LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions.

    Neamah, Wurood Hantoosh / Rutkovsky, Alex / Abdullah, Osama / Wilson, Kiesha / Bloomquist, Ryan / Nagarkatti, Prakash / Nagarkatti, Mitzi

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: Previously, we showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor (AhR) ligand and a potent and persistent toxicant and carcinogenic agent, induces high levels of murine myeloid-derived suppressor cell (MDSC) when ... ...

    Abstract Previously, we showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor (AhR) ligand and a potent and persistent toxicant and carcinogenic agent, induces high levels of murine myeloid-derived suppressor cell (MDSC) when injected into mice. In the current study, we demonstrate that Resveratrol (3,4,5-trihydroxy-trans-stilbene; RSV), an AhR antagonist, reduces TCDD-mediated MDSC induction. RSV decreased the number of MDSCs induced by TCDD in mice but also mitigated the immunosuppressive function of TCDD-induced MDSCs. TCDD caused a decrease in F4/80+ macrophages and an increase in CD11C+ dendritic cells, while RSV reversed these effects. TCDD caused upregulation in CXCR2, a critical molecule involved in TCDD-mediated induction of MDSCs, and Arginase-1 (ARG-1), involved in the immunosuppressive functions of MDSCs, while RSV reversed this effect. Transcriptome analysis of Gr1
    MeSH term(s) Mice ; Animals ; Polychlorinated Dibenzodioxins/toxicity ; Resveratrol/pharmacology ; Myeloid-Derived Suppressor Cells/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; Myeloid Cells/metabolism ; Phenotype
    Chemical Substances Polychlorinated Dibenzodioxins ; Resveratrol (Q369O8926L) ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214667
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: AhR Activation Leads to Alterations in the Gut Microbiome with Consequent Effect on Induction of Myeloid Derived Suppressor Cells in a CXCR2-Dependent Manner.

    Neamah, Wurood Hantoosh / Busbee, Philip Brandon / Alghetaa, Hasan / Abdulla, Osama A / Nagarkatti, Mitzi / Nagarkatti, Prakash

    International journal of molecular sciences

    2020  Volume 21, Issue 24

    Abstract: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent ligand for AhR and a known carcinogen. While AhR activation by TCDD leads to significant immunosuppression, how this ... ...

    Abstract Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent ligand for AhR and a known carcinogen. While AhR activation by TCDD leads to significant immunosuppression, how this translates into carcinogenic signal is unclear. Recently, we demonstrated that activation of AhR by TCDD in naïve C57BL6 mice leads to massive induction of myeloid derived-suppressor cells (MDSCs). In the current study, we investigated the role of the gut microbiota in TCDD-mediated MDSC induction. TCDD caused significant alterations in the gut microbiome, such as increases in
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cells, Cultured ; DNA, Bacterial/genetics ; Dysbiosis/chemically induced ; Fecal Microbiota Transplantation/methods ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Mice ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/metabolism ; Phylogeny ; Polychlorinated Dibenzodioxins/adverse effects ; Receptors, Aryl Hydrocarbon/metabolism ; Receptors, Interleukin-8B/metabolism ; Signal Transduction/drug effects ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Ahr protein, mouse ; Anti-Bacterial Agents ; Basic Helix-Loop-Helix Transcription Factors ; Cxcr2 protein, mouse ; DNA, Bacterial ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon ; Receptors, Interleukin-8B
    Language English
    Publishing date 2020-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota.

    Abdulla, Osama A / Neamah, Wurood / Sultan, Muthanna / Alghetaa, Hasan K / Singh, Narendra / Busbee, Philip Brandon / Nagarkatti, Mitzi / Nagarkatti, Prakash

    Frontiers in immunology

    2021  Volume 12, Page(s) 684727

    Abstract: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates T cell function. The aim of this study was to investigate the effects of AhR ligands, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), and 6-Formylindolo[3,2-b]carbazole ...

    Abstract Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates T cell function. The aim of this study was to investigate the effects of AhR ligands, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), and 6-Formylindolo[3,2-b]carbazole (FICZ), on gut-associated microbiota and T cell responses during delayed-type hypersensitivity (DTH) reaction induced by methylated bovine serum albumin (mBSA) in a mouse model. Mice with DTH showed significant changes in gut microbiota including an increased abundance of
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Butyric Acid/pharmacology ; Carbazoles/toxicity ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Gastrointestinal Microbiome/drug effects ; Hypersensitivity, Delayed/genetics ; Hypersensitivity, Delayed/immunology ; Hypersensitivity, Delayed/metabolism ; Hypersensitivity, Delayed/prevention & control ; Ligands ; Mice ; Mice, Inbred C57BL ; Polychlorinated Dibenzodioxins/toxicity ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/metabolism ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/metabolism
    Chemical Substances 6-formylindolo(3,2-b)carbazole ; AHR protein, human ; Basic Helix-Loop-Helix Transcription Factors ; Carbazoles ; Cytokines ; Ligands ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon ; Butyric Acid (107-92-6)
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.684727
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response.

    Abdulla, Osama A / Neamah, Wurood / Sultan, Muthanna / Chatterjee, Saurabh / Singh, Narendra / Nagarkatti, Mitzi / Nagarkatti, Prakash

    Frontiers in immunology

    2021  Volume 12, Page(s) 635903

    Abstract: Aryl hydrocarbon receptor (AhR), is a transcription factor and an environmental sensor that has been shown to regulate T cell differentiation. Interestingly, AhR ligands exert varying effects from suppression to exacerbation of inflammation through ... ...

    Abstract Aryl hydrocarbon receptor (AhR), is a transcription factor and an environmental sensor that has been shown to regulate T cell differentiation. Interestingly, AhR ligands exert varying effects from suppression to exacerbation of inflammation through induction of Tregs and Th-17 cells, respectively. In the current study, we investigated whether the differential effects of AhR ligands on T cell differentiation are mediated by miRNA during delayed-type hypersensitivity (DTH) reaction against methylated Bovine Serum Albumin (mBSA). Treatment of C57BL/6 mice with TCDD attenuated mBSA-mediated DTH response, induced Tregs, decreased Th-17 cells, and caused upregulation of miRNA-132. TCDD caused an increase in several Treg subsets including inducible peripheral, natural thymic, and Th3 cells. Also, TCDD increased TGF-β and Foxp3 expression. In contrast, treating mice with FICZ exacerbated the DTH response, induced inflammatory Th17 cells, induced IL-17, and RORγ. Analysis of miRNA profiles from draining lymph nodes showed that miR-132 was upregulated in the TCDD group and downregulated in the FICZ group. Transfection studies revealed that miRNA-132 targeted High Mobility Group Box 1 (HMGB1). Downregulation of HMGB1 caused an increase in FoxP3+ Treg differentiation and suppression of Th-17 cells while upregulation of HMGB1 caused opposite effects. Moreover, TCDD was less effective in suppressing DTH response and induction of Tregs in mice that were deficient in miR-132. In summary, this study demonstrates that TCDD and FICZ have divergent effects on DTH response and T cell differentiation, which is mediated through, at least in part, regulation of miRNA-132 that targets HMGB1.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carbazoles/toxicity ; Cell Differentiation/drug effects ; Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Hypersensitivity, Delayed/genetics ; Hypersensitivity, Delayed/immunology ; Hypersensitivity, Delayed/metabolism ; Hypersensitivity, Delayed/prevention & control ; Ligands ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Phenotype ; Polychlorinated Dibenzodioxins/toxicity ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/metabolism ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Mice
    Chemical Substances 6-formylindolo(3,2-b)carbazole ; Ahr protein, mouse ; Basic Helix-Loop-Helix Transcription Factors ; Carbazoles ; Cytokines ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; HMGB1 Protein ; HMGB1 protein, mouse ; Ligands ; MIRN132 microRNA, mouse ; MicroRNAs ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.635903
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes.

    Neamah, Wurood Hantoosh / Singh, Narendra P / Alghetaa, Hasan / Abdulla, Osama A / Chatterjee, Saurabh / Busbee, Philip B / Nagarkatti, Mitzi / Nagarkatti, Prakash

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 203, Issue 7, Page(s) 1830–1844

    Abstract: The compound 2,3,7,8-tetrachlorodibenzo- ...

    Abstract The compound 2,3,7,8-tetrachlorodibenzo-
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Chemokines/immunology ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Immune Tolerance ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/pathology ; Mice ; MicroRNAs ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/pathology ; Polychlorinated Dibenzodioxins/toxicity ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/immunology ; Receptors, Interleukin-8B/immunology
    Chemical Substances Ahr protein, mouse ; Basic Helix-Loop-Helix Transcription Factors ; Chemokines ; MicroRNAs ; Mirn150 microRNA, mouse ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon ; Receptors, Interleukin-8B
    Language English
    Publishing date 2019-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1900291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top