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  1. AU="Neşe Yaralı"
  2. AU="Dunn, Fiona B"
  3. AU="Merkl, Dóra"
  4. AU="Antonio Colantuoni"
  5. AU="Barakat, Abdelhamid"
  6. AU="Cho, Anna"
  7. AU="Lafargeas, Philippe"
  8. AU="Durez, Patrick"
  9. AU="Chaturvedi, Shubhra"
  10. AU="Bhatt, Navin"
  11. AU="Qiongsi Zhang"
  12. AU="Gilbert, Mark R."
  13. AU="Baisden, Joseph M."
  14. AU="Manrique, Soraya Zorro"
  15. AU="Eibensteiner, Fabian"
  16. AU="Kharaishvili, Gvantsa"
  17. AU="Liu, Jianan"
  18. AU="Patel, Harshil"
  19. AU="Min, Thinzar"
  20. AU="Lei, Hui-Min"
  21. AU="Suradi, Haya H"
  22. AU="Chariyalertsak, Chonlisa"
  23. AU="Weber, Konrad P."
  24. AU="Huang, Yan-Jang S"
  25. AU="Karim, Siti Nurhana Abdul"
  26. AU="Jia, Chang-Qi"
  27. AU="Huang, Ziwen"
  28. AU="Benveniste, Marcelo F"
  29. AU="Gokden, Alper"
  30. AU=Naidoo Devashan
  31. AU="Grucza, Richard"

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  1. Artikel ; Online: The use of intravenous immunoglobulin therapy in a tertiary pediatric hospital

    Ali Güngör / Neşe Yaralı

    Saudi Medical Journal, Vol 41, Iss 2, Pp 163-

    2020  Band 167

    Abstract: Objectives: To determine demographic features of patients provided intravenous immunoglobulin (IVIG) excluding replacement therapy in the inpatient services and to evaluate indications for IVIG, and side effects related to therapy. Methods: Patients who ... ...

    Abstract Objectives: To determine demographic features of patients provided intravenous immunoglobulin (IVIG) excluding replacement therapy in the inpatient services and to evaluate indications for IVIG, and side effects related to therapy. Methods: Patients who received IVIG therapy between January 2016 and August 2018 were retrospectively identified. The demographic features, diagnosis, IVIG dose, number of days they underwent IVIG therapy, and whether or not they experienced IVIG-related side effects were recorded. Results: A total of 186 patients were included in this study, and of these, 89 (47.8%) were females. The median age of all of the patients was 48.5 months old (range 13-120 months). When the IVIG indications were examined, the hematological disease group had the highest number of patients (n=73, 39.2%). The US Food and Drug Administration (FDA) labeled use rate was 45.7%. Side effects were seen in 15 (3.81%) of the 394 IVIG infusions, 2 of which were acute kidney failure and nausea/vomiting as delayed onset side effects. The rapid onset side effects included fever (n=5), headache (n=3), rash and redness (n=2), and pain in the infusion area, hypotension, and hypertension (n=1). Conclusion: Intravenous immunoglobulin preparations are used for the treatment of many diseases due to their immunoregulatory effects. In recent years, the use of IVIGs without FDA approval has been increasing.
    Schlagwörter adverse effects ; child ; intravenous immunoglobulin ; immunoregulatory ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Ministry of Defence and Aviation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Dysplastic Changes of Peripheral Blood Cells in COVID-19 Infection

    Yunus Murat Akçabelen, / Dilek Gürlek Gökçebay / Neşe Yaralı

    Turkish Journal of Hematology, Vol 38, Iss 1, Pp 72-

    2021  Band 73

    Schlagwörter coronavirus ; blood smear ; dysplasia ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Rare Presentation of Herpes Virus Lesions in a Case of Acute Pre-B Lymphoblastic Leukemia

    Eylem Şerife Kalkan / Zeliha Güzelküçük / Melek Işık / Neşe Yaralı

    Turkish Journal of Hematology, Vol 37, Iss 1, Pp 75-

    2020  Band 76

    Schlagwörter herpes virus ; leukemia ; child ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Bone Loss in Pediatric Survivors of Acute Lymphoblastic Leukemia

    Arzu Duygu Donmez / Pamir Isik / Semra Cetinkaya / Nese Yarali

    Eurasian Journal of Medicine, Vol 51, Iss 1, Pp 38-

    2019  Band 41

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag AVES
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: A New Perspective for Potential Organ Damage Due to Iron-Mediated Oxidation in Thalassemia Major Patients

    Funda Eren / Ayça Koca Yozgat / Esra Firat Oğuz / Salim Neşelioğlu / Rıdvan Firat / Dilek Gürlek Gökçebay / Hüsniye Neşe Yarali / Namık Yaşar Özbek / Özcan Erel

    Journal of Clinical Medicine, Vol 12, Iss 2422, p

    2023  Band 2422

    Abstract: Background: The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Methods: Seventy patients were included in this study. Blood samples were taken ... ...

    Abstract Background: The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Methods: Seventy patients were included in this study. Blood samples were taken from the patients before and after transfusion. Total thiol, native thiol, disulfide, disulfide/native thiol percentage ratio, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and ferroxidase levels were determined. Additionally, undepleted thiol level (UTL) was determined as a new parameter associated with organ damage. Results: After transfusion, the levels of native thiol, total thiol, disulfide, TAS, ferroxidase, and TOS were higher, while the IMA levels and disulfide/native thiol percent ratio were lower. Significant correlations were found between antioxidant and oxidant tests before and after transfusion. Additionally, a negative correlation was found between the TOS and UTL levels of the patients measured before the transfusion. Conclusion: In the present study, transfusion therapy increased both oxidation and the antioxidant levels. In addition, the term UTL has been introduced as a parameter that enables the determination of the oxidation level that may cause potential organ damage in transfusion-dependent thalassemia patients.
    Schlagwörter antioxidant ; oxidant ; thalassemia ; transfusion ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: A Rare Complication of Congenital Afibrinogenemia

    Ali Fettah / Dilek Gürlek Gökçebay / Vildan Çulha / Neşe Yaralı / Bahattin Tunç / Namık Özbek

    Turkish Journal of Hematology, Vol 34, Iss 2, Pp 183-

    Bone Cysts

    2017  Band 183

    Schlagwörter Afibrinogenemia ; Bone cysts ; Child ; Rare ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Sprache Englisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Evaluation of Endocrine Late Complications in Childhood Acute Lymphoblastic Leukemia Survivors

    Cengiz Bayram / Neşe Yaralı / Ali Fettah / Fatma Demirel / Betül Tavil / Abdurrahman Kara / Bahattin Tunç

    Turkish Journal of Hematology, Vol 34, Iss 1, Pp 40-

    A Report of a Single-Center Experience and Review of the Literature

    2017  Band 45

    Abstract: Objective: Improvement in long-term survival in patients with acute lymphoblastic leukemia (ALL) in childhood has led to the need for monitorization of treatment-related morbidity and mortality. In the current study, we aimed to evaluate endocrine side ... ...

    Abstract Objective: Improvement in long-term survival in patients with acute lymphoblastic leukemia (ALL) in childhood has led to the need for monitorization of treatment-related morbidity and mortality. In the current study, we aimed to evaluate endocrine side effects of treatment in ALL survivors who were in remission for at least 2 years. Materials and Methods: Sixty patients diagnosed with ALL, who were in remission for at least 2 years, were cross-sectionally evaluated for long-term endocrine complications. Results: The median age of the patients at the time of diagnosis, at the time of chemotherapy completion, and at the time of the study was 5 years (minimum-maximum: 1.7-13), 8 years (minimummaximum: 4.25-16), and 11.7 years (minimum-maximum: 7-22), respectively, and median follow-up time was 4 years (minimummaximum: 2-10.1). At least one complication was observed in 81.6% of patients. Vitamin D insufficiency/deficiency (46.6%), overweight/ obesity (33.3%), and dyslipidemia (23.3%) were the three most frequent endocrine complications. Other complications seen in our patients were hyperparathyroidism secondary to vitamin D deficiency (15%), insulin resistance (11.7%), hypertension (8.3%), short stature (6.7%), thyroid function abnormality (5%), precocious puberty (3.3%), and decreased bone mineral density (1.7%). There were no statistically significant correlations between endocrine complications and age, sex, and radiotherapy, except vitamin D insufficiency/deficiency, which was significantly more frequent in pubertal ALL survivors compared to prepubertal ALL survivors (57.5% and 25%, respectively, p=0.011). Conclusion: A high frequency of endocrine complications was observed in the current study. The high frequency of late effects necessitates long-term surveillance of this population to better understand the incidence of late-occurring events and the defining of high-risk features that can facilitate developing intervention strategies for early detection and prevention.
    Schlagwörter Acute lymphoblastic leukemia ; Endocrine ; Late effects ; Children ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Severe Clinical Course in a Patient with Congenital Amegakaryocytic Thrombocytopenia Due to a Missense Mutation of the c-MPL Gene

    İkbal Ok Bozkaya / Neşe Yaralı / Pamir Işık / Rukiye Ünsal Saç / Betül Tavil / Bahattin Tunç

    Turkish Journal of Hematology, Vol 32, Iss 2, Pp 172-

    2015  Band 174

    Abstract: Congenital amegakaryocytic thrombocytopenia (CAMT) generally begins at birth with severe thrombocytopenia and progresses to pancytopenia. It is caused by mutations in the thrombopoietin receptor gene, the myeloproliferative leukemia virus oncogene (c-MPL) ...

    Abstract Congenital amegakaryocytic thrombocytopenia (CAMT) generally begins at birth with severe thrombocytopenia and progresses to pancytopenia. It is caused by mutations in the thrombopoietin receptor gene, the myeloproliferative leukemia virus oncogene (c-MPL). The association between CAMT and c-MPL mutation type has been reported in the literature. Patients with CAMT have been categorized according to their clinical symptoms caused by different mutations. Missense mutations of c-MPL have been classified as type II and these patients have delayed onset of bone marrow failure compared to type I patients. Here we present a girl with severe clinical course of CAMT II having a missense mutation in exon 4 of the c-MPL gene who was admitted to our hospital with intracranial hemorrhage during the newborn period.
    Schlagwörter Congenital amegakaryocytic thrombocytopenia ; Thrombopoietin ; c-MPL ; Homozygous missense mutation ; c-MPL Tryp154Arg ; Amino acid change ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2015-06-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Transcobalamin II Deficiency in Four Cases with Novel Mutations

    Sule Unal / Tony Rupar / Sevgi Yetgin / Nese Yarali / Ali Dursun / Türkiz Gürsel / Mualla Cetin

    Turkish Journal of Hematology, Vol 32, Iss 4, Pp 317-

    2015  Band 322

    Abstract: INTRODUCTION: Transcobalamin II deficiency is one of the rare causes of inherited vitamin B12 disorders in which the patients have characteristically normal or high vitamin B12 levels related to the transport defect of vitamin B12 into the cell, ending ... ...

    Abstract INTRODUCTION: Transcobalamin II deficiency is one of the rare causes of inherited vitamin B12 disorders in which the patients have characteristically normal or high vitamin B12 levels related to the transport defect of vitamin B12 into the cell, ending up with intracellular cobalamin depletion and high homocysteine and methylmalonic acid levels. METHODS: Herein, we describe the findings at presentation of four patients who were diagnosed to have transcobalamin II deficiency with novel mutations. RESULTS: These patients with transcobalamin II deficiency were found to have novel mutations, of whom 2 had the same large deletion (homozygous c.1106+1516-1222+1231del). DISCUSSION AND CONCLUSION: Transcobalamin II deficiency should be considered in differential diagnosis of any infant with pancytopenia, failure to thrive, diarrhea, and vomiting.
    Schlagwörter Vitamin B12 ; Transcobalamin II ; Novel mutation ; Novel deletion ; Vacuolizatio ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-12-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Diagnosis

    Sevgin Taner / Ali Fettah / Neşe Yaralı / Sevde Seçer / Özge Ağlamış / Bahattin Tunç

    Turkish Journal of Hematology, Vol 31, Iss 3, Pp 335-

    Infantile Malign Osteopetrosis

    2014  Band 336

    Schlagwörter Hypocalcemic seizure ; Infantile malign osteopetrosis ; TCIRG1 gene mutation ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Sprache Englisch
    Erscheinungsdatum 2014-09-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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