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  1. Article: A Case of Acute Severe Ulcerative Colitis Triggered by COVID-19 Infection.

    Nawghare, Pankaj / Jain, Shubham / Chandnani, Sanjay / Rathi, Pravin

    Cureus

    2023  Volume 15, Issue 1, Page(s) e34369

    Abstract: Ulcerative colitis is a chronic inflammatory bowel condition. One of the theories for its etiopathogenesis is gastrointestinal infections. Although COVID-19 primarily affects the respiratory tract, gastrointestinal involvement is also common. We have ... ...

    Abstract Ulcerative colitis is a chronic inflammatory bowel condition. One of the theories for its etiopathogenesis is gastrointestinal infections. Although COVID-19 primarily affects the respiratory tract, gastrointestinal involvement is also common. We have reported a case of a 28-year-old male who presented with bloody diarrhea, diagnosed with acute severe ulcerative colitis, triggered by COVID-19 infection after known triggers were excluded.
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.34369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Challenges in Diagnosis of Esophageal Tuberculosis.

    Gandhi, Harsh / Chandnani, Sanjay / Rathi, Pravin / Jain, Shubham / Malokar, Rishikesh / Chudasama, Jay / Nawghare, Pankaj

    The Journal of the Association of Physicians of India

    2024  Volume 72, Issue 1, Page(s) 104–105

    Abstract: Esophageal tuberculosis (TB) is a rare manifestation of extrapulmonary TB, accounting for <0.2% of all TB cases. Esophageal TB most commonly presents with dysphagia, odynophagia, retrosternal pain, and systemic symptoms like decreased appetite, loss of ... ...

    Abstract Esophageal tuberculosis (TB) is a rare manifestation of extrapulmonary TB, accounting for <0.2% of all TB cases. Esophageal TB most commonly presents with dysphagia, odynophagia, retrosternal pain, and systemic symptoms like decreased appetite, loss of weight, and low-grade fever as associated or other presentations. We report a similar case recently encountered as an elderly male patient presented with chronic dysphagia to solids, loss of appetite, and significant loss of weight. Radiological and endoscopy pictures looked like esophageal cancer with histopathological examination (twice) negative for the same. Diagnosis of esophageal TB was confirmed by GeneXpert Ultra of biopsy sample and histopathological examination was suggestive of granulomatous esophagitis. The patient improved on 6 months antitubercular therapy. The unique aspect of this case was how the lesion mimicked an esophageal carcinoma on imaging which posed a diagnostic challenge.
    MeSH term(s) Humans ; Male ; Antitubercular Agents/therapeutic use ; Tuberculosis, Gastrointestinal/diagnosis ; Tuberculosis, Gastrointestinal/drug therapy ; Diagnosis, Differential ; Aged ; Deglutition Disorders/etiology ; Esophageal Neoplasms/diagnosis ; Esophageal Diseases/diagnosis
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2024-05-12
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.59556/japi.71.0402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: A case of COVID-19 presenting as acute liver failure

    Nawghare Pankaj / Nair Sujit / Jain Shubham / Bansal Saurabh / Chandnani Sanjay / Rathi Surbhi / Rathi Pravin

    Scripta Medica, Vol 53, Iss 4, Pp 353-

    2022  Volume 356

    Abstract: Although children with COVID-19 make up a small proportion of patients and have milder symptoms than adults, liver damage is a well-documented side effect of COVID-19 infection. Most liver damage caused by COVID-19 is modest. In this report, a case of a ... ...

    Abstract Although children with COVID-19 make up a small proportion of patients and have milder symptoms than adults, liver damage is a well-documented side effect of COVID-19 infection. Most liver damage caused by COVID-19 is modest. In this report, a case of a 6-year-old child who was hospitalised to a paediatric intensive care unit (PICU) with COVID-19 manifested as acute liver failure is described.
    Keywords covid-19 ; acute liver failure ; children ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Takayasu Arteritis Presenting as Intestinal Angina: Unusual Presentation of a Rare Disease.

    Nawghare, Pankaj / Thanage, Ravi / Jain, Shubham / Chandnani, Sanjay / Rathi, Pravin M

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21548

    Abstract: Intestinal angina refers to abdominal pain resulting from reduced mesenteric blood flow. Although atherosclerosis is the most common cause, large vessel vasculitis is emerging as one of the common causes. We have reported a case of an 18-year-old female ... ...

    Abstract Intestinal angina refers to abdominal pain resulting from reduced mesenteric blood flow. Although atherosclerosis is the most common cause, large vessel vasculitis is emerging as one of the common causes. We have reported a case of an 18-year-old female who presented with classical symptoms of intestinal angina. On evaluation, the patient was found to have an abdominal aortic aneurysm with a compromised mesenteric blood supply. She was started on steroids and methotrexate along with anti-platelets and anticoagulants. She improved following the treatment and didn't have any complaints on follow-up.
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effects of high bilirubin level in pregnancy in Crigler-Najjar syndrome type 2: An extremely rare but important clinical entity to recognize.

    Bansal, Saurabh / Jain, Shubham / Rathi, Pravin M / Chandnani, Sanjay / Debnath, Prasanta / Nawghare, Pankaj

    Medical journal, Armed Forces India

    2021  Volume 79, Issue 5, Page(s) 597–600

    Abstract: Crigler-Najjar is a rare genetic autosomal recessive disorder caused by deficiency of enzyme Uridine 5-Diphosphate Glucuronosyl Transferase (UDP-GT). We report the case of a 24-year-old female with two consecutive pregnancies with a high level of total ... ...

    Abstract Crigler-Najjar is a rare genetic autosomal recessive disorder caused by deficiency of enzyme Uridine 5-Diphosphate Glucuronosyl Transferase (UDP-GT). We report the case of a 24-year-old female with two consecutive pregnancies with a high level of total bilirubin level of 15.1 mg/dl and a direct bilirubin level of 0.8 mg/dl during the first pregnancy. As she was diagnosed case of Crigler Najjar type 2, she was on phenobarbitone 60 mg daily. With careful monitoring, she continued with the same dose. We concluded that even with high bilirubin level (15.1 mg/dl) in pregnancy, no adverse effects to the baby and mother were seen.
    Language English
    Publishing date 2021-09-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/j.mjafi.2021.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6511: Show issues Location:
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  6. Article: Predictors of Severity and Mortality in Chronic Liver Disease Patients With COVID-19 During the Second Wave of the Pandemic in India.

    Nawghare, Pankaj / Jain, Shubham / Chandnani, Sanjay / Bansal, Saurabh / Patel, Sameet / Debnath, Partha / Rane, Siddhesh / Deshmukh, Rahul / Rathi, Pravin / Contractor, Qais

    Cureus

    2022  Volume 14, Issue 1, Page(s) e20891

    Abstract: Background Coronavirus disease 2019 (COVID-19) infection in chronic liver disease patients is associated with poor outcomes. In this study, we aimed to evaluate the predictors of severity and mortality in this group of patients during the second wave of ... ...

    Abstract Background Coronavirus disease 2019 (COVID-19) infection in chronic liver disease patients is associated with poor outcomes. In this study, we aimed to evaluate the predictors of severity and mortality in this group of patients during the second wave of the COVID-19 pandemic in India. In addition, we compared cirrhotic patients with COVID-19 with cirrhotic patients from the pre-COVID-19 period. Methodology This was a single-center observational study. We included data from 50 patients with cirrhosis and COVID-19 retrospectively from the discharge/death files. A comparison group of 100 patients with cirrhosis from the pre-COVID period was also analyzed retrospectively. Results The majority of patients had predominantly respiratory symptoms, with fever being the most common symptom (85%). The most common presentation was acute on chronic liver failure (ACLF). The most common form of decompensation was jaundice followed by hepatic encephalopathy. The overall mortality in cirrhotic patients with COVID-19 was double than that in cirrhotic patients from the pre-COVID-19 period. All patients with ACLF succumbed to multiorgan failure. Diabetes was the only comorbidity that was associated with severe infection. Higher creatinine on admission and high D-dimer levels correlated with severity. D-dimer was the only parameter that correlated with severity and mortality on multivariate analysis. None of the comorbidities predicted mortality. Among various composite scores, the Child-Turcotte-Pugh (CTP) score and CURB-65 correlated with mortality. On the area under the receiver operating characteristic analysis, a D-dimer level of >1.1 mg/L was associated with mortality. Conclusions COVID-19 infection in patients with cirrhosis is associated with poor outcomes. D-dimer levels of >1.1 mg/L on admission are a simple parameter to predict mortality. CTP and CURB-65 are composite scores that correlate with mortality in this group of patients.
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.20891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India.

    Chandnani, Sanjay J / Jain, Shubham / Nawghare, Pankaj / Debnath, Partha / Rane, Siddhesh / Deshmukh, Rahul / Bansal, Saurabh / Patel, Sameet / Thanage, Ravi / Junare, Parmeshwar / Contractor, Qais / Rathi, Pravin M / Singh, Anupam Kumar

    The Indian journal of medical research

    2023  Volume 156, Issue 3, Page(s) 484–499

    Abstract: Background & objectives: Coronavirus disease 2019 (COVID-19) affects respiratory, gastrointestinal, cardiovascular and other systems disease. Studies describing liver involvement and liver function test (LFT) abnormalities are sparse from our population. ...

    Abstract Background & objectives: Coronavirus disease 2019 (COVID-19) affects respiratory, gastrointestinal, cardiovascular and other systems disease. Studies describing liver involvement and liver function test (LFT) abnormalities are sparse from our population. This study was undertaken to estimate the LFT abnormalities in patients with COVID-19 in a tertiary care set up in India.
    Methods: In this retrospective study conducted at a tertiary care centre in Mumbai, India, all consecutive patients with proven COVID-19 by reverse transcriptase-PCR from March 23 to October 31, 2020 were enrolled. Of the 3280 case records profiled, 1474 cases were included in the study. Clinical characteristics, biochemical parameters and outcomes were recorded.
    Results: Overall 681 (46%) patient had deranged LFTs. Hepatocellular type of injury was most common (93%). Patients with deranged LFTs had more probability of developing severe disease (P<0.001) and mortality (P<0.001). Advanced age (P<0.001), male gender (P<0.001), diabetes mellitus (P<0.001), lower oxygen saturation levels at admission (P<0.001), higher neutrophil-lymphocyte ratio (P<0.001), history of diabetes mellitus and cirrhosiss were associated with deranged LFTs. Acute liver injury was seen in 65 (4.3%) cases on admission and 57 (3.5%) cases during hospital stay. On multivariate analysis for predicting mortality, age >60 yr serum creatinine >2 mg%, PaO
    Interpretation & conclusions: In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality.
    MeSH term(s) Humans ; Male ; COVID-19 ; Liver Function Tests ; SARS-CoV-2 ; Tertiary Care Centers ; Retrospective Studies
    Language English
    Publishing date 2023-02-07
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.ijmr_1468_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
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