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  1. Book ; Thesis: Expression des Glukosetransporters 14 beim Magenkarzinom und dessen Relevanz für die [18F]-Fluordesoxyglukose-Positronen-Emissions-Tomographie

    Pinther, Berit Kirsten / Alakus, Hakan / Neumaier, Bernd

    2021  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
    Author's details vorgelegt von Berit Kirsten Pinther ; 1. Gutachter: Privatdozent Dr. med. H. Alakus, 2. Gutachter: Universitätsprofessor Dr. rer. nat. B. Neumaier ; aus dem Zentrum für Operative Medizin der Universität zu Köln, Klinik und Poliklinik für Allgemein- Viszeral- und Thumorchirurgie und Transplantationschirurgie
    Subject code 610
    Language German
    Size 203 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    HBZ-ID HT020871435
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  2. Book ; Thesis: Comparison of a novel 89 Zr-labeled urea-based PSMA inhibitor with 177Lu, 68Ga, 18F and 99mTc labeled analogues for prostate carcinoma targeting

    Vázquez, Sergio Muñoz / Schomäcker, Klaus / Neumaier, Bernd

    2021  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Nuklearmedizin
    Author's details vorgelegt von Sergio Muñoz Vázquez ; 1. Berichterstatter: Professor Dr. rer. nat. K. Schomäcker, 2. Berichterstatter: Universitätsprofessor Dr. rer. nat. B. Neumaier ; aus der Klinik und Poliklinik für Nuklearmedizin der Universität zu Köln
    Subject code 610
    Language English
    Size 125 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    HBZ-ID HT020985135
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  3. Book ; Thesis: Die präklinische Entwicklung neuen PET-Tracer für die Tumor Bildgebung

    Guliyev, Mehrab / Neumaier, Bernd / Maintz, David

    2019  

    Institution Universitätsklinikum Köln / Institut für Radiochemie und Experimentelle Molekulare Bildgebung
    Author's details vorgelegt von Mehrab Guliyev ; 1. Berichterstatter: Universitätsprofessor Dr. rer. nat. B. Neumaier, 2. Berichterstatter: Universitätsprofessor Dr. med. D. Maintz ; aus dem Institut für Radiochemie und Experimentelle Molekulare Bildgebung der Universität zu Köln
    Subject code 610
    Language German
    Size 200 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    HBZ-ID HT020063660
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  4. Article ; Online: Desmethyl SuFEx-IT: SO

    Bertram, Jan / Neumaier, Felix / Zlatopolskiy, Boris D / Neumaier, Bernd

    The Journal of organic chemistry

    2024  Volume 89, Issue 6, Page(s) 3821–3833

    Abstract: Access to SuFExable compounds was remarkably simplified by introduction of the solid ... ...

    Abstract Access to SuFExable compounds was remarkably simplified by introduction of the solid FO
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Synthesis and evaluation of 18F-labeled inhibitors for targeting mutant isocitrate dehydrogenase 1 (mIDH1)

    Cologni, Roberta [Verfasser] / Neumaier, Bernd [Gutachter]

    2023  

    Author's details Roberta Cologni ; Gutachter: Bernd Neumaier
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Thesis: Radiochemische Untersuchungen zur Proteinbindung und Knochenmetastasenaffinität von Y(III)-Komplexen

    Neumaier, Bernd

    1996  

    Author's details vorgelegt von Bernd Neumaier
    Language German
    Size 111 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 1996
    HBZ-ID HT007276678
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  7. Article ; Online: Mutated Isocitrate Dehydrogenase (mIDH) as Target for PET Imaging in Gliomas.

    Neumaier, Felix / Zlatopolskiy, Boris D / Neumaier, Bernd

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Gliomas are the most common primary brain tumors in adults. A diffuse infiltrative growth pattern and high resistance to therapy make them largely incurable, but there are significant differences in the prognosis of patients with different subtypes of ... ...

    Abstract Gliomas are the most common primary brain tumors in adults. A diffuse infiltrative growth pattern and high resistance to therapy make them largely incurable, but there are significant differences in the prognosis of patients with different subtypes of glioma. Mutations in isocitrate dehydrogenase (IDH) have been recognized as an important biomarker for glioma classification and a potential therapeutic target. However, current clinical methods for detecting mutated IDH (mIDH) require invasive tissue sampling and cannot be used for follow-up examinations or longitudinal studies. PET imaging could be a promising approach for non-invasive assessment of the IDH status in gliomas, owing to the availability of various mIDH-selective inhibitors as potential leads for the development of PET tracers. In the present review, we summarize the rationale for the development of mIDH-selective PET probes, describe their potential applications beyond the assessment of the IDH status and highlight potential challenges that may complicate tracer development. In addition, we compile the major chemical classes of mIDH-selective inhibitors that have been described to date and briefly consider possible strategies for radiolabeling of the most promising candidates. Where available, we also summarize previous studies with radiolabeled analogs of mIDH inhibitors and assess their suitability for PET imaging in gliomas.
    MeSH term(s) Adult ; Humans ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Isocitrate Dehydrogenase/genetics ; Glioma/diagnostic imaging ; Glioma/genetics ; Glioma/pathology ; Positron-Emission Tomography ; Mutation
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28072890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Goldnanopartikel

    Pretze, Marc [Verfasser] / Neumaier, Bernd [Gutachter] / Eder, Matthias [Gutachter]

    Eine Plattform für multimodale Diagnostik und Therapie in der experimentellen Nuklearmedizin

    2024  

    Author's details Marc Pretze ; Gutachter: Bernd Neumaier, Matthias Eder
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Online: 8-Bicycloalkyl-CPFPX derivatives as potent and selective tools for in vivo imaging of the A

    Humpert, Swen / Schneider, Daniela / Bier, Dirk / Schulze, Annette / Neumaier, Felix / Neumaier, Bernd / Holschbach, Marcus

    European journal of medicinal chemistry

    2024  Volume 271, Page(s) 116380

    Abstract: Imaging of the ... ...

    Abstract Imaging of the A
    MeSH term(s) Receptor, Adenosine A1/metabolism ; Humans ; Animals ; Xanthines/chemistry ; Xanthines/chemical synthesis ; Rats ; Positron-Emission Tomography ; Caco-2 Cells ; Male ; Molecular Structure ; Structure-Activity Relationship ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/chemical synthesis ; Dose-Response Relationship, Drug ; Fluorine Radioisotopes/chemistry
    Chemical Substances Receptor, Adenosine A1 ; Xanthines ; 8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine ; Radiopharmaceuticals ; Fluorine Radioisotopes
    Language English
    Publishing date 2024-04-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Preparation of

    Kolks, Niklas / Neumaier, Felix / Neumaier, Bernd / Zlatopolskiy, Boris D

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Tryptophan (Trp) is an essential proteinogenic amino acid and metabolic precursor for several signaling molecules that has been implicated in many physiological and pathological processes. Since the two main branches of Trp metabolism-serotonin ... ...

    Abstract Tryptophan (Trp) is an essential proteinogenic amino acid and metabolic precursor for several signaling molecules that has been implicated in many physiological and pathological processes. Since the two main branches of Trp metabolism-serotonin biosynthesis and kynurenine pathway-are differently affected by a variety of neurological and neoplastic diseases, selective visualization of these pathways is of high clinical relevance. However, while positron emission tomography (PET) with existing probes can be used for non-invasive assessment of total Trp metabolism, optimal imaging agents for pathway-specific PET imaging are still lacking. In this work, we describe the preparation of two
    MeSH term(s) Tryptophan/metabolism ; Cell Line, Tumor ; Positron-Emission Tomography/methods ; Kynurenine ; Radiopharmaceuticals/chemistry
    Chemical Substances Tryptophan (8DUH1N11BX) ; Kynurenine (343-65-7) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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