LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Clinical and neural responses to cognitive behavioral therapy for functional tremor.

    Espay, Alberto J / Ries, Scott / Maloney, Thomas / Vannest, Jennifer / Neefus, Erin / Dwivedi, Alok K / Allendorfer, Jane B / Wulsin, Lawson R / LaFrance, W Curt / Lang, Anthony E / Szaflarski, Jerzy P

    Neurology

    2019  Volume 93, Issue 19, Page(s) e1787–e1798

    Abstract: Objectives: To evaluate changes in tremor severity and motor/emotion-processing circuits in response to cognitive behavioral therapy (CBT) delivered as treatment for functional tremor (FT), the most common functional movement disorder in adults.: ... ...

    Abstract Objectives: To evaluate changes in tremor severity and motor/emotion-processing circuits in response to cognitive behavioral therapy (CBT) delivered as treatment for functional tremor (FT), the most common functional movement disorder in adults.
    Methods: Fifteen patients with FT underwent fMRI with motor, basic-emotion, and intense-emotion tasks before and after 12 weeks of CBT. Baseline fMRI was compared to those of 25 healthy controls (HCs). The main clinical endpoint was the tremor score (sum of severity, duration, and incapacitation subscores) adapted from the Rating Scale for Psychogenic Movement Disorders (PMDRS) assessed by a blinded clinician. CBT responders were defined as those with PMDRS score reduction >75%. Anatomic and functional brain images were obtained with a 4T MRI system. Generalized linear model and region-of-interest analyses were used to evaluate before-versus-after treatment-related changes in brain activation.
    Results: CBT markedly reduced tremor severity (
    Conclusions: Tremor severity improved significantly after CBT. The improvement was associated with changes in the anterior cingulate/paracingulate activity, which may represent a marker of emotional dysregulation in FT and a predictor of treatment response.
    Classification of evidence: This study provides Class III evidence that CBT significantly improves tremor severity in patients with functional tremor.
    MeSH term(s) Adult ; Anxiety/psychology ; Brain/diagnostic imaging ; Case-Control Studies ; Cognitive Behavioral Therapy/methods ; Conversion Disorder/diagnostic imaging ; Conversion Disorder/psychology ; Conversion Disorder/therapy ; Depression/psychology ; Depressive Disorder, Major/psychology ; Female ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Stress Disorders, Post-Traumatic/psychology ; Treatment Outcome ; Tremor/diagnostic imaging ; Tremor/psychology ; Tremor/therapy
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000008442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Impaired emotion processing in functional (psychogenic) tremor: A functional magnetic resonance imaging study.

    Espay, Alberto J / Maloney, Thomas / Vannest, Jennifer / Norris, Matthew M / Eliassen, James C / Neefus, Erin / Allendorfer, Jane B / Lang, Anthony E / Szaflarski, Jerzy P

    NeuroImage. Clinical

    2017  Volume 17, Page(s) 179–187

    Abstract: Background: Despite its high prevalence and associated disability, the neural correlates of emotion processing in patients with functional (psychogenic) tremor (FT), the most common functional movement disorder, remain poorly understood.: Methods: In ...

    Abstract Background: Despite its high prevalence and associated disability, the neural correlates of emotion processing in patients with functional (psychogenic) tremor (FT), the most common functional movement disorder, remain poorly understood.
    Methods: In this cross sectional functional magnetic resonance imaging (fMRI) study at 4T, 27 subjects with FT, 16 with essential tremor (ET), and 25 healthy controls (HCs) underwent a finger-tapping motor task, a basic-emotion task, and an intense-emotion task to probe motor and emotion circuitries. Anatomical and functional MRI data were processed with FSL (FMRIB Software Library) and AFNI (Analysis of Functional Neuroimages), followed by seed-to-seed connectivity analyses using anatomical regions defined from the Harvard-Oxford subcortical atlas; all analyses were corrected for multiple comparisons.
    Results: After controlling for depression scores and correcting for multiple comparisons, the FT group showed increased activation in the right cerebellum compared to ET during the motor task; and increased activation in the paracingulate gyrus and left Heschl's gyrus compared with HC with decreased activation in the right precentral gyrus compared with ET during the basic-emotion task. No significant differences were found after adjusting for multiple comparisons during the intense-emotion task but increase in connectivity between the left amygdala and left middle frontal gyrus survived corrections in the FT subjects during this task, compared to HC.
    Conclusions: In response to emotional stimuli, functional tremor is associated with alterations in activation and functional connectivity in networks involved in emotion processing and theory of mind. These findings may be relevant to the pathophysiology of functional movement disorders.
    MeSH term(s) Adult ; Aged ; Brain/physiopathology ; Brain Mapping ; Cerebellum/physiopathology ; Cross-Sectional Studies ; Emotions/physiology ; Facial Expression ; Facial Recognition/physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity ; Neural Pathways/physiopathology ; Tremor/physiopathology
    Language English
    Publishing date 2017-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2017.10.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Dysfunction in emotion processing underlies functional (psychogenic) dystonia.

    Espay, Alberto J / Maloney, Thomas / Vannest, Jennifer / Norris, Matthew M / Eliassen, James C / Neefus, Erin / Allendorfer, Jane B / Chen, Robert / Szaflarski, Jerzy P

    Movement disorders : official journal of the Movement Disorder Society

    2017  Volume 33, Issue 1, Page(s) 136–145

    Abstract: Objective: We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common functional movement disorders.: Methods: Motor and emotion circuits were examined in 12 participants with ...

    Abstract Objective: We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common functional movement disorders.
    Methods: Motor and emotion circuits were examined in 12 participants with functional dystonia, 12 with primary organic dystonia, and 25 healthy controls using functional magnetic resonance imaging at 4T and a finger-tapping task (motor task), a basic emotion-recognition task (emotional faces task), and an intense-emotion stimuli task.
    Results: There were no differences in motor task activation between groups. In the faces task, when compared with the other groups, functional dystonia patients showed areas of decreased activation in the right middle temporal gyrus and bilateral precuneus and increased activation in the right inferior frontal gyrus, bilateral occipital cortex and fusiform gyrus, and bilateral cerebellum. In the intense-emotion task, when compared with the other groups, functional dystonia patients showed decreased activation in the left insular and left motor cortices (compared to organic dystonia, they showed an additional decrease in activation in the right opercular cortex and right motor cortex) and increased activation in the left fusiform gyrus.
    Conclusions: Functional dystonia patients exhibited stimulus-dependent altered activation in networks involved in motor preparation and execution, spatial cognition, and attentional control. These results support the presence of network dysfunction in functional dystonia. © 2017 International Parkinson and Movement Disorder Society.
    MeSH term(s) Adult ; Aged ; Brain Mapping ; Dystonic Disorders/complications ; Dystonic Disorders/psychology ; Face ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mood Disorders/diagnostic imaging ; Mood Disorders/etiology ; Oxygen/blood ; Pattern Recognition, Visual/physiology ; Photic Stimulation ; Psychiatric Status Rating Scales ; Psychomotor Performance/physiology ; Severity of Illness Index ; Young Adult
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27217
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.

    Frank, Samuel / Testa, Claudia M / Stamler, David / Kayson, Elise / Davis, Charles / Edmondson, Mary C / Kinel, Shari / Leavitt, Blair / Oakes, David / O'Neill, Christine / Vaughan, Christina / Goldstein, Jody / Herzog, Margaret / Snively, Victoria / Whaley, Jacquelyn / Wong, Cynthia / Suter, Greg / Jankovic, Joseph / Jimenez-Shahed, Joohi /
    Hunter, Christine / Claassen, Daniel O / Roman, Olivia C / Sung, Victor / Smith, Jenna / Janicki, Sarah / Clouse, Ronda / Saint-Hilaire, Marie / Hohler, Anna / Turpin, Denyse / James, Raymond C / Rodriguez, Ramon / Rizer, Kyle / Anderson, Karen E / Heller, Hope / Carlson, Alexis / Criswell, Susan / Racette, Brad A / Revilla, Fredy J / Nucifora, Frederick / Margolis, Russell L / Ong, MaryJane / Mendis, Tilak / Mendis, Neila / Singer, Carlos / Quesada, Monica / Paulsen, Jane S / Brashers-Krug, Thomas / Miller, Amanda / Kerr, Jane / Dubinsky, Richard M / Gray, Carolyn / Factor, Stewart A / Sperin, Elaine / Molho, Eric / Eglow, Mary / Evans, Sharon / Kumar, Rajeev / Reeves, Christina / Samii, Ali / Chouinard, Sylvain / Beland, Monica / Scott, Burton L / Hickey, Patrick T / Esmail, Sherali / Fung, Wai Lun Alan / Gibbons, Clare / Qi, Lina / Colcher, Amy / Hackmyer, Cory / McGarry, Andrew / Klos, Kevin / Gudesblatt, Mark / Fafard, Lori / Graffitti, Laura / Schneider, Daniel P / Dhall, Rohit / Wojcieszek, Joanne M / LaFaver, Kathrin / Duker, Andrew / Neefus, Erin / Wilson-Perez, Hilary / Shprecher, David / Wall, Paola / Blindauer, Karen A / Wheeler, Lynn / Boyd, James T / Houston, Emily / Farbman, Eric S / Agarwal, Pinky / Eberly, Shirley W / Watts, Arthur / Tariot, Pierre N / Feigin, Andrew / Evans, Scott / Beck, Chris / Orme, Constance / Edicola, Jon / Christopher, Emily

    JAMA

    2017  Volume 316, Issue 1, Page(s) 40–50

    Abstract: Importance: Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity.: ... ...

    Abstract Importance: Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity.
    Objective: To evaluate efficacy and safety of deutetrabenazine treatment to control chorea associated with Huntington disease.
    Design, setting, and participants: Ninety ambulatory adults diagnosed with manifest Huntington disease and a baseline total maximal chorea score of 8 or higher (range, 0-28; lower score indicates less chorea) were enrolled from August 2013 to August 2014 and randomized to receive deutetrabenazine (n = 45) or placebo (n = 45) in a double-blind fashion at 34 Huntington Study Group sites.
    Interventions: Deutetrabenazine or placebo was titrated to optimal dose level over 8 weeks and maintained for 4 weeks, followed by a 1-week washout.
    Main outcomes and measures: Primary end point was the total maximal chorea score change from baseline (the average of values from the screening and day-0 visits) to maintenance therapy (the average of values from the week 9 and 12 visits) obtained by in-person visits. This study was designed to detect a 2.7-unit treatment difference in scores. The secondary end points, assessed hierarchically, were the proportion of patients who achieved treatment success on the Patient Global Impression of Change (PGIC) and on the Clinical Global Impression of Change (CGIC), the change in 36-Item Short Form- physical functioning subscale score (SF-36), and the change in the Berg Balance Test.
    Results: Ninety patients with Huntington disease (mean age, 53.7 years; 40 women [44.4%]) were enrolled. In the deutetrabenazine group, the mean total maximal chorea scores improved from 12.1 (95% CI, 11.2-12.9) to 7.7 (95% CI, 6.5-8.9), whereas in the placebo group, scores improved from 13.2 (95% CI, 12.2-14.3) to 11.3 (95% CI, 10.0-12.5); the mean between-group difference was -2.5 units (95% CI, -3.7 to -1.3) (P < .001). Treatment success, as measured by the PGIC, occurred in 23 patients (51%) in the deutetrabenazine group vs 9 (20%) in the placebo group (P = .002). As measured by the CGIC, treatment success occurred in 19 patients (42%) in the deutetrabenazine group vs 6 (13%) in the placebo group (P = .002). In the deutetrabenazine group, the mean SF-36 physical functioning subscale scores decreased from 47.5 (95% CI, 44.3-50.8) to 47.4 (44.3-50.5), whereas in the placebo group, scores decreased from 43.2 (95% CI, 40.2-46.3) to 39.9 (95% CI, 36.2-43.6), for a treatment benefit of 4.3 (95% CI, 0.4 to 8.3) (P = .03). There was no difference between groups (mean difference of 1.0 unit; 95% CI, -0.3 to 2.3; P = .14), for improvement in the Berg Balance Test, which improved by 2.2 units (95% CI, 1.3-3.1) in the deutetrabenazine group and by 1.3 units (95% CI, 0.4-2.2) in the placebo group. Adverse event rates were similar for deutetrabenazine and placebo, including depression, anxiety, and akathisia.
    Conclusions and relevance: Among patients with chorea associated with Huntington disease, the use of deutetrabenazine compared with placebo resulted in improved motor signs at 12 weeks. Further research is needed to assess the clinical importance of the effect size and to determine longer-term efficacy and safety.
    Trial registration: clinicaltrials.gov Identifier: NCT01795859.
    MeSH term(s) Adrenergic Uptake Inhibitors/therapeutic use ; Chorea/drug therapy ; Cytochrome P-450 CYP2D6/metabolism ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Huntington Disease/drug therapy ; Maintenance Chemotherapy/methods ; Male ; Middle Aged ; Tetrabenazine/analogs & derivatives ; Tetrabenazine/therapeutic use ; Treatment Outcome
    Chemical Substances Adrenergic Uptake Inhibitors ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; deutetrabenazine (P341G6W9NB) ; Tetrabenazine (Z9O08YRN8O)
    Language English
    Publishing date 2017-02-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2016.8655
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top