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  1. Article ; Online: Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets.

    Rechberger, Julian S / Nesvick, Cody L / Daniels, David J

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 3, Page(s) 187–192

    MeSH term(s) Humans ; Neoplasms, Neuroepithelial ; Rhabdoid Tumor/drug therapy ; Rhabdoid Tumor/pathology ; Teratoma/drug therapy ; Teratoma/pathology
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2040017
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    Zs.A 5244: Show issues Location:
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  2. Article ; Online: H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics.

    Rechberger, Julian S / Power, Blake T / Power, Erica A / Nesvick, Cody L / Daniels, David J

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 1, Page(s) 9–17

    Abstract: Introduction: Despite much progress, the prognosis for H3K27-altered diffuse midline glioma (DMG), previously known as diffuse intrinsic pontine glioma when located in the brainstem, remains dark and dismal.: Areas covered: A wealth of research over ... ...

    Abstract Introduction: Despite much progress, the prognosis for H3K27-altered diffuse midline glioma (DMG), previously known as diffuse intrinsic pontine glioma when located in the brainstem, remains dark and dismal.
    Areas covered: A wealth of research over the past decade has revolutionized our understanding of the molecular basis of DMG, revealing potential targetable vulnerabilities for treatment of this lethal childhood cancer. However, obstacles to successful clinical implementation of novel therapies remain, including effective delivery across the blood-brain barrier (BBB) to the tumor site. Here, we review relevant literature and clinical trials and discuss direct drug delivery via convection-enhanced delivery (CED) as a promising treatment modality for DMG. We outline a comprehensive molecular, pharmacological, and procedural approach that may offer hope for afflicted patients and their families.
    Expert opinion: Challenges remain in successful drug delivery to DMG. While CED and other techniques offer a chance to bypass the BBB, the variables influencing successful intratumoral targeting are numerous and complex. We discuss these variables and potential solutions that could lead to the successful clinical implementation of preclinically promising therapeutic agents.
    MeSH term(s) Humans ; Child ; Glioma/pathology ; Brain Stem Neoplasms/drug therapy ; Blood-Brain Barrier/pathology ; Prognosis ; Drug Delivery Systems
    Language English
    Publishing date 2023-02-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2177531
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  3. Article ; Online: Teaching NeuroImage: Olfactory Stem Cell Injection Inducing Actively Secreting Respiratory Epithelium in a Cervical Syrinx.

    Rotter, Juliana / Kumar, Rahul / Nesvick, Cody L / Krauss, William E / Giannini, Caterina / Tobin, William O

    Neurology

    2023  Volume 101, Issue 11, Page(s) 497–498

    MeSH term(s) Humans ; Stem Cells ; Respiratory Mucosa ; Neck
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207463
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  4. Article ; Online: Feasibility of probe washing after stereotactic needle biopsy as a novel technique for developing cell lines and xenografts of H3 K27-altered diffuse midline gliomas.

    Rechberger, Julian S / Zhang, Liang / Ge, Jizhi / Nesvick, Cody L / Miller, Kai J / Daniels, David J

    Journal of neurosurgery. Pediatrics

    2023  Volume 32, Issue 4, Page(s) 413–420

    Abstract: H3 K27-altered diffuse midline gliomas (DMGs) are frequently biopsied to obtain tissue diagnosis, inform clinical decision-making, and determine clinical trial eligibility. Tissue yield from biopsies is typically low, leaving little material available ... ...

    Abstract H3 K27-altered diffuse midline gliomas (DMGs) are frequently biopsied to obtain tissue diagnosis, inform clinical decision-making, and determine clinical trial eligibility. Tissue yield from biopsies is typically low, leaving little material available for research. To advance understanding of disease biology and promote preclinical testing of novel therapeutics, collecting viable cellular material from treatment-naive tumors is of paramount importance. Here, the authors report the feasibility of a practicable technique for creating DMG cell lines and patient-derived xenografts (PDXs) without the need for additional biopsy specimens. Tumor cells are obtained by probe washing immediately after completion of biopsy. Wash fluid is collected, and viable cells are expanded in vitro. Cultured cells are used to establish PDX rodent models. A total of 5 patient samples were collected by this technique. Viable tumor cells were obtained from 3 of the 5 samples, and cell lines suitable for experiments were obtained within 6-8 months. Orthotopic implantation and flank engraftment was successful in 1 of the 3 established cell lines. Animals harboring intracranial tumors were euthanized due to disease burden 6-7 months after stereotactic injection. Flank tumors formed within 4-5 months and were serially passaged. Molecular and tissue analyses confirmed retention of H3 K27M expression and loss of H3 K27me3 in all cell lines and PDXs.
    MeSH term(s) Animals ; Humans ; Glioma/pathology ; Histones/genetics ; Heterografts ; Feasibility Studies ; Brain Neoplasms/pathology ; Biopsy ; Biopsy, Needle ; Cell Line ; Mutation
    Chemical Substances Histones
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2023.5.PEDS22557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pretruncal Subarachnoid Hemorrhage in a Patient with Cerebrospinal Fluid Leak.

    Scheitler, Kristen M / Nesvick, Cody L / Wijdicks, Eelco F

    Neurocritical care

    2020  Volume 34, Issue 1, Page(s) 350–353

    MeSH term(s) Cerebral Angiography ; Cerebrospinal Fluid ; Cerebrospinal Fluid Leak/etiology ; Humans ; Subarachnoid Hemorrhage/etiology
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-020-01030-1
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  6. Article ; Online: Asymptomatic superficial siderosis after posterior fossa tumor resection: illustrative case.

    Goyal, Anshit / Nesvick, Cody L / Spear, Joshua A / Daniels, David J

    Journal of neurosurgery. Case lessons

    2021  Volume 1, Issue 18, Page(s) CASE2174

    Abstract: Background: Superficial siderosis of the central nervous system is a rare syndrome notable for the presence of hemosiderin deposition due to chronic, repetitive hemorrhages into the subarachnoid space.: Observations: The authors presented a case of ... ...

    Abstract Background: Superficial siderosis of the central nervous system is a rare syndrome notable for the presence of hemosiderin deposition due to chronic, repetitive hemorrhages into the subarachnoid space.
    Observations: The authors presented a case of superficial siderosis in a 14-year-old girl. It arose as a late postoperative complication after resection of a medulloblastoma. Despite the patient being asymptomatic, surveillance imaging demonstrated diffuse hemosiderin deposition within the cerebellar folia and cisternal segments of cranial nerves VII and VIII on gradient echo (GRE) sequences. Formal audiometric testing demonstrated bilateral loss of high-frequency tone recognition consistent with early sensorineural hearing loss. A pseudomeningocele due to multiple dural defects was identified as the likely cause, and definitive surgical repair was performed. Intraoperatively, the presence of blood-tinged cerebrospinal fluid confirmed a diagnosis of superficial siderosis.
    Lessons: This case highlighted the potential need to routinely include GRE or susceptibility-weighted sequences in postoperative surveillance imaging after resection of pediatric posterior fossa tumors.
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Case Reports
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE2174
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  7. Article ; Online: Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies.

    Rechberger, Julian S / Bouchal, Samantha M / Power, Erica A / Nonnenbroich, Leo F / Nesvick, Cody L / Daniels, David J

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 11, Page(s) 1071–1086

    Abstract: Introduction: H3 K27-altered diffuse midline glioma (DMG) is the most common malignant brainstem tumor in the pediatric population. Despite enormous preclinical and clinical efforts, the prognosis remains dismal, with fewer than 10% of patients ... ...

    Abstract Introduction: H3 K27-altered diffuse midline glioma (DMG) is the most common malignant brainstem tumor in the pediatric population. Despite enormous preclinical and clinical efforts, the prognosis remains dismal, with fewer than 10% of patients surviving for two years after diagnosis. Fractionated radiation remains the only standard treatment options for DMG. Developing novel treatments and therapeutic delivery methods is critical to improving outcomes in this devastating disease.
    Areas covered: This review addresses recent advances in molecularly targeted pharmacotherapy and immunotherapy in DMG. The clinical presentation, diagnostic workup, unique pathological challenges, and current clinical trials are highlighted throughout.
    Expert opinion: Promising pharmacotherapies targeting various components of DMG pathology and the application of immunotherapies have the potential to improve patient outcomes. However, novel approaches are needed to truly revolutionize treatment for this tumor. First, combinational therapy should be employed, as DMG can develop resistance to single-agent approaches and many therapies are susceptible to rapid clearance from the brain. Second, drug-tumor residence time, i.e. the time for which a therapeutic is present at efficacious concentrations within the tumor, must be maximized to facilitate a durable treatment response. Engineering extended drug delivery methods with minimal off-tumor toxicity should be a focus of future studies.
    MeSH term(s) Humans ; Child ; Glioma/drug therapy ; Glioma/pathology ; Histones ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Brain ; Prognosis ; Mutation
    Chemical Substances Histones
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2277232
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    Zs.A 5244: Show issues Location:
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  8. Article ; Online: Safety of immediate use of nonsteroidal antiinflammatory drugs after pediatric craniotomy for tumor.

    Nesvick, Cody L / Oushy, Soliman / Daniels, David J / Ahn, Edward S

    Journal of neurosurgery. Pediatrics

    2020  Volume 26, Issue 3, Page(s) 327–333

    Abstract: Objective: Postoperative pain can limit the recovery of children undergoing craniotomy for tumor resection, and pain management is highly variable between institutions and practitioners. Nonsteroidal antiinflammatory drugs (NSAIDs) are effective in ... ...

    Abstract Objective: Postoperative pain can limit the recovery of children undergoing craniotomy for tumor resection, and pain management is highly variable between institutions and practitioners. Nonsteroidal antiinflammatory drugs (NSAIDs) are effective in treating postoperative pain following craniotomy, but their use has been limited by concerns about postoperative hemorrhage. The risk of postoperative hemorrhage is not insignificant in patients undergoing craniotomy for tumor resection. No study has specifically addressed the safety of NSAIDs in the immediate postoperative setting following craniotomy for tumor resection in pediatric patients.
    Methods: The authors performed a retrospective cohort study in patients younger than 18 years of age who underwent craniotomy for tumor resection at a single tertiary referral center between 2009 and 2019. The study outcomes were 1) postoperative hemorrhage requiring return to the operating room for decompression, evacuation, or CSF diversion for hemorrhage-associated hydrocephalus; and 2) more-than-minimal hemorrhage on routine postoperative imaging. Patients receiving any NSAID in the hospital formulary on the same day as surgery (postoperative day zero [POD0]) were designated as such.
    Results: Two hundred seventy-six children underwent 308 craniotomies for tumor resection over the study period. One hundred fifty-four patients (50.0%) received at least one dose of an NSAID on POD0. Six patients (1.9%) required a return to the operating room for a hemorrhagic complication, including 3 who received an NSAID on POD0 (OR 1.00, 95% CI 0.20-5.03). Seventeen patients (6.3% of patients imaged) had more-than-minimal hemorrhage on routine postoperative imaging, 9 of whom received an NSAID on POD0 (OR 1.08, 95% CI 0.40-2.89).
    Conclusions: Use of NSAIDs on POD0 was not associated with either an increased risk of hemorrhage requiring a return to the operating room or asymptomatic hemorrhage on routine postoperative imaging. The overall incidence of clinically significant postoperative intracranial hemorrhage is low. These data support the use of NSAIDs as a safe measure for pain control in the postoperative setting for children undergoing craniotomy for tumor resection.
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2020.4.PEDS2055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Efficacy and safety of bevacizumab in progressive pediatric low-grade glioma: a systematic review and meta-analysis of outcome rates.

    Lu, Victor M / Welby, John P / Nesvick, Cody L / Daniels, David J

    Neuro-oncology practice

    2020  Volume 7, Issue 4, Page(s) 359–368

    Abstract: Background: Successful management of pediatric low-grade glioma (pLGG) can be complicated by eloquent anatomical location, as well as specific pathologic and molecular features. Some authors have proposed using the VEGF inhibitor bevacizumab to improve ... ...

    Abstract Background: Successful management of pediatric low-grade glioma (pLGG) can be complicated by eloquent anatomical location, as well as specific pathologic and molecular features. Some authors have proposed using the VEGF inhibitor bevacizumab to improve disease control, but its safety and efficacy are poorly defined. Correspondingly, our aim was to pool systematically identified clinical data in the literature to assess the clinical utility of bevacizumab for pLGG at progression.
    Methods: A systematic search of 7 electronic databases from inception to June 2019 was conducted following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. Articles were screened against prespecified criteria. Outcomes were then pooled by random-effects meta-analyses of proportions.
    Results: Seven pertinent studies described the outcomes of 110 progressive pLGG patients managed with bevacizumab in largely multiagent regimens. While on treatment, the rate of clinical response was 58% (95% CI, 43%-72%), and the rate of response on imaging was 80% (95% CI, 58%-96%). The rate of grade 3 or higher toxicity was 8% (95% CI, 2%-17%), with proteinuria the most commonly described. In the off-treatment period up to median 1 year, the rate of progression was estimated to be 51% (95% CI, 28%-74%).
    Conclusions: Bevacizumab has the potential to control clinical and radiographic disease with relatively low grade 3 or higher toxicity risk in progressive pLGG patients. However, the long-term off-treatment benefits of this therapy are not yet well defined. Heterogeneity in the literature precludes any formal recommendations regarding its use until larger, more standardized investigations can be performed.
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2768945-1
    ISSN 2054-2585 ; 2054-2577
    ISSN (online) 2054-2585
    ISSN 2054-2577
    DOI 10.1093/nop/npz076
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  10. Article ; Online: Precision Medicine in Pediatric Bithalamic Glioma: Significance of the EGFR exon 20 Insertion Mutation.

    Goyal, Anshit / Nesvick, Cody L / Raghunathan, Aditya / Schwartz, Jonathan D / Daniels, David J

    World neurosurgery

    2021  Volume 149, Page(s) 271–273

    MeSH term(s) Adolescent ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/surgery ; Child ; ErbB Receptors/genetics ; Exons/genetics ; Female ; Glioma/diagnostic imaging ; Glioma/genetics ; Glioma/surgery ; Humans ; Mutagenesis, Insertional/genetics ; Precision Medicine/methods ; Thalamus/diagnostic imaging ; Thalamus/surgery
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.03.009
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