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  1. Article ; Online: Gene-Environment Interactions: My Unique Journey.

    Nebert, Daniel W

    Annual review of pharmacology and toxicology

    2023  Volume 64, Page(s) 1–26

    Abstract: I am deeply honored to be invited to write this scientific autobiography. As a physician-scientist, pediatrician, molecular biologist, and geneticist, I have authored/coauthored more than 600 publications in the fields of clinical medicine, biochemistry, ...

    Abstract I am deeply honored to be invited to write this scientific autobiography. As a physician-scientist, pediatrician, molecular biologist, and geneticist, I have authored/coauthored more than 600 publications in the fields of clinical medicine, biochemistry, biophysics, pharmacology, drug metabolism, toxicology, molecular biology, cancer, standardized gene nomenclature, developmental toxicology and teratogenesis, mouse genetics, human genetics, and evolutionary genomics. Looking back, I think my career can be divided into four distinct research areas, which I summarize mostly chronologically in this article: (
    MeSH term(s) Humans ; Animals ; Mice ; Genomics ; Membrane Transport Proteins ; Pharmacogenetics ; Physicians
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-022323-082311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Why are keratins important?

    Fisk, Jeffrey Nicholas / Nebert, Daniel W

    Human genomics

    2022  Volume 16, Issue 1, Page(s) 4

    MeSH term(s) Cytoskeletal Proteins ; Humans ; Keratins/genetics
    Chemical Substances Cytoskeletal Proteins ; Keratins (68238-35-7)
    Language English
    Publishing date 2022-01-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2147618-4
    ISSN 1479-7364 ; 1479-7364
    ISSN (online) 1479-7364
    ISSN 1479-7364
    DOI 10.1186/s40246-022-00379-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling.

    Ingelman-Sundberg, Magnus / Nebert, Daniel W / Lauschke, Volker M

    Human genomics

    2023  Volume 17, Issue 1, Page(s) 105

    MeSH term(s) Humans ; Pharmacogenetics ; Precision Medicine ; Genomics
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2147618-4
    ISSN 1479-7364 ; 1479-7364
    ISSN (online) 1479-7364
    ISSN 1479-7364
    DOI 10.1186/s40246-023-00554-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment.

    Eaton, David L / Simon, Ted W / Kaminski, Norbert E / Perdew, Gary H / Nebert, Daniel W

    Regulatory toxicology and pharmacology : RTP

    2024  Volume 149, Page(s) 105599

    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2024.105599
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    Zs.A 1711: Show issues Location:
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  5. Article ; Online: Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors.

    Eaton, David L / Simon, Ted W / Kaminski, Norbert E / Perdew, Gary H / Nebert, Daniel W

    Regulatory toxicology and pharmacology : RTP

    2024  Volume 149, Page(s) 105598

    Abstract: In 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl ... ...

    Abstract In 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of each study favored in vivo over in vitro studies and was based largely on rodent studies. In this Commentary, we highlight the large body of published studies that demonstrate large species differences in AHR-ligand activation and provide supporting evidence for our position that the WHO 2022 TEF values intended for use in human risk assessment of DLC mixtures will provide highly misleading overestimates of 'Toxic Equivalent Quotients' (TEQs), because of well-recognized striking differences in AHR ligand affinities between rodent (rat, mouse) and human. The data reviewed in our Commentary support the position that human tissue-derived estimates of REP/TEF values for individual DLC congeners, although uncertain, will provide much better, more realistic estimates of potential activation of the human AHR, when exposure to complex DLC mixtures occurs.
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2024.105598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.

    Nebert, Daniel W

    Progress in lipid research

    2017  Volume 67, Page(s) 38–57

    Abstract: The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription factors, found throughout all three kingdoms of life; bHLH/PAS members "sense" innumerable intracellular and extracellular "signals" - including endogenous compounds, ... ...

    Abstract The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription factors, found throughout all three kingdoms of life; bHLH/PAS members "sense" innumerable intracellular and extracellular "signals" - including endogenous compounds, foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and osmotic pressure. These signals then initiate downstream signaling pathways involved in responding to that signal. The term "PAS", abbreviation for "per-Arnt-sim" was first coined in 1991. Although the mouse Arnt gene was not identified until 1991, evidence of its co-transcriptional binding partner, aryl hydrocarbon receptor (AHR), was first reported in 1974 as a "sensor" of foreign chemicals, up-regulating cytochrome P450 family 1 (CYP1) and other enzyme activities that usually metabolize the signaling chemical. Within a few years, AHR was proposed also to participate in inflammation. The mouse [Ah] locus was shown (1973-1989) to be relevant to chemical carcinogenesis, mutagenesis, toxicity and teratogenesis, the mouse Ahr gene was cloned in 1992, and the first Ahr(-/-) knockout mouse line was reported in 1995. After thousands of studies from the early 1970s to present day, we now realize that AHR participates in dozens of signaling pathways involved in critical-life processes, affecting virtually every organ and cell-type in the animal, including many invertebrates.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction
    Chemical Substances Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Receptors, Aryl Hydrocarbon ; PAS domain kinases (EC 2.7.1.11) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282560-0
    ISSN 1873-2194 ; 0079-6832 ; 0163-7827
    ISSN (online) 1873-2194
    ISSN 0079-6832 ; 0163-7827
    DOI 10.1016/j.plipres.2017.06.001
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  7. Article ; Online: Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis

    Chen, Ying / Holland, Katherine D. / Shertzer, Howard G. / Nebert, Daniel W. / Dalton, Timothy P.

    Antioxidants. 2023 Feb. 10, v. 12, no. 2

    2023  

    Abstract: Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. Gclmᴷᴼ knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; Gclmᴷᴼ ... ...

    Abstract Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. Gclmᴷᴼ knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; Gclmᴷᴼ mice exhibit 10–40% of normal tissue GSH levels and show no overt phenotype. Guloᴷᴼ knockout mice, lacking a functional Gulo gene encoding L-gulono-γ-lactone oxidase, cannot synthesize AA and depend on dietary ascorbic acid for survival. To elucidate functional crosstalk between GSH and AA in vivo, we generated the Gclmᴷᴼ/Guloᴷᴼ double-knockout (DKO) mouse. DKO mice exhibited spontaneous epileptic seizures, proceeding to death between postnatal day (PND)14 and PND23. Histologically, DKO mice displayed neuronal loss and glial proliferation in the neocortex and hippocampus. Epileptic seizures and brain pathology in young DKO mice could be prevented with AA supplementation in drinking water (1 g/L). Remarkably, in AA-rescued adult DKO mice, the removal of AA supplementation for 2–3 weeks resulted in similar, but more severe, neocortex and hippocampal pathology and seizures, with death occurring between 12 and 21 days later. These results provide direct evidence for an indispensable, yet underappreciated, role for the interplay between GSH and AA in normal brain function and neuronal health. We speculate that the functional crosstalk between GSH and AA plays an important role in regulating glutamatergic neurotransmission and in protecting against excitotoxicity-induced brain damage.
    Keywords Gulo ; adults ; ascorbic acid ; biosynthesis ; brain damage ; death ; genes ; glutathione ; hippocampus ; mice ; neocortex ; neurons ; oxidoreductases ; phenotype ; synaptic transmission
    Language English
    Dates of publication 2023-0210
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020448
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis.

    Chen, Ying / Holland, Katherine D / Shertzer, Howard G / Nebert, Daniel W / Dalton, Timothy P

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. ...

    Abstract Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues.
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020448
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  9. Article ; Online: SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside.

    Nebert, Daniel W / Liu, Zijuan

    Human genomics

    2019  Volume 13, Issue Suppl 1, Page(s) 51

    Abstract: SLC39A8 is an evolutionarily highly conserved gene that encodes the ZIP8 metal cation transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent embryonic stem cells; SLC39A8 expression occurs in every cell type examined. ... ...

    Abstract SLC39A8 is an evolutionarily highly conserved gene that encodes the ZIP8 metal cation transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent embryonic stem cells; SLC39A8 expression occurs in every cell type examined. Uptake of ZIP8-mediated Mn
    MeSH term(s) Animals ; Cation Transport Proteins/genetics ; Evolution, Molecular ; Glycosylation ; Humans ; Ions ; Metals/metabolism ; Organ Specificity ; Translational Research, Biomedical
    Chemical Substances Cation Transport Proteins ; Ions ; Metals
    Language English
    Publishing date 2019-09-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2147618-4
    ISSN 1479-7364 ; 1479-7364
    ISSN (online) 1479-7364
    ISSN 1479-7364
    DOI 10.1186/s40246-019-0233-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Corrigendum to "Personalized medicine: Genetic risk prediction of drug response" [Pharmacol. Ther. 175 (2017) 75-90.].

    Zhang, Ge / Nebert, Daniel W

    Pharmacology & therapeutics

    2018  Volume 183, Page(s) 205–206

    Language English
    Publishing date 2018-01-08
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2017.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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