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Article ; Online: Cluster randomized controlled trial: A matter of independence.

Netuveli, Gopalakrishnan

International journal for quality in health care : journal of the International Society for Quality in Health Care

2022 Volume 34, Issue 2

MeSH term(s)	Cluster Analysis ; Humans ; Research Design
Language	English
Publishing date	2022-05-09
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1194150-9
ISSN	1464-3677 ; 1353-4505
ISSN (online)	1464-3677
ISSN	1353-4505
DOI	10.1093/intqhc/mzac022
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Article: Depression Earlier on in Life Predicts Frailty at 50 Years: Evidence from the 1958 British Birth Cohort Study.

Watts, Paul / Menon, Mukil / Netuveli, Gopalakrishnan

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Frailty and depression in older ages have a bidirectional relationship, sharing some symptoms and characteristics. Most evidence for this has come from cross-sectional studies, or longitudinal studies with limited follow-up periods. We used data from the ...

Abstract	Frailty and depression in older ages have a bidirectional relationship, sharing some symptoms and characteristics. Most evidence for this has come from cross-sectional studies, or longitudinal studies with limited follow-up periods. We used data from the National Child Development Study (1958 Birth Cohort) to investigate the relationship between depression and early-onset frailty using a life course perspective. The primary outcome was frailty based on a 30-item inventory of physical health conditions, activities of daily living and cognitive function at 50 years. The main exposure was depression (based on a nine-item Malaise score ≥ 4) measured at 23, 33 and 42 years. We investigated this relationship using multiple logistic regression models adjusted for socio-demographic factors, early life circumstances and health behaviours. In fully adjusted models, when modelled separately, depression at each timepoint was associated with around twice the odds of frailty. An accumulated depression score showed increases in the odds of frailty with each unit increase (once: OR 1.92, 95%CI 1.65, 2.23; twice OR 2.33, 95%CI 1.85, 2.94; thrice: OR 2.95, 95%CI 2.11, 4.11). The public health significance of this finding is that it shows the potential to reduce the physical burden of disease later in life by paying attention to mental health at younger ages.
Language	English
Publishing date	2023-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175568
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Article ; Online: Thinking fast and slow in pneumonia.

Netuveli, Gopalakrishnan

Primary care respiratory journal : journal of the General Practice Airways Group

2013 Volume 22, Issue 2, Page(s) 139–140

MeSH term(s)	Cross Infection/diagnosis ; Female ; Humans ; Male ; Nursing Homes/statistics & numerical data ; Pneumonia/diagnosis ; Severity of Illness Index
Language	English
Publishing date	2013-05-24
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2129033-7
ISSN	1475-1534 ; 1475-1534
ISSN (online)	1475-1534
ISSN	1475-1534
DOI	10.4104/pcrj.2013.00051
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Article ; Online: Adverse events over the life course and later-life wellbeing and depressive symptoms in older people.

Richardson, Sol / Carr, Ewan / Netuveli, Gopalakrishnan / Sacker, Amanda

International psychogeriatrics

2020 Volume 35, Issue 5, Page(s) 243–257

Abstract: Objectives: Exposures to adverse events are associated with impaired later-life psychological health. While these associations depend on the type of event, the manner in which associations for different event types depend on when they occur within the ... ...

Abstract	Objectives: Exposures to adverse events are associated with impaired later-life psychological health. While these associations depend on the type of event, the manner in which associations for different event types depend on when they occur within the life course has received less attention. We investigated associations between counts of adverse events over the life course, and wellbeing and mental health outcomes in older people, according to their timing (age of occurrence), orientation (self or other) and, both their timing and orientation. Design: Linear and logistic random-effects models for repeated observations. Setting: England, 2002-2015. Participants: A total of 4,208 respondents aged >50 years with 22,146 observations across Waves 1-7 of the English Longitudinal Study of Ageing. Measurements: Cumulative adversity was measured by counts of 16 types of events occurring within four age ranges over the life course using retrospective life history data. These were categorized into other- (experienced through harms to others) and self-oriented events. Outcomes included CASP-12 (control, autonomy, self-realization, and pleasure), the eight-item Centre of Epidemiological Studies Depression Scale, and self-appraised subjective life satisfaction. Results: Additional adverse events were associated with lower CASP-12 and life satisfaction scores, and higher odds of probable depressive caseness. In childhood, other-oriented events had a larger negative association with later-life wellbeing than self-oriented events; the converse was found for events occurring in adulthood. Conclusions: Events occurring at all life course stages were independently associated with both later-life wellbeing and depression in a cumulative fashion. Certain age ranges may represent sensitive periods for specific event types.
MeSH term(s)	Humans ; Aged ; Life Change Events ; Depression/epidemiology ; Depression/psychology ; Retrospective Studies ; Longitudinal Studies ; Aging ; Quality of Life/psychology
Language	English
Publishing date	2020-10-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610220003373
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Zs.A 2621: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Minimum income for healthy living and frailty in adults over 65 years old in the English Longitudinal Study of Ageing: a population-based cohort study.

Watts, Paul Nicholas / Blane, David / Netuveli, Gopalakrishnan

BMJ open

2019 Volume 9, Issue 2, Page(s) e025334

Abstract: Objective: To test whether minimum income for healthy living of a person aged 65 years or older (MIHL: Design and setting: Secondary analysis of the English Longitudinal Study of Ageing, a multiwave prospective cohort study in England, UK.: ... ...

Abstract	Objective: To test whether minimum income for healthy living of a person aged 65 years or older (MIHL Design and setting: Secondary analysis of the English Longitudinal Study of Ageing, a multiwave prospective cohort study in England, UK. Participants: A subset (n=1342) of English Longitudinal Study of Ageing participants, who at wave 1 in 2002 were aged 65 years or older, without any limiting long-standing illnesses, and who had the information required to calculate MIHL Main outcome measures: Frailty defined using Fried's phenotype criteria and Rockwood's Index of deficits. Results: The odds of frailty in 2008 were significantly higher for participants living below MIHL Conclusions: These results provide some support for the idea that frailty at older ages is associated with not having sufficient income to lead a healthy life.
MeSH term(s)	Aged ; Aged, 80 and over ; England ; Female ; Frail Elderly ; Frailty ; Geriatric Assessment/methods ; Health Status ; Humans ; Income ; Life Style ; Logistic Models ; Longitudinal Studies ; Male ; Phenotype ; Prospective Studies
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2747269-3
ISSN	2044-6055 ; 2044-6055 ; 2053-3624
ISSN (online)	2044-6055
ISSN	2044-6055 ; 2053-3624
DOI	10.1136/bmjopen-2018-025334
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Article ; Online: Country-level welfare-state measures and change in wellbeing following work exit in early old age: evidence from 16 European countries.

Richardson, Sol / Carr, Ewan / Netuveli, Gopalakrishnan / Sacker, Amanda

International journal of epidemiology

2018 Volume 48, Issue 2, Page(s) 389–401

Abstract: Background: Although the effects of individual-level factors on wellbeing change following work exit have been identified, the role of welfare-state variables at the country level has yet to be investigated.: Methods: Data on 8037 respondents aged 50 ...

Abstract	Background: Although the effects of individual-level factors on wellbeing change following work exit have been identified, the role of welfare-state variables at the country level has yet to be investigated. Methods: Data on 8037 respondents aged 50 years and over in 16 European countries were drawn from the Survey of Health, Ageing and Retirement in Europe (SHARE) and the English Longitudinal Study of Ageing (ELSA). We employed multilevel models to assess determinants of change in wellbeing following work exit, using CASP-12 change scores. After adjusting for institutionally defined route and timing of work exit, in addition to other individual-level variables, we tested country-level variables including welfare-state regime and measures of disaggregated welfare spending to determine their associations with wellbeing change and the proportion of between-country variance explained. Results: Individuals whose exit from paid work was involuntary or diverged from the typical retirement age experienced declines in wellbeing. Country effects accounted for 7% of overall variance in wellbeing change. Individuals residing in countries with a Mediterranean welfare regime experienced more negative changes in wellbeing, with a difference of -2.15 (-3.23, -1.06) CASP-12 points compared with those in Bismarckian welfare states. Welfare regime explained 62% of between-country variance. National per-capita expenditure on non-healthcare in-kind benefits (services) was associated with more positive wellbeing outcomes. Conclusions: National expenditure on in-kind benefits, particularly non-healthcare services, is associated with more favourable wellbeing change outcomes following work exit in early old age. Welfare-state effects explain the majority of between-country differences in change in wellbeing.
MeSH term(s)	Aged ; Aging ; Disabled Persons/statistics & numerical data ; Employment/statistics & numerical data ; Europe/ethnology ; Female ; Health Status ; Health Surveys ; Humans ; Male ; Middle Aged ; Quality of Life ; Retirement/statistics & numerical data ; Risk Factors ; Social Welfare ; Unemployment/statistics & numerical data
Language	English
Publishing date	2018-10-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyy205
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Zs.A 893: Show issues

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Article ; Online: The role of sports clubs in helping older people to stay active and prevent frailty: a longitudinal mediation analysis.

Watts, Paul / Webb, Elizabeth / Netuveli, Gopalakrishnan

The international journal of behavioral nutrition and physical activity

2017 Volume 14, Issue 1, Page(s) 95

Abstract: Background: Frailty is a common syndrome in older adults characterised by increased vulnerability to adverse health outcomes as a result of decline in functional and physiological measures. Frailty predicts a range of poor health and social outcomes and ...

Abstract	Background: Frailty is a common syndrome in older adults characterised by increased vulnerability to adverse health outcomes as a result of decline in functional and physiological measures. Frailty predicts a range of poor health and social outcomes and is associated with increased risk of hospital admission. The health benefits of sport and physical activity and the health risks of inactivity are well known. However, less is known about the role of sports clubs and physical activity in preventing and managing frailty in older adults. The objective of this study is to examine the role of membership of sports clubs in promoting physical activity and reducing levels of frailty in older adults. Methods: We used data from waves 1 to 7 of the English Longitudinal Study of Ageing (ELSA). Survey items on physical activity were combined to produce a measure of moderate or vigorous physical activity for each wave. Frailty was measured using an index of accumulated deficits. A total of sixty deficits, including symptoms, disabilities and diseases were recorded through self-report and tests. Direct and indirect relationships between sports club membership, levels of physical activity and frailty were examined using a cross-lagged panel model. Results: We found evidence for an indirect relationship between sports club membership and frailty, mediated by physical activity. This finding was observed when examining time-specific indirect pathways and the total of all indirect pathways across seven waves of survey data (Est = -0.097 [95% CI = -0.124,-0.070], p = <0.001). Conclusions: These analyses provide evidence to suggest that sports clubs may be useful in preventing and managing frailty in older adults, both directly and indirectly through increased physical activity levels. Sports clubs accessible to older people may improve health in this demographic by increasing activity levels and reducing frailty and associated comorbidities. There is a need for investment in these organisations to provide opportunities for older people to achieve the levels of physical activity necessary to prevent health problems associated with inactivity.
Language	English
Publishing date	2017-07-14
Publishing country	England
Document type	Journal Article
ISSN	1479-5868
ISSN (online)	1479-5868
DOI	10.1186/s12966-017-0552-5
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Article: Employment and health trajectories

Netuveli, Gopalakrishnan

Spatial and social disparities : understanding population trends and processes - Volume 2 , p. 129-141

2010 , Page(s) 129–141

Author's details	Gopalakrishnan Netuveli
Keywords	Gesundheit ; Risiko ; Erwerbstätigkeit ; Großbritannien
Language	English
Size	graph. Darst.
Publisher	Springer Netherland
Publishing place	Dordrecht [u.a.]
Document type	Article
ISBN	978-90-481-8749-2 ; 90-481-8749-4
Database	ECONomics Information System

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Article ; Online: Impact on health and provision of healthcare services during the COVID-19 lockdown in India: a multicentre cross-sectional study.

Raman, Rajiv / Rajalakshmi, Ramachandran / Surya, Janani / Ramakrishnan, Radha / Sivaprasad, Sobha / Conroy, Dolores / Thethi, Jitendra Pal / Mohan, V / Netuveli, Gopalakrishnan

BMJ open

2021 Volume 11, Issue 1, Page(s) e043590

Abstract: Introduction: The COVID-19 pandemic resulted in a national lockdown in India from midnight on 25 March 2020, with conditional relaxation by phases and zones from 20 April. We evaluated the impact of the lockdown in terms of healthcare provisions, ... ...

Abstract	Introduction: The COVID-19 pandemic resulted in a national lockdown in India from midnight on 25 March 2020, with conditional relaxation by phases and zones from 20 April. We evaluated the impact of the lockdown in terms of healthcare provisions, physical health, mental health and social well-being within a multicentre cross-sectional study in India. Methods: The SMART India study is an ongoing house-to-house survey conducted across 20 regions including 11 states and 1 union territory in India to study diabetes and its complications in the community. During the lockdown, we developed an online questionnaire and delivered it in English and seven popular Indian languages (Hindi, Tamil, Marathi, Telegu, Kannada, Bengali, Malayalam) to random samples of SMART-India participants in two rounds from 5 May 2020 to 24 May 2020. We used multivariable logistic regression to evaluate the overall impact on health and healthcare provision in phases 3 and 4 of lockdown in red and non-red zones and their interactions. Results: A total of 2003 participants completed this multicentre survey. The bivariate relationships between the outcomes and lockdown showed significant negative associations. In the multivariable analyses, the interactions between the red zones and lockdown showed that all five dimensions of healthcare provision were negatively affected (non-affordability: OR 1.917 (95% CI 1.126 to 3.264), non-accessibility: OR 2.458 (95% CI 1.549 to 3.902), inadequacy: OR 3.015 (95% CI 1.616 to 5.625), inappropriateness: OR 2.225 (95% CI 1.200 to 4.126) and discontinuity of care: OR 6.756 (95% CI 3.79 to 12.042)) and associated depression and social loneliness. Conclusion: The impact of COVID-19 pandemic and lockdown on health and healthcare was negative. The exaggeration of income inequality during lockdown can be expected to extend the negative impacts beyond the lockdown.
MeSH term(s)	Adult ; Aged ; COVID-19/prevention & control ; COVID-19/transmission ; Cross-Sectional Studies ; Delivery of Health Care/standards ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/psychology ; Female ; Health Services ; Humans ; India ; Logistic Models ; Loneliness ; Male ; Mental Health ; Middle Aged ; Multivariate Analysis ; Social Isolation/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-043590
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Article ; Online: Evaluating the Performance of the Indian Diabetes Risk Score in Different Ethnic Groups.

Nugawela, Manjula D / Sivaprasad, Sobha / Mohan, Viswanathan / Rajalakshmi, Ramachandran / Netuveli, Gopalakrishnan

Diabetes technology & therapeutics

2019 Volume 22, Issue 4, Page(s) 285–300

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Adult ; African Americans/statistics & numerical data ; Area Under Curve ; Diabetes Mellitus, Type 2/ethnology ; Ethnic Groups/statistics & numerical data ; European Continental Ancestry Group/statistics & numerical data ; Female ; Hispanic Americans/statistics & numerical data ; Humans ; India/epidemiology ; India/ethnology ; Male ; Middle Aged ; Risk Assessment/ethnology ; Risk Factors ; Sensitivity and Specificity ; United States/epidemiology
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2019.0354
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