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  1. AU="Nelson, Noah T"
  2. AU="Surana, Amit"
  3. AU="Praetzel-Wunder, Silke"
  4. AU="Nabil, Fatima Mohamed"
  5. AU="Lindh, Christian"
  6. AU="Vetkas, Artur"
  7. AU="Gorelick, Root"
  8. AU="Mezdari, Zaineb"
  9. AU=Wilkinson Beverley
  10. AU=Halbower Ann C AU=Halbower Ann C
  11. AU="Ghosh, Ananya"
  12. AU="Spoletini, Gabriele"
  13. AU="Gracefo, Sara"
  14. AU="Works, Kaitlyn R"
  15. AU="LIU Lei"
  16. AU="McLennan, John D"
  17. AU=Dickinson Gordon M AU=Dickinson Gordon M
  18. AU=Hertzler Dean A 2nd
  19. AU="Yan, Xinrui"
  20. AU="Seal, M L"
  21. AU="Seka, Devin J"
  22. AU="Nguyen, Phuong T B"

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  1. Artikel ; Online: Network Architecture of Gap Junctional Coupling among Parallel Processing Channels in the Mammalian Retina.

    Sigulinsky, Crystal L / Anderson, James R / Kerzner, Ethan / Rapp, Christopher N / Pfeiffer, Rebecca L / Rodman, Taryn M / Emrich, Daniel P / Rapp, Kevin D / Nelson, Noah T / Lauritzen, J Scott / Meyer, Miriah / Marc, Robert E / Jones, Bryan W

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2020  Band 40, Heft 23, Seite(n) 4483–4511

    Abstract: Gap junctions are ubiquitous throughout the nervous system, mediating critical signal transmission and integration, as well as emergent network properties. In mammalian retina, gap junctions within the Aii amacrine cell-ON cone bipolar cell (CBC) network ...

    Abstract Gap junctions are ubiquitous throughout the nervous system, mediating critical signal transmission and integration, as well as emergent network properties. In mammalian retina, gap junctions within the Aii amacrine cell-ON cone bipolar cell (CBC) network are essential for night vision, modulation of day vision, and contribute to visual impairment in retinal degenerations, yet neither the extended network topology nor its conservation is well established. Here, we map the network contribution of gap junctions using a high-resolution connectomics dataset of an adult female rabbit retina. Gap junctions are prominent synaptic components of ON CBC classes, constituting 5%-25% of all axonal synaptic contacts. Many of these mediate canonical transfer of rod signals from Aii cells to ON CBCs for night vision, and we find that the uneven distribution of Aii signals to ON CBCs is conserved in rabbit, including one class entirely lacking direct Aii coupling. However, the majority of gap junctions formed by ON CBCs unexpectedly occur between ON CBCs, rather than with Aii cells. Such coupling is extensive, creating an interconnected network with numerous lateral paths both within, and particularly across, these parallel processing streams. Coupling patterns are precise with ON CBCs accepting and rejecting unique combinations of partnerships according to robust rulesets. Coupling specificity extends to both size and spatial topologies, thereby rivaling the synaptic specificity of chemical synapses. These ON CBC coupling motifs dramatically extend the coupled Aii-ON CBC network, with implications for signal flow in both scotopic and photopic retinal networks during visual processing and disease.
    Mesh-Begriff(e) Animals ; Female ; Gap Junctions/physiology ; Gap Junctions/ultrastructure ; Nerve Net/physiology ; Rabbits ; Retina/physiology ; Retina/ultrastructure
    Sprache Englisch
    Erscheinungsdatum 2020-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1810-19.2020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Rod-cone crossover connectome of mammalian bipolar cells.

    Lauritzen, J Scott / Sigulinsky, Crystal L / Anderson, James R / Kalloniatis, Michael / Nelson, Noah T / Emrich, Daniel P / Rapp, Christopher / McCarthy, Nicholas / Kerzner, Ethan / Meyer, Miriah / Jones, Bryan W / Marc, Robert E

    The Journal of comparative neurology

    2016  Band 527, Heft 1, Seite(n) 87–116

    Abstract: The basis of cross-suppression between rod and cone channels has long been an enigma. Using rabbit retinal connectome RC1, we show that all cone bipolar cell (BC) classes inhibit rod BCs via amacrine cell (AC) motifs (C1-6); that all cone BC classes are ... ...

    Abstract The basis of cross-suppression between rod and cone channels has long been an enigma. Using rabbit retinal connectome RC1, we show that all cone bipolar cell (BC) classes inhibit rod BCs via amacrine cell (AC) motifs (C1-6); that all cone BC classes are themselves inhibited by AC motifs (R1-5, R25) driven by rod BCs. A sparse symmetric AC motif (CR) is presynaptic and postsynaptic to both rod and cone BCs. ON cone BCs of all classes drive inhibition of rod BCs via motif C1 wide-field GABAergic ACs (γACs) and motif C2 narrow field glycinergic ON ACs (GACs). Each rod BC receives ≈10 crossover AC synapses and each ON cone BC can target ≈10 or more rod BCs via separate AC processes. OFF cone BCs mediate monosynaptic inhibition of rod BCs via motif C3 driven by OFF γACs and GACs and disynaptic inhibition via motifs C4 and C5 driven by OFF wide-field γACs and narrow-field GACs, respectively. Motifs C4 and C5 form halos of 60-100 inhibitory synapses on proximal dendrites of AI γACs. Rod BCs inhibit surrounding arrays of cone BCs through AII GAC networks that access ON and OFF cone BC patches via motifs R1, R2, R4, R5 and a unique ON AC motif R3 that collects rod BC inputs and targets ON cone BCs. Crossover synapses for motifs C1, C4, C5, and R3 are 3-4× larger than typical feedback synapses, which may be a signature for synaptic winner-take-all switches. J. Comp. Neurol. 527:87-116, 2019. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
    Mesh-Begriff(e) Amacrine Cells/cytology ; Amacrine Cells/physiology ; Animals ; Connectome ; Neural Pathways/anatomy & histology ; Neural Pathways/physiology ; Rabbits ; Retinal Bipolar Cells/cytology ; Retinal Bipolar Cells/physiology ; Retinal Cone Photoreceptor Cells/cytology ; Retinal Cone Photoreceptor Cells/physiology ; Retinal Rod Photoreceptor Cells/cytology ; Retinal Rod Photoreceptor Cells/physiology
    Sprache Englisch
    Erscheinungsdatum 2016-08-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.24084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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