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  1. Article: A Single Belief-Changing Psychedelic Experience Is Associated With Increased Attribution of Consciousness to Living and Non-living Entities.

    Nayak, Sandeep M / Griffiths, Roland R

    Frontiers in psychology

    2022  Volume 13, Page(s) 852248

    Abstract: Introduction: Although the topic of consciousness is both mysterious and controversial, psychedelic drugs are popularly believed to provide unique insights into the nature of consciousness despite a lack of empirical evidence.: Methods: This study ... ...

    Abstract Introduction: Although the topic of consciousness is both mysterious and controversial, psychedelic drugs are popularly believed to provide unique insights into the nature of consciousness despite a lack of empirical evidence.
    Methods: This study addresses the question of whether psychedelics change the attribution of consciousness to a range of living and non-living entities. A survey was conducted in 1,606 respondents who endorsed a belief changing psychedelic experience.
    Results: Participants rated their attributions of consciousness to a range of living and non-living entities before and after their psychedelic experience. Superstitious beliefs and belief in freewill were also assessed. From before the experience to after, there were large increases in attribution of consciousness to various entities including non-human primates (63-83%), quadrupeds (59-79%), insects (33-57%), fungi (21-56%), plants (26-61%), inanimate natural objects (8-26%), and inanimate manmade objects (3-15%). Higher ratings of mystical experience were associated with greater increases in the attribution of consciousness. Moreover, the increased attributions of consciousness did not decrease in those who completed the survey years after the psychedelic experience. In contrast to attributions of consciousness, beliefs in freewill and superstitions did not change. Notably, all findings were similar when restricted to individuals reporting on their first psychedelic experience.
    Discussion: This study demonstrates that, among people who reported belief-changing psychedelic experiences, attribution of consciousness to various entities increases. Future prospective psychedelic drug administration studies that control for expectancies are needed.
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.852248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Psilocybin in Bipolar II Study Provides Preliminary Data on Safety.

    Yaden, David B / Gukasyan, Natalie / Nayak, Sandeep M

    JAMA psychiatry

    2023  

    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.4680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Psychedelics, placebo effects, and set and setting: Insights from common factors theory of psychotherapy.

    Gukasyan, Natalie / Nayak, Sandeep M

    Transcultural psychiatry

    2021  Volume 59, Issue 5, Page(s) 652–664

    Abstract: Psychedelic-assisted treatment is at first glance markedly different in structure and approach from mainstream forms of psychotherapy in the West. A major criticism of clinical psychedelic research rests on the difficulty of executing placebo-controlled ... ...

    Abstract Psychedelic-assisted treatment is at first glance markedly different in structure and approach from mainstream forms of psychotherapy in the West. A major criticism of clinical psychedelic research rests on the difficulty of executing placebo-controlled studies and distinguishing drug effects from those of the psychotherapeutic container in which psychedelics are typically presented. Detractors also tend to find fault in spiritual or mystical themes that often arise in the context of psychedelic use. Common factors theory of psychotherapy is a useful and extensively studied framework that can help make sense of these issues, and has much to contribute to our understanding of contextual effects that are often discussed in psychedelic literature as "set and setting." In this article, we examine four major contextual "common factors" shared by various healing traditions: 1) the therapeutic relationship; 2) the healing setting; 3) the rationale, conceptual scheme, or myth; and 4) the ritual. We explain how these factors show up in psychedelic-assisted treatment and how they may contribute to therapeutic effects. Lastly, we discuss the implications of these factors for the concept of placebo, and for future research.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Placebo Effect ; Psychotherapy ; Ceremonial Behavior
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1378978-8
    ISSN 1461-7471 ; 1363-4615
    ISSN (online) 1461-7471
    ISSN 1363-4615
    DOI 10.1177/1363461520983684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to "Capturing Synergy Holistically in Psychedelic Clinical Trials".

    Dworkin, Robert H / McDermott, Michael P / Nayak, Sandeep M / Strain, Eric C

    Clinical pharmacology and therapeutics

    2024  Volume 115, Issue 3, Page(s) 401–402

    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute Subjective Effects of Psychedelics within and Beyond WEIRD Contexts.

    Graziosi, Marianna / Singh, Manvir / Nayak, Sandeep M / Yaden, David B

    Journal of psychoactive drugs

    2023  Volume 55, Issue 5, Page(s) 558–569

    Abstract: Reports of psychedelic experiences may contain similarities and differences across cultural contexts, but most current characterizations and quantifications of psychedelic experiences come from Western medical and naturalistic settings. In this article, ... ...

    Abstract Reports of psychedelic experiences may contain similarities and differences across cultural contexts, but most current characterizations and quantifications of psychedelic experiences come from Western medical and naturalistic settings. In this article, we begin with a brief history of the diversity of psychedelic use in non-Western settings. We then compare and contrast accounts of psychedelic experiences within and beyond Western, educated, industrialized, rich, and democratic (WEIRD) contexts. We focus on specific reports of direct testimony of the acute subjective effects of psychedelics experienced across these contexts. We compare themes from each of these various contexts, with special emphasis on psychometric measures such as the mystical experiences questionnaire (MEQ), the five-dimensional altered states of consciousness (5D-ASC) scale, the Survey of God Encounters, and the Survey of Entity Encounters, the Challenging Experiences Questionnaire, and the Inventory of Nonordinary Experiences (INOE). Finally, we offer recommendations for future research to quantify these similarities and differences across cultures to assess them empirically in the future.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Mysticism ; Consciousness ; Surveys and Questionnaires ; Psychometrics
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2023.2255274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Psychedelics and Psychotherapy: Is the Whole Greater than the Sum of its Parts?

    Dworkin, Robert H / McDermott, Michael P / Nayak, Sandeep M / Strain, Eric C

    Clinical pharmacology and therapeutics

    2023  Volume 114, Issue 6, Page(s) 1166–1169

    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Psychotherapy ; Combined Modality Therapy
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use.

    Gukasyan, Natalie / Griffiths, Roland R / Yaden, David B / Antoine, Denis G / Nayak, Sandeep M

    Journal of psychopharmacology (Oxford, England)

    2023  Volume 37, Issue 7, Page(s) 707–716

    Abstract: Background: Psilocybin is being studied for depression, but little is known about how it interacts with common antidepressants. Limited data suggest that psilocybin's effects may be diminished by serotonergic antidepressants acutely and even after a ... ...

    Abstract Background: Psilocybin is being studied for depression, but little is known about how it interacts with common antidepressants. Limited data suggest that psilocybin's effects may be diminished by serotonergic antidepressants acutely and even after a medication washout period.
    Aims: To learn the extent to which antidepressants may diminish the effects of psilocybin-containing mushrooms both concurrently and after discontinuation of antidepressants.
    Methods: Online retrospective survey of individuals with use of psilocybin mushrooms (1) with an antidepressant and/or (2) within 2 years of discontinuing an antidepressant. Participants who took mushrooms with an antidepressant and either took the same dose pre-antidepressant or took the same dose with other people not on antidepressant reported the strength of drug effects relative to their expectation. Participants who took mushrooms following discontinuation of an antidepressant also reported the presence of weakened effects.
    Results: In reports (
    Conclusions: SSRI/SNRIs appear to weaken psilocybin drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation.
    MeSH term(s) Humans ; Serotonin and Noradrenaline Reuptake Inhibitors ; Psilocybin/pharmacology ; Retrospective Studies ; Agaricales ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Selective Serotonin Reuptake Inhibitors/pharmacology
    Chemical Substances Serotonin and Noradrenaline Reuptake Inhibitors ; Psilocybin (2RV7212BP0) ; Antidepressive Agents ; Selective Serotonin Reuptake Inhibitors
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/02698811231179910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reconsidering "dissociation" as a predictor of antidepressant efficacy for esketamine.

    Mathai, David S / Nayak, Sandeep M / Yaden, David B / Garcia-Romeu, Albert

    Psychopharmacology

    2023  Volume 240, Issue 4, Page(s) 827–836

    Abstract: Rationale: The relationship between subjective drug experience and antidepressant outcomes for ketamine derivatives is poorly understood but of high clinical relevance. Esketamine is the patented (S)-enantiomer of ketamine and has regulatory approval ... ...

    Abstract Rationale: The relationship between subjective drug experience and antidepressant outcomes for ketamine derivatives is poorly understood but of high clinical relevance. Esketamine is the patented (S)-enantiomer of ketamine and has regulatory approval for psychiatric applications.
    Objectives: We examined the relationship between acute dissociation, as measured by the Clinician-Administered Dissociative States Scale (CADSS), and antidepressant efficacy, as measured by the Montgomery-Åsberg Depression Rating Scale (MADRS), for esketamine across the 4-week induction phase of treatment.
    Methods: This post hoc analysis combined data (N = 576) from the TRANSFORM-1 and TRANSFORM-2 clinical trials of esketamine for treatment-resistant depression. Linear mixed models were performed using total MADRS score as the outcome variable with the following independent variables: baseline MADRS score, treatment condition × time interaction, and CADSS × time interaction. To assess whether initial dissociation predicted rapid antidepressant benefit with esketamine, a separately planned regression was performed with day 2 MADRS as the outcome variable with the following dependent variables: baseline MADRS, treatment condition, and day 1 CADSS.
    Results: The linear mixed model did not show any effect of a CADSS × time interaction (p = 0.7). Looking solely at the effect of day 1 CADSS on day 2 MADRS revealed that each additional CADSS point was associated with a - .04 [95% CI - .08, - .002] (p = .04) decrease in MADRS score.
    Conclusions: We found no evidence of a clinically significant positive or negative association between dissociation and antidepressant effect for esketamine. Our findings suggest that subsequent inquiry in this area will benefit from improved characterization of drug experiences relevant to therapeutic outcomes.
    MeSH term(s) Humans ; Ketamine/pharmacology ; Double-Blind Method ; Antidepressive Agents/pharmacology ; Administration, Intranasal ; Depressive Disorder, Treatment-Resistant/drug therapy ; Treatment Outcome
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Antidepressive Agents
    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-023-06324-8
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  9. Article ; Online: Belief changes associated with psychedelic use.

    Nayak, Sandeep M / Singh, Manvir / Yaden, David B / Griffiths, Roland R

    Journal of psychopharmacology (Oxford, England)

    2022  Volume 37, Issue 1, Page(s) 80–92

    Abstract: Background: Psychedelic use is anecdotally associated with belief changes, although few studies have tested these claims.: Aim: Characterize a broad range of psychedelic occasioned belief changes.: Survey: A survey was conducted in 2374 ... ...

    Abstract Background: Psychedelic use is anecdotally associated with belief changes, although few studies have tested these claims.
    Aim: Characterize a broad range of psychedelic occasioned belief changes.
    Survey: A survey was conducted in 2374 respondents who endorsed having had a belief changing psychedelic experience. Participants rated their agreement with belief statements Before and After the psychedelic experience as well as at the time of survey administration.
    Results: Factor analysis of 45 belief statements revealed five factors: "Dualism," "Paranormal/Spirituality," "Non-mammal consciousness," "Mammal consciousness," and "Superstition." Medium to large effect sizes from Before to After the experience were observed for increases in beliefs in "Dualism" (β = 0.72), "Paranormal/Spirituality" (β = 0.90), "Non-mammal consciousness" (β = 0.72), and "Mammal consciousness" (β = 0.74). In contrast, negligible changes were observed for "Superstition" (β = -0.18).). At the individual item level, increases in non-physicalist beliefs included belief in reincarnation, communication with the dead, existence of consciousness after death, telepathy, and consciousness of inanimate natural objects (e.g., rocks). The percentage of participants who identified as a "Believer (e.g., in Ultimate Reality, Higher Power, and/or God, etc.)" increased from 29% Before to 59% After." At both the factor and individual item level, higher ratings of mystical experience were associated with greater changes in beliefs. Belief changes assessed after the experience (an average 8.4 years) remained largely unchanged at the time of survey.
    Conclusions: A single psychedelic experience increased a range of non-physicalist beliefs as well as beliefs about consciousness, meaning, and purpose. Further, the magnitude of belief change is associated with qualitative features of the experience.
    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Substance Withdrawal Syndrome/drug therapy ; Surveys and Questionnaires ; Consciousness ; Spiritual Therapies
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/02698811221131989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Psychedelic Experiences Increase Mind Perception but do not Change Atheist-Believer Status: A Prospective Longitudinal Study.

    Nayak, Sandeep M / White, Sydney H / Hilbert, Samantha N / Lowe, Matthew X / Jackson, Heather / Griffiths, Roland R / Garcia-Romeu, Albert / Yaden, David B

    Journal of psychoactive drugs

    2024  , Page(s) 1–10

    Abstract: Recent studies suggest psychedelic use may be associated with changes in a variety of beliefs or belief-like states, including increased 1) mind perception, 2) non-naturalistic beliefs, and 3) Atheist-Believer status (e.g. believer, agnostic, or ... ...

    Abstract Recent studies suggest psychedelic use may be associated with changes in a variety of beliefs or belief-like states, including increased 1) mind perception, 2) non-naturalistic beliefs, and 3) Atheist-Believer status (e.g. believer, agnostic, or nonbeliever). We conducted a prospective longitudinal study among participants (
    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2024.2346130
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