, Vijaya / Arora, Ripudaman / Pathak, Madhumallika / Shambharkar, Martina S / Naveen, Prithvi

International ophthalmology

2023 Volume 43, Issue 7, Page(s) 2363–2370

Abstract: Aim: To report cumulative mortality rates using survival analysis from an outbreak of 211 patients with post COVID-19 rhino-orbito-cerebral mucormycosis (ROCM) in central India.: Methods: Case files of eligible patients were evaluated and mucor was ... ...

Abstract	Aim: To report cumulative mortality rates using survival analysis from an outbreak of 211 patients with post COVID-19 rhino-orbito-cerebral mucormycosis (ROCM) in central India. Methods: Case files of eligible patients were evaluated and mucor was identified from deep nasal swabs using freshly prepared KOH mount. All patients underwent contrast enhanced MRI and disease staging was done based on the extent of anatomical involvement. All patients received intravenous Amphotericin B and sinus debridement was done when possible. Orbital exenteration was reserved for patients with advanced orbital disease. Results: The mean age was 50.7 ± 10.2 of which 147 (70%) were men. At presentation, ROCM was limited to sinuses in 72 (34%), orbital extension was seen in 102 (48%) and 31 (15%) had CNS extension. Sinus debridement was possible in 82% cases (n = 173). Thirty-five (16.6%) patients died due to ROCM. The mean follow-up of patients who survived was 126.6 ± 16.4 days. The cumulative mortality rate at day 10 was 4.8% (95%CI = 2.6-8.8%) and increased 13.1% (95%CI = 9.1-18.7%) at day 30 and to 18.4% (95%CI = 13.6-24.8%) at day 60. Majority of deaths (n = 26, 75%) occurred within 1-month of ROCM presentation. Multivariable hazards analysis showed that patients with CNS involvement had a 6.5 times higher risk of death (Hazard Ratio = 6.71, 95% CI = 2.9-15.5, p < 0.001). Conclusion: We report significantly lower mortality rates compared to recent literature that varies from 30 to 80% at 1-month follow-up. Timely sinus debridement and systemic Amphotericin B can help reduce mortality. Presence of CNS extension significantly increased the mortality risk with patients with ROCM.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Female ; Mucormycosis/diagnosis ; Mucormycosis/epidemiology ; Mucormycosis/drug therapy ; Amphotericin B/therapeutic use ; Antifungal Agents/therapeutic use ; COVID-19/epidemiology ; Orbital Diseases/diagnosis ; Orbital Diseases/epidemiology ; Disease Outbreaks
Chemical Substances	Amphotericin B (7XU7A7DROE) ; Antifungal Agents
Language	English
Publishing date	2023-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02634-0
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Article ; Online: Phacoemulsification, pinhole pupilloplasty, and pre-Descemet's endothelial keratoplasty for keratoconus with Fuchs' endothelial dystrophy.

Kumar, Dhivya Ashok / Jacob, Soosan / Naveen, Preethi / Sivagnanam, Soundari / Agarwal, Amar

Indian journal of ophthalmology

2023 Volume 71, Issue 9, Page(s) 3242–3245

Abstract: The comorbidity of keratoconus with Fuchs' endothelial dystrophy with cataract is a rare clinical combination. We present an amalgamation of surgical techniques to manage the above clinical conditions and its complications in single setting. The modified ...

Abstract	The comorbidity of keratoconus with Fuchs' endothelial dystrophy with cataract is a rare clinical combination. We present an amalgamation of surgical techniques to manage the above clinical conditions and its complications in single setting. The modified triple procedure, namely, the phacoemulsification, pinhole pupilloplasty, and pre-Descemet's endothelial keratoplasty (PDEK) in the order of description is followed in single sitting. Lens removal by phacoemulsification, correction of irregular astigmatism by pinhole pupilloplasty (pinhole optics), and exchanging the endothelial layer for PDEK forms the main segments of the triple procedure. This combination of techniques may decrease the risk of multiple surgeries and its related complications. Moreover, it will allow the patient for faster visual rehabilitation by improving the uncorrected visual acuity and visual quality.
MeSH term(s)	Humans ; Phacoemulsification ; Keratoconus/complications ; Keratoconus/diagnosis ; Keratoconus/surgery ; Fuchs' Endothelial Dystrophy/complications ; Fuchs' Endothelial Dystrophy/diagnosis ; Fuchs' Endothelial Dystrophy/surgery ; Descemet Stripping Endothelial Keratoplasty ; Cataract Extraction
Language	English
Publishing date	2023-08-04
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_3023_22
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Article: Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in

Naveen, P / Lingaraju, H B / Anitha / Prasad, K Shyam

International journal of pharmaceutical investigation

2017 Volume 7, Issue 2, Page(s) 94–100

Abstract: Objective: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of : Materials and methods: RP-HPLC analysis was performed by gradient elution with ... ...

Abstract	Objective: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of Materials and methods: RP-HPLC analysis was performed by gradient elution with a low-pressure gradient using 0.5% acetic acid: acetonitrile as a mobile phase with a flow rate of 1.0 ml/min. The separation was done at 26°C using a Kinetex XB-C18 column as stationary phase and the detection wavelength at 356 nm. The proposed method was validated as per International Conference on Harmonisation guidelines with respect to specificity, linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). Results: The validated results were within the acceptable limits. In specificity, the retention time of rutin, isoquercetin, and quercetin peak in the sample was matched with the reference standard peak and showed good resolution. An excellent linearity was obtained with correlation coefficient (r) higher than 0.999. In precision, the repeatability and intermediate showed <1.0% of % relative standard deviation of peak area percentage indicating high precision and accurate. The recovery rate for rutin, isoquercetin, and quercetin was between 99.85%-101.37%, 101.90%-103.24%, and 101.74%-106.73%, respectively. The lower LOD and LOQ of rutin, isoquercetin, and quercetin enable the detection and quantitation of these flavonoids in Conclusion: The developed analytical method is convenient for the determination of flavonoids content in herbal drugs.
Language	English
Publishing date	2017-02-09
Publishing country	India
Document type	Journal Article
ISSN	2230-973X
ISSN	2230-973X
DOI	10.4103/jphi.JPHI_33_17
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Article ; Online: A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins.

Sudeep, H V / Venkatakrishna, K / Amritharaj / Gouthamchandra, K / Reethi, B / Naveen, P / Lingaraju, H B / Shyamprasad, K

Journal of food biochemistry

2021 Volume 45, Issue 12, Page(s) e13994

Abstract: β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using ... ...

Abstract	β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using supercritical fluid extraction, standardized to contain 30% BCP (Viphyllin
MeSH term(s)	Amnesia/chemically induced ; Amnesia/drug therapy ; Animals ; Brain-Derived Neurotrophic Factor ; Cognition ; Male ; Mice ; Piper nigrum ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Polycyclic Sesquiterpenes ; Scopolamine/toxicity
Chemical Substances	Brain-Derived Neurotrophic Factor ; Plant Extracts ; Polycyclic Sesquiterpenes ; caryophyllene (BHW853AU9H) ; Scopolamine (DL48G20X8X)
Language	English
Publishing date	2021-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13994
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Article ; Online: The emergence and implications of SARS-CoV-2 omicron subvariant BA.2.86 on global health.

Satapathy, Prakasini / Kumar, Pawan / Gupta, Jeetendra K / Rabaan, Ali A / Al Kaabi, Nawal A / Mohanty, Dibyalochan / Naveen, Pathakala / Khatib, Mahalaqua Nazli / Gaidhane, Shilpa / Zahiruddin, Quazi Syed / Neyazi, Ahmad

International journal of surgery (London, England)

2024 Volume 110, Issue 4, Page(s) 2498–2501

Abstract: The SARS-CoV-2 subvariant BA.2.86 'Pirola', first identified in Denmark in August 2023, has manifested with a significantly mutated spike protein profile, suggesting a heightened ability to evade vaccine-induced and infection-induced antibodies. This ... ...

Abstract	The SARS-CoV-2 subvariant BA.2.86 'Pirola', first identified in Denmark in August 2023, has manifested with a significantly mutated spike protein profile, suggesting a heightened ability to evade vaccine-induced and infection-induced antibodies. This article outlines the epidemiological spread, immune response implications, and global responses to BA.2.86. Preliminary observations indicate community transmissions of the subvariant, even among those previously infected or vaccinated. Notably, the BA.2.86 infection has shown a potential to amplify antibody responses. The variant's emergence has evoked memories of the Omicron variant's rise in late 2021, though global immunity levels might modulate the impact of BA.2.86 impact differently. Continuous genomic surveillance, coupled with integrated diagnostic and epidemiological strategies, proves crucial in early detection and management. The emergence of BA.2.86 reaffirms the unpredictable nature of the COVID-19 pandemic, emphasizing the need for ongoing research, adaptability, and global collaboration.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/genetics ; Global Health ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; COVID-19 Vaccines/immunology
Chemical Substances	Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines ; spike protein, SARS-CoV-2
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001070
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