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  1. AU="Nepal, Gaurav"
  2. AU=Pietrobelli Angelo AU=Pietrobelli Angelo
  3. AU="Lopeztello-Santillan, Adriana L"
  4. AU="Iaquinta, Angela"
  5. AU="Layne, Diana M"
  6. AU=Nadesalingam Ajantha
  7. AU=Kieser D C
  8. AU=Borthwick L. A.
  9. AU="Ding, Yiming"
  10. AU="Sid Ahmed, Mazen A"
  11. AU="Bermudez-Lekerika, Paola"
  12. AU="Ter Hoeve, Natalie D"
  13. AU="Yang, X-D"
  14. AU="Jerry J Shih"
  15. AU=Kapil Vikas
  16. AU="Sanda Cosarca"
  17. AU=Murthy J M K
  18. AU="Ward Chiasson, Stephanie"
  19. AU="Kinsella, Paul"
  20. AU="Alyaqout, Khaled"
  21. AU="J Joshua Smith"
  22. AU="Kotak, Dinesh"
  23. AU="Michael Holland"
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  26. AU=Congreve Miles
  27. AU="Li, Yunfeng" AU="Li, Yunfeng"
  28. AU="Shankar, Ganesh"
  29. AU="Ruginsk, Silvia G"
  30. AU="Aquilante, Francesco"
  31. AU="Dillon, Robert C"
  32. AU="Yuan Qu"
  33. AU="Dufour, A"
  34. AU="Hannus, Jill"
  35. AU="Rieber, Julia"
  36. AU="Gulmuradov, Tashpulat"
  37. AU="Romeu Fontanillas, Teresa"
  38. AU="Fleming, Renée"
  39. AU="Cao, Fang"
  40. AU="Sally J L Moore"
  41. AU="Moreno, Yolanda"
  42. AU="Vasiliy Ya. Kolyuchkin"

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  1. Artikel ; Online: Developing Systems of Emergency and Inpatient Neurologic Care in Resource-Limited Settings.

    Shrestha, Gentle Sunder / Nepal, Gaurav / Prust, Morgan Lippitt

    Seminars in neurology

    2024  Band 44, Heft 2, Seite(n) 105–118

    Abstract: Neurologic diseases represent a significant global health challenge, leading to disability and mortality worldwide. Healthcare systems in low- and middle-income countries are disproportionally affected. In these resource-limited settings, numerous ... ...

    Abstract Neurologic diseases represent a significant global health challenge, leading to disability and mortality worldwide. Healthcare systems in low- and middle-income countries are disproportionally affected. In these resource-limited settings, numerous barriers hinder the effective delivery of emergency and inpatient neurologic care, including shortages of trained personnel, limited access to diagnostics and essential medications, inadequate facilities, and absence of rehabilitation services. Disparities in the neurology workforce, limited access to neuroimaging, and availability of acute interventions further exacerbate the problem. This article explores strategies to enhance global capacity for inpatient neurologic care, emphasizing the importance of workforce development, context-specific protocols, telehealth solutions, advocacy efforts, and collaborations.
    Mesh-Begriff(e) Humans ; Resource-Limited Settings ; Inpatients ; Delivery of Health Care ; Nervous System Diseases ; Workforce
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1778638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Developing Systems of Emergency and Inpatient Neurologic Care in Resource-Limited Settings

    Shrestha, Gentle Sunder / Nepal, Gaurav / Prust, Morgan Lippitt

    Seminars in Neurology

    (Neurology in Underserved and Marginalized Populations)

    2024  Band 44, Heft 02, Seite(n) 105–118

    Abstract: Neurologic diseases represent a significant global health challenge, leading to disability and mortality worldwide. Healthcare systems in low- and middle-income countries are disproportionally affected. In these resource-limited settings, numerous ... ...

    Serientitel Neurology in Underserved and Marginalized Populations
    Abstract Neurologic diseases represent a significant global health challenge, leading to disability and mortality worldwide. Healthcare systems in low- and middle-income countries are disproportionally affected. In these resource-limited settings, numerous barriers hinder the effective delivery of emergency and inpatient neurologic care, including shortages of trained personnel, limited access to diagnostics and essential medications, inadequate facilities, and absence of rehabilitation services. Disparities in the neurology workforce, limited access to neuroimaging, and availability of acute interventions further exacerbate the problem. This article explores strategies to enhance global capacity for inpatient neurologic care, emphasizing the importance of workforce development, context-specific protocols, telehealth solutions, advocacy efforts, and collaborations.
    Schlagwörter emergency care ; healthcare systems ; inpatient care ; neurologic care ; resource-limited settings
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Verlag Thieme Medical Publishers, Inc.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1778638
    Datenquelle Thieme Verlag

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  3. Artikel ; Online: Cost-effectiveness of neurocritical care in settings with limited resources.

    Shrestha, Gentle Sunder / Nepal, Gaurav / Prabhakar, Hemanshu / Prust, Morgan L

    The Lancet. Global health

    2023  Band 11, Heft 9, Seite(n) e1343

    Mesh-Begriff(e) Humans ; Cost-Benefit Analysis ; Cost-Effectiveness Analysis
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00326-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Neurological and neuro-ophthalmological manifestations of snake bite: a systematic review.

    Pandit, Kamal / Rawal, Aastha / Maskey, Himang Man Singh / Nepal, Gaurav

    Annals of medicine and surgery (2012)

    2023  Band 86, Heft 1, Seite(n) 392–400

    Abstract: Objective: Snakebites, a major health concern in developing countries, affect rural farming communities. Venom, primarily neurotoxin, injected during a snake bite disrupts the nervous system, causing symptoms like muscle weakness, paralysis, altered ... ...

    Abstract Objective: Snakebites, a major health concern in developing countries, affect rural farming communities. Venom, primarily neurotoxin, injected during a snake bite disrupts the nervous system, causing symptoms like muscle weakness, paralysis, altered sensation, and coordination issues. This review focuses on evaluating neurological and neuro-ophthalmological manifestations associated with snakebites.
    Methods: A database search was conducted in EMBASE and PubMed for studies published from 2000 to 2023. The investigation centered on examining neurological and neuro-ophthalmological symptoms and signs, treatment approaches, treatment outcomes, and long-term complications of snake bites.
    Results: Neurological and neuro-ophthalmological symptoms were common in both neurotoxic and hemotoxic snake bites, especially in neurotoxic cases. Ptosis was a prevalent manifestation across various snake bites, along with respiratory paralysis, limb weakness, dysphasia, and visual disturbances in some instances. However, most patients improved without residual neurological symptoms after treatment.
    Conclusions: Understanding patterns of neurological manifestations contributes valuable insights for the comprehensive management of snakebite.
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000001523
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Schizencephaly diagnosed after an episode of seizure during labor: A case report.

    Paudel, Kusum / Prasad, Tanisha / Gyawali, Prashant / Nepal, Gaurav / Jaiswal, Vikash

    Clinical case reports

    2023  Band 11, Heft 5, Seite(n) e7328

    Abstract: Schizencephaly, an extremely rare anomaly of the cortex, is characterized by abnormal clefts in the cerebral cortex. Very often, this condition is diagnosed early in the childhood period but few instances exist in literature where schizencephaly- ... ...

    Abstract Schizencephaly, an extremely rare anomaly of the cortex, is characterized by abnormal clefts in the cerebral cortex. Very often, this condition is diagnosed early in the childhood period but few instances exist in literature where schizencephaly-associated seizures and hemiparesis have presented later in life too. Here, we report a rare case scenario of a lady in her late 30s who initially presented to us with obstetric concerns wherein schizencephaly remained an incidental finding despite the significantly large cortical cleft along with lobar holoprosencephaly and lissencephaly.
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7328
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Post-COVID-19 acute disseminated encephalomyelitis in a 51-year-old female from Nepal: A case report with literature review.

    Adhikari, Aayush / Yadav, Sushil Kumar / Kafle, Yashaswi / Yadav, Kundan / Nepal, Gaurav / Ojha, Rajeeb

    SAGE open medical case reports

    2023  Band 11, Seite(n) 2050313X231183579

    Abstract: There have been a growing number of acute disseminated encephalomyelitis cases following coronavirus disease-19 (COVID-19) infection. Given the rare occurrence, studies eliciting the clinical features, treatment response, and outcomes are still limited. ... ...

    Abstract There have been a growing number of acute disseminated encephalomyelitis cases following coronavirus disease-19 (COVID-19) infection. Given the rare occurrence, studies eliciting the clinical features, treatment response, and outcomes are still limited. In patients recovering from COVID-19, multifocal neurologic symptoms in the presence or absence of encephalopathy must be closely evaluated by neurologists and physicians. Early radiographic evaluation using magnetic resonance imaging and timely administration of glucocorticoid-based treatment reduces mortality and leads to satisfactory outcomes.
    Sprache Englisch
    Erscheinungsdatum 2023-06-30
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231183579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Neurological manifestations and complications of COVID-19 in patients admitted to a tertiary care center in Nepal during the second wave.

    Gajurel, Bikram Prasad / Yadav, Sushil Kumar / Nepal, Gaurav / Pant, Sobin / Yadav, Manish / Shah, Ravi / Shah, Sumit

    Medicine

    2024  Band 103, Heft 7, Seite(n) e36017

    Abstract: Neurological symptoms and signs of Coronavirus disease-19 (COVID-19) can accompany, follow, or precede respiratory symptoms and signs; hence, they are important in the diagnosis and management of COVID-19 patients. In this retrospective study conducted ... ...

    Abstract Neurological symptoms and signs of Coronavirus disease-19 (COVID-19) can accompany, follow, or precede respiratory symptoms and signs; hence, they are important in the diagnosis and management of COVID-19 patients. In this retrospective study conducted during the second wave of COVID-19, we included all patients diagnosed with COVID-19 using real-time polymerase chain reaction and admitted to the Tribhuvan University Teaching Hospital between June 2021 and October 2021. The patients were categorized into 2 groups: group A (with neurological manifestations or complications) and Group-B (without neurological manifestations or complications). The 2 groups were compared in terms of intensive care unit (ICU) admission, need for ventilatory support, length of hospital stay, and various outcomes. The study included 235 participants ranging in age from 13 to 102 years (mean age = 54 years, standard deviation = 18). Among the participants, 54.50% were male. The proportion of individuals in group A was higher (59.15%, N = 139) than that in Group-B (40.85%, N = 96). Notably, a significantly greater number of patients were admitted to the ICU in Group B than in Group A. However, there were no statistically significant differences in the need for ventilatory support or hospital stay between the 2 groups. Interestingly, group A showed a higher rate of improvement (Z = -3.1145, P = .00188, 95% CI), while Group-B had a higher rate of mortality (Z = 4.5562, P < .00001, 95% CI). Altered mental status and stroke have been specifically linked to poorer outcomes, whereas typical neurological manifestations, such as hyposmia, hypogeusia, dizziness, headache, and myalgia, are associated with better outcomes.
    Mesh-Begriff(e) Humans ; Male ; Middle Aged ; Adolescent ; Young Adult ; Adult ; Aged ; Aged, 80 and over ; Female ; COVID-19/complications ; SARS-CoV-2 ; Retrospective Studies ; Tertiary Care Centers ; Nepal/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: An institutional experience of hydatidosis and cysticercosis in Nepal: a retrospective chart review.

    Sharma, Nisha / Tiwari, Sansar B / Gaire, Prabin / Manandhar, Usha / Bohara, Sujan / Nepal, Gaurav

    Annals of medicine and surgery (2012)

    2023  Band 85, Heft 6, Seite(n) 2598–2602

    Abstract: This study aimed to investigate the demographic characteristics, anatomical distribution, and histopathological features of hydatidosis and cysticercosis in a Nepalese population presenting to a tertiary care hospital. The study also aimed to provide a ... ...

    Abstract This study aimed to investigate the demographic characteristics, anatomical distribution, and histopathological features of hydatidosis and cysticercosis in a Nepalese population presenting to a tertiary care hospital. The study also aimed to provide a better understanding of the clinical and pathological aspects of these diseases in the local context.
    Methods: This retrospective study analyzed all cases of hydatidosis and cysticercosis reported in the Department of Pathology at Tribhuvan University Teaching Hospital between January 2013 and December 2019. Demographic, clinical, radiological, and histopathological data were collected and analyzed from hospital charts.
    Results: During the 7-year study period, the authors identified 112 cases of hydatid cysts and 26 cases of cysticercosis. The mean age of patients with hydatidosis was 33.86 years (range: 5-74 years), while the mean age of patients with cysticercosis was 25.39 years (range: 4-63 years). Females were more commonly affected with hydatidosis (68, 61.7%) than males (44, 39.3%), resulting in a male-to-female ratio of 0.6:1. In contrast, there was no significant sex difference in cysticercosis cases, with 14 (53.85%) males and 12 (46.15%) females affected. The most commonly affected site for hydatid cysts was the lung (47 cases, 42%), followed by the liver (41 cases, 36.6%). The study identified three cases of neurocysticercosis. The average diameter of hydatid cysts and cysticercosis was 8.7 cm and 1.7 cm, respectively.
    Conclusion: In conclusion, our study provides important insights into the clinical and pathological features of hydatidosis and cysticercosis in a Nepalese population. These zoonotic diseases pose a significant health burden, particularly among the poor and marginalized populations. Our findings highlight the need to integrate prevention and control measures into the healthcare system to decrease the overall burden of these diseases.
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000840
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Self-medication with Antibiotics in WHO Southeast Asian Region: A Systematic Review.

    Nepal, Gaurav / Bhatta, Shekhar

    Cureus

    2018  Band 10, Heft 4, Seite(n) e2428

    Abstract: Antibiotics are essential treatments, especially in the developing world like World Health Organization (WHO) Southeast Asian region where infectious diseases are still the most common cause of death. In this part of the world, antibiotics are purchased ... ...

    Abstract Antibiotics are essential treatments, especially in the developing world like World Health Organization (WHO) Southeast Asian region where infectious diseases are still the most common cause of death. In this part of the world, antibiotics are purchased and used without the prescription of a physician. Self-medication of antibiotics is associated with the risk of inappropriate drug use, which predisposes patients to drug interactions, masking symptoms of an underlying disease, and development of microbial resistance. Antibiotic resistance is shrinking the range of effective antibiotics and is a global health problem. The appearance of multidrug-resistant bacterial strains, which are highly resistant to many antibiotic classes, has raised a major concern regarding antibiotic resistance worldwide. Even after decades of economic growth and development in countries that belong to the WHO Southeast Asian region, most of the countries in this region still have a high burden of infectious diseases. The magnitude and consequence of self-medication with antibiotics is unknown in this region. There is a need for evidence from well-designed studies on community use of antibiotics in these settings to help in planning and implementing specific strategies and interventions to prevent their irrational use and consequently to reduce the spread of antibiotic resistance. To quantify the frequency and effect of self-medication with antibiotics, we did a systematic review of published work from the Southeast Asian region.
    Sprache Englisch
    Erscheinungsdatum 2018-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2428
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Bilateral thalamic infarction following cerebral venous thrombosis in a patient with ulcerative colitis.

    Yadav, Jayant Kumar / Nepal, Gaurav / Thapa, Aakar / Jaiswal, Sandip / Thapa, Shreejana / Chandra, Avinash

    Clinical case reports

    2022  Band 10, Heft 2, Seite(n) e05404

    Abstract: Cerebral Venous Thrombosis is a rare extra-intestinal manifestation of ulcerative colitis. Ulcerative colitis is a hypercoagulable state and, if poorly managed, can predispose to thrombosis, including thrombosis of the cerebral veins. ...

    Abstract Cerebral Venous Thrombosis is a rare extra-intestinal manifestation of ulcerative colitis. Ulcerative colitis is a hypercoagulable state and, if poorly managed, can predispose to thrombosis, including thrombosis of the cerebral veins.
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5404
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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