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  1. Article ; Online: The epidemiology of FIRS in term and late preterm births.

    Nelson, Karin B

    Seminars in fetal & neonatal medicine

    2020  Volume 25, Issue 4, Page(s) 101141

    Abstract: The definition of FIRS requires systemic inflammation and elevated levels of IL-6 in fetal plasma. That definition does not specify how systemic inflammation is to be recognized, and perinatal measurement of IL-6 is not a standard procedure. FIRS has not ...

    Abstract The definition of FIRS requires systemic inflammation and elevated levels of IL-6 in fetal plasma. That definition does not specify how systemic inflammation is to be recognized, and perinatal measurement of IL-6 is not a standard procedure. FIRS has not been examined in a population-based study that included post-neonatal outcome so its incidence and natural history are not known. The overlap, and similarities and differences, of FIRS as compared with other causes of neonatal encephalopathy, and how these relate to findings in the placenta, have not been jointly examined in a generalizable sample. FIRS has chiefly been discussed in the obstetric literature because of the need for decisions about management of delivery and antibiotic use. If the term "FIRS" is to be employed in other contexts, consensus should be sought as to which clinical, placental, and laboratory findings are most appropriate for identification of perinatal inflammatory processes, infectious or sterile.
    MeSH term(s) Biomarkers/blood ; Chorioamnionitis/epidemiology ; Chorioamnionitis/immunology ; Female ; Fetal Blood/immunology ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Placenta/immunology ; Pregnancy ; Pregnancy Outcome/epidemiology ; Premature Birth/epidemiology ; Premature Birth/immunology ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-07-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2020.101141
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  2. Article ; Online: 'Outgrowing' a cerebral palsy diagnosis.

    Nelson, Karin B

    Developmental medicine and child neurology

    2019  Volume 62, Issue 1, Page(s) 12

    MeSH term(s) Cerebral Palsy ; Humans
    Language English
    Publishing date 2019-07-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.14308
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  3. Book ; Conference proceedings: FEBRILE SEIZURES

    NELSON, KARIN B.

    1981  

    Event/congress Consensus Development Conference on the Long-Term Management of Febrile Seizures (1980, BethesdaMd.)
    Author's details [CONSENSUS DEVELOPMENT CONF. ON THE LONG-TERM MANAGEMENT OF FEBRILE SEIZURES, BETHESDA, MD., MAY 19 TO 21, 1980]. ED. KARIN B. NELSON
    Keywords FEVER / CONGRESSES ; SEIZURES / CONGRESSES ; Fieber
    Size XVII, 360 S. : ILL., GRAPH. DARST.
    Publisher RAVEN PR
    Publishing place NEW YORK
    Publishing country United States
    Document type Book ; Conference proceedings
    Note A CONSENSUS DEVELOPMENT CONFERENCE ON THE MANAGEMENT OF FEBRILE SEIZURES WAS HELD AT THE NATIONAL INST. OF HEALTH ON MAY 19 TO 21, 1980
    HBZ-ID HT002636398
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1983 A 136 order for loan Magazin

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  4. Article ; Online: Prenatal Factors in Cerebral Palsy.

    Nelson, Karin B / Blair, Eve

    The New England journal of medicine

    2015  Volume 373, Issue 23, Page(s) 2288–2289

    MeSH term(s) Cerebral Palsy/etiology ; Congenital Abnormalities ; Fetal Growth Retardation ; Humans
    Language English
    Publishing date 2015-12-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1512559
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  5. Article ; Online: Prenatal Factors in Singletons with Cerebral Palsy Born at or near Term.

    Nelson, Karin B / Blair, Eve

    The New England journal of medicine

    2015  Volume 373, Issue 10, Page(s) 946–953

    MeSH term(s) Cerebral Palsy/etiology ; Cerebral Palsy/genetics ; Congenital Abnormalities ; Fetal Growth Retardation ; Gestational Age ; Humans ; Microcephaly/complications ; Risk Factors ; Term Birth
    Language English
    Publishing date 2015-09-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1505261
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  6. Article ; Online: Fetal growth restriction and risk of cerebral palsy in singletons born after at least 35 weeks' gestation.

    Blair, Eve M / Nelson, Karin B

    American journal of obstetrics and gynecology

    2015  Volume 212, Issue 4, Page(s) 520.e1–7

    Abstract: Objective: The objective of the study was to improve the understanding of etiological paths to cerebral palsy (CP) that include fetal growth restriction by examining factors associated with growth restriction that modify CP risk.: Study design: In a ... ...

    Abstract Objective: The objective of the study was to improve the understanding of etiological paths to cerebral palsy (CP) that include fetal growth restriction by examining factors associated with growth restriction that modify CP risk.
    Study design: In a total population of singletons born at or after 35 weeks, there were 493 children with CP and 508 matched controls for whom appropriateness of fetal growth could be estimated. Fetal growth was considered markedly restricted if birthweight was more than 2 SD below optimal for gender, gestation, maternal height, and parity. We examined maternal blood pressure in pregnancy, smoking, birth asphyxia, and major birth defects recognized by age 6 years as potential modifiers of CP risk in growth-restricted births.
    Results: More than 80% of term and late preterm markedly growth-restricted singletons were born following a normotensive pregnancy and were at statistically significantly increased risk of CP (odds ratio, 4.81; 95% confidence interval, 2.7-8.5), whereas growth-restricted births following a hypertensive pregnancy were not. Neither a clinical diagnosis of birth asphyxia nor potentially asphyxiating birth events occurred more frequently among growth-restricted than among appropriately grown infants with CP. Major birth defects, particularly cerebral defects, occurred in an increasing proportion of CP with increasing growth deficit. The factor most predictive of CP in growth-restricted singletons was a major birth defect, present in 53% of markedly growth-restricted neonates with later CP. Defects observed in CP were similar whether growth restricted or not, except for an excess of isolated congenital microcephaly in those born growth restricted. The highest observed CP risk was in infants with both growth restriction and a major birth defect (8.9% of total CP in this gestational age group, 0.4% of controls: odds ratio, 30.9; 95% confidence interval, 7.0-136).
    Conclusion: The risk of CP was increased in antenatally growth-restricted singletons born at or near term to normotensive mothers. In growth-restricted singletons, a major birth defect was the dominant predictor, associated with a 30-fold increase in odds of CP. Identification of birth defects in the growth-restricted fetus or neonate may provide significant prognostic information.
    MeSH term(s) Adult ; Asphyxia Neonatorum/complications ; Case-Control Studies ; Cerebral Palsy/etiology ; Child ; Child, Preschool ; Congenital Abnormalities ; Female ; Fetal Growth Retardation ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Logistic Models ; Male ; Odds Ratio ; Pregnancy ; Premature Birth ; Risk Factors ; Term Birth
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2014.10.1103
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  7. Article ; Online: Infection in pregnancy and cerebral palsy.

    Nelson, Karin B

    Developmental medicine and child neurology

    2009  Volume 51, Issue 4, Page(s) 253–254

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Cerebral Palsy/epidemiology ; Cerebral Palsy/etiology ; Female ; Humans ; Male ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/epidemiology ; Risk Factors ; Urinary Tract Infections/complications ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2009-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.2008.03256.x
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  8. Article ; Online: Preventing cerebral palsy: paths not (yet) taken.

    Nelson, Karin B

    Developmental medicine and child neurology

    2009  Volume 51, Issue 10, Page(s) 765–766

    MeSH term(s) Cerebral Palsy/etiology ; Cerebral Palsy/prevention & control ; Humans
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Editorial
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.2009.03489.x
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  9. Article ; Online: Authors' reply to Lees.

    Nelson, Karin B / Sartwelle, Thomas P / Rouse, Dwight J

    BMJ (Clinical research ed.)

    2017  Volume 356, Page(s) j835

    Language English
    Publishing date 2017-02-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.j835
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  10. Article ; Online: Is infection a factor in neonatal encephalopathy?

    Nelson, Karin B / Penn, Anna A

    Archives of disease in childhood. Fetal and neonatal edition

    2014  Volume 100, Issue 1, Page(s) F8–F10

    MeSH term(s) Brain Diseases/etiology ; Brain Diseases/mortality ; Chorioamnionitis/microbiology ; Female ; Humans ; Hypoxia-Ischemia, Brain/complications ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Infectious
    Language English
    Publishing date 2014-08-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2014-306192
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