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  1. Book ; Online: Fast Facts : Comprehensive Genomic Profiling

    Rapoport, Bernardo L. / Troncone, Giancarlo / Schmitt, Fernando / Nayler, Simon J.

    Making precision medicine possible

    2020  

    Abstract: Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: ...

    Title variant Comprehensive Genomic Profiling
    Author's details Bernardo L. Rapoport, Giancarlo Troncone, Fernando Schmitt, Simon Nayler
    Abstract Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
    MeSH term(s) Neoplasms/genetics. ; DNA Fingerprinting/methods.
    Keywords Oncology ; Biochemical markers
    Language English
    Size 1 online resource (108 pages) :, 17 figures, 17 in color, 13 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 3-318-06819-5 ; 3-318-06818-7 ; 978-3-318-06819-1 ; 978-3-318-06818-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Myxoinflammatory fibroblastic sarcoma: a tumor not restricted to acral sites.

    Jurcić, Vesna / Zidar, Andreja / Montiel, Maria Delia Perez / Frković-Grazio, Snjezana / Nayler, Simon J / Cooper, Kumarasen / Suster, Saul / Lamovec, Janez

    Annals of diagnostic pathology

    2002  Volume 6, Issue 5, Page(s) 272–280

    Abstract: We report on nine new cases of myxoinflammatory fibroblastic sarcoma; in six of them the location of the tumor was distal (acral), and proximal in three (forearm, arm, and thigh). Tumors varied in size from 1.5 to 18 cm, were well-circumscribed, yellow- ... ...

    Abstract We report on nine new cases of myxoinflammatory fibroblastic sarcoma; in six of them the location of the tumor was distal (acral), and proximal in three (forearm, arm, and thigh). Tumors varied in size from 1.5 to 18 cm, were well-circumscribed, yellow-tan, and focally myxomatous. Histologically, they were similar in appearance and showed vaguely lobular architecture and oval, spindle, and epithelioid neoplastic cells with scattered, focally aggregated inflammatory cells. In all cases, in different numbers, bizarre giant cells with large, lobulated, or multiple nuclei were also admixed, some of them morphologically imitating Reed-Sternberg cells, lipoblasts, or ganglion cells; they showed distinct nucleoli or intranuclear inclusions. Myxoid areas were always present, to different extent. Immunohistochemically, tumor cells were uniformly positive for vimentin; some cells were also positive for CD68 and CD34. Ultrastructurally, tumor cells were nondescript, consistent with fibroblastic origin. On flow cytometry, two of the examined cases showed diploid pattern with low S-phase fraction. In none of the cases, metastases were observed, in one case the tumor recurred 5 years following surgery. We conclude that myxoinflammatory fibroblastic sarcoma is a distinct soft tissue tumor of low-grade malignancy and, until now, described only in extremities, although not confined to acral sites.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Arm/pathology ; Female ; Fibrosarcoma/metabolism ; Fibrosarcoma/pathology ; Fibrosarcoma/surgery ; Fingers/pathology ; Flow Cytometry ; Foot/pathology ; Forearm/pathology ; Hand/pathology ; Humans ; Immunohistochemistry ; Inflammation/pathology ; Male ; Microscopy, Electron ; Myxoma/metabolism ; Myxoma/pathology ; Myxoma/surgery ; Neoplasm Recurrence, Local ; Soft Tissue Neoplasms/metabolism ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Thigh/pathology ; Treatment Outcome
    Language English
    Publishing date 2002-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1053/adpa.2002.35738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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