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  1. Article: The nutrition and therapeutic potential of millets: an updated narrative review.

    Jacob, Jinu / Krishnan, Veda / Antony, Chris / Bhavyasri, Masimukka / Aruna, C / Mishra, Kiran / Nepolean, Thirunavukkarasu / Satyavathi, Chellapilla Tara / Visarada, Kurella B R S

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1346869

    Abstract: Millets are ancient small grains grown in arid and semiarid regions of the world. They are staple food for many people in Asia and Africa. They are abundant sources of minerals and vitamins, giving them the name Nutricereals. Moreover, millets contain ... ...

    Abstract Millets are ancient small grains grown in arid and semiarid regions of the world. They are staple food for many people in Asia and Africa. They are abundant sources of minerals and vitamins, giving them the name Nutricereals. Moreover, millets contain valuable phytochemicals that impart therapeutic properties for various disorders and diseases, thus giving them nutraceutical value. A wide array of biochemical compounds are present in the plant parts as well as the grains. In the oldest texts of medicine in India and China, millets are mentioned for use for their medicinal value. There has been expanding interest and emerging facts about millets and their therapeutic uses. Ample evidence shows that consumption of millets amounts to correction of life style and metabolic disorders. Therapeutic properties of millets can be viewed in two ways, supplementary nutrition through minerals and vitamins, and therapeutic value through the presence of phytochemicals and specialty compounds that include flavonoids, phenolics, anthocyanidins and others that have antioxidant potential. Millets are gluten free, have low glycemic index and the phytochemicals aid in correction of lifestyle disorders and prevention of ailments like carcinogenesis. Supplementary benefits include treatment of anemia and calcium deficiency especially for pregnant women and young children. With the improvements in analytical methods for detection of various compounds, it is possible to identify the compound-specific genotypes in millets that can cater to the pharmacy industry. End-use specific genotypes can be bred to meet the demand. Millets being climate resilient, can contribute to a healthier life and better world through economic usage of natural resources.
    Language English
    Publishing date 2024-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1346869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Identification of stable reference gene for transcript normalization in black pepper-

    Umadevi, P / Suraby, E J / Anandaraj, M / Nepolean, T

    Physiology and molecular biology of plants : an international journal of functional plant biology

    2019  Volume 25, Issue 4, Page(s) 945–952

    Abstract: A systematic validation of reference genes is a pre-requisite for the proper normalization of gene transcripts. In the present study, the annotated sequences from black pepper ( ...

    Abstract A systematic validation of reference genes is a pre-requisite for the proper normalization of gene transcripts. In the present study, the annotated sequences from black pepper (
    Language English
    Publishing date 2019-05-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2487126-6
    ISSN 0974-0430 ; 0971-5894
    ISSN (online) 0974-0430
    ISSN 0971-5894
    DOI 10.1007/s12298-019-00653-9
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  3. Conference proceedings ; Online: Identification of Fe and Zn Responsive Genes in Pearl Millet (Pennisetum glaucum L.) through Whole Genome Transcriptome Approach

    Goud, Anjali C / Vanisre, S / Govindaraj, M / Nepolean, T

    2020  

    Abstract: Micronutrient malnutrition due to iron and zinc deficiencies is a serious public health problem in developing countries. In India alone, about 80% of the pregnant women and 74% of children suffer from iron and zinc deficiency. At present, knowledge of ... ...

    Abstract Micronutrient malnutrition due to iron and zinc deficiencies is a serious public health problem in developing countries. In India alone, about 80% of the pregnant women and 74% of children suffer from iron and zinc deficiency. At present, knowledge of the genes controlling specific steps in the Fe and Zn pathways is still rudimentary hence studying genes of Fe and Zn density has become important. A whole genome RNA-Seq approach was carried out to understand the genes and pathways related to Fe and Zn accumulation in pearl millet. Seedlings of a high Fe and Zn grain density pearl millet inbred ICMB 1505 were exposed to four Fe and Zn stress treatments namely, –Fe –Zn, –Fe +Zn, +Fe –Zn and +Fe +Zn in hydroponics for 12 days (Figure 1). Seedlings were expressed interveinal chlorosis in the leaves due to the non-availability of Fe and Zn compared to control during the stress treatments. At that time, the leaf and root tissues in four treatments were harvested separately. Total RNA was extracted from the treated samples followed by cDNA synthesis. Illumina HiSeq 2500 platform was used to sequence the constructed cDNA libraries. Analysis of differentially expressed genes and pathways associated Fe and Zn is underway. Simultaneously, a set of 40 genotypes with variable Fe and Zn grain density were selected and tissue samples from different plant parts such as seed, flag leaf, root, stem sheath, panicles at anthesis and panicle at milky-stage were collected. RNA was extracted from the samples to validate the genes associated with Fe and Zn homeostasis. The information will be used for accelerated breeding programmes to improve the Fe and Zn density in pearl millet.
    Keywords Plant Breeding ; Pearl Millet ; Plant Nutrition ; Food and Nutrition
    Subject code 580
    Language English
    Publishing country in
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Identification of genes controlling compatible and incompatible reactions of pearl millet (Pennisetum glaucum) against blast (Magnaporthe grisea) pathogen through RNA-Seq

    Singh, S / Sharma, R / Nepolean, T / Nayak, S N / Pushpavathi, B / Khan, A W / Srivastava, R K / Varshney, R K

    2022  

    Abstract: Blast [Magnaporthe grisea (Herbert) Barr] is an economically important disease in Asian pearl millet production ecologies. The recurrent occurrence of blast in the past one decade has caused enormous strain on grain and forage production. Identification ... ...

    Abstract Blast [Magnaporthe grisea (Herbert) Barr] is an economically important disease in Asian pearl millet production ecologies. The recurrent occurrence of blast in the past one decade has caused enormous strain on grain and forage production. Identification of resistance genes is an important step to develop durable varieties. The present study is the first attempt to use RNA-Seq to investigate the transcript dynamics in a pearl millet inbred ICMB 93333, which had a unique differential reaction to two isolates—Pg 45 (avirulent) and Pg 174 (virulent) of M. grisea. The inbred was inoculated by both isolates and samples taken at six different time intervals for genome-wide RNA-Seq experiment. The transcriptome results revealed the differential expression of more than 2,300 genes. The time-specific comparison showed activation or repression of specific genes in various pathways. Genes and transcriptions factors related to pathogenesis-related proteins, reactive oxygen species generating and its scavenging genes, cell wall defense, primary and secondary metabolic pathways, and signaling pathways were identified by comparing the host-plant compatible and incompatible interactions. The genes identified from this experiment could be useful to understand the host-plant resistance and design novel strategies to manage blast disease in pearl millet.
    Keywords Pearl Millet ; Genetics and Genomics ; Plant Pathology
    Subject code 580
    Language English
    Publishing date 2022-09-23
    Publisher Frontiers Media
    Publishing country in
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Mapping QTLs for important agronomic traits in an Iniadi-derived immortal population of pearl millet

    Kumar, Sushil / Hash, Charles Thomas / Singh, Govind / Nepolean, T. / Srivastava, Rakesh K.

    Biotechnology notes. 2021, v. 2

    2021  

    Abstract: Pearl millet [Pennisetum glaucum (L.) R. Br.] is a climate-hardy nutricereal and an essential staple for the people living in dry regions. Substantial improvement has been achieved for seed yield stability in pearl millet, the cultivable area under pearl ...

    Abstract Pearl millet [Pennisetum glaucum (L.) R. Br.] is a climate-hardy nutricereal and an essential staple for the people living in dry regions. Substantial improvement has been achieved for seed yield stability in pearl millet, the cultivable area under pearl millet reduces. Deployment of early-flowering, bold-seeded and dwarf genotypes in pearl millet is a vital breeding strategy to improve grain production and enhance the adaptability of pearl millet in low-input farms. Therefore, an experiment was performed for mapping agronomically important traits like flowering time (FT), plant height (PH), panicle length (PL), and 1000-grain weight (TGW) in 317 recombinant inbred line (RIL) population derived from ICMS 8511-S1-17-2-1-1-B-P03 × AIMP 92901-S1-183-2-2-B-08 cross. Broad-sense heritability estimates were high to very high, ranging from 0.52 (PL) to 0.86 (PH). FT showed a significant positive correlation with PH. A key QTL for FT was mapped on LG 1, 15 QTLs for PH scattered on 10 chromosomes, five QTLs for PL dispersed on four chromosomes, and two QTLs for TGW spanned linkage groups 3 and 7. One QTL on LG1 was common for FT and PH. Two major QTLs for PH, one each on LG4B/8 cM and LG7/110 cM were detected. The large effect QTL for TGW on LG7 had a phenotypic variance (R²) of 24.3%. The R² for PH and PL ranged between 5.2 - 24.5% and 5.0–11.5%, respectively. The QTLs mapped for FT and other agronomic traits in the current study can be exploited to develop elite hybrid parental genotypes/cultivars through marker-assisted breeding and genomic selection.
    Keywords Cenchrus americanus ; biotechnology ; cultivars ; early flowering ; heritability ; hybrids ; inbred lines ; marker-assisted selection ; panicles ; people ; phenotypic variation ; plant height ; seed yield
    Language English
    Size p. 26-32.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2665-9069
    DOI 10.1016/j.biotno.2021.06.001
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Genomics-Enabled Next-Generation Breeding Approaches for Developing System-Specific Drought Tolerant Hybrids in Maize.

    Nepolean, Thirunavukkarsau / Kaul, Jyoti / Mukri, Ganapati / Mittal, Shikha

    Frontiers in plant science

    2018  Volume 9, Page(s) 361

    Abstract: Breeding science has immensely contributed to the global food security. Several varieties and hybrids in different food crops including maize have been released through conventional breeding. The ever growing population, decreasing agricultural land, ... ...

    Abstract Breeding science has immensely contributed to the global food security. Several varieties and hybrids in different food crops including maize have been released through conventional breeding. The ever growing population, decreasing agricultural land, lowering water table, changing climate, and other variables pose tremendous challenge to the researchers to improve the production and productivity of food crops. Drought is one of the major problems to sustain and improve the productivity of food crops including maize in tropical and subtropical production systems. With advent of novel genomics and breeding tools, the way of doing breeding has been tremendously changed in the last two decades. Drought tolerance is a combination of several component traits with a quantitative mode of inheritance. Rapid DNA and RNA sequencing tools and high-throughput SNP genotyping techniques, trait mapping, functional characterization, genomic selection, rapid generation advancement, and other tools are now available to understand the genetics of drought tolerance and to accelerate the breeding cycle. Informatics play complementary role by managing the big-data generated from the large-scale genomics and breeding experiments. Genome editing is the latest technique to alter specific genes to improve the trait expression. Integration of novel genomics, next-generation breeding, and informatics tools will accelerate the stress breeding process and increase the genetic gain under different production systems.
    Language English
    Publishing date 2018-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2018.00361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Identification of genes controlling compatible and incompatible reactions of pearl millet (

    Singh, Shweta / Sharma, Rajan / Nepolean, Thirunavukkarasu / Nayak, Spurthi N / Pushpavathi, Bheemavarapu / Khan, Aamir W / Srivastava, Rakesh K / Varshney, Rajeev K

    Frontiers in plant science

    2022  Volume 13, Page(s) 981295

    Abstract: Blast [ ...

    Abstract Blast [
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.981295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Thesis ; Online: Identification of QTLs for yield and its component traits, and downy mildrew (Sclerospora graminicola (Sacc.) J. Schrot.) resistance in pearl millet (Pennisetum glaucum (L.)R. Br)

    Nepolean, T

    2002  

    Keywords Millets
    Language English
    Publishing country in
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Thesis ; Online: Identification of QTLs for yield and its component traits, and downy mildrew (Sclerospora graminicola (Sacc.) J. Schrot.) resistance in pearl millet (Pennisetum glaucum (L.)R. Br)

    Nepolean, T

    2002  

    Keywords Millets
    Language English
    Publishing country in
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  10. Article: Identification of stable reference gene for transcript normalization in black pepper-Phytophthora capsici pathosystem

    Umadevi, P / Suraby, E. J / Anandaraj, M / Nepolean, T

    Physiology and molecular biology of plants. 2019 July, v. 25, no. 4

    2019  

    Abstract: A systematic validation of reference genes is a pre-requisite for the proper normalization of gene transcripts. In the present study, the annotated sequences from black pepper (Piper nigrum L.) leaf transcriptome were used as reference genes namely actin ...

    Abstract A systematic validation of reference genes is a pre-requisite for the proper normalization of gene transcripts. In the present study, the annotated sequences from black pepper (Piper nigrum L.) leaf transcriptome were used as reference genes namely actin (PnACT), glyceraldehyde phosphate dehydrogenase (PnGAPDH), β-tubulin (PnTUB), ubiquitin conjugating enzyme (PnUBCE), 18srRNA and elongation factor-1-α (PnElF) to identify the stable reference gene. We focused the selection of stable reference gene on important biotic stress (Phytophthora) with different algorithms (geNorm, NormFinder and BestKeeper) along with Reffinder which resulted in identification of PnGAPDH and PnUBCE as stable genes. Norm qPCR (R package) was also used to estimate the stability of the selected genes. We elucidated the expression patterns of a target gene PnBGLU which codes for 1,3 beta glucanase with most stable as well as least stable reference genes by which the importance of selecting the stable gene for gene expression studies in this system was emphasized. The mean expression levels of PnBGLU was significantly overestimated and misinterpreted when least stable reference gene was used as normalizer. The selected reference genes on further analysis of the expression dynamics of PnBGLU among resistant and susceptible genotypes showed PnGAPDH as the suitable reference gene for P. nigrum–P. capsici pathosystem.
    Keywords Phytophthora ; Piper nigrum ; actin ; aldehyde oxidoreductases ; algorithms ; biotic stress ; black pepper ; computer software ; gene expression ; genes ; genotype ; leaves ; messenger RNA ; quantitative polymerase chain reaction ; transcriptome ; tubulin ; ubiquitin
    Language English
    Dates of publication 2019-07
    Size p. 945-952.
    Publishing place Springer India
    Document type Article
    ZDB-ID 2487126-6
    ISSN 0974-0430 ; 0971-5894
    ISSN (online) 0974-0430
    ISSN 0971-5894
    DOI 10.1007/s12298-019-00653-9
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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