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  1. AU="Nazarenko, Tatiana A"
  2. AU=Boff Daiane
  3. AU="Michaels, Zachary"
  4. AU="Sovel, Mindy"
  5. AU="Lukyanov, Sergey"
  6. AU="Baptistella, Amanda"
  7. AU="Dichter, Gabriel S"
  8. AU="D Urbano, Vanessa"
  9. AU="Farhad Shirini"
  10. AU="Wu, Wenming"
  11. AU="Wiedermann, Christian J"
  12. AU="Corradin, Giampietro"
  13. AU="Guan, Xiaodong"
  14. AU=Burmester Gerd R.
  15. AU="Mańczak, Rafał"
  16. AU="Cristina Ceron"
  17. AU=Scardapane Arnaldo
  18. AU="Taylor, Daniel J"
  19. AU="Sabanadzovic, Sead"
  20. AU=Lee Yangsoon AU=Lee Yangsoon
  21. AU="Sahoo, Aditi"
  22. AU="Reyes, Peter Andrew C"
  23. AU="Collobert, Géromine"
  24. AU="Guevara, Katterine"
  25. AU=Ahmadivand Arash

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  1. Artikel: Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency.

    Martirosyan, Yana O / Silachev, Denis N / Nazarenko, Tatiana A / Birukova, Almina M / Vishnyakova, Polina A / Sukhikh, Gennadiy T

    Life (Basel, Switzerland)

    2023  Band 13, Heft 12

    Abstract: Despite advancements in assisted reproductive technology (ART), achieving successful pregnancy rates remains challenging. Diminished ovarian reserve and premature ovarian insufficiency hinder IVF success-about 20% of in vitro fertilization (IVF) patients ...

    Abstract Despite advancements in assisted reproductive technology (ART), achieving successful pregnancy rates remains challenging. Diminished ovarian reserve and premature ovarian insufficiency hinder IVF success-about 20% of in vitro fertilization (IVF) patients face a poor prognosis due to a low response, leading to higher cancellations and reduced birth rates. In an attempt to address the issue of premature ovarian insufficiency (POI), we conducted systematic PubMed and Web of Science research, using keywords "stem cells", "extracellular vesicles", "premature ovarian insufficiency", "diminished ovarian reserve" and "exosomes". Amid the complex ovarian dynamics and challenges like POI, stem cell therapy and particularly the use of extracellular vesicles (EVs), a great potential is shown. EVs trigger paracrine mechanisms via microRNAs and bioactive molecules, suppressing apoptosis, stimulating angiogenesis and activating latent regenerative potential. Key microRNAs influence estrogen secretion, proliferation and apoptosis resistance. Extracellular vesicles present a lot of possibilities for treating infertility, and understanding their molecular mechanisms is crucial for maximizing EVs' therapeutic potential in addressing ovarian disorders and promoting reproductive health.
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122247
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Clinical Relevance of Secreted Small Noncoding RNAs in an Embryo Implantation Potential Prediction at Morula and Blastocyst Development Stages.

    Timofeeva, Angelika V / Fedorov, Ivan S / Shamina, Maria A / Chagovets, Vitaliy V / Makarova, Nataliya P / Kalinina, Elena A / Nazarenko, Tatiana A / Sukhikh, Gennady T

    Life (Basel, Switzerland)

    2021  Band 11, Heft 12

    Abstract: Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30-40%. In this connection, there ... ...

    Abstract Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30-40%. In this connection, there is an acute question of the development of a non-invasive, sensitive, and specific method for assessing the implantation potential of an embryo. A total of 110 subfertile couples were included in the study to undergo the IVF/ICSI program. Obtained embryos for transfer into the uterine cavity of patient cohort 1 (
    Sprache Englisch
    Erscheinungsdatum 2021-12-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121328
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Outcomes of ovarian stimulation in the follicular and luteal phases of the menstrual cycle in cancer patients.

    Nazarenko, Tatiana A / Martirosyan, Yana O / Birukova, Almina M / Korneeva, Irina E / Sokolova, JuliaV / Khubaeva, Diana G

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2021  Band 37, Heft sup1, Seite(n) 13–16

    Abstract: Objective: The purpose of the study was to evaluate the effectiveness of controlled ovarian stimulation in different phases of the menstrual cycle in cancer patients seeking for the preservation of reproductive material before gonadotoxic therapy.: ... ...

    Abstract Objective: The purpose of the study was to evaluate the effectiveness of controlled ovarian stimulation in different phases of the menstrual cycle in cancer patients seeking for the preservation of reproductive material before gonadotoxic therapy.
    Methods: A total of 140 patients with oncological diseases underwent ovarian stimulation in the standard protocol with GnRH antagonists in the follicular phase of the cycle (
    Results: All patients included in the study were comparable in age and AMH level. There were no differences in the mean number of oocytes retrieved in the follicular phase group, and luteal phase group. Similarly, no significant differences were observed in the number of M II oocytes.
    Conclusions: The results of the study demonstrate the equal effectiveness of stimulation protocols in different phases of the menstrual cycle, which allows us to develop a personalized approach to the implementation of reproductive function both in cancer patients and in the routine practice of ART.
    Mesh-Begriff(e) Adult ; Cryopreservation ; Female ; Fertility Preservation/methods ; Follicular Phase ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Hormone Antagonists/administration & dosage ; Humans ; Luteal Phase ; Neoplasms ; Oocyte Retrieval/methods ; Ovulation Induction/methods ; Prospective Studies
    Chemische Substanzen Hormone Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2)
    Sprache Englisch
    Erscheinungsdatum 2021-12-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2021.2006458
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2284: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Artikel ; Online: Recovery of ovarian function and pregnancy in a patient with AML after myeloablative busulphan-based conditioning regimen.

    Balashov, Dmitry N / Papusha, Ludmila I / Nazarenko, Tatiana A / Trakhtman, Pavel E / Revishvili, Nino A / Maschan, Alexei A / Persiantseva, Marina I / Andriutsa, Anna V / Skorobogatova, Elena V / Skvortsova, Yulia V / Rumiantsev, Alexander G

    Journal of pediatric hematology/oncology

    2011  Band 33, Heft 4, Seite(n) e154–5

    Abstract: We report a rare case of ovarian function recovery and pregnancy after hormone-replacement therapy (HRT) in the acute myeloblastic leukemia (AML) patient in third complete remission received hematopoietic stem cell transplantation (HSCT) with busulphan- ... ...

    Abstract We report a rare case of ovarian function recovery and pregnancy after hormone-replacement therapy (HRT) in the acute myeloblastic leukemia (AML) patient in third complete remission received hematopoietic stem cell transplantation (HSCT) with busulphan-based conditioning regimen. Successful engraftment of the donor cells and full donor's chimerism was achieved without the signs of leukemia. One year after HSCT the patient received a course of HRT as a treatment of hypergonadotropic hypogonadism. After 12 months of HRT the recovery of ovarian function was confirmed. Eight years after the HSCT spontaneous pregnancy occurred; heartbeat of the fetus was registered on week 7. Three weeks later a nonsevere vaginal bleeding occurred and the ultrasound examination showed a nondeveloping pregnancy. Genetic examination of the abortion material showed a full triploid genotype (69 XXX). To our knowledge this is a first case of ovarian function restoration and spontaneous pregnancy in a AML patient after multiple courses of high-dose chemotherapy and busulphan-based myeloablative conditioning for HSCT.
    Mesh-Begriff(e) Adolescent ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Busulfan/administration & dosage ; Busulfan/adverse effects ; Child ; Combined Modality Therapy ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Hypogonadism/drug therapy ; Leukemia, Myeloid, Acute/drug therapy ; Myeloablative Agonists/administration & dosage ; Myeloablative Agonists/adverse effects ; Ovary/physiology ; Pregnancy ; Pregnancy Outcome ; Recovery of Function ; Transplantation Conditioning/adverse effects ; Transplantation Conditioning/methods ; Young Adult
    Chemische Substanzen Antineoplastic Agents ; Myeloablative Agonists ; Busulfan (G1LN9045DK)
    Sprache Englisch
    Erscheinungsdatum 2011-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0b013e3181faf7b5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1537: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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