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  1. Article: Dynamics of Antibodies to Ebolaviruses in an Eidolon helvum Bat Colony in Cameroon

    Djomsi, Dowbiss Meta / Mba Djonzo, Flaubert Auguste / Ndong Bass, Innocent / Champagne, Maëliss / Lacroix, Audrey / Thaurignac, Guillaume / Esteban, Amandine / De Nys, Helene / Bourgarel, Mathieu / Akoachere, Jane-Francis / Delaporte, Eric / Ayouba, Ahidjo / Cappelle, Julien / Mpoudi Ngole, Eitel / Peeters, Martine

    Viruses. 2022 Mar. 09, v. 14, no. 3

    2022  

    Abstract: The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (Eidolon helvum) are the most common fruit bats in Africa and antibodies to ebolaviruses have been documented ...

    Abstract The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (Eidolon helvum) are the most common fruit bats in Africa and antibodies to ebolaviruses have been documented in this species. Between December 2018 and November 2019, samples were collected at approximately monthly intervals in roosting and feeding sites from 820 bats from an Eidolon helvum colony. Dried blood spots (DBS) were tested for antibodies to Zaire, Sudan, and Bundibugyo ebolaviruses. The proportion of samples reactive with GP antigens increased significantly with age from 0–9/220 (0–4.1%) in juveniles to 26–158/225 (11.6–70.2%) in immature adults and 10–225/372 (2.7–60.5%) in adult bats. Antibody responses were lower in lactating females. Viral RNA was not detected in 456 swab samples collected from 152 juvenile and 214 immature adult bats. Overall, our study shows that antibody levels increase in young bats suggesting that seroconversion to Ebola or related viruses occurs in older juvenile and immature adult bats. Multiple year monitoring would be needed to confirm this trend. Knowledge of the periods of the year with the highest risk of Ebolavirus circulation can guide the implementation of strategies to mitigate spill-over events.
    Keywords Ebolavirus ; RNA ; adults ; antibodies ; blood ; ecology ; fruits ; juveniles ; risk ; seroconversion ; Cameroon ; Democratic Republic of the Congo ; Sudan
    Language English
    Dates of publication 2022-0309
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030560
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Dynamics of Antibodies to Ebolaviruses in an

    Djomsi, Dowbiss Meta / Mba Djonzo, Flaubert Auguste / Ndong Bass, Innocent / Champagne, Maëliss / Lacroix, Audrey / Thaurignac, Guillaume / Esteban, Amandine / De Nys, Helene / Bourgarel, Mathieu / Akoachere, Jane-Francis / Delaporte, Eric / Ayouba, Ahidjo / Cappelle, Julien / Mpoudi Ngole, Eitel / Peeters, Martine

    Viruses

    2022  Volume 14, Issue 3

    Abstract: The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats ( ...

    Abstract The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (
    MeSH term(s) Animals ; Antibodies, Viral ; Cameroon/epidemiology ; Chiroptera ; Ebolavirus/genetics ; Female ; Lactation
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Seroprevalence of IgG Antibodies Against Multiple Arboviruses in Bats from Cameroon, Guinea, and the Democratic Republic of Congo.

    Raulino, Raisa / Thaurignac, Guillaume / Keita, Alpha K / Esteban, Amandine / Goumou, Souana / Diallo, Ramadan / Ndimbo-Kumugo, Simon-Pierre / Ndong Bass, Innocent / Mbala Kingebeni, Placide / Toure, Abdoulaye / Delaporte, Eric / Ahuka-Mundeke, Steve / Muyembe Tamfum, Jean-Jacques / Mpoudi-Ngole, Eitel / Peeters, Martine / Ayouba, Ahidjo

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2022  Volume 22, Issue 4, Page(s) 252–262

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Antibodies, Viral ; Arboviruses ; Cameroon/epidemiology ; Chiroptera ; Democratic Republic of the Congo/epidemiology ; Guinea ; Humans ; Immunoglobulin G ; Mosquito Vectors ; Seroepidemiologic Studies ; Zika Virus ; Zika Virus Infection/veterinary
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2021.0076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Seroprevalence of IgG Antibodies Against Multiple Arboviruses in Bats from Cameroon, Guinea, and the Democratic Republic of Congo

    Raulino, Raisa / Thaurignac, Guillaume / Keita, Alpha K. / Esteban, Amandine / Goumou, Souana / Diallo, Ramadan / Ndimbo-Kumugo, Simon-Pierre / Ndong Bass, Innocent / Mbala Kingebeni, Placide / Toure, Abdoulaye / Delaporte, Eric / Ahuka-Mundeke, Steve / Muyembe Tamfum, Jean-Jacques / Mpoudi-Ngole, Eitel / Peeters, Martine / Ayouba, Ahidjo

    Vector borne and zoonotic diseases. 2022 Apr. 01, v. 22, no. 4

    2022  

    Abstract: Background: Emergence of mosquito-borne arboviruses has caused significant public health burden. The life cycle of arboviruses comprises sylvatic and urban cycles, including a wildlife reservoir, a human host, and an arthropod vector. However, many ... ...

    Abstract Background: Emergence of mosquito-borne arboviruses has caused significant public health burden. The life cycle of arboviruses comprises sylvatic and urban cycles, including a wildlife reservoir, a human host, and an arthropod vector. However, many questions remain on the sylvatic cycles of arboviruses. In this study, we investigate the prevalence of IgG antibodies to arboviruses of public health importance in African bats. Material and Methods: We collected dried blood spots from bats in Cameroon, Guinea, and the Democratic Republic of the Congo (DRC). To detect IgG antibodies to 10 antigens of 6 arboviruses (Dengue, Zika, West Nile, Usutu, Chikungunya, and O'nyong nyong viruses), we adapted a previously validated multiplex detection assay based on the Luminex technology. Results: We tested samples from 2579 bats, representing 1917 frugivorous and 641 insectivorous bats distributed in 7 families and 21 species. Overall, 218/2579 (8.45%) bat samples reacted with at least 1 of the 10 antigens tested. The highest prevalence was observed against Usutu virus with 2.3% (59/2579), followed by 1.9% (49/2579) and 1.35% (35/2579) for the Dengue virus serotypes 4 and 3, respectively. The global seroprevalence varied by country and collection site: 11% (151/1376) in Cameroon, 3.5% (20/565) in DRC, and 7.3% (47/638) in Guinea. The highest rates were observed in Hypsignathus monstrosus (17.9%), Rousettus aegyptiacus (16.4%), and Eidolon helvum (10.7%), and in species from the insectivorous Molossidae family (7.8–8.9%). Finally, we observed changes in seroprevalence over the year in E. helvum and H. monstrosus colonies, which could be related to population structure. Conclusion: On more than 2500 bat samples tested, we showed variable IgG seroprevalences against multiple arboviruses. Overall, the prevalence of IgG antibodies of 8.45% against arboviruses found in bats suggest that they could play a role in arboviruses cycles in the wild, in addition to other animal species.
    Keywords Dengue virus ; Molossidae ; Rousettus ; Usutu virus ; arboviruses ; arthropods ; blood ; dengue ; frugivores ; humans ; insectivores ; population structure ; public health ; seroprevalence ; serotypes ; wildlife ; Cameroon ; Democratic Republic of the Congo ; Guinea
    Language English
    Dates of publication 2022-0401
    Size p. 252-262.
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2021.0076
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Extensive Survey and Analysis of Factors Associated with Presence of Antibodies to Orthoebolaviruses in Bats from West and Central Africa.

    Peeters, Martine / Champagne, Maëliss / Ndong Bass, Innocent / Goumou, Souana / Ndimbo Kumugo, Simon-Pierre / Lacroix, Audrey / Esteban, Amandine / Meta Djomsi, Dowbiss / Soumah, Abdoul Karim / Mbala Kingebeni, Placide / Mba Djonzo, Flaubert Auguste / Lempu, Guy / Thaurignac, Guillaume / Mpoudi Ngole, Eitel / Kouanfack, Charles / Mukadi Bamuleka, Daniel / Likofata, Jacques / Muyembe Tamfum, Jean-Jacques / De Nys, Helene /
    Capelle, Julien / Toure, Abdoulaye / Delaporte, Eric / Keita, Alpha Kabinet / Ahuka Mundeke, Steve / Ayouba, Ahidjo

    Viruses

    2023  Volume 15, Issue 9

    Abstract: The seroprevalence to orthoebolaviruses was studied in 9594 bats (5972 frugivorous and 3622 insectivorous) from Cameroon, the Democratic Republic of Congo (DRC) and Guinea, with a Luminex-based serological assay including recombinant antigens of ... ...

    Abstract The seroprevalence to orthoebolaviruses was studied in 9594 bats (5972 frugivorous and 3622 insectivorous) from Cameroon, the Democratic Republic of Congo (DRC) and Guinea, with a Luminex-based serological assay including recombinant antigens of four
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses.

    Meta Djomsi, Dowbiss / Lacroix, Audrey / Soumah, Abdoul Karim / Kinganda Lusamaki, Eddy / Mesdour, Asma / Raulino, Raisa / Esteban, Amandine / Ndong Bass, Innocent / Mba Djonzo, Flaubert Auguste / Goumou, Souana / Ndimbo-Kimugu, Simon Pierre / Lempu, Guy / Mbala Kingebeni, Placide / Bamuleka, Daniel Mukadi / Likofata, Jacques / Muyembe Tamfum, Jean-Jacques / Toure, Abdoulaye / Mpoudi Ngole, Eitel / Kouanfack, Charles /
    Delaporte, Eric / Keita, Alpha Kabinet / Ahuka-Mundeke, Steve / Ayouba, Ahidjo / Peeters, Martine

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Bats are at the origin of human coronaviruses, either directly or via an intermediate host. We tested swabs from 4597 bats (897 from the Democratic Republic of Congo (DRC), 2191 from Cameroon and 1509 from Guinea) with a broadly reactive PCR in the RdRp ... ...

    Abstract Bats are at the origin of human coronaviruses, either directly or via an intermediate host. We tested swabs from 4597 bats (897 from the Democratic Republic of Congo (DRC), 2191 from Cameroon and 1509 from Guinea) with a broadly reactive PCR in the RdRp region. Coronaviruses were detected in 903 (19.6%) bats and in all species, with more than 25 individuals tested. The highest prevalence was observed in
    MeSH term(s) Animals ; Cameroon ; Chiroptera/virology ; Coronavirus/isolation & purification
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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