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  1. Article ; Online: Monitoring Renal Function in HIV Patients Without Kidney Disease Using Endothelial Biomarkers: A Prospective Pilot Study.

    Cavalcante, Malena Gadelha / Gomes, Pedro Eduardo Andrade de Carvalho / Parente, Matheus de Sá Roriz / Meneses, Gdayllon Cavalcante / Silva Junior, Geraldo Bezerra da / Neto, Roberto da Justa Pires / Martins, Alice Maria Costa / Daher, Elizabeth De Francesco

    AIDS research and human retroviruses

    2023  Volume 39, Issue 9, Page(s) 468–474

    Abstract: This study aimed to investigate the association between novel biomarkers and renal injury in people with HIV (PWH). A cohort study was carried out with PWH under chronic use of antiretroviral therapy (ART), followed at a public outpatient service. ... ...

    Abstract This study aimed to investigate the association between novel biomarkers and renal injury in people with HIV (PWH). A cohort study was carried out with PWH under chronic use of antiretroviral therapy (ART), followed at a public outpatient service. Clinical and laboratory parameters of the patients were evaluated year by year, from 2015 [at baseline (year 1, Y1)] to 2019 [year 5 (Y5)]. At baseline, biomarkers of renal damage (e.g., neutrophil gelatinase-associated lipocalin-NGAL, monocyte chemoattractant protein-1-MCP-1, and kidney injury molecule-1-KIM-1) and endothelial activation or glycocalyx damage [e.g., intercellular adhesion molecule 1 (ICAM-1), E-selectin, and syndecan-1] were quantified using enzyme-linked immunosorbent assays and their levels were used to classify patients into different groups. However, only syndecan-1 showed a significant correlation with serum creatinine (
    MeSH term(s) Humans ; Pilot Projects ; Syndecan-1 ; Cohort Studies ; Prospective Studies ; Creatinine ; HIV Infections/complications ; HIV Infections/drug therapy ; Kidney/physiology ; Kidney Diseases ; Biomarkers ; Glomerular Filtration Rate
    Chemical Substances Syndecan-1 ; Creatinine (AYI8EX34EU) ; Biomarkers
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2022.0113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Cytokines, chemokines, and cells growth factors in patients with mild to moderate SARS-CoV-2 infection: A case-control study.

    Gondim, Rafhaella N D G / de Arruda, Erico Antônio Gomes / Neto, Roberto da Justa Pires / Medeiros, Melissa Soares / Quirino-Filho, José / Clementino, Marco A / Magalhães, Lyvia Maria Vasconcelos Carneiro / Cavalcante, Karene Ferreira / Viana, Vânia Angelica Feitosa / Mello, Liana Perdigão / Carlos, Luciana M B / Havt, Alexandre / Lima, Aldo A M

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e29044

    Abstract: Several biomarkers have been evaluated as predictors of severity or in directing the treatment of COVID-19, however there are no conclusive results. In this study, we evaluated serum levels of cytokines, chemokines, and cell growth factors in association ...

    Abstract Several biomarkers have been evaluated as predictors of severity or in directing the treatment of COVID-19, however there are no conclusive results. In this study, we evaluated serum levels of cytokines, chemokines, and cell growth factors in association with the pathobiology of mild to moderate SARS-CoV-2 infection. Serum levels of SARS-CoV-2 infected patients (n = 113) and flu symptoms individuals negative for SARS-CoV-2 (n = 58), tested by the RT-qPCR test-nasal swab were compared to healthy controls (n = 53). Results showed that the proinflammatory cytokines IL-1β, MCP-3, TNF-α, and G-CSF were increased in symptomatic patients and the cytokines IL-6 and IL-10 were associated with patients positive for SARS-CoV-2 when compared to healthy controls. Symptoms associated with COVID-19 were fever, anosmia, ageusia, and myalgia. For patients without SARS-CoV-2 infection, their major symptom was sore throat. The pathobiology of mild to moderate SARS-CoV-2 infection was associated with increasing proinflammatory cytokines and a pleiotropic IL-6 and anti-inflammatory IL-10 cytokines compared to healthy controls. Thus, knowledge about the pathophysiology and the involvement of biomarkers in the mild to moderate profile of the disease should be evaluated. Monitoring these biomarkers in patients with mild to moderate disease can help establish adequate treatment and prevention strategies for long-term COVID-19.
    MeSH term(s) Humans ; Cytokines ; Interleukin-10 ; Case-Control Studies ; Interleukin-6 ; COVID-19 ; SARS-CoV-2 ; Chemokines
    Chemical Substances Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-6 ; Chemokines
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Endothelial Glycocalyx Damage and Renal Dysfunction in HIV Patients Receiving Combined Antiretroviral Therapy.

    Meneses, Gdayllon Cavalcante / Cavalcante, Malena Gadelha / da Silva Junior, Geraldo Bezerra / Martins, Alice Maria Costa / Neto, Roberto da Justa Pires / Libório, Alexandre Braga / De Francesco Daher, Elizabeth

    AIDS research and human retroviruses

    2017  Volume 33, Issue 7, Page(s) 703–710

    Abstract: Widespread use of combined antiretroviral therapy (cART) increased HIV patients' life expectancy, however, favored the development of kidney and cardiovascular diseases. The aim of this study was to investigate endothelial glycocalyx (eGC) damage and its ...

    Abstract Widespread use of combined antiretroviral therapy (cART) increased HIV patients' life expectancy, however, favored the development of kidney and cardiovascular diseases. The aim of this study was to investigate endothelial glycocalyx (eGC) damage and its association with renal function in HIV patients receiving cART. This is a cross-sectional study with HIV-infected patients with no renal and cardiovascular disease, recruited in public health centers in Brazil. Clinical and laboratory parameters of HIV patients were compared according to cART use and with a healthy control group. Blood ICAM-1 and syndecan-1 levels were quantified by ELISA kit. Estimated glomerular filtration rate (eGFR) was evaluated. A total of 69 HIV patients were included, with mean age of 33.4 ± 8.9 years, and 77.3% were male. Serum urea, creatinine, and eGFR were similar in all groups. No HIV patient had decreased GFR <60 ml/min. All HIV patients had higher systemic syndecan-1 compared with healthy controls (71.8 ± 25.4 ng/ml vs. 36.5 ± 14.3 ng/ml, p < .001). Syndecan-1 showed a significant positive correlation with serum creatinine (r = 0.437, p = .001), serum urea levels (r = 0.352, p = .006), and a negative correlation with eGFR (r = -0.315, p = .015) in HIV patients. Syndecan-1 remained independently associated with serum creatinine and reduced GFR even after we forced variables related with HIV infection status, tenofovir use, treatment time, dyslipidemia, and others in a multivariate analysis. HIV patients using cART with no clinical renal and cardiovascular disease presented eGC damage and it is associated with clinical markers of kidney dysfunction. Syndecan-1 may be a useful early biomarker to monitoring renal dysfunction in HIV patients in chronic use of cART. Further research is needed to evaluate this applicability.
    MeSH term(s) Adolescent ; Adult ; Anti-Retroviral Agents/therapeutic use ; Brazil ; Creatinine/blood ; Cross-Sectional Studies ; Endothelial Cells/physiology ; Female ; Glomerular Filtration Rate ; Glycocalyx ; HIV Infections/drug therapy ; HIV Infections/pathology ; Humans ; Kidney/physiology ; Male ; Middle Aged ; Syndecan-1/blood ; Urea/blood ; Young Adult
    Chemical Substances Anti-Retroviral Agents ; SDC1 protein, human ; Syndecan-1 ; Urea (8W8T17847W) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2016.0284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: HIV or human papillomavirus co-infection among Brazilian individuals infected with hepatitis B and/or hepatitis C.

    Bomfim-Hyppólito, Silvia / Eleuterio, Jose / Nunes, George Chaves / Bomfim-Hyppólito, Elodie / Franco, Eugenio S / Neto, Roberto da Justa Pires

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2013  Volume 122, Issue 3, Page(s) 258–260

    Abstract: Objective: To investigate the incidence of co-infection with HIV and human papillomavirus (HPV) among Brazilian individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.: Methods: A prospective study was conducted that enrolled ... ...

    Abstract Objective: To investigate the incidence of co-infection with HIV and human papillomavirus (HPV) among Brazilian individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
    Methods: A prospective study was conducted that enrolled 103 individuals from the Ceará region of Brazil between January 4, 2010, and August 9, 2012. Eligible participants were men (n=45) or women (n=58) infected with HBV and/or HCV. Pap smears were collected from female patients. Material from male (urethra) and female (cervix) patients was then collected via DNA-HPV test and visual inspection with acetic acid.
    Results: In all, 48 participants tested positive for HBV and 55 tested positive for HCV; 2 had dual infection with HBV and HCV. Co-infection with HIV was detected among 15 participants, whereas 20 participants were found to be co-infected with HPV.
    Conclusion: A high prevalence of co-infection with HIV and HPV was detected among Brazilian individuals with HBV and/or HCV.
    MeSH term(s) Adult ; Brazil/epidemiology ; DNA, Viral/isolation & purification ; Female ; HIV Infections/epidemiology ; Hepatitis B/epidemiology ; Hepatitis C/epidemiology ; Humans ; Male ; Middle Aged ; Papanicolaou Test ; Papillomavirus Infections/epidemiology ; Prevalence ; Prospective Studies ; Vaginal Smears
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1016/j.ijgo.2013.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 183: Show issues

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