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  1. Article ; Online: Idiotype/anti-idiotype antibodies: as a glorious savior in COVID-19 pandemics.

    Naveed, Ahsan / Naz, Deeba / Rahman, Sajjad Ur

    Translational medicine communications

    2021  Volume 6, Issue 1, Page(s) 18

    Abstract: The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak of Severe ...

    Abstract The idiotype network is experimentally modified to provide protective immunity against various microbial pathogens. Both internal and non-internal image-idiotype antibodies can trigger specific immune responses to antigens. The current outbreak of Severe Acute Respiratory Syndrome 2 (SARS-2) has provided a great opportunity to take advantage of idiotype / anti-idiotype antibodies as a protective regimen when no approved vaccine is available on earth. The current review identifies successful applications of idiotype/ anti-idiotype antibodies in various viral diseases and highlights their importance in COVID-19 pandemics. In the absence of vaccines and targeted therapies, polyclonal idiotype/ anti-idiotype antibodies against the viral structure may be a potential approach to the prevention and treatment of COVID-19 patients.
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2396-832X
    ISSN (online) 2396-832X
    DOI 10.1186/s41231-021-00097-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Newcastle disease virus in poultry with an interface as a human vector

    Naz, Deeba / Rahman, Sajjad ur / Aslam, Muhammad Aamir / Muhammad, Faqir

    Veterinary vaccine. 2022,

    2022  

    Abstract: Newcastle disease (ND) is an infectious and economically important disease of poultry caused by virulent avian Paramyxovirus 1 (APMV-1). For decades, live and inactivated vaccines have been used as conventional therapy in poultry, even then failure is ... ...

    Abstract Newcastle disease (ND) is an infectious and economically important disease of poultry caused by virulent avian Paramyxovirus 1 (APMV-1). For decades, live and inactivated vaccines have been used as conventional therapy in poultry, even then failure is reported due to mismatch antigenicity, presence of maternal antibodies, cold chain disruption, and uneven vaccine applications. Many experimental vaccines have been in trial for many years, but the disease is still rampant in many parts of the world. From acute onset with high mortality to mild disease in birds, Newcastle disease virus potential as a vector has been exploited for the treatment of different cancers and vaccination of humans. The objective of this review is to understand the Newcastle disease virus, immune mechanism, prevention and control strategies adapted for the Newcastle disease in poultry, and its beneficial use as a candidate vector for human vaccines and cancer therapy.
    Keywords Avian orthoavulavirus 1 ; Newcastle disease ; cancer therapy ; cold chain ; humans ; mortality ; poultry ; vaccination ; vaccines ; virulence
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 2772-5359
    DOI 10.1016/j.vetvac.2022.100003
    Database NAL-Catalogue (AGRICOLA)

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