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  1. Article ; Online: Atraumatic Bone Marrow Edema Involving the Epiphyses.

    Woertler, Klaus / Neumann, Jan

    Seminars in musculoskeletal radiology

    2023  Volume 27, Issue 1, Page(s) 45–53

    Abstract: Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from ... ...

    Abstract Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from cellular infiltration of bone marrow and to be aware of the differential diagnosis of underlying causes. With a general focus on the adult musculoskeletal system, this article reviews the pathophysiology, clinical presentation, histopathology, and imaging findings of nontraumatic conditions associated with epiphyseal BME-like signal intensity: transient bone marrow edema syndrome, subchondral insufficiency fracture, avascular necrosis, osteoarthritis, arthritis, and bone neoplasms.
    MeSH term(s) Adult ; Humans ; Bone Marrow ; Epiphyses ; Diagnosis, Differential ; Edema ; Fractures, Stress
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1761498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Book ; Thesis: Quantifizierung des UL30-Gens des Cytomegalievirus mittels Realtime-PCR

    Neumann, Jan Kristian

    eine Untersuchung zur Früherkennung von Cytomegalievirus-Infektionen bei Transplantationspatienten

    2005  

    Author's details vorgelegt von Jan Kristian Neumann
    Language German
    Size IV, 62 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2005
    HBZ-ID HT014519834
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 D 1813 order for loan Magazin

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  3. Article ; Online: Artificial Intelligence Resolves Kinetic Pathways of Magnesium Binding to RNA.

    Neumann, Jan / Schwierz, Nadine

    Journal of chemical theory and computation

    2022  Volume 18, Issue 2, Page(s) 1202–1212

    Abstract: Magnesium is an indispensable cofactor in countless vital processes. In order to understand its functional role, the characterization of the binding pathways to biomolecules such as RNA is crucial. Despite the importance, a molecular description is still ...

    Abstract Magnesium is an indispensable cofactor in countless vital processes. In order to understand its functional role, the characterization of the binding pathways to biomolecules such as RNA is crucial. Despite the importance, a molecular description is still lacking since the transition from the water-mediated outer-sphere to the direct inner-sphere coordination is on the millisecond time scale and therefore out of reach for conventional simulation techniques. To fill this gap, we use transition path sampling to resolve the binding pathways and to elucidate the role of the solvent in the binding process. The results reveal that the molecular void provoked by the leaving phosphate oxygen of the RNA is immediately filled by an entering water molecule. In addition, water molecules from the first and second hydration shell couple to the concerted exchange. To capture the intimate solute-solvent coupling, we perform a committor analysis as the basis for a machine learning algorithm that derives the optimal deep learning model from thousands of scanned architectures using hyperparameter tuning. The results reveal that the properly optimized deep network architecture recognizes the important solvent structures, extracts the relevant information, and predicts the commitment probability with high accuracy. Our results provide detailed insights into the solute-solvent coupling which is ubiquitous for kosmotropic ions and governs a large variety of biochemical reactions in aqueous solutions.
    MeSH term(s) Artificial Intelligence ; Magnesium/chemistry ; RNA/chemistry ; Solvents/chemistry ; Water/chemistry
    Chemical Substances Solvents ; Water (059QF0KO0R) ; RNA (63231-63-0) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.1c00752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Atraumatic Bone Marrow Edema Involving the Epiphyses

    Woertler, Klaus / Neumann, Jan

    Seminars in Musculoskeletal Radiology

    (Nontumor Marrow Changes)

    2023  Volume 27, Issue 01, Page(s) 45–53

    Abstract: Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from ... ...

    Series title Nontumor Marrow Changes
    Abstract Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from cellular infiltration of bone marrow and to be aware of the differential diagnosis of underlying causes. With a general focus on the adult musculoskeletal system, this article reviews the pathophysiology, clinical presentation, histopathology, and imaging findings of nontraumatic conditions associated with epiphyseal BME-like signal intensity: transient bone marrow edema syndrome, subchondral insufficiency fracture, avascular necrosis, osteoarthritis, arthritis, and bone neoplasms.
    Keywords transient bone marrow edema syndrome ; subchondral insufficiency fracture ; avascular necrosis ; osteoarthritis ; bone neoplasms
    Language English
    Publishing date 2023-02-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1761498
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Faktoren der steigenden Inanspruchnahme von Notaufnahmen

    Neumann, Jan

    Recht und Politik im Gesundheitswesen

    2019  Volume 25, Issue 4, Page(s) 78

    Language German
    Document type Article
    ZDB-ID 1308617-0
    ISSN 0948-3209
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4625: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Thesis: Die Lebervenen und ihre Drainagegebiete

    Neumann, Jan-Oliver

    computergestützte Analyse mit Hilfe des Operationsplanungssystems LENA

    2006  

    Author's details vorgelegt von Jan-Oliver Neumann
    Subject code 617.5
    Language German
    Size VIII, 97 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2006
    HBZ-ID HT014862385
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 1945 order for loan Magazin

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  7. Book ; Online ; Thesis: Die Koordination des WTO-Rechts mit anderen völkerrechtlichen Ordnungen.

    Neumann, Jan [Verfasser]

    Konflikte des materiellen Rechts und Konkurrenzen der Streitbeilegung.

    2020  

    Author's details Jan Neumann
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Duncker & Humblot
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    ISBN 978-3-428-50802-0 ; 3-428-50802-5
    Database Digital theses on the web

    Full text online

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  8. Article: Feasibility of Fluid Responsiveness Assessment in Patients at Risk for Increased Intracranial Pressure.

    Zivkovic, Aleksandar R / Kjaev, Aleko / Schönenberger, Silvia / Krieg, Sandro M / Weigand, Markus A / Neumann, Jan-Oliver

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stereotactic frame-based biopsy of infratentorial lesions via the suboccipital-transcerebellar approach with the Zamorano-Duchovny stereotactic system-a retrospective analysis of 79 consecutive cases.

    Kaes, Manuel / Beynon, Christopher / Kiening, Karl / Neumann, Jan-Oliver / Jakobs, Martin

    Acta neurochirurgica

    2024  Volume 166, Issue 1, Page(s) 147

    Abstract: Objective: Lesions of the posterior fossa (brainstem and cerebellum) are challenging in diagnosis and treatment due to the fact that they are often located eloquently and total resection is rarely possible. Therefore, frame-based stereotactic biopsies ... ...

    Abstract Objective: Lesions of the posterior fossa (brainstem and cerebellum) are challenging in diagnosis and treatment due to the fact that they are often located eloquently and total resection is rarely possible. Therefore, frame-based stereotactic biopsies are commonly used to asservate tissue for neuropathological diagnosis and further treatment determination. The aim of our study was to assess the safety and diagnostic success rate of frame-based stereotactic biopsies for lesions in the posterior fossa via the suboccipital-transcerebellar approach.
    Methods: We performed a retrospective database analysis of all frame-based stereotactic biopsy cases at our institution since 2007. The aim was to identify all surgical cases for infratentorial lesion biopsies via the suboccipital-transcerebellar approach. We collected clinical data regarding outcomes, complications, diagnostic success, radiological appearances, and stereotactic trajectories.
    Results: A total of n = 79 cases of stereotactic biopsies for posterior fossa lesions via the suboccipital-transcerebellar approach (41 female and 38 male) utilizing the Zamorano-Duchovny stereotactic system were identified. The mean age at the time of surgery was 42.5 years (± 23.3; range, 1-87 years). All patients were operated with intraoperative stereotactic imaging (n = 62 MRI, n = 17 CT). The absolute diagnostic success rate was 87.3%. The most common diagnoses were glioma, lymphoma, and inflammatory disease. The overall complication rate was 8.7% (seven cases). All patients with complications showed new neurological deficits; of those, three were permanent. Hemorrhage was detected in five of the cases having complications. The 30-day mortality rate was 7.6%, and 1-year survival rate was 70%.
    Conclusions: Our data suggests that frame-based stereotactic biopsies with the Zamorano-Duchovny stereotactic system via the suboccipital-transcerebellar approach are safe and reliable for infratentorial lesions bearing a high diagnostic yield and an acceptable complication rate. Further research should focus on the planning of safe trajectories and a careful case selection with the goal of minimizing complications and maximizing diagnostic success.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Retrospective Studies ; Stereotaxic Techniques ; Brain Stem/surgery ; Cerebellum/surgery ; Biopsy/methods ; Brain Neoplasms/surgery
    Language English
    Publishing date 2024-03-23
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-06036-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.180: Show issues Location:
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  10. Book: Change Monitoring in Veränderungsprozessen

    Neumann, Jan / Rank, Susanne

    Grundlagen, Methoden und Praxisbeispiele

    2017  

    Institution Springer Fachmedien Wiesbaden GmbH
    Author's details Susanne Rank, Jan Neumann (Hrsg.)
    Keywords Change Management ; Organisatorischer Wandel ; Projektbewertung ; Deutschland
    Language German
    Size XI, 187 Seiten, Illustrationen, 24 cm x 16.8 cm, 0 g
    Publisher Springer Gabler
    Publishing place Wiesbaden
    Document type Book
    Note Enthält 12 Beiträge
    ISBN 3658126450 ; 9783658126452 ; 9783658126469 ; 3658126469
    Database ECONomics Information System

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