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Article ; Online: Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species.

Nedergaard, Signe / Jensen, Anne B / Haubek, Dorte / Nørskov-Lauritsen, Niels

2021 Volume 9, Issue 3, Page(s) e0108521

Abstract: We developed a multilocus sequence typing scheme (MLST) for Aggregatibacter actinomycetemcomitans based on seven housekeeping genes, ...

Abstract	We developed a multilocus sequence typing scheme (MLST) for Aggregatibacter actinomycetemcomitans based on seven housekeeping genes,
MeSH term(s)	Adolescent ; Aggregatibacter actinomycetemcomitans/classification ; Aggregatibacter actinomycetemcomitans/genetics ; Aggregatibacter actinomycetemcomitans/isolation & purification ; DNA, Bacterial/genetics ; Genes, Essential/genetics ; Genetics, Population ; Genome, Bacterial/genetics ; Genotype ; Humans ; Multilocus Sequence Typing/methods ; Periodontitis/microbiology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Whole Genome Sequencing/methods
Chemical Substances	DNA, Bacterial ; RNA, Ribosomal, 16S
Language	English
Publishing date	2021-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/Spectrum.01085-21
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Article ; Online: Endothelin-1 induces a strong pressor effect in ball pythons (Python regius).

Jensen, Maja Fuhlendorff / Nedergaard, Signe / Nielsen, Hang Nguyen / Skovgaard, Nini / Stevnsner, Tinna V / Wang, Tobias

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2019 Volume 241, Page(s) 110620

Abstract: Endothelin-1 (ET-1) is a very potent vasoactive peptide released from endothelial cells, and ET-1 plays an important role in the maintenance and regulation of blood pressure in mammals. ET-1 signaling is mediated by two receptors: ... ...

Abstract	Endothelin-1 (ET-1) is a very potent vasoactive peptide released from endothelial cells, and ET-1 plays an important role in the maintenance and regulation of blood pressure in mammals. ET-1 signaling is mediated by two receptors: ET
MeSH term(s)	Animals ; Blood Pressure/drug effects ; Boidae/physiology ; Endothelin Receptor Antagonists/pharmacology ; Endothelin-1/pharmacology ; Mesenteric Arteries/drug effects ; Nitric Oxide/metabolism ; Pulmonary Artery/drug effects ; Receptors, Endothelin/chemistry ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; Vasoconstriction/drug effects ; Vasodilation/drug effects
Chemical Substances	Endothelin Receptor Antagonists ; Endothelin-1 ; Receptors, Endothelin ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2019-11-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121246-1
ISSN	1531-4332 ; 0300-9629 ; 1095-6433
ISSN (online)	1531-4332
ISSN	0300-9629 ; 1095-6433
DOI	10.1016/j.cbpa.2019.110620
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Article: Whole Genome Sequencing of

Nedergaard, Signe / Kobel, Carl M / Nielsen, Marie B / Møller, Rikke T / Jensen, Anne B / Nørskov-Lauritsen, Niels

Pathogens (Basel, Switzerland)

2019 Volume 8, Issue 4

Abstract: Twenty-nine strains ... ...

Abstract	Twenty-nine strains of
Language	English
Publishing date	2019-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens8040256
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Article ; Online: Only repeated administration of the serotonergic agonist 8-OH-DPAT improves place learning of rats subjected to fimbria-fornix transection.

Malá, Hana / Arnberg, Kasper / Chu, David / Nedergaard, Signe Kjær / Witmer, Jacqlyn / Mogensen, Jesper

Pharmacology, biochemistry, and behavior

2013 Volume 109, Page(s) 50–58

Abstract: Serotonergic agonists may act neuroprotectively against brain injury. This study addressed the therapeutic potential of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT), a selective 5-HT1A/7 receptor agonist, after mechanical brain injury, and evaluated ...

Abstract	Serotonergic agonists may act neuroprotectively against brain injury. This study addressed the therapeutic potential of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT), a selective 5-HT1A/7 receptor agonist, after mechanical brain injury, and evaluated its effects in terms of acquisition of an allocentric place learning task in a water maze. Rats were divided into 6 experimental groups, three of which were subjected to bilateral transection of fimbria-fornix (FF), while three groups were given control surgery (Sham). After surgery, within both the lesioned, and sham-operated animals, respectively, one group was administered a single dose of saline, one group was given a single dose (0.5 mg/kg/b.w.) of 8-OH-DPAT, and one group was treated with daily administration of 8-OH-DPAT (0.5 mg/kg/b.w.) for eight days. The acquisition of the water maze based place learning task started on the 8th day post-surgery and continued for 20 days. The results show that the lesioned group subjected to repeated administration of 8-OH-DPAT demonstrated a significantly improved acquisition of the place learning task compared to the vehicle injected lesion group. In contrast, the lesioned group treated with a single administration displayed impaired performance compared to the baseline lesion group. There were no significant effects of the 8-OH-DPAT administration in the sham control groups. We conclude that only the repeated stimulation of the 5-HT1A/7 system was associated with beneficial, recovery enhancing effects.
MeSH term(s)	8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage ; 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology ; Animals ; Fornix, Brain/surgery ; Male ; Maze Learning/drug effects ; Rats ; Rats, Wistar ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/pharmacology
Chemical Substances	Serotonin Receptor Agonists ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191042-5
ISSN	1873-5177 ; 0091-3057
ISSN (online)	1873-5177
ISSN	0091-3057
DOI	10.1016/j.pbb.2013.05.008
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Article ; Online: Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain.

Hald, Andreas / Nedergaard, Signe / Hansen, Rikke R / Ding, Ming / Heegaard, Anne-Marie

European journal of pain (London, England)

2009 Volume 13, Issue 2, Page(s) 138–145

Abstract: Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury pain models and is thought to exacerbate pain perception. Following a nerve injury, a transient increase in the presence of microglia takes place while the ... ...

Abstract	Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury pain models and is thought to exacerbate pain perception. Following a nerve injury, a transient increase in the presence of microglia takes place while the increased numbers of astrocytes stay elevated for an extended period of time. It has been proposed that activated microglia are crucial for the development of neuropathic pain and that they lead to activation of astrocytes which then play a role in maintaining the long term pathological pain sensation. In the present report, we examined the time course of spinal cord glial activation in three different murine pain models to investigate if microglial activation is a general prerequisite for astrocyte activation in pain models. We found that two different types of cancer induced pain resulted in severe spinal astrogliosis without activation of microglia. In contrast, sciatic nerve injury led to a transient activation of microglia and sustained astrogliosis. These results show that development of hypersensitivity and astrocyte activation in pain models can take place independent of microglial activation.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Bone Neoplasms/complications ; Bone Neoplasms/pathology ; Cell Line ; Glial Fibrillary Acidic Protein/biosynthesis ; Glial Fibrillary Acidic Protein/genetics ; Gliosis/pathology ; Immunohistochemistry ; Mice ; Mice, Inbred C3H ; Neoplasms/complications ; Neuroglia/pathology ; Pain/etiology ; Pain/pathology ; Pain Measurement ; Peripheral Nervous System Diseases/complications ; Peripheral Nervous System Diseases/pathology ; Peripheral Nervous System Neoplasms/complications ; Peripheral Nervous System Neoplasms/pathology ; Physical Stimulation ; Spinal Cord/pathology ; Substance P/metabolism ; Tomography, X-Ray Computed
Chemical Substances	Glial Fibrillary Acidic Protein ; Substance P (33507-63-0)
Language	English
Publishing date	2009-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1016/j.ejpain.2008.03.014
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Article ; Online: Delayed intensive acquisition training alleviates the lesion-induced place learning deficits after fimbria-fornix transection in the rat.

Malá, Hana / Rodríguez Castro, María / Pearce, Hadley / Kingod, Siff Camilla / Nedergaard, Signe Kjær / Scharff, Zakaryiah / Zandersen, Maja / Mogensen, Jesper

Brain research

2012 Volume 1445, Page(s) 40–51

Abstract: This study evaluates the effects of two learning paradigms, intensive vs. baseline, on the posttraumatic acquisition of a water maze based place learning task. Rats were subjected either to a control operation (Sham) or to a fimbria-fornix (FF) ... ...

Abstract	This study evaluates the effects of two learning paradigms, intensive vs. baseline, on the posttraumatic acquisition of a water maze based place learning task. Rats were subjected either to a control operation (Sham) or to a fimbria-fornix (FF) transection, which renders the hippocampus dysfunctional and disrupts the acquisition of allocentric place learning. All animals were administered 30 post-lesion acquisition sessions, which spanned either 10 or 30days. The acquisition period was followed by a 7day pause after which a retention probe was administered. The lesioned animals were divided into 3 groups: i) Baseline Acquisition Paradigm (BAP) once daily for 30days starting 1week post-surgery; ii) Early Intensive Acquisition Paradigm (EIAP) 3 times daily for 10days starting 1week post-surgery; and iii) Late Intensive Acquisition Paradigm (LIAP) 3 times daily for 10days starting 3weeks post-surgery. Within the control animals, one group followed the schedule of BAP, and one group followed the schedule of Intensive Acquisition Paradigm (IAP). All lesioned animals showed an impaired task acquisition. LIAP was beneficial in FF animals, in that it led to a better acquisition of the place learning task than the two other acquisition paradigms. The FF/EIAP group did not show improved acquisition compared to the FF/BAP group. The control animals were not differentially affected by the two learning schedules. The findings have implications for cognitive rehabilitation after brain injury and support the assumption that intensive treatment can lead to an improved learning, even when the neural structures underlying such a process are compromised. However, the timing of intensive treatment needs to be considered further.
MeSH term(s)	Analysis of Variance ; Animals ; Behavior Therapy/methods ; Denervation ; Fornix, Brain/injuries ; Learning Disorders/etiology ; Learning Disorders/pathology ; Learning Disorders/rehabilitation ; Male ; Maze Learning/physiology ; Rats ; Rats, Wistar ; Retention (Psychology)/physiology ; Spatial Behavior/physiology ; Statistics, Nonparametric ; Swimming ; Time Factors
Language	English
Publishing date	2012-03-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2012.01.035
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Article: Delayed intensive acquisition training alleviates the lesion-induced place learning deficits after fimbria–fornix transection in the rat

Malá, Hana / Rodríguez Castro, María / Pearce, Hadley / Kingod, Siff Camilla / Nedergaard, Signe Kjær / Scharff, Zakaryiah / Zandersen, Maja / Mogensen, Jesper

Brain research. 2012 Mar. 22, v. 1445

2012

Abstract	This study evaluates the effects of two learning paradigms, intensive vs. baseline, on the posttraumatic acquisition of a water maze based place learning task. Rats were subjected either to a control operation (Sham) or to a fimbria–fornix (FF) transection, which renders the hippocampus dysfunctional and disrupts the acquisition of allocentric place learning. All animals were administered 30 post-lesion acquisition sessions, which spanned either 10 or 30days. The acquisition period was followed by a 7day pause after which a retention probe was administered. The lesioned animals were divided into 3 groups: i) Baseline Acquisition Paradigm (BAP) once daily for 30days starting 1week post-surgery; ii) Early Intensive Acquisition Paradigm (EIAP) 3 times daily for 10days starting 1week post-surgery; and iii) Late Intensive Acquisition Paradigm (LIAP) 3 times daily for 10days starting 3weeks post-surgery. Within the control animals, one group followed the schedule of BAP, and one group followed the schedule of Intensive Acquisition Paradigm (IAP). All lesioned animals showed an impaired task acquisition. LIAP was beneficial in FF animals, in that it led to a better acquisition of the place learning task than the two other acquisition paradigms. The FF/EIAP group did not show improved acquisition compared to the FF/BAP group. The control animals were not differentially affected by the two learning schedules. The findings have implications for cognitive rehabilitation after brain injury and support the assumption that intensive treatment can lead to an improved learning, even when the neural structures underlying such a process are compromised. However, the timing of intensive treatment needs to be considered further.
Keywords	cognition ; hippocampus ; learning ; rats
Language	English
Dates of publication	2012-0322
Size	p. 40-51.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2012.01.035
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Core and Shell Song Systems Unique to the Parrot Brain.

Chakraborty, Mukta / Walløe, Solveig / Nedergaard, Signe / Fridel, Emma E / Dabelsteen, Torben / Pakkenberg, Bente / Bertelsen, Mads F / Dorrestein, Gerry M / Brauth, Steven E / Durand, Sarah E / Jarvis, Erich D

PloS one

2015 Volume 10, Issue 6, Page(s) e0118496

Abstract: The ability to imitate complex sounds is rare, and among birds has been found only in parrots, songbirds, and hummingbirds. Parrots exhibit the most advanced vocal mimicry among non-human animals. A few studies have noted differences in connectivity, ... ...

Abstract	The ability to imitate complex sounds is rare, and among birds has been found only in parrots, songbirds, and hummingbirds. Parrots exhibit the most advanced vocal mimicry among non-human animals. A few studies have noted differences in connectivity, brain position and shape in the vocal learning systems of parrots relative to songbirds and hummingbirds. However, only one parrot species, the budgerigar, has been examined and no differences in the presence of song system structures were found with other avian vocal learners. Motivated by questions of whether there are important differences in the vocal systems of parrots relative to other vocal learners, we used specialized constitutive gene expression, singing-driven gene expression, and neural connectivity tracing experiments to further characterize the song system of budgerigars and/or other parrots. We found that the parrot brain uniquely contains a song system within a song system. The parrot "core" song system is similar to the song systems of songbirds and hummingbirds, whereas the "shell" song system is unique to parrots. The core with only rudimentary shell regions were found in the New Zealand kea, representing one of the only living species at a basal divergence with all other parrots, implying that parrots evolved vocal learning systems at least 29 million years ago. Relative size differences in the core and shell regions occur among species, which we suggest could be related to species differences in vocal and cognitive abilities.
MeSH term(s)	Animals ; Brain/physiology ; Humans ; Learning ; Music ; New Zealand ; Parrots/physiology ; Vocalization, Animal/physiology
Language	English
Publishing date	2015-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0118496
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Article: Delayed intensive acquisition training alleviates the lesion-induced place learning deficits after fimbria–fornix transection in the rat

Malá, Hana / Rodríguez Castro, María / Pearce, Hadley / Kingod, Siff Camilla / Nedergaard, Signe Kjær / Scharff, Zakaryiah / Zandersen, Maja / Mogensen, Jesper

Brain research

Volume v. 1445

Abstract	This study evaluates the effects of two learning paradigms, intensive vs. baseline, on the posttraumatic acquisition of a water maze based place learning task. Rats were subjected either to a control operation (Sham) or to a fimbria–fornix (FF) transection, which renders the hippocampus dysfunctional and disrupts the acquisition of allocentric place learning. All animals were administered 30 post-lesion acquisition sessions, which spanned either 10 or 30days. The acquisition period was followed by a 7day pause after which a retention probe was administered. The lesioned animals were divided into 3 groups: i) Baseline Acquisition Paradigm (BAP) once daily for 30days starting 1week post-surgery; ii) Early Intensive Acquisition Paradigm (EIAP) 3 times daily for 10days starting 1week post-surgery; and iii) Late Intensive Acquisition Paradigm (LIAP) 3 times daily for 10days starting 3weeks post-surgery. Within the control animals, one group followed the schedule of BAP, and one group followed the schedule of Intensive Acquisition Paradigm (IAP). All lesioned animals showed an impaired task acquisition. LIAP was beneficial in FF animals, in that it led to a better acquisition of the place learning task than the two other acquisition paradigms. The FF/EIAP group did not show improved acquisition compared to the FF/BAP group. The control animals were not differentially affected by the two learning schedules. The findings have implications for cognitive rehabilitation after brain injury and support the assumption that intensive treatment can lead to an improved learning, even when the neural structures underlying such a process are compromised. However, the timing of intensive treatment needs to be considered further.
Keywords	hippocampus ; learning ; cognition ; rats
Language	English
Document type	Article
ISSN	0006-8993
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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