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Article ; Online: Ten millennia of hepatitis B virus evolution.

Kocher, Arthur / Papac, Luka / Barquera, Rodrigo / Key, Felix M / Spyrou, Maria A / Hübler, Ron / Rohrlach, Adam B / Aron, Franziska / Stahl, Raphaela / Wissgott, Antje / van Bömmel, Florian / Pfefferkorn, Maria / Mittnik, Alissa / Villalba-Mouco, Vanessa / Neumann, Gunnar U / Rivollat, Maïté / van de Loosdrecht, Marieke S / Majander, Kerttu / Tukhbatova, Rezeda I /
Musralina, Lyazzat / Ghalichi, Ayshin / Penske, Sandra / Sabin, Susanna / Michel, Megan / Gretzinger, Joscha / Nelson, Elizabeth A / Ferraz, Tiago / Nägele, Kathrin / Parker, Cody / Keller, Marcel / Guevara, Evelyn K / Feldman, Michal / Eisenmann, Stefanie / Skourtanioti, Eirini / Giffin, Karen / Gnecchi-Ruscone, Guido Alberto / Friederich, Susanne / Schimmenti, Vittoria / Khartanovich, Valery / Karapetian, Marina K / Chaplygin, Mikhail S / Kufterin, Vladimir V / Khokhlov, Aleksandr A / Chizhevsky, Andrey A / Stashenkov, Dmitry A / Kochkina, Anna F / Tejedor-Rodríguez, Cristina / de Lagrán, Íñigo García-Martínez / Arcusa-Magallón, Héctor / Garrido-Pena, Rafael / Royo-Guillén, José Ignacio / Nováček, Jan / Rottier, Stéphane / Kacki, Sacha / Saintot, Sylvie / Kaverzneva, Elena / Belinskiy, Andrej B / Velemínský, Petr / Limburský, Petr / Kostka, Michal / Loe, Louise / Popescu, Elizabeth / Clarke, Rachel / Lyons, Alice / Mortimer, Richard / Sajantila, Antti / de Armas, Yadira Chinique / Hernandez Godoy, Silvia Teresita / Hernández-Zaragoza, Diana I / Pearson, Jessica / Binder, Didier / Lefranc, Philippe / Kantorovich, Anatoly R / Maslov, Vladimir E / Lai, Luca / Zoledziewska, Magdalena / Beckett, Jessica F / Langová, Michaela / Danielisová, Alžběta / Ingman, Tara / Atiénzar, Gabriel García / de Miguel Ibáñez, Maria Paz / Romero, Alejandro / Sperduti, Alessandra / Beckett, Sophie / Salter, Susannah J / Zilivinskaya, Emma D / Vasil'ev, Dmitry V / von Heyking, Kristin / Burger, Richard L / Salazar, Lucy C / Amkreutz, Luc / Navruzbekov, Masnav / Rosenstock, Eva / Alonso-Fernández, Carmen / Slavchev, Vladimir / Kalmykov, Alexey A / Atabiev, Biaslan Ch / Batieva, Elena / Calmet, Micaela Alvarez / Llamas, Bastien / Schultz, Michael / Krauß, Raiko / Jiménez-Echevarría, Javier / Francken, Michael / Shnaider, Svetlana / de Knijff, Peter / Altena, Eveline / Van de Vijver, Katrien / Fehren-Schmitz, Lars / Tung, Tiffiny A / Lösch, Sandra / Dobrovolskaya, Maria / Makarov, Nikolaj / Read, Chris / Van Twest, Melanie / Sagona, Claudia / Ramsl, Peter C / Akar, Murat / Yener, K Aslihan / Ballestero, Eduardo Carmona / Cucca, Francesco / Mazzarello, Vittorio / Utrilla, Pilar / Rademaker, Kurt / Fernández-Domínguez, Eva / Baird, Douglas / Semal, Patrick / Márquez-Morfín, Lourdes / Roksandic, Mirjana / Steiner, Hubert / Salazar-García, Domingo Carlos / Shishlina, Natalia / Erdal, Yilmaz Selim / Hallgren, Fredrik / Boyadzhiev, Yavor / Boyadzhiev, Kamen / Küßner, Mario / Sayer, Duncan / Onkamo, Päivi / Skeates, Robin / Rojo-Guerra, Manuel / Buzhilova, Alexandra / Khussainova, Elmira / Djansugurova, Leyla B / Beisenov, Arman Z / Samashev, Zainolla / Massy, Ken / Mannino, Marcello / Moiseyev, Vyacheslav / Mannermaa, Kristiina / Balanovsky, Oleg / Deguilloux, Marie-France / Reinhold, Sabine / Hansen, Svend / Kitov, Egor P / Dobeš, Miroslav / Ernée, Michal / Meller, Harald / Alt, Kurt W / Prüfer, Kay / Warinner, Christina / Schiffels, Stephan / Stockhammer, Philipp W / Bos, Kirsten / Posth, Cosimo / Herbig, Alexander / Haak, Wolfgang / Krause, Johannes / Kühnert, Denise

Science (New York, N.Y.)

2021  Volume 374, Issue 6564, Page(s) 182–188

Abstract: Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10, ... ...

Abstract Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
MeSH term(s) American Indians or Alaska Natives ; Americas ; Asia ; Asians ; Communicable Diseases, Emerging/history ; Communicable Diseases, Emerging/virology ; Europe ; Evolution, Molecular ; Genetic Variation ; Genomics ; Hepatitis B/history ; Hepatitis B/virology ; Hepatitis B virus/classification ; Hepatitis B virus/genetics ; History, Ancient ; Humans ; Paleontology ; Phylogeny ; Whites
Language English
Publishing date 2021-10-07
Publishing country United States
Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 128410-1
ISSN 1095-9203 ; 0036-8075
ISSN (online) 1095-9203
ISSN 0036-8075
DOI 10.1126/science.abi5658
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