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  1. Book: Personalized treatment options in dermatology

    Bieber, Thomas / Nestle, F. O

    2015  

    Author's details Thomas Bieber, Frank Nestle, editors
    MeSH term(s) Skin Diseases/therapy ; Dermatology ; Precision Medicine/methods
    Language English
    Size v, 146 pages :, illustrations
    Document type Book
    ISBN 9783662458396 ; 366245839X ; 9783662458402 ; 3662458403
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article: Vaccines and melanoma.

    Nestle, F O

    Clinical and experimental dermatology

    2003  Volume 27, Issue 7, Page(s) 597–601

    Abstract: Melanoma is one of the prototypic immunogenic tumors. Various immunotherapeutic approaches for melanoma have been developed in the past decades. Recent scientific progress includes the discovery of defined melanoma antigens, new tools for monitoring of ... ...

    Abstract Melanoma is one of the prototypic immunogenic tumors. Various immunotherapeutic approaches for melanoma have been developed in the past decades. Recent scientific progress includes the discovery of defined melanoma antigens, new tools for monitoring of an anti-cancer immune response and application of novel adjuvants for amplification of the immune response such as dendritic cells. These and other advances in the field of melanoma vaccines will be discussed.
    MeSH term(s) Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Dendritic Cells/immunology ; Humans ; Melanoma/immunology ; Melanoma/prevention & control ; Skin Neoplasms/immunology ; Skin Neoplasms/prevention & control
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2003-01-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1046/j.1365-2230.2002.01152.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1278: Show issues Location:
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  3. Article: Dendritic cell vaccination for cancer therapy.

    Nestle, F O

    Oncogene

    2000  Volume 19, Issue 56, Page(s) 6673–6679

    Abstract: A growing list of defined tumor-antigens opens the way to antigen specific immunotherapy of cancer. However current approaches are often limited in their potential to induce an effective anti-tumor response. Dendritic cells (DC) are natural adjuvants for ...

    Abstract A growing list of defined tumor-antigens opens the way to antigen specific immunotherapy of cancer. However current approaches are often limited in their potential to induce an effective anti-tumor response. Dendritic cells (DC) are natural adjuvants for the induction of antigen specific T cell response. They have been successfully used in clinical pilot trials to induce tumor specific immunity as well as clinical response in selected patients. Current research focuses on optimization of DC source, choice of antigen, antigen loading, mode of injection, as well as immuno-monitoring. Finally, a variety of immune escape mechanisms are operative at the tumor site and have to be overcome for successful vaccination.
    MeSH term(s) Antigens, Neoplasm/immunology ; Clinical Trials as Topic ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; Forecasting ; Hematopoietic Stem Cells/immunology ; Humans ; Immunotherapy, Adoptive ; Melanoma/therapy ; Neoplasms/immunology ; Neoplasms/therapy ; Vaccination
    Chemical Substances Antigens, Neoplasm
    Language English
    Publishing date 2000-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/sj.onc.1204095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Konzepte zur Immunintervention bei Psoriasis vulgaris.

    Nestle, F O

    Praxis

    2000  Volume 89, Issue 37, Page(s) 1468–1470

    Abstract: Psoriasis vulgaris is a chronic inflammatory skin condition with a genetic background. Activated T-cells and their secreted products seem to play an essential role in the induction as well as the promotion of the psoriatic plaque. We will focus on some ... ...

    Title translation Concepts for immune intervention in psoriasis vulgaris.
    Abstract Psoriasis vulgaris is a chronic inflammatory skin condition with a genetic background. Activated T-cells and their secreted products seem to play an essential role in the induction as well as the promotion of the psoriatic plaque. We will focus on some recent concepts on the immunopathogenesis of psoriasis highlighting the role of dendritic cells as initiators of the disease as well as the recruitment of disease specific T-cells. Concepts for immunointervention will be introduced.
    MeSH term(s) Chemokines/antagonists & inhibitors ; Chemokines/physiology ; Cytokines/antagonists & inhibitors ; Cytokines/physiology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Interleukin-10/adverse effects ; Interleukin-10/therapeutic use ; Psoriasis/drug therapy ; Psoriasis/immunology ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th2 Cells/drug effects ; Th2 Cells/immunology
    Chemical Substances Chemokines ; Cytokines ; Immunosuppressive Agents ; Interleukin-10 (130068-27-8)
    Language German
    Publishing date 2000-09-14
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Melanoma vaccines in development: looking to the future.

    Dummer, R / Nestle, F O

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2007  Volume 13, Issue 4, Page(s) 227–231

    Abstract: There is a body of evidence indicating that melanoma is an antigenic tumour. Since the efficacy of standard therapy in advanced stages of melanoma is rather poor, experimental immunotherapy aims to target this aggressive neoplasm. After the ... ...

    Abstract There is a body of evidence indicating that melanoma is an antigenic tumour. Since the efficacy of standard therapy in advanced stages of melanoma is rather poor, experimental immunotherapy aims to target this aggressive neoplasm. After the identification of several melanoma antigens, vaccination trials have been initiated in patients with metastatic disease using peptides, dendritic cells and gene therapy approaches including viral vectors or naked DNA. If the problems in inducing a constant and potent T cell response are solved, the stability of melanoma antigens and their presentation will decide whether these treatment approaches will reach significant relevance in daily clinical practice.
    Language English
    Publishing date 2007-10-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.2165/00063030-200013040-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4112: Show issues Location:
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  6. Book: 85 Jahre Universitätsklinik für Dermatologie und Venerologie Zürich (1916-2001)

    Nestle, F. O

    eine Bilanz der letzten 10 Jahre anlässlich des 60. Geburtstages von Herrn Professor Dr. G. Burg

    2001  

    Institution Universitätsklinik für Dermatologie und Venerologie (Zurich (Switzerland))
    Author's details herausgegeben von F. Nestle und R. Dummer
    MeSH term(s) Hospitals, University/history ; Dermatology/history
    Keywords Switzerland
    Language German
    Size xvii, 212 p. :, ill., ports.
    Publisher Steinkopff
    Publishing place Darmstadt
    Document type Book
    ISBN 9783798512894 ; 3798512892
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Dermatologic immunity

    Nickoloff, Brian J / Nestle, F. O

    (Current directions in autoimmunity, ; v. 10)

    2008  

    Author's details volume editors, Brian J. Nickoloff, Frank O. Nestle
    Series title Current directions in autoimmunity, ; v. 10
    MeSH term(s) Skin Diseases/immunology ; Immune System Diseases
    Language English
    Size viii, 381 p. :, ill.
    Publisher Karger
    Publishing place Basel ; New York
    Document type Book
    ISBN 9783805583916 ; 9783805583923 ; 3805583915 ; 3805583923
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Progress in understanding the immunopathogenesis of psoriasis.

    Mak, R K H / Hundhausen, C / Nestle, F O

    Actas dermo-sifiliograficas

    2010  Volume 100 Suppl 2, Page(s) 2–13

    Abstract: This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms ... ...

    Abstract This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms behind psoriasis is described. The roles of different components of the adaptive and innate immune systems involved in driving the inflammatory response are explained. Discovery of new immune pathways i.e. the IL23/Th17 axis and its subsequent impact on the development of novel biological therapies is highlighted. Identification of potential targets warranting further research for future therapeutic development are also discussed.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Interleukin-12/immunology ; Psoriasis/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2010-01-22
    Publishing country Spain
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 390255-9
    ISSN 0001-7310 ; 1138-8196
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/s0001-7310(09)73372-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Melanomvakzinierung

    Nestle, F. O.

    H+G

    2002  Volume 77, Issue 12, Page(s) 675

    Language German
    Document type Article
    ZDB-ID 124647-1
    Database Current Contents Medicine

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  10. Article: From classical mouse models of psoriasis to a spontaneous xenograft model featuring use of AGR mice.

    Nestle, F O / Nickoloff, B J

    Ernst Schering Research Foundation workshop

    2004  , Issue 50, Page(s) 203–212

    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Mutation/genetics ; Psoriasis/genetics ; Psoriasis/immunology ; Psoriasis/therapy ; Transplantation, Heterologous/immunology
    Language English
    Publishing date 2004-10-22
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0947-6075
    ISSN 0947-6075
    DOI 10.1007/3-540-26811-1_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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