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  1. Article: Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure.

    Marinescu, Mihai Cristian / Oprea, Violeta Diana / Munteanu, Sorina Nicoleta / Nechita, Aurel / Tutunaru, Dana / Nechita, Luiza Camelia / Romila, Aurelia

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 8

    Abstract: Background: Heart failure is a global major healthcare problem with millions of hospitalizations annually and with a very high mortality. There is an increased interest in finding new and reliable biomarkers for the diagnostic, prognostic and ... ...

    Abstract Background: Heart failure is a global major healthcare problem with millions of hospitalizations annually and with a very high mortality. There is an increased interest in finding new and reliable biomarkers for the diagnostic, prognostic and therapeutic guidance of patients hospitalized for acute heart failure; Our review aims to summarize in an easy-to-follow flow recent relevant research evaluating the possible use and the clinical value of measuring CA 125 serum levels in acute HF.
    Methods: A thorough search in the main international databases identified a relevant pool of 170 articles, providing recently published data for this narrative review that used PRISMA guidelines.
    Results: There are data to sustain the role of carbohydrate antigen 125 (CA 125), a worldwide used marker of ovarian cancer, in patients with heart failure. Several studies have shown links between CA 125 levels and congestion seen in acute heart failure, high mortality and readmission rates at 6 months follow-up after discharge from acute heart failure and also a role of CA 125 in the guidance of heart failure therapy. There are also clinical trials that showed that several particularities of CA 125 make it even better than N-terminal pro b-type natriuretic peptide (NT-pro BNP)-a classical and more utilized marker of heart failure) in several scenarios of acute heart failure.
    Conclusions: Although the mechanism behind the upregulation of serum CA 125 in patients with congestive HF has not been confirmed nor fully understood.
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14080795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Use of Brain Natriuretic Peptide in the Evaluation of Heart Failure in Geriatric Patients.

    Marinescu, Mihai / Oprea, Violeta Diana / Nechita, Aurel / Tutunaru, Dana / Nechita, Luiza-Camelia / Romila, Aurelia

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: Heart failure is one of the main morbidity and mortality factors in the general population and especially in elderly patients. Thus, at the European level, the prevalence of heart failure is 1% in people under 55 years of age but increases to over 10% in ...

    Abstract Heart failure is one of the main morbidity and mortality factors in the general population and especially in elderly patients. Thus, at the European level, the prevalence of heart failure is 1% in people under 55 years of age but increases to over 10% in people over 70 years of age. The particularities of the elderly patient, which make the management of heart failure difficult, are the presence of comorbidities, frailty, cognitive impairment and polypharmacy. However, elderly patients are under-represented in clinical trials on the diagnosis and treatment of heart failure. The need for complementary methods (biomarkers) for differential and early diagnosis of heart failure is becoming more and more evident, even in its subclinical stages. These methods need to have increased specificity and sensitivity and be widely available. Natriuretic peptides, in particular B-type natriuretic peptide (BNP) and its fraction NTproBNP, have gained an increasingly important role in the screening, diagnosis and treatment of heart failure in recent years.
    Language English
    Publishing date 2023-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13091512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pathogenesis of Musculotendinous and Fascial Injuries After Physical Exercise - Short Review.

    Musat, Carmina Liana / Niculet, Elena / Craescu, Mihaela / Nechita, Luiza / Iancu, Lina / Nechita, Aurel / Voinescu, Doina-Carina / Bobeica, Carmen

    International journal of general medicine

    2023  Volume 16, Page(s) 5247–5254

    Abstract: Purpose: The identification of sports and physical exercises with injury risk is necessary to preserve the capacity of athletes and people who perform physical education and also to prevent the installation of functional deficiencies.: Methods: We ... ...

    Abstract Purpose: The identification of sports and physical exercises with injury risk is necessary to preserve the capacity of athletes and people who perform physical education and also to prevent the installation of functional deficiencies.
    Methods: We have selected the articles related to the pathogenic mechanisms involved in musculotendinous and fascial injuries produced as a result of physical exercise.
    Results and discussions: The lesional pathogenesis is complex and incompletely clarified. Recent theories put in a new light the mechanisms of muscle pain and tendinopathy production. The accumulation of lactate anion, known to be a residue that induces fatigue and muscle pain, has been reconsidered by some authors. It appears that lactate anion is an excellent fuel for the myocardial fiber. Moreover, the accumulation of lactic acid after intense physical exercise could prevent the inexcitability of the sarcolemma induced by the increased concentration of interstitial K
    Conclusion: The benefits brought by physical education and sports are indisputable, but their practice requires a coordinated program to prevent possible traumatic and overuse injuries.
    Language English
    Publishing date 2023-11-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S432749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Case Report. Diagnostic Challenges: Liver Metastases from Mammary Gland Origin or Cholangiocarcinoma?

    Tocu, George / Popa, Ioana Teodora / Ivan, Iuliana / Anghel, Lucretia / Nechita, Luiza A / Musat, Carmina Liana / Rebegea, Laura Florentina / Tutunaru, Dana

    International journal of women's health

    2023  Volume 15, Page(s) 1205–1211

    Abstract: Liver metastases are secondary malignant tumor formations due to the dissemination of primary malignant tumors, which are often the first clinical manifestation of mammary cancer. We present the case of a 52-year-old female patient from an urban area who ...

    Abstract Liver metastases are secondary malignant tumor formations due to the dissemination of primary malignant tumors, which are often the first clinical manifestation of mammary cancer. We present the case of a 52-year-old female patient from an urban area who came to the walk-in service at the "Sf. Ap. Andrei" Emergency County Hospital, Galati, for laboratory investigations. These revealed a significant increase in CA 15-3 tumor markers and a slight increase in CA 125 and CA 19-9 markers; however, clinical examination did not reveal tumors in the breast and there were no axillary adenopathies. CT exam revealed a large tumor formation in the hepatic right lobe and, close to it, a smaller one. The mammograph showed millimetric lesions at the level of the left mammary gland and bilateral axillary adenopathies. Subsequently, the patient underwent two liver biopsies in two different hospitals, which produced different histological and immunohistochemical results. PET-CT drew attention to a lung tumor and disclosed a different origin of metastases. In the end, correlating all investigations, the final diagnosis was cholangiocarcinoma with liver metastases and lung tumor with lung and bone metastases.
    Language English
    Publishing date 2023-07-27
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2508161-5
    ISSN 1179-1411
    ISSN 1179-1411
    DOI 10.2147/IJWH.S408055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sleep Disorders Associated with Neurodegenerative Diseases.

    Anghel, Lucreția / Ciubară, Anamaria / Nechita, Aurel / Nechita, Luiza / Manole, Corina / Baroiu, Liliana / Ciubară, Alexandru Bogdan / Mușat, Carmina Liana

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 18

    Abstract: Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington's disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy ... ...

    Abstract Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington's disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB). This article reviews the prevalence and characteristics of sleep disorders in these conditions, highlighting their impact on patients' quality of life and disease progression. Sleep-related breathing disorders, insomnia, restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), and rapid eye movement sleep behavior disorder (RBD) are among the common sleep disturbances reported. Both pharmacological and non-pharmacological interventions play crucial roles in managing sleep disturbances and enhancing overall patient care.
    Language English
    Publishing date 2023-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13182898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antiviral Therapy of Chronic Hepatitis B Virus between Present and Future.

    Ignat, Mariana Daniela / Balta, Alexia Anastasia Stefania / Barbu, Raisa Eloise / Draganescu, Miruna Luminita / Nechita, Luiza / Voinescu, Doina Carina / Nechita, Aurel / Stefanopol, Ioana Anca / Busila, Camelia / Baroiu, Liliana

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: Background/ ... ...

    Abstract Background/Objectives
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13072055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond.

    Anghel, Lucreția / Manole, Corina / Nechita, Aurel / Tatu, Alin Laurențiu / Ștefănescu, Bogdan Ioan / Nechita, Luiza / Bușilă, Camelia / Zainea, Pușica / Baroiu, Liliana / Mușat, Carmina Liana

    Biomedicines

    2023  Volume 11, Issue 9

    Abstract: The coronavirus disease (COVID-19) pandemic caused by the novel coronavirus SARS-CoV-2 has had a profound impact on global health, leading to a surge in research to better understand the pathophysiology of the disease. Among the various aspects under ... ...

    Abstract The coronavirus disease (COVID-19) pandemic caused by the novel coronavirus SARS-CoV-2 has had a profound impact on global health, leading to a surge in research to better understand the pathophysiology of the disease. Among the various aspects under investigation, disruptions in mineral homeostasis have emerged as a critical area of interest. This review aims to provide an overview of the current evidence linking calcium, phosphorus and magnesium abnormalities with COVID-19 infection and explores the potential implications beyond the acute phase of the disease. Beyond the acute phase of COVID-19, evidence suggests a potential impact of these mineral abnormalities on long-term health outcomes. Persistent alterations in calcium, phosphorus and magnesium levels have been linked to increased cardiovascular risk, skeletal complications and metabolic disorders, warranting continuous monitoring and management in post-COVID-19 patients.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11092362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Benefits and adverse events of melatonin use in the elderly (Review).

    Anghel, Lucreția / Baroiu, Liliana / Popazu, Corina Rișcă / Pătraș, Diana / Fotea, Silvia / Nechifor, Alexandru / Ciubara, Anamaria / Nechita, Luiza / Mușat, Carmina Liana / Stefanopol, Ioana Anca / Tatu, Alin Laurențiu / Ciubara, Alexandru Bogdan

    Experimental and therapeutic medicine

    2022  Volume 23, Issue 3, Page(s) 219

    Abstract: Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting ... ...

    Abstract Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and β-blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β and tumor necrosis factor-α. Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area.
    Language English
    Publishing date 2022-01-14
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Influence of Living in Rural Areas on the Evolution and Management of Pediatric Ovarian Cystic Lesions: A Retrospective Study on a Cohort from South Eastern Romania.

    Stefanopol, Ioana Anca / Baroiu, Liliana / Chirila, Sergiu / Miulescu, Magdalena / Anghel, Lucreţia / Nechita, Luiza / Dinu, Ciprian Adrian / Stefanescu, Victorita / Bobeica, Carmen / Nechifor, Alexandru / Tatu, Alin Laurenţiu

    International journal of general medicine

    2022  Volume 15, Page(s) 5273–5284

    Abstract: Background: The incidence of ovarian cystic lesions (OCLs) in pediatric patients has been increasing in recent years. An early diagnosis is mandatory for a favourable prognosis but it depends on the primary medical care services and on the socioeconomic ...

    Abstract Background: The incidence of ovarian cystic lesions (OCLs) in pediatric patients has been increasing in recent years. An early diagnosis is mandatory for a favourable prognosis but it depends on the primary medical care services and on the socioeconomic status of the patient. The present study aims at assessing the prevalence and the age-specific frequencies of pediatric OCLs, as well as identifying disparities between subjects in the urban and the rural areas, in order to explore the extent to which OCLs occurrence, diagnosis, evolution and treatment differ in the case of patients living in rural areas.
    Methods: A 3-year retrospective study was conducted between 2017 and 2019. All the female patients aged between 0 and 18 with OCLs ≥10 mm (N = 488), diagnosed and treated at "Sf.Ioan" Clinical Emergency Hospital for Children in Galaţi were included in the study. The Chi
    Results: The prevalence of OCLs ≥10 mm was 14.85%, 47.13% of the subjects originating in rural area (p = 0.62). Different from the urban areas, the rural ones are characterised by a lower proportion of patients with BMI ≥25 (
    Conclusion: Taking into consideration the socio-economic situation of south eastern Romania, patients living in rural areas have proven exposed to a higher risk of presenting with larger, complex and complicated OCLs, which most often require surgical treatment.
    Language English
    Publishing date 2022-05-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S368202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Hearing Loss Secondary to Systemic Sclerosis Vasculopathy: Case Study with a Short Review.

    Bobeica, Carmen / Niculet, Elena / Craescu, Mihaela / Parapiru, Elena-Laura / Musat, Carmina Liana / Dinu, Ciprian / Chiscop, Iulia / Nechita, Luiza / Stefanescu, Victorita / Stefanopol, Ioana Anca / Pelin, Ana Maria / Nechifor, Alexandru / Balan, Gabriela / Tatu, Alin Laurentiu

    Clinical, cosmetic and investigational dermatology

    2022  Volume 15, Page(s) 967–973

    Abstract: Systemic sclerosis (SSc) is a collagenosis with a substrate of chronic inflammation, which is determined by autoimmunity. The pathogenesis of this disease involves microvasculopathy (small vessel pathology) followed by excessive cutaneous and visceral ... ...

    Abstract Systemic sclerosis (SSc) is a collagenosis with a substrate of chronic inflammation, which is determined by autoimmunity. The pathogenesis of this disease involves microvasculopathy (small vessel pathology) followed by excessive cutaneous and visceral fibrosis. Although acoustic and vestibular impairment is not classified as being a secondary pathology of SSc, several studies have identified cases of SSc that associate hearing loss and especially vertigo and tinnitus. This paper presents data from the medical literature that have identified vestibular and auditory symptoms among patients with SSc, associating the clinical case presentation of a patient suffering from SSc, which is associated with hearing loss. The need for additional studies on larger groups of patients is underlined, in order to clarify the impact of vasculopathy and fibrosis on the acoustic and vestibular analyzer in patients with SSc.
    Language English
    Publishing date 2022-05-30
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S356818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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