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  1. Book: Tissue morphogenesis

    Nelson, Celeste M.

    methods and protocols

    (Methods in molecular biology ; 1189 ; Springer protocols)

    2015  

    Author's details ed. by Celeste M. Nelson
    Series title Methods in molecular biology ; 1189
    Springer protocols
    Collection
    Keywords Morphogenesis
    Subject code 571.833
    Language English
    Size XII, 351 S. : Ill., graph. Darst., 27 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Formerly CIP. ; Includes bibliographical references and index
    Accompanying material Hinweis auf zusätzliches Internetmaterial im Buch
    HBZ-ID HT018450237
    ISBN 978-1-4939-1163-9 ; 9781493911646 ; 1-4939-1163-5 ; 1493911643
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  2. Article ; Online: Mechanical Control of Cell Differentiation: Insights from the Early Embryo.

    Nelson, Celeste M

    Annual review of biomedical engineering

    2022  Volume 24, Page(s) 307–322

    Abstract: Differentiation is the process by which a cell activates the expression of tissue-specific genes, downregulates the expression of potency markers, and acquires the phenotypic characteristics of its mature fate. The signals that regulate differentiation ... ...

    Abstract Differentiation is the process by which a cell activates the expression of tissue-specific genes, downregulates the expression of potency markers, and acquires the phenotypic characteristics of its mature fate. The signals that regulate differentiation include biochemical and mechanical factors within the surrounding microenvironment. We describe recent breakthroughs in our understanding of the mechanical control mechanisms that regulate differentiation, with a specific emphasis on the differentiation events that build the early mouse embryo. Engineering approaches that reproducibly mimic the mechanical regulation of differentiation will permit new insights into early development and applications in regenerative medicine.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Humans ; Mice ; Regenerative Medicine ; Tissue Engineering
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1448425-0
    ISSN 1545-4274 ; 1523-9829
    ISSN (online) 1545-4274
    ISSN 1523-9829
    DOI 10.1146/annurev-bioeng-060418-052527
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  3. Article ; Online: Interplay between hormonal and mechanical signals in mammary morphodynamics.

    Anlaş, Alişya A / Nelson, Celeste M

    Trends in cell biology

    2024  

    Abstract: Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone ... ...

    Abstract Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2024.03.004
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  4. Article ; Online: The mechanics of crypt morphogenesis.

    Nelson, Celeste M

    Nature cell biology

    2021  Volume 23, Issue 7, Page(s) 678–679

    MeSH term(s) Morphogenesis
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-021-00703-z
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  5. Article ; Online: Mechanical properties pattern the skin.

    Banavar, Samhita P / Nelson, Celeste M

    Science (New York, N.Y.)

    2023  Volume 382, Issue 6673, Page(s) 880

    Abstract: Morphogens induce variations in tissue mechanics to promote feather budding. ...

    Abstract Morphogens induce variations in tissue mechanics to promote feather budding.
    MeSH term(s) Animals ; Feathers/growth & development ; Skin/growth & development ; Chick Embryo ; Mechanical Phenomena ; Morphogenesis
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adl2004
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  6. Article ; Online: Analysis of Cre lines for targeting embryonic airway smooth muscle.

    Goodwin, Katharine / Nelson, Celeste M

    Developmental biology

    2023  Volume 496, Page(s) 63–72

    Abstract: During development of the embryonic mouse lung, the pulmonary mesenchyme differentiates into smooth muscle that wraps around the airway epithelium. Inhibiting smooth muscle differentiation leads to cystic airways, while enhancing it stunts epithelial ... ...

    Abstract During development of the embryonic mouse lung, the pulmonary mesenchyme differentiates into smooth muscle that wraps around the airway epithelium. Inhibiting smooth muscle differentiation leads to cystic airways, while enhancing it stunts epithelial branching. These findings support a conceptual model wherein the differentiation of smooth muscle sculpts the growing epithelium into branches at precise positions and with stereotyped morphologies. Unfortunately, most approaches to manipulate the differentiation of airway smooth muscle rely on pharmacological or physical perturbations that are conducted ex vivo. Here, we explored the use of diphtheria toxin-based genetic ablation strategies to eliminate airway smooth muscle in the embryonic mouse lung. Surprisingly, neither airway smooth muscle wrapping nor epithelial branching were affected in embryos in which the expression of diphtheria toxin or its receptor were driven by several different smooth muscle-specific Cre lines. Close examination of spatial patterns of Cre activity in the embryonic lung revealed that none of these commonly used Cre lines target embryonic airway smooth muscle robustly or specifically. Our findings demonstrate the need for airway smooth muscle-specific Cre lines that are active in the embryonic lung, and serve as a resource for researchers contemplating the use of these commonly used Cre lines for studying embryonic airway smooth muscle.
    MeSH term(s) Mice ; Animals ; Diphtheria Toxin/metabolism ; Lung ; Muscle, Smooth ; Integrases
    Chemical Substances Cre recombinase (EC 2.7.7.-) ; Diphtheria Toxin ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2023.01.008
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  7. Article ; Online: Spatial patterning of energy metabolism during tissue morphogenesis.

    Lemma, Bezia / Nelson, Celeste M

    Current opinion in cell biology

    2023  Volume 85, Page(s) 102235

    Abstract: Biophysical signaling organizes forces to drive tissue morphogenesis, a process co-opted during disease progression. The systematic buildup of forces at the tissue scale is energetically demanding. Just as mechanical forces, gene expression, and ... ...

    Abstract Biophysical signaling organizes forces to drive tissue morphogenesis, a process co-opted during disease progression. The systematic buildup of forces at the tissue scale is energetically demanding. Just as mechanical forces, gene expression, and concentrations of morphogens vary spatially across a developing tissue, there might similarly be spatial variations in energy consumption. Recent studies have started to uncover the connections between spatial patterns of mechanical forces and spatial patterns of energy metabolism. Here, we define and review the concept of energy metabolism during tissue morphogenesis. We highlight experiments showing spatial variations in energy metabolism across several model systems, categorized by morphogenetic motif, including convergent extension, branching, and migration. Finally, we discuss approaches to further enable quantitative measurements of energy production and consumption during morphogenesis.
    MeSH term(s) Morphogenesis ; Signal Transduction ; Energy Metabolism
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102235
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  8. Article ; Online: Epithelial Packing: Even the Best of Friends Must Part.

    Nelson, Celeste M

    Current biology : CB

    2018  Volume 28, Issue 20, Page(s) R1197–R1200

    Abstract: Textbooks commonly describe epithelia as tissues composed of regular arrays of prism-shaped cells. A recent study combining mathematical modeling with quantitative imaging has uncovered the scutoid, a new shape that is necessary for epithelial cells to ... ...

    Abstract Textbooks commonly describe epithelia as tissues composed of regular arrays of prism-shaped cells. A recent study combining mathematical modeling with quantitative imaging has uncovered the scutoid, a new shape that is necessary for epithelial cells to pack into curved tissues.
    MeSH term(s) Epithelial Cells ; Epithelium ; Friends ; Humans
    Language English
    Publishing date 2018-10-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2018.08.055
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  9. Article ; Online: Revealing epithelial morphogenetic mechanisms through live imaging.

    Farahani, Payam E / Nelson, Celeste M

    Current opinion in genetics & development

    2021  Volume 72, Page(s) 61–68

    Abstract: Epithelial morphogenesis is guided by mechanical forces and biochemical signals that vary spatiotemporally. As many morphogenetic events are driven by rapid cellular processes, understanding morphogenesis requires monitoring development in real time. ... ...

    Abstract Epithelial morphogenesis is guided by mechanical forces and biochemical signals that vary spatiotemporally. As many morphogenetic events are driven by rapid cellular processes, understanding morphogenesis requires monitoring development in real time. Here, we discuss how live-imaging approaches can help identify morphogenetic mechanisms otherwise missed in static snapshots of development. We begin with a summary of live-imaging strategies, including recent advances that push the limits of spatiotemporal resolution and specimen size. We then describe recent efforts that employ live imaging to uncover morphogenetic mechanisms. We conclude by discussing how information collected from live imaging can be enhanced by genetically encoded biosensors and spatiotemporal perturbation techniques to determine the dynamics of patterning of developmental signals and their importance for guiding morphogenesis.
    MeSH term(s) Mechanical Phenomena ; Morphogenesis/genetics
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2021.10.007
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  10. Article ; Online: Dynamic changes in epithelial cell packing during tissue morphogenesis.

    Lemke, Sandra B / Nelson, Celeste M

    Current biology : CB

    2021  Volume 31, Issue 18, Page(s) R1098–R1110

    Abstract: Cell packing - the spatial arrangement of cells - determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, ...

    Abstract Cell packing - the spatial arrangement of cells - determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.
    MeSH term(s) Animals ; Cell Shape ; Epithelial Cells ; Epithelium ; Models, Biological ; Morphogenesis
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.07.078
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