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  1. Article ; Online: Low correlation between serum thyroglobulin and

    Thai, Janice N / De Marchena, Ingrid Rymer / Nehru, Vijeyaluxmy Motilal / Landau, Elliot / Demissie, Seleshi / Josemon, Raina / Peti, Steven / Brenner, Arnold I

    Clinical imaging

    2022  Volume 87, Page(s) 1–4

    Abstract: Purpose: To evaluate postoperative serum thyroglobulin (Tg) as a reliable tumor marker in low-risk differentiated thyroid cancer (DTC).: Methods: Two hundred and three patients met the selection criteria of >18 years old; who had undergone total or ... ...

    Abstract Purpose: To evaluate postoperative serum thyroglobulin (Tg) as a reliable tumor marker in low-risk differentiated thyroid cancer (DTC).
    Methods: Two hundred and three patients met the selection criteria of >18 years old; who had undergone total or near total thyroidectomy; had a postoperative Tg, and had undergone
    Results: One hundred ten patients (54.1%) had discordant results (p < 0.05) with positive PA-WBS and Tg <1 ng/ml, while 93 patients (45.9%) had concordant results. For concordant results, 88 patients had positive PA-WBS and Tg >1 ng/ml, and 5 patients had negative PA-WBS and Tg <1 ng/ml. There was no patient with Tg >1 ng/ml and negative PA-WBS. There were 74 patients with high TSH (>30 mU/l) on abstention (thyroxine withdrawal protocol). Twenty-four (32.5%) had discordant results (p < 0.001) and 50 (67.5%) had concordant results.
    Conclusion: There is low correlation between postoperative Tg and PA-WBS. The sole use of Tg as a serum biomarker for postoperative disease status may not be reliable.
    MeSH term(s) Adenocarcinoma ; Humans ; Iodine Radioisotopes/therapeutic use ; Radionuclide Imaging ; Thyroglobulin/blood ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyrotropin ; Thyroxine ; Whole Body Imaging
    Chemical Substances Iodine Radioisotopes ; Iodine-131 ; Thyrotropin (9002-71-5) ; Thyroglobulin (9010-34-8) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2022.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1469: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fluorescence microscopy of H&E stained cervical biopsies to assist the diagnosis and grading of CIN.

    Castellanos, Mario R / Nehru, Vijeyaluxmy Motilal / Pirog, Edyta C / Optiz, Lynne

    Pathology, research and practice

    2018  Volume 214, Issue 5, Page(s) 605–611

    Abstract: Background: Prevention of cervical cancer is based upon the accurate diagnosis and grading of cervical lesions identified during screening. The pathological classification of cervical intraepithelial neoplasia (CIN) is problematic, as it relies on ... ...

    Abstract Background: Prevention of cervical cancer is based upon the accurate diagnosis and grading of cervical lesions identified during screening. The pathological classification of cervical intraepithelial neoplasia (CIN) is problematic, as it relies on subjective criteria and is known to have high interobserver variability and low reproducibility. These limitations can result in either over or under treatment of patients. Biomarkers to improve CIN diagnosis have not overcome all these challenges.
    Main body: Here we review the use of a promising optical imaging method using eosin-based fluorescence spectroscopy. This technique is able to perform fluorescent analysis of cervical biopsies directly from hematoxylin and eosin (H&E) stained tissues. Eosin is a brominated derivative of fluorescein. Fluorescence characteristics of protein-eosin complexes can demonstrate tissue changes associated with dysplasia and cancer. In this article we review the progress made towards developing eosin-based fluorescence spectroscopy. We describe the various morphologies seen among the CIN grades with this optical method and highlight the progress made to quantitate the spectral image characteristics.
    Conclusion: Eosin-based fluorescence spectroscopy can be used to directly examine H&E stained tissue slides. Relevant areas can be imaged and spectral analysis done to obtain objective data to identify and grade cervical lesions.
    MeSH term(s) Biomarkers, Tumor/analysis ; Biopsy/methods ; Female ; Humans ; Microscopy, Fluorescence/methods ; Neoplasm Grading ; Staining and Labeling/methods ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2018-03-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2018.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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