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  1. Article: The Lifespan of

    Balakireva, Yevgenia / Nikitina, Maria / Makhnovskii, Pavel / Kukushkina, Inna / Kuzmin, Ilya / Kim, Alexander / Nefedova, Lidia

    Insects

    2024  Volume 15, Issue 1

    Abstract: 1) Background: ... ...

    Abstract (1) Background: The
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects15010068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Vitamin K in the Development of Neurodegenerative Diseases.

    Diachenko, Anna I / Rodin, Igor A / Krasnova, Tatiana N / Klychnikov, Oleg I / Nefedova, Lidia N

    Biochemistry. Biokhimiia

    2024  Volume 89, Issue Suppl 1, Page(s) S57–S70

    Abstract: Neurodegenerative diseases are a growing global health problem with enormous consequences for individuals and society. The most common neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, can be caused by both genetic factors ( ... ...

    Abstract Neurodegenerative diseases are a growing global health problem with enormous consequences for individuals and society. The most common neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, can be caused by both genetic factors (mutations) and epigenetic changes caused by the environment, in particular, oxidative stress. One of the factors contributing to the development of oxidative stress that has an important effect on the nervous system is vitamin K, which is involved in redox processes. However, its role in cells is ambiguous: accumulation of high concentrations of vitamin K increases the content of reactive oxygen species increases, while small amounts of vitamin K have a protective effect and activate the antioxidant defense systems. The main function of vitamin K is its involvement in the gamma carboxylation of the so-called Gla proteins. Some Gla proteins are expressed in the nervous system and participate in its development. Vitamin K deficiency can lead to a decrease or loss of function of Gla proteins in the nervous system. It is assumed that the level of vitamin K in the body is associated with specific changes involved in the development of dementia and cognitive abilities. Vitamin K also influences the sphingolipid profile in the brain, which also affects cognitive function. The role of vitamin K in the regulation of biochemical processes at the cellular and whole-organism levels has been studied insufficiently. Further research can lead to the discovery of new targets for vitamin K and development of personalized diets and therapies.
    MeSH term(s) Humans ; Vitamin K/metabolism ; Neurodegenerative Diseases/metabolism ; Antioxidants/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
    Chemical Substances Vitamin K (12001-79-5) ; Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297924140049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stress Induced Activation of LTR Retrotransposons in the

    Milyaeva, Polina A / Kukushkina, Inna V / Kim, Alexander I / Nefedova, Lidia N

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Domesticated LTR-Retrotransposon

    Nefedova, Lidia / Gigin, Alexey / Kim, Alexander

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 3

    Abstract: The most important sources of new components of genomes are transposable elements, which can occupy more than half of the nucleotide sequence of the genome in higher eukaryotes. Among the mobile components of a genome, a special place is occupied by ... ...

    Abstract The most important sources of new components of genomes are transposable elements, which can occupy more than half of the nucleotide sequence of the genome in higher eukaryotes. Among the mobile components of a genome, a special place is occupied by retroelements, which are similar to retroviruses in terms of their mechanisms of integration into a host genome. The process of positive selection of certain sequences of transposable elements and retroviruses in a host genome is commonly called molecular domestication. There are many examples of evolutionary adaptations of
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12030364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanisms of LTR-Retroelement Transposition: Lessons from Drosophila melanogaster.

    Nefedova, Lidia / Kim, Alexander

    Viruses

    2017  Volume 9, Issue 4

    Abstract: Long terminal repeat (LTR) retrotransposons occupy a special place among all mobile genetic element families. The structure of LTR retrotransposons that have three open reading frames is identical to DNA forms of retroviruses that are integrated into the ...

    Abstract Long terminal repeat (LTR) retrotransposons occupy a special place among all mobile genetic element families. The structure of LTR retrotransposons that have three open reading frames is identical to DNA forms of retroviruses that are integrated into the host genome. Several lines of evidence suggest that LTR retrotransposons share a common ancestry with retroviruses and thus are highly relevant to understanding mechanisms of transposition. Drosophila melanogaster is an exceptionally convenient model for studying the mechanisms of retrotransposon movement because many such elements in its genome are transpositionally active. Moreover, two LTRretrotransposons of D. melanogaster, gypsy and ZAM, have been found to have infectious properties and have been classified as errantiviruses. Despite numerous studies focusing on retroviral integration process, there is still no clear understanding of integration specificity in a target site. Most LTR retrotransposons non-specifically integrate into a target site. Site-specificity of integration at vertebrate retroviruses is rather relative. At the same time, sequence-specific integration is the exclusive property of errantiviruses and their derivatives with two open reading frames. The possible basis for the errantivirus integration specificity is discussed in the present review.
    MeSH term(s) Animals ; Drosophila melanogaster/genetics ; Drosophila melanogaster/virology ; Open Reading Frames ; Recombination, Genetic ; Retroelements ; Retroviridae/genetics ; Retroviridae/physiology ; Terminal Repeat Sequences ; Transcription, Genetic ; Virus Integration
    Chemical Substances Retroelements
    Language English
    Publishing date 2017-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v9040081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Domesticated <i>gag</i> Gene of <i>Drosophila</i> LTR Retrotransposons Is Involved in Response to Oxidative Stress

    Makhnovskii, Pavel / Balakireva, Yevheniia / Nefedova, Lidia / Lavrenov, Anton / Kuzmin, Ilya / Kim, Alexander

    Genes. 2020 Apr. 06, v. 11, no. 4

    2020  

    Abstract: ... Drosophila melanogaster ... is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons ... ...

    Abstract Drosophila melanogaster is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons has been insufficiently studied in Drosophila, as well as in other invertebrates. The present work is devoted to studying the role of the domesticated gag gene, Gagr, in the Drosophila genome. The Gagr gene has been shown to be involved in the response to stress caused by exposure to ammonium persulfate, but not in the stress response to oligomycin A, zeomycin, and cadmium chloride. Ammonium persulfate tissue specifically activates the expression of Gagr in the tissues of the carcass, but not in the gut. We found that the Gagr gene promoter contains one binding motif for the transcription factor kayak, a component of the JNK signaling pathway, and two binding motifs for the transcription factor Stat92E, a component of the Jak-STAT signaling pathway. Remarkably, Gagr orthologs contain the second binding motif for Stat92E only in D. melanogaster, D. simulans and D. sechellia, whereas in D. yakuba and D. erecta, Gagr orthologs contain a single motif, and there are no binding sites for Stat92E in the promoters of Gagr orthologs in D. ananassae and in species outside the melanogaster group. The data obtained indicate the formation of the protective function of the Gagr gene during evolution.
    Keywords Drosophila melanogaster ; Drosophila sechellia ; Drosophila simulans ; Drosophila yakuba ; ammonium persulfate ; binding sites ; cadmium chloride ; digestive system ; domestication ; genes ; genetic models ; invertebrates ; mitogen-activated protein kinase ; oligomycin ; oxidative stress ; retrotransposons ; signal transduction ; stress response ; tissues ; transcription factors
    Language English
    Dates of publication 2020-0406
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11040396
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Domesticated

    Makhnovskii, Pavel / Balakireva, Yevheniia / Nefedova, Lidia / Lavrenov, Anton / Kuzmin, Ilya / Kim, Alexander

    Genes

    2020  Volume 11, Issue 4

    Abstract: Drosophila ... ...

    Abstract Drosophila melanogaster
    MeSH term(s) Animals ; Binding Sites/genetics ; Domestication ; Drosophila melanogaster/genetics ; Gene Expression Regulation ; Genes, gag/genetics ; Genome, Insect/genetics ; Oxidative Stress/genetics ; Promoter Regions, Genetic/genetics ; Retroelements/genetics ; Transcription Factors/genetics
    Chemical Substances Retroelements ; Transcription Factors
    Language English
    Publishing date 2020-04-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11040396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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