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  1. Article ; Online: The wound healing effect of botanicals and pure natural substances used in in vivo models.

    El-Sherbeni, S A / Negm, W A

    Inflammopharmacology

    2023  Volume 31, Issue 2, Page(s) 755–772

    Abstract: Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for ... ...

    Abstract Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.
    MeSH term(s) Rats ; Mice ; Rabbits ; Animals ; Wound Healing ; Skin ; Plant Extracts/pharmacology ; Plants, Medicinal ; Burns
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01157-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3274: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Unravelling the antibacterial potential of biosynthesized selenium nanoparticles against Salmonella Typhimurium food pathogen: in vitro and in vivo investigation.

    Saleh, A / El-Masry, T A / Negm, W A / Alotaibi, B / Elharty, M E / Alotaibi, K N / Elekhnawy, E

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 8, Page(s) 3631–3644

    Abstract: Objective: It is highly required to find novel alternatives to the antibiotics currently used due to the increasing dissemination of antibiotic resistance among bacteria, especially enteric bacteria. The current study aimed to produce selenium ... ...

    Abstract Objective: It is highly required to find novel alternatives to the antibiotics currently used due to the increasing dissemination of antibiotic resistance among bacteria, especially enteric bacteria. The current study aimed to produce selenium nanoparticles (SeNPs) by Euphorbia milii Des Moul leaves extract (EME).
    Materials and methods: The produced SeNPs were characterized using different techniques. After that, in vitro and in vivo antibacterial activity against Salmonella typhimurium was elucidated. Moreover, phytochemical identification and quantification of the chemical compositions of EME were performed using HPLC. The broth microdilution method determined the minimum inhibitory concentrations (MICs).
    Results: The MIC values of SeNPs ranged from 128 to 512 µg/mL. Additionally, the impact of SeNPs on membrane integrity and permeability was investigated. A marked decline in the membrane integrity and inner and outer membrane permeability was noticed in 50%, 46.15%, and 50% of the tested bacteria, respectively. Subsequently, a gastrointestinal tract infection model was used to study the in vivo antibacterial potential of SeNPs. Remarkably, treatment with SeNPs resulted in average-sized intestinal villi and colonic mucosa in the small intestine and caecum, respectively. In addition, it was revealed there was no inflammation or dysplasia in the studied tissues. SeNPs also enhanced the survival rate and significantly decreased the number of colony-forming units per gram tissues in the small intestine and caecum. Concerning the inflammatory markers, SeNPs significantly (p < 0.05) decreased interleukins (6 and 1β).
    Conclusions: The biosynthesized SeNPs revealed antibacterial potential in vivo and in vitro; however, this finding should be elucidated clinically in the future.
    MeSH term(s) Selenium/pharmacology ; Salmonella typhimurium ; Nanoparticles/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria
    Chemical Substances Selenium (H6241UJ22B) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202304_32149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  3. Article ; Online: Most common over-the-counter medications and effects on patients.

    Kamal, M / Negm, W A / Abdelkader, A M / Alshehri, A A / El-Saber Batiha, G / Osama, H

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 4, Page(s) 1654–1666

    Abstract: Objective: The self-medicating practice of using over-the-counter (OTC) medications are more common than prescription drug use worldwide. OTC drugs are primarily used to treat conditions that do not require direct medical attention or supervision, and ... ...

    Abstract Objective: The self-medicating practice of using over-the-counter (OTC) medications are more common than prescription drug use worldwide. OTC drugs are primarily used to treat conditions that do not require direct medical attention or supervision, and OTC drugs must be demonstrated to be reasonably safe and well-tolerated. The pharmacy profession describes their role in dispensing over-the-counter (OTC) products as "selecting the best medication according to reported symptoms". This study aimed to evaluate the use of most common over-the-counter (OTC) medications and their effect on patients.
    Patients and methods: A cross-sectional survey-based study was conducted on 442 participants who used OTC drugs from June to November 2021.
    Results: The most common OTC drugs used by patients involved in the study were paracetamol (13.35%), followed by ibuprofen (2.04%). Gender of patients was significantly related to (duration, frequency, suggestion, and misuse) of OTC use and patient counseling by the pharmacist (p<0.05).
    Conclusions: OTC medications can easily be obtained at pharmacies for the purpose of self-treatment. The most common OTC drugs used by the studied patients were paracetamol, followed by ibuprofen. It is suggested that an awareness program among community people be conducted at the community level regarding over-the-counter (OTC) drugs.
    MeSH term(s) Humans ; Acetaminophen ; Cross-Sectional Studies ; Ibuprofen ; Nonprescription Drugs
    Chemical Substances Acetaminophen (362O9ITL9D) ; Ibuprofen (WK2XYI10QM) ; Nonprescription Drugs
    Language English
    Publishing date 2023-03-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202302_31409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.

    Al-Kuraishy, H M / Abd Hasan, R R / Al-Gareeb, A I A / Aggad, S S / Aljohani, A S M / El-Ashmawy, I M / Elekhnawy, E / Mostafa, S A / Negm, W A / Batiha, G E

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 6, Page(s) 2277–2287

    Abstract: Objective: Although methotrexate (MTX) is used to treat several malignancies and chronic inflammatory diseases, its clinical use is constrained because of its negative side effects, the most prevalent of which are hepatotoxicity and nephrotoxicity. So, ... ...

    Abstract Objective: Although methotrexate (MTX) is used to treat several malignancies and chronic inflammatory diseases, its clinical use is constrained because of its negative side effects, the most prevalent of which are hepatotoxicity and nephrotoxicity. So, this study aims to determine whether α-lipoic acid (ALA) and vitamin C can protect mice against the liver damage that methotrexate causes.
    Materials and methods: A total of 49 male mice were divided into seven groups at random. Group I received sodium bicarbonate, while groups II to VII received an intraperitoneal injection of MTX (20 mg/kg) on the tenth day, following ten days of pretreatment with ALA (60 mg/Kg), ALA (120 mg/Kg), vitamin C (100 mg/Kg), vitamin C (200 mg/Kg), ALA (60 mg/Kg), and vitamin C (100 mg/kg).
    Results: When compared to mice in group I, mice in group II (the control group) had significantly higher levels of the enzymes malondialdehyde (MDA), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and significantly lower (p <0.05) levels of the enzymes superoxide dismutase (SOD) and glutathione (GSH). As compared to the control group, pretreatment groups with ALA and vitamin C showed a dose-dependent substantial rise (p <0.05) in GSH and SOD levels, a dose-dependent notable decrease (p <0.05) in MDA, ALT, ALP, and LDH levels, and better liver histological architecture. In order to increase the antioxidant capacity, pretreatment with ALA and vitamin C may be able to prevent MTX-induced hepatotoxicity.
    Conclusions: These results imply that ALA and vitamin C are useful in the treatment of MTX-induced liver damage.
    MeSH term(s) Rats ; Male ; Mice ; Animals ; Thioctic Acid/pharmacology ; Thioctic Acid/therapeutic use ; Methotrexate/toxicity ; Ascorbic Acid/pharmacology ; Rats, Wistar ; Antioxidants/metabolism ; Vitamins/pharmacology ; Glutathione/metabolism ; Liver/pathology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Superoxide Dismutase/metabolism ; Oxidative Stress
    Chemical Substances Thioctic Acid (73Y7P0K73Y) ; Methotrexate (YL5FZ2Y5U1) ; Ascorbic Acid (PQ6CK8PD0R) ; Antioxidants ; Vitamins ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-05-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202303_31761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA genes expression in colorectal cancer patients: novel diagnostic biomarkers.

    El Nakib, A M / Elsaeed, M / Abdelsalam, R A / Wafi, K / Elekhnawy, E / Alrouji, M / Alsaleem, M / Aljarba, N H / Batiha, G E / Negm, W A / Mostafa, S A

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 17, Page(s) 7946–7955

    Abstract: Objective: This study aimed to investigate the CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA mRNA expression in the blood of colorectal cancer patients in Egypt. This was performed to elucidate if there's a link between this gene expression and other ... ...

    Abstract Objective: This study aimed to investigate the CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA mRNA expression in the blood of colorectal cancer patients in Egypt. This was performed to elucidate if there's a link between this gene expression and other clinicopathological characteristics of the tumor.
    Patients and methods: A case-control study including 50 colorectal cancer patients and 50 healthy controls was conducted. Real-time polymerase chain reaction (rt-PCR) was utilized to assess the expression of CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA mRNA in blood samples.
    Results: Patients with colorectal cancer had significantly higher levels of mRNA for the genes CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA (p<0.001, p=0.021, p<0.001, and p<0.001, respectively) compared to controls. Remarkedly, the gene expression of AHR, TRIP13, and PIK3CA genes did not exhibit a significant correlation with the tumor stages (p=0.379, p=0.095, and p=0.526, respectively). However, there was a strong correlation between CYP24A1 and CPEB4 gene expression and tumor stages (p<0.001 and p=0.002, respectively).
    Conclusions: Therefore, we can conclude that increased mRNA levels of CYP24A1, AHR, CPEB4, TRIP13, and PIK3CA in blood samples withdrawn from colorectal cancer patients could be a biomarker for the disease.
    MeSH term(s) Humans ; Vitamin D3 24-Hydroxylase ; Case-Control Studies ; Class I Phosphatidylinositol 3-Kinases/genetics ; RNA, Messenger/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; RNA-Binding Proteins ; ATPases Associated with Diverse Cellular Activities ; Cell Cycle Proteins
    Chemical Substances Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; RNA, Messenger ; PIK3CA protein, human (EC 2.7.1.137) ; CPEB4 protein, human ; RNA-Binding Proteins ; TRIP13 protein, human (EC 3.6.4.-) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Cell Cycle Proteins ; CYP24A1 protein, human (EC 1.14.15.16)
    Language English
    Publishing date 2023-09-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202309_33554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A randomized placebo-controlled, double-blind study to investigate the effect of a high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients, new insights on serum STAT-3 and hepassocin.

    Alarfaj, S J / Bahaa, M M / Yassin, H A / El-Khateeb, E / Kotkata, F A / El-Gammal, M A / Elberri, A I / Habba, E / Zien El-Deen, E E / Khrieba, M O / El-Masry, T A / Negm, W A / Elberri, E I

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 16, Page(s) 7607–7619

    Abstract: Objective: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease affecting millions globally. This study aimed to assess the safety and efficacy of a high oral loading dose of cholecalciferol supplement on NAFLD patients ... ...

    Abstract Objective: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease affecting millions globally. This study aimed to assess the safety and efficacy of a high oral loading dose of cholecalciferol supplement on NAFLD patients and to investigate its potential role on serum inflammatory biomarkers.
    Patients and methods: One hundred patients with NAFLD and type 2 diabetes mellitus were involved in the study. Eligible patients were randomized among two equal groups. Group 1 received the standard conventional therapy in addition to a placebo. Group 2 received the conventional therapy plus cholecalciferol for 4 months. The improvement in the patients' glycaemic control parameters, liver function tests, lipid profile, and serum 25-hydroxy vitamin D at the end of the study was set as a primary outcome. The secondary outcome was the decrease in steatosis grade in the ultrasound and high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), signal transducer and activator of factor-3 (STAT-3), nitric oxide (NO), malondialdehyde (MDA), and hepassocin serum levels at the end of the study.
    Results: Group 2 revealed a significant reduction in the serum levels of lipid profile measures, hs-CRP, alanine aminotransferase (ALT), STAT-3, NO, hepassocin, and MDA compared to the baseline and group 1 results. Whereas group 1 did not show these significant changes. Both groups observed no significant changes in glycemic index, TNF-α, aspartate aminotransferase (AST), and albumin levels.
    Conclusions: Cholecalciferol is recommended as additional therapy to modulate lipid peroxidation and systemic inflammation alongside other NAFLD therapies.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Cholecalciferol ; Double-Blind Method ; C-Reactive Protein ; Diabetes Mellitus, Type 2/drug therapy ; Tumor Necrosis Factor-alpha
    Chemical Substances Cholecalciferol (1C6V77QF41) ; C-Reactive Protein (9007-41-4) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-09-05
    Publishing country Italy
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202308_33413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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