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Article ; Online: Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study.

Neinaa, Yomna Mazid El-Hamd / El-Maadawy, Iman Hamed / Atteia, Iman Aly / Mohamed, Dareen Abd El-Aziz

2023 Volume 315, Issue 8, Page(s) 2403–2411

Abstract: Cell adhesion molecule 1 (CADM1) is one of the immunoglobulin super family adhesion molecules, that is proposed to contribute in the pathogenesis of various types of cutaneous T-cell lymphoma, including mycosis fungoides (MF). In this work, we decided to ...

Abstract	Cell adhesion molecule 1 (CADM1) is one of the immunoglobulin super family adhesion molecules, that is proposed to contribute in the pathogenesis of various types of cutaneous T-cell lymphoma, including mycosis fungoides (MF). In this work, we decided to examine the immunohistochemical expression of CADM1 in MF specimens compared to premycotic parapsoriasis, benign inflammatory dermatosis and normal control skin specimens. 125 participants were enrolled (50 MF, 25 parapsoriasis, 25 inflammatory dermatosis, and 25 healthy controls). Patients were selected from the Outpatient Clinic of Dermatology and Venereology Department, Tanta University Hospitals. From all, 4 mm punch skin biopsies were taken and examined for CADM1 immunohistochemical expression. The current study revealed statistically significant upregulation of CADM1 expression in MF specimens in comparison to parapsoriasis, inflammatory dermatosis, and normal control specimens. Additionally, there was statistically significant positive correlation between CADM1 expression and progression of TNMB staging of MF disease. Therefore, it is possible to recommend CADM1 as a beneficial diagnostic immunohistochemical marker for differentiation between early stages of MF and both the premycotic parapsoriasis and benign inflammatory dermatosis. Moreover, it may be of value in early detection of neoplastic transformation of parapsoriasis as well as in assessment of MF progression.
MeSH term(s)	Humans ; Cell Adhesion Molecule-1 ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/pathology ; Skin/pathology ; Parapsoriasis/complications ; Parapsoriasis/diagnosis ; Parapsoriasis/pathology ; Dermatitis/pathology ; Skin Neoplasms/pathology
Chemical Substances	Cell Adhesion Molecule-1 ; CADM1 protein, human
Language	English
Publishing date	2023-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02600-x
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Article ; Online: Efficacy of prostaglandin E2 versus prostaglandin F2 alpha assisted with narrowband-UVB in stable vitiligo.

Neinaa, Yomna Mazid El-Hamd / Mahmoud, Myada Abd Elmohsen / El Maghraby, Gamal Mohamed / Ibrahim, Zeinab Abd Elsamd

Archives of dermatological research

2023 Volume 315, Issue 9, Page(s) 2647–2653

Abstract: In the recent decades, prostaglandins were recommended as a new therapeutic modality of stable vitiligo with promising efficacy. Therefore, we designed the current work to compare the significance of two different subtypes of prostaglandins [ ... ...

Abstract	In the recent decades, prostaglandins were recommended as a new therapeutic modality of stable vitiligo with promising efficacy. Therefore, we designed the current work to compare the significance of two different subtypes of prostaglandins [prostaglandin E2 (PGE2) versus prostaglandin F2 alpha (PGF2α)], assisted with NB-UVB phototherapy, in treatment of stable vitiligo. This study was conducted on 30 patients with stable non-segmental vitiligo. Three approximately similar vitiliginous areas were chosen in each patient and assigned into 3 groups. Each group treated with intradermal injection of either PGE2 (group I), PGF2α (group II), or saline as placebo (group III) at frequency once/week for 12 weeks. Concomitantly, all groups received NB-UVB phototherapy twice weekly for 3 months. The outcomes of this study discovered that the therapeutic efficacy of intradermal injection of either PGE2 or PGF2α assisted with NB-UVB phototherapy was comparable with non-significant difference between them in spite of being significantly higher than NB-UVB alone. However, there were a significantly earlier onset of repigmentation and higher degree of satisfaction regarding areas treated with PGE2 than those treated with PGF2α. In conclusion, both PGF2α and PGE2 intradermal injection could be considered as quite simple and affordable techniques in the treatment of stable vitiligo with no reported side effects and good patient satisfaction.
MeSH term(s)	Humans ; Dinoprostone ; Dinoprost ; Vitiligo/radiotherapy ; Hypopigmentation ; Prostaglandins ; Ultraviolet Therapy
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Dinoprost (B7IN85G1HY) ; Prostaglandins
Language	English
Publishing date	2023-08-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02700-8
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Article ; Online: YKL-40 immunoexpression as a prognosticator of mycosis fungoides.

Neinaa, Yomna Mazid El-Hamd / Elsayed, Hadeer Tarek Ismaiel / Alshenawy, Hanan Alsaeid / Gamei, Mohamed Mahmoud

International journal of dermatology

2023 Volume 62, Issue 9, Page(s) 1147–1153

Abstract: Background: YKL-40 is a 40 kDa chitinase-like glycoprotein that is predicted to contribute to the pathogenesis of several inflammatory and neoplastic conditions.: Objectives: To assess YKL-40 immunoexpression in different stages of mycosis fungoides ( ...

Abstract	Background: YKL-40 is a 40 kDa chitinase-like glycoprotein that is predicted to contribute to the pathogenesis of several inflammatory and neoplastic conditions. Objectives: To assess YKL-40 immunoexpression in different stages of mycosis fungoides (MF) to find out if YKL-40 is playing a possible role in disease pathophysiology and progression. Methods: This work included 50 patients with different stages of MF diagnosed on the basis of clinical, histopathological, and both CD4 and CD8 immunophenotyping, in addition to 25 normal control skin. The Immune Reactive Score (IRS) of YKL-40 expression was determined in all specimens and statistically analyzed. Results: YKL-40 expression reported a significant rise in MF lesions compared to control skin. Among MF specimens, the mildest expression was observed in the early patch stage followed by the plaque stage, while the strongest was in tumor stages. Positive correlations were discovered between IRS of YKL-40 expression in MF specimens and patients' age, disease chronicity, clinical staging, and TNMB classification. Conclusion: YKL-40 might participate in MF pathophysiology, and the highest expression is associated with advanced stages of the disease and poor outcomes. Therefore, it might be of value as a prognosticator for monitoring high-risk MF patients and follow-up assessment of treatment success.
MeSH term(s)	Humans ; Skin Neoplasms/pathology ; Chitinase-3-Like Protein 1 ; Mycosis Fungoides/pathology ; Skin/pathology ; Treatment Outcome
Chemical Substances	Chitinase-3-Like Protein 1
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16758
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Article ; Online: Synergistic effect of platelet-rich plasma in combination with fractional carbon dioxide laser versus its combination with pulsed dye laser in striae distensae: A comparative study.

Neinaa, Yomna Mazid El-Hamd / Gheida, Shereen Farouk / Mohamed, Dareen Abd El-Aziz

Photodermatology, photoimmunology & photomedicine

2021 Volume 37, Issue 3, Page(s) 214–223

Abstract: Background: Striae distensae (SD) are very common atrophic cutaneous scarring that are therapeutically challenging. Various kinds of laser had been suggested as effective treatment modalities for SD. In addition, platelet-rich plasma (PRP) was recently ... ...

Abstract	Background: Striae distensae (SD) are very common atrophic cutaneous scarring that are therapeutically challenging. Various kinds of laser had been suggested as effective treatment modalities for SD. In addition, platelet-rich plasma (PRP) was recently recommended for its therapy. Objective: To evaluate the synergistic role of PRP injection as a combined modality to fractional CO Patients and methods: Thirty SD patients were included in this study and treated by intradermal injection of autologous PRP on both sides, followed by laser therapy (Fr CO Results: Both treatment sides reported significant clinical improvements of SD lesions, evidenced by significant reduction of width of striae lesions and significant improvement of skin texture. Furthermore, significantly higher degree of clinical improvements were observed in response to treatment sessions by combined PRP with Fr CO Conclusions: PRP injection in combination with Fr CO
MeSH term(s)	Carbon Dioxide ; Humans ; Lasers, Dye/therapeutic use ; Lasers, Gas/therapeutic use ; Patient Satisfaction ; Platelet-Rich Plasma ; Striae Distensae/therapy ; Treatment Outcome
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12636
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Article ; Online: Impact of NB-UVB phototherapy on Caveolin-1 expression in chronic plaque psoriasis.

Elsherbeni, Marwa B / Neinaa, Yomna Mazid El-Hamd / Fawzy, Mohamed M / Elwan, Nagwa M

Photodermatology, photoimmunology & photomedicine

2022 Volume 39, Issue 3, Page(s) 218–225

Abstract: Background: Caveolin-1 (Cav-1) is a significant structural and regulatory constituent of cell membranes that has been implicated in cell kinetics and inflammation.: Objective: To assess Cav-1 expression in psoriasis before and after phototherapy.: ... ...

Abstract	Background: Caveolin-1 (Cav-1) is a significant structural and regulatory constituent of cell membranes that has been implicated in cell kinetics and inflammation. Objective: To assess Cav-1 expression in psoriasis before and after phototherapy. Patients and methods: Thirty psoriasis cases and 30 healthy controls were recruited. Cases were managed with narrow band-ultraviolet B (NB-UVB) phototherapy at frequency three times per week for 12 weeks. From every case, two biopsy specimens were gained from psoriatic lesions (pre and post phototherapy), in addition to one from apparently normal skin of psoriasis cases. Regarding the control group, one biopsy was taken from a matched site. All were studied for Cav-1 antibody immuno-expression. Results: There was a significant decrease in Cav-1 expression in psoriatic lesions compared to both the apparently normal skin of psoriasis patients and standard control skin of healthy individuals. After NB-UVB phototherapy, significant upregulation of Cav-1 immunostaining score was observed in previously psoriatic skin when compared to that before treatment. In addition, there were significant negative correlations between Cav-1 immunostaining score and the clinical scores of psoriasis severity including; the erythema, scaling, and induration (ESI) score and the patient psoriasis area and severity index (PASI) score. Conclusion: Induction of Cav-1 expression may be a likely pathway for the effectiveness of NB-UVB in psoriasis. Cav-1 may be a useful marker for evaluation of psoriasis severity, disease progression, and therapeutic efficacy.
MeSH term(s)	Humans ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Phototherapy ; Psoriasis/radiotherapy ; Psoriasis/drug therapy ; Treatment Outcome ; Ultraviolet Therapy
Chemical Substances	Caveolin 1
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12822
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Article ; Online: Clinical and dermoscopic assessment of ablative carbon dioxide laser versus intradermal heparin sodium in xanthelasma.

Neinaa, Yomna Mazid El-Hamd / Awara, Bassant Sherif El-Sayed / Shalaby, Osama El-Said / Abd El-Naby, Naeim Mohammed

Photodermatology, photoimmunology & photomedicine

2023 Volume 39, Issue 6, Page(s) 648–656

Abstract: Background: Ablative carbon dioxide (CO: Objective: The aim of this work was to compare the therapeutic value of ablative CO: Methods: This study was piloted on 30 xanthelasma patients, whose lesions were randomly categorized into two groups. ... ...

Abstract	Background: Ablative carbon dioxide (CO Objective: The aim of this work was to compare the therapeutic value of ablative CO Methods: This study was piloted on 30 xanthelasma patients, whose lesions were randomly categorized into two groups. Group A was managed with CO Results: Significant reduction of xanthelasma lesions was reported in response to both therapeutic interventions. However, the ablative CO Conclusions: Intradermal injection of heparin sodium could be suggested as a safe and cost-effective therapeutic technique for early mild grade I and II xanthelasma. Moreover, it could be recommended as a pre-operative management of grade III and IV xanthelasma to reduce the lesions to be easily ablated with CO
MeSH term(s)	Humans ; Heparin ; Lasers, Gas/therapeutic use ; Carbon Dioxide ; Hyperpigmentation/etiology ; Cicatrix ; Treatment Outcome
Chemical Substances	Heparin (9005-49-6) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12915
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Article ; Online: A comparative study of combined microneedling and narrowband ultraviolet B phototherapy versus their combination with topical latanoprost in the treatment of vitiligo.

Neinaa, Yomna Mazid El-Hamd / Lotfy, Sarah Sanad / Ghaly, Nahla Ramzy / Doghaim, Noha Nabil

Dermatologic therapy

2021 Volume 34, Issue 2, Page(s) e14813

Abstract: Regardless of the continuous discovery of innovative modalities for the treatment of vitiligo, none of them ensure excellent therapeutic outcome. Microneedling had been suggested either singly or concomitantly with other therapeutic modalities for ... ...

Abstract	Regardless of the continuous discovery of innovative modalities for the treatment of vitiligo, none of them ensure excellent therapeutic outcome. Microneedling had been suggested either singly or concomitantly with other therapeutic modalities for vitiligo with encouraging results. Latanoprost, a prostaglandin F2-alpha (PGF2α), and their analogues are recently recommended for vitiligo treatment. This study was designed to assess the therapeutic efficacy of microneedling in combination with NB-UVB phototherapy versus their combination with latanoprost in vitiligo. It was conducted on 50 patients presented with stable bilateral localized nonsegmental vitiligo. In every patient; two bilateral, nearly symmetrical lesions were selected and treated by microneedling (12 sessions at 2-week interval) followed by topical application of latanoprost 0.005% solution on one side, and topical saline (as placebo) on the other side. In addition, all patients received concomitant NB-UVB phototherapy (three sessions/week) for 6 months. Significant clinical improvement of vitiligo lesions with significant increase in the degree of repigmentation were reported in response to both treatment regimens. Latanoprost in combination with microneedling and NB-UVB provides more significant therapeutic outcomes than combined microneedling and NB-UVB. In conclusion, topical latanoprost 0.005% enhances the therapeutic efficacy of combined microneedling and NB-UVB phototherapy in localized stable nonsegmental vitiligo.
MeSH term(s)	Combined Modality Therapy ; Humans ; Latanoprost ; Prospective Studies ; Treatment Outcome ; Ultraviolet Therapy/adverse effects ; Vitiligo/diagnosis ; Vitiligo/therapy
Chemical Substances	Latanoprost (6Z5B6HVF6O)
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.14813
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Article ; Online: Efficacy of platelet-poor plasma gel in combination with fractional CO

Gad, Samar El-Sayed / Neinaa, Yomna Mazid El-Hamd / Rizk, Omnia Kamel / Ghaly, Nahla El-Sayed Ramzy

Journal of cosmetic dermatology

2021 Volume 20, Issue 10, Page(s) 3236–3244

Abstract: Background: Platelet-poor plasma gel is a semi-solid plasma formulation that recently recommended as autologous bio-filler for treatment of atrophic dermal scars.: Aim: To compare the therapeutic efficacy and safety of intradermal injection of plasma ...

Abstract	Background: Platelet-poor plasma gel is a semi-solid plasma formulation that recently recommended as autologous bio-filler for treatment of atrophic dermal scars. Aim: To compare the therapeutic efficacy and safety of intradermal injection of plasma gel in combination with fractional CO Patients and methods: This study included 36 SD patients treated by three sessions (one session/1.5 months) of fractional CO Results: Significant clinical improvements associated with remarkable narrowing of SD lesions and prominent enhancement of skin texture were observed on both treatment sides. Obviously, higher degrees of clinical improvements of SD lesions were reported following combined therapy with fractional CO Conclusion: Plasma gel in combination with fractional CO
MeSH term(s)	Carbon Dioxide ; Humans ; Injections, Intradermal ; Lasers, Gas/adverse effects ; Patient Satisfaction ; Striae Distensae/therapy ; Treatment Outcome
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14102
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Article ; Online: Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids.

Neinaa, Yomna Mazid El-Hamd / Elsayed, Toka Ahmad / Mohamed, Dareen Ali / Elfar, Nashwa Naeem

Dermatologic therapy

2021 Volume 34, Issue 3, Page(s) e14900

Abstract: Keloids characterize a definitely challenging type of cutaneous scars for which a diversity of therapeutic modalities has been suggested. The aim of this work was to compare the therapeutic efficacy of intralesional injection of botulinum toxin type-A ( ... ...

Abstract	Keloids characterize a definitely challenging type of cutaneous scars for which a diversity of therapeutic modalities has been suggested. The aim of this work was to compare the therapeutic efficacy of intralesional injection of botulinum toxin type-A (BTX-A), platelet rich plasma (PRP), and triamcinolone acetonide (TAC) in keloids. A total of 60 keloids patients were enrolled and divided randomly into three equal groups. Group I treated by intralesional BTX-A injection, group II treated by intralesional PRP injection, and group III treated by intralesional TAC injection. Clinical assessment was done by Vancouver Scar Scale (VSS), Verbal Rating Scale (VRS), and dermoscopic examination. Additionally, histopathology and immunohistochemistry of connective tissue growth factor (CTGF) expression were evaluated. The results of this study revealed significant improvement of both VSS and VRS in response to all treatment modalities. There was significant improvement of VSS in BTX-A and PRP groups more than TAC group. However, no significant difference observed between BTX-A and PRP groups. Immunohistochemical examination showed significant decrease of CTGF expression after treatment in BTX-A and PRP groups more than TAC group. In conclusion, both BTX-A and PRP could yield a chance for cosmetically better outcomes in keloids treatment than conventional TAC injection.
MeSH term(s)	Humans ; Injections, Intralesional ; Keloid/drug therapy ; Keloid/pathology ; Platelet-Rich Plasma ; Treatment Outcome ; Triamcinolone Acetonide
Chemical Substances	Triamcinolone Acetonide (F446C597KA)
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.14900
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Article ; Online: Borderline Lepromatous Leprosy: Uncommon Clinical Presentation.

Elwan, Nagwa Mohammad / Neinaa, Yomna Mazid El-Hamd

The American Journal of dermatopathology

2018 Volume 41, Issue 3, Page(s) 211–213

MeSH term(s)	Adolescent ; Humans ; Leprosy, Lepromatous/diagnosis ; Leprosy, Lepromatous/pathology ; Leprosy, Multibacillary/diagnosis ; Leprosy, Multibacillary/pathology ; Male
Language	English
Publishing date	2018-09-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000001262
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