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  1. Article ; Online: The impact of poverty-reduction intervention on child mental health mediated by family relations: Findings from a cluster-randomized trial in Uganda.

    Karimli, Leyla / Ssewamala, Fred M / Neilands, Torsten B

    Social science & medicine (1982)

    2023  Volume 332, Page(s) 116102

    Abstract: Reviews that synthesize global evidence on the impact of poverty reduction interventions on child and adolescent mental health (CAMH) report inconclusive results and highlight the need to unpack the mechanisms that connect poverty-reduction to CAMH. To ... ...

    Abstract Reviews that synthesize global evidence on the impact of poverty reduction interventions on child and adolescent mental health (CAMH) report inconclusive results and highlight the need to unpack the mechanisms that connect poverty-reduction to CAMH. To address this gap, we examine the proposition that family relations is an important relational factor transmitting effect of poverty on CAMH, and test whether family relations mediate the effect of poverty-reduction intervention on depression, hopelessness, and self-concept among AIDS orphans in Uganda. We use longitudinal data collected over the course of 48 months in a cluster-randomized controlled trial conducted among N = 1410 AIDS orphans from n = 48 schools in Uganda. To examine the relationship between intervention, latent mediator (family relations and support) and CAMH outcomes (Beck Hopelessness Scale (BHS), Tennessee Self-Concept Scale (TSCS), and Depression), we ran structural equation models adjusting for clustering of individuals within schools. Relative to the control group, participants in both treatment arms reported lower levels of hopelessness and depression, and significantly higher levels of self-concept. They also report significantly higher levels of latent family relationship in all three models. In both treatment arms, the direct effect of the intervention on all three outcomes is still significant when the latent family relations mediator is included in the analyses. This suggests partial mediation. In other words, in both treatment arms, the significant positive effect of the intervention on children's depression, hopelessness, and self-concept is partially mediated by their family relationship quality. Our findings support the argument put forward by the Family Stress Model showing that the poverty-reduction program improves children's mental health functioning by improving family relationships. The implications of our study extend beyond the narrow focus of poverty reduction, suggesting that asset-building interventions have broader impacts on family dynamics and child mental health.
    MeSH term(s) Adolescent ; Humans ; Child ; Acquired Immunodeficiency Syndrome/psychology ; Mental Health ; Uganda ; Poverty ; Family Relations
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.116102
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  2. Article ; Online: Economic Empowerment, HIV Risk Behavior, and Mental Health Among School-Going Adolescent Girls in Uganda: Longitudinal Cluster-Randomized Controlled Trial, 2017‒2022.

    Ssewamala, Fred M / Brathwaite, Rachel / Neilands, Torsten B

    American journal of public health

    2023  Volume 113, Issue 3, Page(s) 306–315

    Abstract: Objectives. ...

    Abstract Objectives.
    MeSH term(s) Female ; Young Adult ; Humans ; Adolescent ; Aged ; Mental Health ; Uganda ; HIV Infections/prevention & control ; Schools ; Risk-Taking ; Adolescent Behavior
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.307169
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  3. Article ; Online: Young Adult Responses to Peer Crowd-Based Targeting in E-cigarette Advertisements: An Experimental Study.

    Kim, Minji / Neilands, Torsten B / Gregorich, Steven E / Jordan, Jeffrey W / Ling, Pamela M

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2024  Volume 25, Issue 6, Page(s) 1125–1134

    Abstract: Aims: To examine the effects of psychographically targeted e-cigarette advertisements on young adults.: Methods: A total of 2100 young adults (18-29 years old) representing five peer crowds (groups with shared values, interests, and lifestyle: ... ...

    Abstract Aims: To examine the effects of psychographically targeted e-cigarette advertisements on young adults.
    Methods: A total of 2100 young adults (18-29 years old) representing five peer crowds (groups with shared values, interests, and lifestyle: Mainstream, Young Professional, Hip Hop, Hipster, and Partier) were recruited from a nationwide opt-in online panel. Participants were randomly assigned to view e-cigarette advertisements featuring characters that either did or did not match their own peer crowd affiliation and evaluated advertising effectiveness using Likert-type and semantic differential scales. Participants also reported their attitudes toward using e-cigarettes.
    Results: No significant overall effect of peer crowd matching was observed. However, significant two-way interaction effects emerged where matching advertisements yielded higher evaluations than mismatching advertisements among those who currently do not use tobacco and nicotine products and among Mainstream participants. Advertisements featuring Mainstream characters were in general rated more highly than other advertisements. Additional analyses found significant effects of peer crowd matching among those who viewed advertisements featuring non-Mainstream characters.
    Conclusions: Peer crowd-based targeting can increase the effectiveness of e-cigarette advertisements which may impact initiation among current nonusers, requiring stricter marketing regulations. More research is needed to determine if anti-tobacco messaging tailored by peer crowds may effectively counteract targeted e-cigarette marketing.
    Implications: E-cigarette advertisements often use psychographic targeting strategies, using lifestyles, attitudes, and values. Low-risk young adults (eg, those who currently do not use tobacco and nicotine products) are susceptible to psychographically targeted e-cigarette advertisements. This may result in the initiation of e-cigarette use among young adults who would otherwise be less likely to use tobacco and nicotine products. Stricter marketing regulations for emerging tobacco and nicotine products are required to reduce marketing exposure.
    MeSH term(s) Humans ; Young Adult ; Adolescent ; Adult ; Advertising ; Electronic Nicotine Delivery Systems ; Nicotine ; Smoking ; Peer Group ; Social Identification ; Tobacco Products
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntac292
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  4. Article ; Online: Associations Between Product Type and Intensity of Tobacco and Cannabis Co-use on the Same Day Among Young Adult Smokers: Smartphone-Based Daily-Diary Study.

    Nguyen, Nhung / Thrul, Johannes / Neilands, Torsten B / Ling, Pamela M

    JMIR mHealth and uHealth

    2023  Volume 11, Page(s) e40736

    Abstract: Background: Co-use of tobacco and cannabis is highly prevalent among young US adults. Same-day co-use of tobacco and cannabis (ie, use of both substances on the same day) may increase the extent of use and negative health consequences among young adults. ...

    Abstract Background: Co-use of tobacco and cannabis is highly prevalent among young US adults. Same-day co-use of tobacco and cannabis (ie, use of both substances on the same day) may increase the extent of use and negative health consequences among young adults. However, much remains unknown about same-day co-use of tobacco and cannabis, in part due to challenges in measuring this complex behavior. Nuanced understanding of tobacco and cannabis co-use in terms of specific products and intensity (ie, quantity of tobacco and cannabis use within a day) is critical to inform prevention and intervention efforts.
    Objective: We used a daily-diary data collection method via smartphone to capture occurrence of tobacco and cannabis co-use within a day. We examined (1) whether the same route of administration would facilitate co-use of 2 substances on the same day and (2) whether participants would use more tobacco on a day when they use more cannabis.
    Methods: This smartphone-based study collected 2891 daily assessments from 147 cigarette smokers (aged 18-26 years, n=76, 51.7% female) during 30 consecutive days. Daily assessments measured type (ie, cigarette, cigarillo, or e-cigarette) and intensity (ie, number of cigarettes or cigarillos smoked or number of times vaping e-cigarettes per day) of tobacco use and type (ie, combustible, vaporized, or edible) and intensity (ie, number of times used per day) of cannabis use. We estimated multilevel models to examine day-level associations between types of cannabis use and each type of tobacco use, as well as day-level associations between intensities of using cannabis and tobacco. All models controlled for demographic covariates, day-level alcohol use, and time effects (ie, study day and weekend vs weekday).
    Results: Same-day co-use was reported in 989 of the total 2891 daily assessments (34.2%). Co-use of cigarettes and combustible cannabis (885 of the 2891 daily assessments; 30.6%) was most commonly reported. Participants had higher odds of using cigarettes (adjusted odds ratio [AOR] 1.92, 95% CI 1.31-2.81) and cigarillos (AOR 244.29, 95% CI 35.51-1680.62) on days when they used combustible cannabis. Notably, participants had higher odds of using e-cigarettes on days when they used vaporized cannabis (AOR 23.21, 95% CI 8.66-62.24). Participants reported a greater intensity of using cigarettes (AOR 1.35, 95% CI 1.23-1.48), cigarillos (AOR 2.04, 95% CI 1.70-2.46), and e-cigarettes (AOR 1.48, 95% CI 1.16-1.88) on days when they used more cannabis.
    Conclusions: Types and intensities of tobacco and cannabis use within a day among young adult smokers were positively correlated, including co-use of vaporized products. Prevention and intervention efforts should address co-use and pay attention to all forms of use and timeframes of co-use (eg, within a day or at the same time), including co-use of e-cigarettes and vaporized cannabis, to reduce negative health outcomes.
    MeSH term(s) Young Adult ; Female ; Humans ; Male ; Cannabis ; Nicotiana ; Electronic Nicotine Delivery Systems ; Smokers ; Smartphone
    Language English
    Publishing date 2023-02-20
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2719220-9
    ISSN 2291-5222 ; 2291-5222
    ISSN (online) 2291-5222
    ISSN 2291-5222
    DOI 10.2196/40736
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  5. Article ; Online: Pilot Trial Results of Mlambe: An Economic and Relationship-Strengthening Intervention to Address Heavy Drinking and Adherence to Antiretroviral Therapy in Malawi.

    Conroy, Amy A / Hahn, Judith A / Neilands, Torsten B / Darbes, Lynae A / Tebbetts, Scott / Mulauzi, Nancy / Mkandawire, James / Ssewamala, Fred M

    AIDS and behavior

    2024  

    Abstract: We evaluated the feasibility, acceptability, and preliminary efficacy of an economic and relationship-strengthening intervention to reduce heavy alcohol use among couples living with HIV in Malawi (Mlambe). Mlambe consisted of training on financial ... ...

    Abstract We evaluated the feasibility, acceptability, and preliminary efficacy of an economic and relationship-strengthening intervention to reduce heavy alcohol use among couples living with HIV in Malawi (Mlambe). Mlambe consisted of training on financial literacy and relationship skills, combined with 1:1 matched savings accounts to invest in an income-generating activity. In a randomized controlled trial, we compared Mlambe to enhanced usual care (EUC). We enrolled 78 married couples having a partner on antiretroviral therapy (ART) who reported heavy alcohol use based on the AUDIT-C. Using targets of 75%, primary outcomes included retention rates at 10 and 15-months, session attendance rates, and satisfaction with Mlambe. Exploratory outcomes were heavy alcohol use (AUDIT-C and/or PEth positive), number of drinking days in the past month, AUDIT-C score, optimal adherence to ART (95% or higher), and viral suppression. We exceeded our targets for feasibility and acceptability metrics. Retention rates were 96% at 15-months. Session attendance and satisfaction levels were both 100%. From baseline to 15-months, Mlambe participants reported decreases in mean number of drinking days (from 6.8 to 2.1) and AUDIT-C scores (from 7.5 to 3.1); while ART adherence rates improved across the same period (from 63.2 to 73.9%). Participants in Mlambe, as compared to those in EUC, had lower rates of heavy alcohol use (89.5% vs. 97.2%) and higher rates of viral suppression (100% vs. 91.9%) at 10-months. Differences between arms were not statistically significant in this small pilot study. Mlambe was highly feasible and acceptable, and shows promise for reducing heavy alcohol use and viral non-suppression among couples with HIV in a larger efficacy study.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-024-04326-x
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  6. Article ; Online: Supportive couple relationships buffer against the harms of HIV stigma on HIV treatment adherence.

    Gutin, Sarah A / Ruark, Allison / Darbes, Lynae A / Neilands, Torsten B / Mkandawire, James / Conroy, Amy A

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1878

    Abstract: Introduction: HIV stigma can impact couple relationships through stress or bring partners closer through shared experiences. Conversely, couple relationships may protect against the harms of stigma, including anticipated stigma on negative health ... ...

    Abstract Introduction: HIV stigma can impact couple relationships through stress or bring partners closer through shared experiences. Conversely, couple relationships may protect against the harms of stigma, including anticipated stigma on negative health outcomes. Yet few studies have assessed the potential link between HIV stigma, relationship dynamics, and antiretroviral therapy (ART) adherence. Using dyadic data from a cross-sectional study of Malawian couples living with HIV, we tested associations between anticipated stigma and: 1) relationship dynamics (e.g., trust, sexual satisfaction, communication) and partner support; and 2) self-reported ART adherence.
    Methods: Heterosexual couples (211 couples, 422 individuals) with at least one partner on ART were recruited from clinics in Zomba, Malawi. Partners completed separate surveys on anticipated stigma, relationship dynamics, and ART adherence. Linear mixed models evaluated associations between anticipated stigma and relationship dynamics, and whether associations varied by gender. Generalized estimating equation models tested for associations between anticipated stigma and high ART adherence (90-100% vs. < 90%) at the individual level, and whether they were moderated by relationship dynamics at the couple level.
    Results: Couples' relationship length averaged 12.5 years, 66.8% were HIV sero-concordant, and 95.6% reported high ART adherence. In multivariable models, sexual satisfaction (β = -0.22, 95%CI = -0.41;-0.03, p = 0.020) and partner social support (β = -0.02, 95%CI = -0.04;-0.01, p < 0.01) were negatively associated with anticipated stigma. Significant interaction effects showed that adherence is moderated in couples with higher partner support and sexual satisfaction such that adherence is lowest when anticipated stigma is high and social support is low, and that adherence is lowest when anticipated stigma is high and sexual satisfaction is low.
    Conclusions: Increased anticipated stigma is most associated with lower ART non-adherence at lower levels of social support and sexual satisfaction. Conversely, supportive and fulfilling relationships may buffer the negative association between stigma and ART adherence. Couples' interventions that focus on improving communication and support systems within couples could reduce the negative impacts of anticipated stigma on couples living with HIV.
    MeSH term(s) Humans ; Sexual Partners ; Cross-Sectional Studies ; HIV Infections/drug therapy ; Anti-Retroviral Agents/therapeutic use ; Treatment Adherence and Compliance ; Medication Adherence ; Social Stigma
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-16762-w
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  7. Article ; Online: Patterns of and Factors Associated With Mental Health Service Utilization Among School-Going Adolescent Girls in Southwestern Uganda: A Latent Class Analysis.

    Byansi, William / Ssewamala, Fred M / Neilands, Torsten B / Mwebembezi, Abel / Nakigozi, Gertrude

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2023  Volume 72, Issue 5S, Page(s) S24–S32

    Abstract: Purpose: The study aimed to improve understanding of patterns of multiple family group intervention engagement and associated factors among adolescent girls in a low-resource country, Uganda.: Methods: The data used in this analysis were part of a ... ...

    Abstract Purpose: The study aimed to improve understanding of patterns of multiple family group intervention engagement and associated factors among adolescent girls in a low-resource country, Uganda.
    Methods: The data used in this analysis were part of a larger cluster randomized controlled trial consisting of 1260 adolescent girls across 47 public secondary schools. The sample in the current study consisted of 317 adolescent girls (ages 14-17 at enrollment) recruited from senior one and senior two classes across 12 secondary schools in the southwestern region of Uganda. Participants in this study participated in the multiple family group intervention-a 16-week manualized intervention. Attendance data from 16 sessions were used to identify the heterogeneity of intervention engagement using latent class analysis modeling. Logistic regression analysis was conducted to assess the association between predisposing, enabling, need factors, and mental health utilization patterns.
    Results: On average, participants attended 10 sessions (standard deviation = 5.90), 34.38% (N = 109) completed all 16 sessions, and 13.56% (N = 43) did not attend any of the sessions. Two attendance groups were identified: low and high attendants using latent class analysis. In addition, two family-level factors, the number of adults and the number of children in the family, were associated with an increase in the utilization of mental health services.
    Discussion: Findings suggest that enhancing family support systems may be useful in promoting mental health utilization among adolescent girls with the potential to improve self-esteem, reduce feelings of inadequacy, and ultimately achieve better mental health outcomes.
    MeSH term(s) Child ; Female ; Humans ; Adolescent ; Uganda ; Latent Class Analysis ; Mental Health Services ; Mental Health ; Schools
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2022.09.037
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  8. Article ; Online: A Structural-Environmental Model of Alcohol and Substance-Related Sexual HIV Risk in Latino Migrant Day Laborers.

    Organista, Kurt C / Jung, Woojin / Neilands, Torsten B

    AIDS and behavior

    2020  Volume 24, Issue 11, Page(s) 3176–3191

    Abstract: A structural-environmental model of alcohol and substance-related sexual HIV risk in 344 Latino migrant day laborers, participants in a cross-sectional survey, is tested using structural equation modeling. Hypothesized pathways include: (1) direct paths ... ...

    Abstract A structural-environmental model of alcohol and substance-related sexual HIV risk in 344 Latino migrant day laborers, participants in a cross-sectional survey, is tested using structural equation modeling. Hypothesized pathways include: (1) direct paths between environmental conditions and both distress related risk factors, and cultural and community protective factors; (2) indirect paths between environmental conditions and distress through cultural and community protective factors; and (3) indirect paths between environmental conditions and sexual risk through both distress risk factors and cultural and community protective factors. As hypothesized, the environmental factors, discrimination and working conditions, were indirectly related to sexual risk through the distress related factor, problem drinking, and through the protective factor, contact with family in country of origin. More specifically, as discrimination and working conditions worsen, contact with family decreases, problem drinking increases, and sexual risk increases. Implications for multi-level interventions are discussed.
    MeSH term(s) Adult ; Alcohol Drinking/epidemiology ; Behavior, Addictive/psychology ; Cross-Sectional Studies ; Female ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Health Surveys ; Hispanic or Latino/psychology ; Humans ; Male ; Risk Factors ; Risk-Taking ; Sexual Behavior/statistics & numerical data ; Substance-Related Disorders/epidemiology ; Transients and Migrants/psychology ; Transients and Migrants/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-020-02876-4
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  9. Article ; Online: Development of the Mobile Technology Vulnerability Scale among Youth and Young Adults Living with HIV.

    Lisha, Nadra E / Neilands, Torsten B / Erguera, Xavier A / Saberi, Parya

    International journal of environmental research and public health

    2021  Volume 18, Issue 8

    Abstract: Introduction: Youth and young adults living with HIV (YLWH) in the US have the lowest viral suppression percentage. Lack of sufficient technology access may be correlated with HIV health outcomes in this population.: Methods: We developed a Mobile ... ...

    Abstract Introduction: Youth and young adults living with HIV (YLWH) in the US have the lowest viral suppression percentage. Lack of sufficient technology access may be correlated with HIV health outcomes in this population.
    Methods: We developed a Mobile Technology Vulnerability Scale (MTVS; 18 items) among 18-29-year-olds. Exploratory factor analysis (EFA) was performed on baseline data (N = 79), followed by a confirmatory factor analysis (CFA) of 6-month follow-up data (N = 69). Cronbach's alpha for internal consistency and test-retest reliability were examined. We also correlated the scale with self-report antiretroviral therapy (ART) adherence.
    Results: EFA yielded a single-factor solution at baseline after dropping one item. CFA at follow-up corroborated the single-factor. Cronbach's alpha was high and MTVS was correlated with ART adherence at both time points. MTVS at baseline and 6 months were correlated.
    Conclusion: The 17-item MTVS scale was found to be valid and reliable and related to ART adherence.
    MeSH term(s) Adolescent ; Anti-Retroviral Agents/therapeutic use ; Factor Analysis, Statistical ; HIV Infections/drug therapy ; Humans ; Reproducibility of Results ; Technology ; Young Adult
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18084170
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  10. Article: Exploration of a Mobile Technology Vulnerability Scale's association with antiretroviral adherence among young adults living with HIV in the United States.

    Saberi, Parya / Eskaf, Shadi / Campbell, Chadwick K / Neilands, Torsten B / Sauceda, John A / Dubé, Karine

    mHealth

    2022  Volume 8, Page(s) 23

    Abstract: Background: Young adults living with HIV (YLWH) have suboptimal adherence to antiretroviral therapy (ART) and HIV care outcomes. Mobile health technologies are increasingly used to deliver interventions to address HIV health outcomes. However, not all ... ...

    Abstract Background: Young adults living with HIV (YLWH) have suboptimal adherence to antiretroviral therapy (ART) and HIV care outcomes. Mobile health technologies are increasingly used to deliver interventions to address HIV health outcomes. However, not all YLWH have equal and consistent access to mobile technologies.
    Methods: Using our novel Mobile Technology Vulnerability Scale (MTVS) to evaluate how vulnerable an individual feels with regard to their personal access to mobile technology in the past 6 months, we conducted a cross-sectional online survey with 271 YLWH (18-29 years) in the US to evaluate the relationships between MTVS and self-reported ART adherence.
    Results: Participants reported changes in phone numbers (25%), stolen (14%) or lost (22%) phones, and disconnections of phone service due to non-payment (39%) in the past 6 months. On a scale of 0 to 1 (0 having no mobile technology vulnerability and 1 having complete mobile technology vulnerability), participants had a mean MTVS of 0.33 (SD =0.26). Black and financially constrained participants had the highest MTVS, which was significantly higher that other racial/ethnic and financially non-constrained groups, respectively. Higher MTVS was significantly associated with ART non-adherence and non-persistence.
    Conclusions: Findings suggest the need to measure MTVS to recognize pitfalls when using mobile health interventions and identify populations whose inconsistent mobile technology access may be related to worse health outcomes.
    Language English
    Publishing date 2022-07-20
    Publishing country China
    Document type Journal Article
    ISSN 2306-9740
    ISSN 2306-9740
    DOI 10.21037/mhealth-21-54
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