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  1. Article: Medication Management Program: Adherence, Disease-related Knowledge, Health-related Quality of Life, and Glycemic Control for Type 2 Diabetes Mellitus.

    Nazir, Saeed Ur Rashid / Hassali, Mohamed Azmi / Saleem, Fahad / Haque, Naheed

    Alternative therapies in health and medicine

    2019  Volume 26, Issue S2, Page(s) 4–10

    Abstract: Context: Escalation in rates of diabetes in Pakistan is posing threats to the economy and to the people's quality of life due to poor glycemic control and very high rates of complications. Cost of care is very high, and many barriers to quality care ... ...

    Abstract Context: Escalation in rates of diabetes in Pakistan is posing threats to the economy and to the people's quality of life due to poor glycemic control and very high rates of complications. Cost of care is very high, and many barriers to quality care exist. Most often patients are unable to afford the high cost of treatment. Patients' knowledge about diabetes is associated with better medication adherence and better glycemic control.
    Objective: The current study intended to evaluate the effects of an educational intervention in a pharmacist led, medication management program (MTM) tailored for patients with type 2 diabetes (T2DM).
    Design: The research team conducted a nonclinical, randomized controlled trial.
    Setting: The study took place at District Headquarters and Teaching Hospital, a public-sector hospital (Sargodha, Pakistan).
    Participants: Participants were 392 individuals with T2DM.
    Intervention: Participants were randomly assigned to one of 2 groups-intervention and control-with 196 patients in each. The intervention group, instead of receiving standard care, received pharmaceutical care through the Medication Therapy Management program, whereas the control group received standard care.
    Outcome measures: At baseline and 3 mo post ntervention, the study assessed participants' diabetes-related knowledge, medication adherence, and health-related quality of life (HRQoL) using the 14-item Michigan Diabetes Knowledge Test, the 8-item Morisky Medication Adherence Scale, and the European Quality of Life scales, respectively. To determine glycemic control, participants' baseline HbA1c levels were taken from their medical records, and the final HbA1c result was obtained postintervention.
    Results: For the intervention and control groups at baseline, diabetes-related knowledge was average, at 7.99 ± 2.65 and 8.03 ± 2.49, respectively; medication adherence was low, at 4.54 ± 1.69 and 4.41 ± 1.84, respectively; and glycemic control was poor, at 9.47 ± 1.57 and 9.41 ± 1.57, respectively. After the educational intervention, the intervention group had increased its diabetes-related knowledge, medication adherence, and HRQoL scores, with the results being 10.55 ± 2.56, 5.24 ± 1.48, and 0.6115 ± 0.286, respectively. The group's glycemic control has also improved to 8.97 ± 1.362. A statistically significant difference between the groups had occurred, with P < .001. The control group's scores had remained approximately the same for medication adherence, HRQoL, and glycemic control, and little difference had occurred as compared with the group's baseline analysis.
    Conclusion: The study found that the educational program increased the intervention group's level of diabetes-related knowledge, and improved its adherence to medication and its glycemic control, all due to its improved HRQoL. Patients' beliefs about the effects of long-term use of medicines were also addressed by the MTM program. The program was successful because it decreased participants' HbA1c values, which is a positive indicator of successful T2DM therapy.
    MeSH term(s) Adult ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/psychology ; Glycated Hemoglobin A/metabolism ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Humans ; Hypoglycemic Agents/therapeutic use ; Medication Adherence ; Medication Therapy Management ; Pakistan ; Patient Education as Topic ; Quality of Life/psychology ; Treatment Outcome
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents
    Language English
    Publishing date 2019-10-21
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  2. Article: Evaluation of Disease Related Knowledge in Patients of Osteoporosis: An Observational Study.

    Amer, Muhammad / Noor, Saba / Kashif, S M / Nazir, Saeed Ur Rashid / Ghazanfar, Tayyaba / Yousaf, Salma

    Alternative therapies in health and medicine

    2020  Volume 27, Issue S1, Page(s) 97–103

    Abstract: Objective: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue which results in consequent increase in bone fragility and susceptibility to fracture and more common in post- ... ...

    Abstract Objective: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue which results in consequent increase in bone fragility and susceptibility to fracture and more common in post-menopausal women and elderly people. This study was aimed to assess the knowledge of osteoporosis among patients in tertiary healthcare systems, as well as their knowledge of associated lifestyle, risk factors, and preventive measures.
    Methods: A cross-sectional study design was used to determine the knowledge of outpatients towards osteoporosis. The survey was carried out in a tertiary care hospital Federal Government Polyclinic Hospital, Islamabad. This study included patients visiting various outpatient departments of Federal Government Polyclinic Hospital, Islamabad. A structured questionnaire was used as a tool to collect the data from the participants. The compiled data was analyzed by using the Statistical Package for Social Sciences (SPSS) software version 21.0. Chi-square test was performed to determine association level among study variables. Multiple regression was used to predict the impact of two or more independent variables on dependent variable. p-value of < .05 was considered to be significant.
    Results: The mean score of knowledge was 8.73 ± 3.72. 159 (63.6%) respondents had poor knowledge, 78 (31.2%) had moderate knowledge and 13 (5.2%) had good knowledge. The results showed that most respondents had poor knowledge. Differences were statistically significant when age, gender, marital status and education were analyzed (P < .001).
    Conclusion: According to the results of all aspects of current study, it was concluded that mostly patients had inadequate knowledge regarding their disease which leads to an increased risk and progression of osteoporosis.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Female ; Humans ; Osteoporosis ; Risk Factors ; Surveys and Questionnaires
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  3. Article: Formulation, evaluation and in vitro characterization of gastroretentive floating tablet of diclofenac sodium.

    Shehzad, Muhammad Qaiser / Nazir, Taha / Nazir, Saeed-Ur-Rashid / Taha, Nida / Jamil, Tahir / Akram, Muhammad Abdullah

    Pakistan journal of pharmaceutical sciences

    2020  Volume 32, Issue 6, Page(s) 2573–2578

    Abstract: Currently a variety of tools and techniques are used to deliver complex medicines. Whereas, certain advanced methods assure the safety and usefulness by regulating the pharmacokinetic and pharmacodynamic. Thus, we aimed this study to develop a novel ... ...

    Abstract Currently a variety of tools and techniques are used to deliver complex medicines. Whereas, certain advanced methods assure the safety and usefulness by regulating the pharmacokinetic and pharmacodynamic. Thus, we aimed this study to develop a novel gastro retentive floating tablets. The formulation was designed to provide the desired controlled and complete release of drug for prolonged period of time. The formulations were evaluated for physical characterization. The obtained results of hardness (4.6-5.1), friability (0.20-0.43%), weight variation (350 ±2 - 350±5) and in vitro buoyancy were found within official limits of United Stated Pharmacopoeia (USP). Whereas, the F-7 showed most optimized intra gastric floating characteristics and exhibited 93.87% release of diclofenac sodium in 9 hours. The Floating Lag Time of 8 minutes and Total Floating Time >12 hours were recorded. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Zero Order and Peppas model for the release of both the drugs. DSC thermograph and FTIR spectra depicted that there was no chemical incompatibility between drugs and polymers. In conclusion the desgined tablet can be use in clinical practice as model drug. Because, the pre-compression and post-compression parameters were satisfactory and within desired limits.
    MeSH term(s) Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacokinetics ; Diclofenac/administration & dosage ; Diclofenac/pharmacokinetics ; Drug Compounding/methods ; Drug Liberation ; Humans ; Spectroscopy, Fourier Transform Infrared ; Tablets
    Chemical Substances Delayed-Action Preparations ; Tablets ; Diclofenac (144O8QL0L1)
    Language English
    Publishing date 2020-01-22
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: sessment Of Blood Pressure and Health-Related Quality of Life Among Hypertensive Patients: An Observational Study.

    Amer, Muhammad / Ur-Rahman, Nisar / Nazir, Saeed-Ur-Rashid / Jabeen, Musarat / Ehsan-Ul-Haq, M

    Alternative therapies in health and medicine

    2019  Volume 25, Issue 3, Page(s) 26–31

    Abstract: Objectives: Objective • Health-related quality of life (HRQoL) is an important tool in the assessment of treatment outcomes. Healthcare professionals use the concept of HRQoL to measure factors other than illness which affect human health and its status. ...

    Abstract Objectives: Objective • Health-related quality of life (HRQoL) is an important tool in the assessment of treatment outcomes. Healthcare professionals use the concept of HRQoL to measure factors other than illness which affect human health and its status. Patient's everyday activities are adversely affected by hypertension (HTN) and results in decreased self-confidence. The present study was aimed to assess blood pressure and health-related quality of life (HRQoL) of hypertensive patients in Pakistan.
    Methods: A questionnaire-based cross-sectional study was undertaken with 384 hypertensive patients attending a tertiary care public sector hospital in Islamabad, Pakistan. The assessment of HRQoL was done by using an EuroQol EQ-5D scale. Values derived from the UK general population survey were used to score HRQoL. The blood pressure of each patient was measured by using a calibrated sphygmomanometer. Data analysis was performed by using SPSS version 21 (SPSS Inc., Chicago, IL, USA). P ≤ .05 was taken as significant.
    Results: Two hundred and fifteen (56%) patients were male with 3.31 ± 2.13 years of history of hypertension. The majority (n = 138, 35.9%) was categorized in the age group of 41 to 50 years with mean age of 50.21 ± 9.51. Mean (SD) systolic BP and mean (SD) diastolic BP was measured as 140.39 ± 15.485 and 88.74 ± 10.683 in mmHg respectively. Poor HRQoL was measured among the study participants (0.6456 ± 0.2317). Age, gender, education, occupation and monthly income had a significant relation with HRQoL score.
    Conclusion: Hypertension imposes an adverse effect on patient's HRQoL. Results from this study could be useful in clinical practice. Attention is required to highlight determinants of HRQoL and policies should be implemented for better management of HTN, particularly in early treatment phases where it is still possible to improve HRQoL.
    MeSH term(s) Adult ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Chicago ; Cross-Sectional Studies ; Humans ; Hypertension/drug therapy ; Hypertension/psychology ; Male ; Middle Aged ; Pakistan ; Quality of Life ; Surveys and Questionnaires ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  5. Article: Biochemical Dynamics and Clinical Features of Novel Corona Virus (2019-nCoV).

    Nazir, Taha / Nazir, Saeed Ur Rashid / Sultana, Misbah / Taha, Nida / Riaz, Humayun / Islam, Azharul / Rasheed Kayani, Ruqaiya / Manzoor, Saba

    Alternative therapies in health and medicine

    2020  Volume 26, Issue S2, Page(s) 50–53

    Abstract: Context: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% ... ...

    Abstract Context: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic.
    Objective: The study intended to examine the data from studies on nCoV-19.
    Design: The research team performed a literature review, searching relevant literature databases. The sources of data included bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, WanFang Data and PubMed. The search terms were novel Corona Virus, and nCoV-19 structure.
    Setting: The study took place in the main library of the University of Sargodha, Sargodha, Pakistan.
    Results: The study identified 22 studies that had reported and confirmed over 2000 cases of nCoV-19 by January 26, 2020. The studies found that the virus was transmitted through respiratory droplets. The virus has two serotypes, OC43 and 229E.
    Conclusions: No specific curative therapy is available for CoVid-19. However, certain precautionary measures may potentially reduce the transmission, including washing hands, using sanitizers frequently, avoiding public gatherings, and quarantining or isolating patients. This virus has spread globally and immunocompromised individuals, and especially older individuals, are at significant risk. Community and healthcare professionals have a positive role to play in controlling the spread of the disease.
    MeSH term(s) Betacoronavirus/classification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Serogroup
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  6. Article: Devoid Knowledge and Low Adherence Precipitate Uncontrolled Blood Pressure: A Depiction From Cross-Sectional Study.

    Amer, Muhammad / Ur Rehman, Nisar / Nazir, Saeed Ur Rashid / Ehsan-Ul-Haq, M / Sultana, Misbah / Jabeen, Musarat

    Alternative therapies in health and medicine

    2020  Volume 27, Issue 5, Page(s) 24–32

    Abstract: Objective: The present study was aimed to assess knowledge regarding disease, adherence to medication and blood pressure control among hypertensive patients.: Methods: A cross-sectional study involving 384 hypertensive patients attending a tertiary ... ...

    Abstract Objective: The present study was aimed to assess knowledge regarding disease, adherence to medication and blood pressure control among hypertensive patients.
    Methods: A cross-sectional study involving 384 hypertensive patients attending a tertiary care, public sector hospital in Islamabad, Pakistan, was conducted. Data was collected by using Urdu versions of pre-validated hypertension knowledge questionnaire and Medication Adherence Scale by Morisky. Each patient's blood pressure was measured through a calibrated mercury sphygmomanometer. Data was analyzed statistically by using SPSS software version 21.0. Chi-square test was performed to determine association level among study variables. Mann-Whitney and Kruskal-Wallis tests were performed to assess for statistically significant differences of demographic variables with systolic BP and diastolic BP. Multiple regression was used to predict the impact of two or more independent variables on dependent variable. P value of <.05 was considered to be significant.
    Results: Mean (SD) systolic and diastolic blood pressures of 384 patients were 140.39 ± 15.485 and 88.74 ± 10.683 in mmHg respectively. The mean knowledge score was (13.26 ± 5.16 out of 22) and median score was 13. 103 (26.8%) of the patients had poor knowledge, whereas, 191 (49.7%) had moderate knowledge regarding hypertension with most of them at bottom line in the scale of moderate knowledge. The mean medication adherence score was (4.66 ± 2.743 out of 8), while 204 (53.1%) were categorized as poor adherent.
    Conclusion: The current study concluded that knowledge regarding hypertension, adherence to treatment and blood pressure control among hypertensive patients was found poor.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Blood Pressure ; Cross-Sectional Studies ; Humans ; Hypertension/drug therapy ; Medication Adherence
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  7. Article: Literature review: pharmacists' interventions to improve control and management in type 2 diabetes mellitus.

    Hassali, Mohamed Azmi Ahmad / Nazir, Saeed Ur Rashid / Saleem, Fahad / Masood, Imran

    Alternative therapies in health and medicine

    2015  Volume 21, Issue 1, Page(s) 28–35

    Abstract: Diabetes mellitus (DM) is a common disease in which excessive levels of blood glucose (sugar) occur. In simple terms, diabetes is generally due to failure in the effective functioning of insulin. Common types of diabetes include type 1 and type 2, which ... ...

    Abstract Diabetes mellitus (DM) is a common disease in which excessive levels of blood glucose (sugar) occur. In simple terms, diabetes is generally due to failure in the effective functioning of insulin. Common types of diabetes include type 1 and type 2, which have different treatment options. In the general population, type 2 diabetes is more prevalent than type 1, and type 2 accounts for more than 90% of all known cases of diabetes. The current review examines the contributions of pharmacists to the more positive, long-term prognosis of patients with DM through improvements in its control and management. The authors conducted a systematic literature search. Twenty-seven studies were identified that demonstrated the effects of a pharmacist's intervention on glycated hemoglobin (HbA1c). In all cases, it was reported that the intervention was successful in reducing HbA1c in patients with DM. Pharmacist interventions have also proven successful in improving patient lipid profiles, cardiovascular outcomes, and body mass indexes (BMIs), and in reducing other complications associated with the disease. It was also reported that economic advantages were associated with a pharmacist's management of DM.
    MeSH term(s) Blood Pressure ; Body Mass Index ; Diabetes Complications ; Diabetes Mellitus, Type 2/drug therapy ; Health Knowledge, Attitudes, Practice ; Humans ; Medication Adherence ; Patient Satisfaction ; Pharmacists ; Professional-Patient Relations ; Quality of Life
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Medicinal Plants and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Treatment of Arthritis: A Literature Review.

    Rasheed Kayani, Ruqaiya / Shamim, Rahat / Sultana Munir, Safia / Sultana, Misbah / Nazir, Saeed Ur Rashid / Riaz, Humayun / Nazir, Taha / Maaz Ali, Muhammad / Islam, Azharul

    Alternative therapies in health and medicine

    2021  Volume 28, Issue 7, Page(s) 58–64

    Abstract: Context: Arthritis is an inflammatory disease of diarthrodial joints and is associated with swollen inflamed joints, disruption of joints, and loss of integrity of articular cartilage and synovial joints.: Objective: The current review intended to ... ...

    Abstract Context: Arthritis is an inflammatory disease of diarthrodial joints and is associated with swollen inflamed joints, disruption of joints, and loss of integrity of articular cartilage and synovial joints.
    Objective: The current review intended to examine the data on the epidemiology, causes, clinical diagnosis, and prevention and control of different types of arthritis and on the use of medicinal plants in gouty arthritis.
    Design: The research team performed a literature review, searching relevant literature databases, including bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, and PubMed. The search terms were arthritis, diarthodial joints, use of medicinal plants in gouty arthritis, and synovial joints.
    Setting: The study took place in the main library of the University of Sargodha in Sargodha, Pakistan.
    Results: The research team identified 135 studies, and eventually 92 unique academic publications were included in the analysis. Arthritis can develop and progress in any musculoskeletal joint, and most commonly occurs in knees, hips, shoulders, and hands. Major risk factors for arthritis include age, obesity, trauma, other diseases, and smoking. Arthritis is classified into various types, including rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis, septic arthritis, and psoriatic arthritis (PsA). RA and OA are the most common types worldwide. RA is an autoimmune disease in which the body's immune cells attack the joints. OA develops due to damage of cartilage, tissues, and joints due to age, obesity, or stress on joints. Gouty arthritis develops due to hyperuricemia; deposits of monosodium urate crystals can lead to gouty arthritis. Septic arthritis occurs due to a microbial infection in synovial joints because in synovial joints the basement membrane is absent. PsA develops due to the psoriasis-skin disease.
    Conclusions: The current review showed that different types of arthritis has different causes and pathogeneses. Pain in joints is a major and common symptom in all types of arthritis. Arthritis is managed pharmacologically and nonpharmacologically. Treatment is different for each class of arthritis according to its cause and symptoms.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthritis, Gouty/drug therapy ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Humans ; Obesity ; Osteoarthritis/drug therapy ; Plants, Medicinal ; Uric Acid/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  9. Article: Association Between Diabetes-related Knowledge and Medication Adherence: Results From Cross-sectional Analysis.

    Nazir, Saeed Ur Rashid / Hassali, Mohamed Azmi / Saleem, Fahad / Bashir, Sajid / Aljadhey, Hisham

    Alternative therapies in health and medicine

    2016  Volume 22, Issue 6, Page(s) 8–13

    Abstract: Context • Type 2 diabetes mellitus (T2DM) is a growing health problem worldwide. To have optimal glycemic control, T2DM patients must have sufficient diabetes-related knowledge and must adhere positively and closely to a prescribed regimen. Medication ... ...

    Abstract Context • Type 2 diabetes mellitus (T2DM) is a growing health problem worldwide. To have optimal glycemic control, T2DM patients must have sufficient diabetes-related knowledge and must adhere positively and closely to a prescribed regimen. Medication adherence is a key determinant of therapeutic success in patients with T2DM. However, adherence to medications among T2DM patients varies widely, with estimates ranging from 36%-94%. Objective • The purpose of the study was to assess the level of and the association between diabetes-related knowledge and medication adherence among T2DM patients in Pakistan. Design • The research team conducted a cross-sectional survey. Setting • The study was carried out at the outpatient clinic of a public-sector teaching hospital in Sargodha, Pakistan. Participants • Participants were 392 diabetic patients of the hospital. Outcome Measures • In addition to the collection of data on the demographic and disease-related characteristics of the participants, the Urdu versions of the Morisky Medication Adherence Scale (MMAS-U) and the Michigan Diabetes Knowledge Test (MDKT-U) were used to assess medication adherence and diabetes-related knowledge, respectively. Descriptive statistics were used to determine the demographic and disease characteristics, whereas a Spearman rank correlation was used to measure the association between medication adherence and diabetes-related knowledge. Results • The mean age of the participants was 50.77 ± 9.671 y, with males being the dominant gender (n = 222, 56.6%). The mean duration of diabetes was 5.58 ± 4.09 y. Of the 392 patients, 245 (62.5%) had an average knowledge of diabetes. Furthermore, 282 (71.9%) were categorized as showing poor adherence. A significant but weak positive correlation between diabetes-related knowledge and medication adherence was found for the study (r = 0.036, P < .05). Conclusions • Although diabetes-related knowledge among the patients was average, the adherence to treatment was poor. Because patients' knowledge about diabetes was positively associated with medication adherence, the research team believes that educating patients about the disease and medication management can result in better control of T2DM.
    MeSH term(s) Adult ; Aged ; Ambulatory Care Facilities ; Blood Glucose/metabolism ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Glycated Hemoglobin A/metabolism ; Health Knowledge, Attitudes, Practice ; Hospitals, University ; Humans ; Hypoglycemic Agents/therapeutic use ; Male ; Medication Adherence ; Middle Aged ; Pakistan ; Surveys and Questionnaires
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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  10. Article ; Online: Disease related knowledge, medication adherence and glycaemic control among patients with type 2 diabetes mellitus in Pakistan.

    Nazir, Saeed Ur Rashid / Hassali, Mohamed Azmi / Saleem, Fahad / Bashir, Sajid / Aljadhey, Hisham

    Primary care diabetes

    2016  Volume 10, Issue 2, Page(s) 136–141

    Abstract: Aims: The purpose of this study was to investigate the association of diabetes-related knowledge and treatment adherence with glycaemic control among patients with type 2 diabetes mellitus (T2DM) in Pakistan.: Methods: The study was designed as a ... ...

    Abstract Aims: The purpose of this study was to investigate the association of diabetes-related knowledge and treatment adherence with glycaemic control among patients with type 2 diabetes mellitus (T2DM) in Pakistan.
    Methods: The study was designed as a questionnaire-based, cross-sectional analysis. T2DM patients attending a public outpatient clinic in Sargodha, Pakistan, were targeted for the study. In addition to the demographic information, the Urdu version of Michigan Diabetes Knowledge Test and Morisky Medication Adherence Scale was used for data collection. Patients' medical records were reviewed for glycated haemoglobin levels (HbA1c). Descriptive statistics were used to elaborate sociodemographic characteristics. The Spearman's Rho correlation was used to measure association of disease-related knowledge and treatment adherence with glycaemic control. SPSS V 20.0 was used for data analysis and p<0.05 was taken as significant.
    Result: In total, 392 T2DM patients were included in the study. The mean age (SD) of these patients was 50.77±9.671 years, 56.6% were males and 90% (n=353) of respondents were married. The mean (SD) duration of disease was 5.58 (4.09) years with median HbA1c of 9.00 (IQR=8.20-10.40). The median knowledge score was 8.0 (IQR=6.0-10.0), while the median adherence score was 4.7 (IQR=3.0-6.0). HbA1c had non-significant and weak negative association with diabetes-related knowledge (r=-0.036, p=0.404) and treatment adherence (r=-0.071, p=0.238).
    Conclusion: There was negative association reported between HbA1c, treatment adherence and diabetes-related knowledge. Greater efforts are clearly required to investigate other factors affecting glycaemic control among T2DM patients in Pakistan.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/psychology ; Female ; Glycated Hemoglobin A/metabolism ; Health Knowledge, Attitudes, Practice ; Humans ; Hypoglycemic Agents/therapeutic use ; Male ; Medication Adherence ; Middle Aged ; Pakistan ; Risk Factors ; Surveys and Questionnaires ; Treatment Outcome
    Chemical Substances Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2015.09.004
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