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  1. Article ; Online: Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR

    Lorenzini, Jenna / Scott Fites, J / Nett, Jeniel / Klein, Bruce S

    Cellular microbiology

    2017  Volume 19, Issue 9

    Abstract: Blastomycosis elicits a pyogranulomatous inflammatory response that involves a prominent recruitment of neutrophils to the site of infection. Although neutrophils are efficiently recruited to the site of infection, this event is paradoxically coupled ... ...

    Abstract Blastomycosis elicits a pyogranulomatous inflammatory response that involves a prominent recruitment of neutrophils to the site of infection. Although neutrophils are efficiently recruited to the site of infection, this event is paradoxically coupled with the host's inability to control infection by Blastomyces dermatitidis, the causative agent. The mechanisms underlying this characteristic pyogranulomatous response and inability of neutrophils to kill the yeast are poorly understood. We recently reported that the fungal protease dipeptidyl peptidase IVA (DppIVA) promotes B. dermatitidis virulence by cleaving a dipeptide from the N-terminus of C-C chemokines and granulocyte/macrophage-colony stimulating factor, thereby inactivating them. Herein, we present evidence that DppIVA can also truncate the N-terminus of members of the ELR
    MeSH term(s) Animals ; Blastomyces/enzymology ; Blastomyces/immunology ; Blastomycosis/immunology ; Blastomycosis/microbiology ; Cells, Cultured ; Chemokine CXCL1/metabolism ; Chemokine CXCL2/metabolism ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism ; Humans ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mice, Inbred C57BL ; Neutrophils/immunology ; Reactive Oxygen Species/immunology
    Chemical Substances Chemokine CXCL1 ; Chemokine CXCL2 ; Cxcl1 protein, mouse ; Cxcl2 protein, mouse ; Reactive Oxygen Species ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Mmp9 protein, mouse (EC 3.4.24.35)
    Language English
    Publishing date 2017-05-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/cmi.12741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The ethics of workplace diversity

    McNett, Jeanne

    Understanding and managing diversity , p. 278-290

    2009  , Page(s) 278–290

    Author's details Jeanne McNett
    Language English
    Size graph. Darst.
    Publisher Pearson/Prentice Hall
    Publishing place Upper Saddle River, NJ
    Document type Article
    Database ECONomics Information System

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  3. Article ; Online: Conservation and Divergence in the

    Dominguez, Eddie / Zarnowski, Robert / Sanchez, Hiram / Covelli, Antonio S / Westler, William M / Azadi, Parastoo / Nett, Jeniel / Mitchell, Aaron P / Andes, David R

    mBio

    2018  Volume 9, Issue 2

    Abstract: ... ...

    Abstract Candida
    MeSH term(s) Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Candida/chemistry ; Candida/drug effects ; Candida/genetics ; Candida/metabolism ; Drug Resistance, Fungal ; Enzymes/metabolism ; Extracellular Polymeric Substance Matrix/chemistry ; Extracellular Polymeric Substance Matrix/metabolism ; Glucans/chemistry ; Glucans/metabolism ; Mannans/chemistry ; Mannans/metabolism ; Metabolic Networks and Pathways
    Chemical Substances Antifungal Agents ; Enzymes ; Glucans ; Mannans
    Language English
    Publishing date 2018-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00451-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Medical emergency response in non-hospitalized patients (Code Whites) in a rural tertiary academic medical center: A 7 year observational study.

    Nett, Sholeen / Kong, Lixi / Nett, Josephine / Fussell, Melissa / Slogic, Scott T / Gill, Harman S / Braga, Matthew S

    Resuscitation

    2018  Volume 129, Page(s) 13–18

    MeSH term(s) Academic Medical Centers ; Aged ; Emergencies ; Emergency Responders/statistics & numerical data ; Female ; Follow-Up Studies ; Hospital Rapid Response Team/statistics & numerical data ; Hospitals, Rural ; Humans ; Male ; New Hampshire ; Patient Care Team ; Time Factors ; Triage
    Language English
    Publishing date 2018-05-24
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2018.05.027
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  5. Article: Candida albicans biofilm development, modeling a host-pathogen interaction.

    Nett, Jeniel / Andes, David

    Current opinion in microbiology

    2006  Volume 9, Issue 4, Page(s) 340–345

    Abstract: Medical device-associated infections involve the attachment of cells to a surface, production of an extracellular matrix and development of a mature biofilm. Many Candida albicans disease states involve biofilm growth. These infections have great impact ... ...

    Abstract Medical device-associated infections involve the attachment of cells to a surface, production of an extracellular matrix and development of a mature biofilm. Many Candida albicans disease states involve biofilm growth. These infections have great impact on public health because organisms in biofilms exhibit dramatically reduced susceptibility to antifungal therapy. Progression to a mature biofilm is dependent on cell adhesion, extracellular matrix production and the yeast-to-hyphae transition. Numerous in vitro biofilm model systems have been successfully used to examine biofilm architecture, development, cell phenotypes and drug resistance. Although these studies have included a number of experimental variables to mimic infections in patients, it is difficult to accurately account for the multitude of host and infection-site variables that are probably important in humans. Recent studies have begun to explore C. albicans biofilms using animal biofilm infection models in order to more completely reflect the complexity of this host-fungal interaction.
    MeSH term(s) Animals ; Biofilms/growth & development ; Candida albicans/physiology ; Equipment and Supplies/microbiology ; Humans ; Models, Biological
    Language English
    Publishing date 2006-06-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2006.06.007
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  6. Article: Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole.

    Lepak, A / Nett, J / Lincoln, L / Marchillo, K / Andes, D

    Antimicrobial agents and chemotherapy

    2005  Volume 50, Issue 4, Page(s) 1311–1319

    Abstract: Pharmacodynamics (PD) considers the relationship between drug exposure and effect. The two factors that have been used to distinguish the PD behaviors of antimicrobials are the impact of concentration on the extent of organism killing and the duration of ...

    Abstract Pharmacodynamics (PD) considers the relationship between drug exposure and effect. The two factors that have been used to distinguish the PD behaviors of antimicrobials are the impact of concentration on the extent of organism killing and the duration of persistent microbiologic suppression (postantibiotic effect). The goals of these studies were (i) to examine the relationship between antimicrobial PD and gene expression and (ii) to gain insight into the mechanism of fluconazole effects persisting following exposure. Microarrays were used to estimate the transcriptional response of Candida albicans to a supra-MIC F exposure over time in vitro. Fluconazole at four times the MIC was added to a log-phase C. albicans culture, and cells were collected to determine viable growth and for microarray analyses. We identified differential expression of 18% of all genes for at least one of the time points. More genes were upregulated (n=1,053 [16%]) than downregulated (174 [3%]). Of genes with known function that were upregulated during exposure, most were related to plasma membrane/cell wall synthesis (18%), stress responses (7%), and metabolism (6%). The categories of downregulated genes during exposure included protein synthesis (15%), DNA synthesis/repair (7%), and transport (7%) genes. The majority of genes identified at the postexposure time points were from the protein (17%) and DNA (7%) synthesis categories. In subsequent studies, three genes (CDR1, CDR2, and ERG11) were examined in greater detail (more concentration and time points) following fluconazole exposure in vitro and in vivo. Expression levels from the in vitro and in vivo studies were congruent. CDR1 and CDR2 transcripts were reduced during in vitro fluconazole exposure and during supra-MIC exposure in vivo. However, in the postexposure period, the mRNA abundance of both pumps increased. ERG11 expression increased during exposure and fell in the postexposure period. The expression of the three genes responded in a dose-dependent manner. In sum, the microarray data obtained during and following fluconazole exposure identified genes both known and unknown to be affected by this drug class. The expanded in vitro and in vivo expression data set underscores the importance of considering the time course of exposure in pharmacogenomic investigations.
    MeSH term(s) ATP-Binding Cassette Transporters/genetics ; Animals ; Antifungal Agents/pharmacology ; Candida albicans/drug effects ; Candida albicans/genetics ; Fluconazole/pharmacokinetics ; Fluconazole/pharmacology ; Fungal Proteins/genetics ; Gene Expression Profiling ; Membrane Transport Proteins/genetics ; Mice ; Microbial Sensitivity Tests ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/analysis
    Chemical Substances ATP-Binding Cassette Transporters ; Antifungal Agents ; CDR1 protein, Candida albicans ; Fungal Proteins ; Membrane Transport Proteins ; RNA, Messenger ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2005-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.50.4.1311-1319.2006
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  7. Article: In vivo fluconazole pharmacodynamics and resistance development in a previously susceptible Candida albicans population examined by microbiologic and transcriptional profiling.

    Andes, D / Lepak, A / Nett, J / Lincoln, L / Marchillo, K

    Antimicrobial agents and chemotherapy

    2005  Volume 50, Issue 7, Page(s) 2384–2394

    Abstract: Antimicrobial drug resistance can limit the ability to effectively treat patients. Numerous factors have been proposed to impact the development of antimicrobial resistance, including those specific to the drug and the dosing regimen. The field of ... ...

    Abstract Antimicrobial drug resistance can limit the ability to effectively treat patients. Numerous factors have been proposed to impact the development of antimicrobial resistance, including those specific to the drug and the dosing regimen. The field of investigation that examines the relationship between dosing regimen and outcome is termed antimicrobial pharmacokinetics and pharmacodynamics. Our prior in vivo investigations examined the relationship between fluconazole pharmacodynamics and the modulation of isogenic resistant and susceptible Candida albicans populations in a mixed-inoculum design (1). The goal of the current studies was to examine the impact of fluconazole pharmacodynamics on resistance emergence from a susceptible parent population over time using a murine systemic-candidiasis model. Both microbiologic and transcriptional endpoints were examined during the evolution of cell populations. As in our previous investigation, the more frequently administered dosing regimen prevented the emergence of a resistant cell phenotype. Conversely, dosing regimens that produced prolonged sub-MIC concentrations were associated with resistance development. The studies also demonstrated a striking relationship between fluconazole pharmacodynamic exposures and the mRNA abundance of drug resistance-associated efflux pumps. Global transcriptional profiling of cell populations during the progressive emergence of a resistance phenotype provides insight into the mechanisms underlying this complex physiologic process.
    MeSH term(s) Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans/drug effects ; Candida albicans/genetics ; Candida albicans/metabolism ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Colony Count, Microbial ; Drug Resistance, Fungal/genetics ; Female ; Fluconazole/administration & dosage ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Profiling ; Humans ; Mice ; Microbial Sensitivity Tests ; Specific Pathogen-Free Organisms ; Transcription, Genetic
    Chemical Substances Antifungal Agents ; Fungal Proteins ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2005-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01305-05
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  8. Article: Diversity in the workplace: ethics, pragmatism, or some of both?

    McNett, Jeanne

    Harvey : Carol P.

    2005  

    Author's details Jeanne McNett
    Language English
    Publisher Pearson Prentice Hall
    Publishing place Upper Saddle River, N.J
    Document type Article
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  9. Article: Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.

    Uppuluri, Priya / Nett, Jeniel / Heitman, Joseph / Andes, David

    Antimicrobial agents and chemotherapy

    2008  Volume 52, Issue 3, Page(s) 1127–1132

    Abstract: Calcineurin is a Ca2+-calmodulin-activated serine/threonine-specific protein phosphatase that governs multiple aspects of fungal physiology, including cation homeostasis, morphogenesis, antifungal drug susceptibility, and virulence. Growth of Candida ... ...

    Abstract Calcineurin is a Ca2+-calmodulin-activated serine/threonine-specific protein phosphatase that governs multiple aspects of fungal physiology, including cation homeostasis, morphogenesis, antifungal drug susceptibility, and virulence. Growth of Candida albicans planktonic cells is sensitive to the calcineurin inhibitors FK506 and cyclosporine A (CsA) in combination with the azole antifungal fluconazole. This drug synergism is attributable to two effects: first, calcineurin inhibitors render fluconazole fungicidal rather than simply fungistatic, and second, membrane perturbation by azole inhibition of ergosterol biosynthesis increases intracellular calcineurin inhibitor concentrations. C. albicans cells in biofilms are up to 1,000-fold more resistant to fluconazole than planktonic cells. In both in vitro experiments and in an in vivo rat catheter model, C. albicans cells in biofilms were resistant to individually delivered fluconazole or calcineurin inhibitors but exquisitely sensitive to the combination of FK506-fluconazole or CsA-fluconazole. C. albicans strains lacking FKBP12 or expressing a dominant FK506-resistant calcineurin mutant subunit (Cnb1-1) formed biofilms that were resistant to FK506-fluconazole but susceptible to CsA-fluconazole, demonstrating that drug synergism is mediated via direct calcineurin inhibition. These findings reveal that calcineurin contributes to fluconazole resistance of biofilms and provide evidence that synergistic drug combinations may prove efficacious as novel therapeutic interventions to treat or prevent biofilms.
    MeSH term(s) Animals ; Antifungal Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Calcineurin Inhibitors ; Candida albicans/drug effects ; Candida albicans/genetics ; Candida albicans/growth & development ; Cyclosporine/pharmacology ; Drug Resistance, Fungal ; Drug Synergism ; Fluconazole/pharmacology ; Humans ; Microbial Sensitivity Tests ; Rats ; Tacrolimus/pharmacology
    Chemical Substances Antifungal Agents ; Calcineurin Inhibitors ; Cyclosporine (83HN0GTJ6D) ; Fluconazole (8VZV102JFY) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2008-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01397-07
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  10. Article: Glücksspielsucht

    Jaussi, Chantal / Nett, Jachen C.

    Sucht

    Die Problemwahrnehmung in der deutschsprachigen Schweiz

    2008  Volume 54, Issue 2, Page(s) 78–85

    Abstract: Fragestellung: Im Jahr 2002 wurde in der Schweiz ein neues Spielbankengesetz implementiert, welches mit erhöhter Zugänglichkeit zu Glücksspielen verbunden ist. In diesem Zusammenhang untersucht die vorliegende Studie, in welchem Ausmaß die Bevölkerung ... ...

    Title translation Pathological gambling: Perception of the problem in Switzerland
    Abstract Fragestellung: Im Jahr 2002 wurde in der Schweiz ein neues Spielbankengesetz implementiert, welches mit erhöhter Zugänglichkeit zu Glücksspielen verbunden ist. In diesem Zusammenhang untersucht die vorliegende Studie, in welchem Ausmaß die Bevölkerung indirekt von problematischem Glücksspielverhalten betroffen ist und auf welche Weise die Glücksspielsucht als Problematik wahrgenommen wird. Methodik: Eine für die deutschsprachige Schweiz repräsentative Stichprobe von 706 Personen ab 18 Jahren wurde im September 2005 telefonisch befragt. Ergebnisse: Es zeigte sich, dass häufiger internale als externale Attributionen zur Erklärung des Verhaltens Glücksspielsüchtiger vorgenommen werden und dass soziodemografische Eigenschaften, indirekte Betroffenheit und persönliche Glücksspielerfahrung das Attributionsverhalten beeinflussen. Vergleiche mit bereits verfügbaren Daten zur Haltung gegenüber substanzgebundenem Suchtverhalten machten deutlich, dass Heroinabhängigkeit der Bevölkerung mehr Sorgen bereitet als Alkohol- oder Glücksspielsucht. Schlussfolgerungen: Die Notwendigkeit einer verstärkten Problemsensibilisierung im Sinne einer Gleichstellung von Glücksspielsucht mit substanzgebundenen Süchten wird diskutiert.
    Keywords Addiction ; Attitudes ; Attribution ; Einstellungen ; Gambling ; Gambling Disorder ; Glücksspiel ; Public Opinion ; Risikowahrnehmung ; Risk Perception ; Spielsucht ; Sucht ; Öffentliche Meinung
    Language German
    Document type Article
    ZDB-ID 627798-6
    ISSN 0939-5911
    ISSN 0939-5911
    DOI 10.1024/2008.02.04
    Database PSYNDEX

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