LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Neumayer, Sophia"
  2. AU="Becker, B"

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts.

    Balam, Saidou / Buchtler, Simone / Winter, Frederike / Schmidbauer, Kathrin / Neumayer, Sophia / Talke, Yvonne / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Frontiers in immunology

    2022  Volume 12, Page(s) 816509

    Abstract: Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, ... ...

    Abstract Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, we sought to determine whether tissue-resident donor-derived cells or allograft-infiltrating recipient-derived cells are responsible for allograft fibrosis, and whether hematopoietic cells contribute to collagen production. A fully MHC-mismatched mouse heterotopic heart transplantation model was used, with transient depletion of CD4
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Collagen Type I/biosynthesis ; Collagen Type I/immunology ; Disease Models, Animal ; Disease Susceptibility ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/metabolism ; Heart Transplantation/adverse effects ; Heart Transplantation/methods ; Immunophenotyping ; Mice ; Mice, Transgenic ; Tissue Donors ; Transplantation, Homologous
    Chemical Substances Biomarkers ; Collagen Type I
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.816509
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: B-cell modulation with anti-CD79b antibodies ameliorates experimental autoimmune encephalitis in mice.

    Renner, Kerstin / Neumayer, Sophia / Talke, Yvonne / Buchtler, Simone / Schmidbauer, Kathrin / Nimmerjahn, Falk / Lux, Anja / Winter, Frederike / Salewski, Jan-Nicklas / Mack, Matthias

    European journal of immunology

    2022  Volume 52, Issue 4, Page(s) 656–668

    Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion ... ...

    Abstract B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on targeting CD79b that induces only partial B-cell depletion and achieves therapeutic effects by B-cell modulation. Prophylactic and therapeutic treatment with an antibody against CD79b and also a deglycosylated variant of this antibody, lacking effector function like antibody-dependent cellular cytotoxicity or complement activation, significantly reduced the development and progression of EAE in mice. Our data show that modulation of B cells via CD79b is equally effective as almost complete B-cell depletion with anti-CD20 antibodies and may constitute an alternative approach to treat MS.
    MeSH term(s) Animals ; Antibodies ; Antigens, CD20 ; Autoimmune Diseases ; Autoimmunity ; B-Lymphocytes ; Encephalitis/drug therapy ; Encephalitis/pathology ; Mice
    Chemical Substances Antibodies ; Antigens, CD20
    Language English
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149523
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Expression of IL-3 receptors and impact of IL-3 on human T and B cells.

    Renner, Kerstin / Metz, Sophia / Metzger, Anne-Mieke / Neumayer, Sophia / Schmidbauer, Kathrin / Talke, Yvonne / Buchtler, Simone / Halbritter, Dagmar / Mack, Matthias

    Cellular immunology

    2018  Volume 334, Page(s) 49–60

    Abstract: A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL- ... ...

    Abstract A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4
    MeSH term(s) Autoimmune Diseases/immunology ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/immunology ; Humans ; Interleukin-3/immunology ; Interleukin-3 Receptor alpha Subunit/immunology ; Lymphocyte Activation/immunology ; Receptors, Interleukin-3/immunology ; Up-Regulation/immunology
    Chemical Substances Cytokines ; IL3 protein, human ; Interleukin-3 ; Interleukin-3 Receptor alpha Subunit ; Receptors, Interleukin-3
    Language English
    Publishing date 2018-09-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils.

    Balam, Saidou / Schiechl-Brachner, Gabriela / Buchtler, Simone / Halbritter, Dagmar / Schmidbauer, Kathrin / Talke, Yvonne / Neumayer, Sophia / Salewski, Jan-Niklas / Winter, Frederike / Karasuyama, Hajime / Yamanishi, Yoshinori / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 202, Issue 12, Page(s) 3514–3523

    Abstract: Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with ... ...

    Abstract Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with depletion of CD4
    MeSH term(s) Animals ; Basophils/immunology ; Cell Movement ; Cells, Cultured ; Chronic Disease ; Disease Models, Animal ; Graft Rejection/immunology ; Heart Transplantation ; Humans ; Interleukin-3/genetics ; Interleukin-3/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Transplantation, Homologous ; Up-Regulation
    Chemical Substances Interleukin-3 ; Interleukin-6
    Language English
    Publishing date 2019-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1801269
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Cellular Origin and Functional Relevance of Collagen I Production in the Kidney.

    Buchtler, Simone / Grill, Alexandra / Hofmarksrichter, Stefanie / Stöckert, Petra / Schiechl-Brachner, Gabriela / Rodriguez Gomez, Manuel / Neumayer, Sophia / Schmidbauer, Kathrin / Talke, Yvonne / Klinkhammer, Barbara M / Boor, Peter / Medvinsky, Alexander / Renner, Kerstin / Castrop, Hayo / Mack, Matthias

    Journal of the American Society of Nephrology : JASN

    2018  Volume 29, Issue 7, Page(s) 1859–1873

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Acute Kidney Injury/physiopathology ; Adenine ; Animals ; Bone Marrow Cells/metabolism ; Cell Lineage ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Epithelial Cells/metabolism ; Female ; Fibroblasts/metabolism ; Fibrosis ; Glomerular Filtration Rate ; Hematopoiesis ; Kidney/pathology ; Kidney/physiopathology ; Kidney Tubules/cytology ; Mice ; Mice, Knockout ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/physiopathology ; Ureteral Obstruction/complications
    Chemical Substances Collagen Type I ; Adenine (JAC85A2161)
    Language English
    Publishing date 2018-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2018020138
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top