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  1. Article ; Online: B-cell non-Hodgkin lymphomas in Uganda: an immunohistochemical appraisal on tissue microarray.

    Tumwine, Lynnette K / Campidelli, Cristina / Righi, Simona / Neda, Sophia / Byarugaba, Wilson / Pileri, Stefano A

    Human pathology

    2008  Volume 39, Issue 6, Page(s) 817–823

    Abstract: The most common non-Hodgkin lymphomas in Uganda are neoplasms of B-cell derivation. The field of B-cell lymphoma immunophenotype has rapidly progressed because of the increasing availability of markers applicable to routine sections. Although the latter ... ...

    Abstract The most common non-Hodgkin lymphomas in Uganda are neoplasms of B-cell derivation. The field of B-cell lymphoma immunophenotype has rapidly progressed because of the increasing availability of markers applicable to routine sections. Although the latter have allowed the identification of distinctive lymphoma entities in the developed countries, such approach has not yet been used in Uganda. One hundred twenty-nine formalin-fixed, paraffin-embedded tissue samples from the Department of Pathology of Makerere University were used for tissue micro-array (TMA) construction. Four-micrometer-thick sections were cut from TMAs and stained with hematoxylin and eosin and Giemsa. They were also used for immunohistochemistry and in situ hybridization. According to morphology and immunohistochemistry, lymphoid neoplasms were classified as Burkitt's lymphoma (BL) (95 cases), diffuse large B-cell lymphoma (19 cases), mantle cell lymphoma (4 cases), and B-cell lymphoblastic lymphoma (1 case). In BL, a homogeneous phenotype (CD10(+), Bcl-6(+), Bcl-2(-), MUM1/IRF4-, and Ki-67 approximately 100%) and a stable Epstein-Barr virus integration were found. A distinctive and unusual feature was the frequent plasma cellular differentiation, along with the positivity for CD30 and CD138 (recorded in 35 and 43 cases, respectively). According to our findings, most non-Hodgkin B-cell tumors in Uganda are endemic BLs followed by diffuse large B-cell lymphomas. The rest consist of rare but clinically important entities such as mantle cell lymphoma and B-cell lymphoblastic lymphoma. The availability of TMAs and immunohistochemistry has enabled us to precisely categorize tumors that have so far been diagnosed in Uganda as "high-grade/aggressive" lymphomas on the basis of cell morphology alone.
    MeSH term(s) Adolescent ; Adult ; Biomarkers, Tumor/metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; DNA, Neoplasm/analysis ; Female ; Herpesviridae Infections/complications ; Herpesviridae Infections/virology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization ; Ki-1 Antigen/metabolism ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/virology ; Male ; Middle Aged ; Plasma Cells/metabolism ; Plasma Cells/pathology ; RNA, Viral/analysis ; Syndecan-1/metabolism ; Tissue Array Analysis/methods ; Uganda
    Chemical Substances Biomarkers, Tumor ; DNA, Neoplasm ; Ki-1 Antigen ; RNA, Viral ; Syndecan-1
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2007.10.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 722: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The intra- and inter-observer reliability of the physical examination methods used to assess patients with patellofemoral joint instability.

    Smith, Toby O / Clark, Allan / Neda, Sophia / Arendt, Elizabeth A / Post, William R / Grelsamer, Ronald P / Dejour, David / Almqvist, Karl Fredrik / Donell, Simon T

    The Knee

    2012  Volume 19, Issue 4, Page(s) 404–410

    Abstract: Background: An accurate physical examination of patients with patellar instability is an important aspect of the diagnosis and treatment. While previous studies have assessed the diagnostic accuracy of such physical examination tests, little has been ... ...

    Abstract Background: An accurate physical examination of patients with patellar instability is an important aspect of the diagnosis and treatment. While previous studies have assessed the diagnostic accuracy of such physical examination tests, little has been undertaken to assess the inter- and intra-tester reliability of such techniques. The purpose of this study was to determine the inter- and intra-tester reliability of the physical examination tests used for patients with patellar instability.
    Methods: Five patients (10 knees) with bilateral recurrent patellar instability were assessed by five members of the International Patellofemoral Study Group. Each surgeon assessed each patient twice using 18 reported physical examination tests. The inter- and intra-observer reliability was assessed using weighted Kappa statistics with 95% confidence intervals.
    Results: The findings of the study suggested that there were very poor inter-observer reliability for the majority of the physical tests, with only the assessments of patellofemoral crepitus, foot arch position and the J-sign presenting with fair to moderate agreement respectively. The intra-observer reliability indicated largely moderate to substantial agreement between the first and second tests performed by each assessor, with the greatest agreement seen for the assessment of tibial torsion, popliteal angle and the Bassett's sign.
    Conclusions: For the common physical examination tests used in the management of patients with patellar instability inter-observer reliability is poor, while intra-observer reliability is moderate. Standardization of physical exam assessments and further study of these results among different clinicians and more divergent patient groups is indicated.
    MeSH term(s) Adult ; Female ; Humans ; Joint Instability/diagnosis ; Patellofemoral Joint ; Physical Examination/methods ; Reproducibility of Results ; Young Adult
    Language English
    Publishing date 2012-08
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial ; Validation Studies
    ZDB-ID 1200476-5
    ISSN 1873-5800 ; 0968-0160
    ISSN (online) 1873-5800
    ISSN 0968-0160
    DOI 10.1016/j.knee.2011.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4043: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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