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  1. Article: The multiple functions of miR-574-5p in the neuroblastoma tumor microenvironment.

    Proestler, Eva / Donzelli, Julia / Nevermann, Sheila / Breitwieser, Kai / Koch, Leon F / Best, Tatjana / Fauth, Maria / Wickström, Malin / Harter, Patrick N / Kogner, Per / Lavieu, Grégory / Larsson, Karin / Saul, Meike J

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1183720

    Abstract: Neuroblastoma is the most common extracranial solid tumor in childhood and arises from neural crest cells of the developing sympathetic nervous system. Prostaglandin ... ...

    Abstract Neuroblastoma is the most common extracranial solid tumor in childhood and arises from neural crest cells of the developing sympathetic nervous system. Prostaglandin E
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1183720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Extracellular Vesicle-Based Detection of Pancreatic Cancer.

    Verel-Yilmaz, Yesim / Fernández, Juan Pablo / Schäfer, Agnes / Nevermann, Sheila / Cook, Lena / Gercke, Norman / Helmprobst, Frederik / Jaworek, Christian / Pogge von Strandmann, Elke / Pagenstecher, Axel / Bartsch, Detlef K / Bartsch, Jörg W / Slater, Emily P

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 697939

    Abstract: Due to a grim prognosis, there is an urgent need to detect pancreatic ductal adenocarcinoma (PDAC) prior to metastasis. However, reliable diagnostic imaging methods or biomarkers for PDAC or its precursor lesions are still scarce. ADAM8, a ... ...

    Abstract Due to a grim prognosis, there is an urgent need to detect pancreatic ductal adenocarcinoma (PDAC) prior to metastasis. However, reliable diagnostic imaging methods or biomarkers for PDAC or its precursor lesions are still scarce. ADAM8, a metalloprotease-disintegrin, is highly expressed in PDAC tissue and negatively correlates with patient survival. The aim of our study was to determine the ability of ADAM8-positive extracellular vesicles (EVs) and cargo microRNAs (miRNAs) to discriminate precursor lesions or PDAC from healthy controls. In order to investigate enrichment of ADAM8 on EVs, these were isolated from serum of patients with PDAC (
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.697939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer.

    Donzelli, Julia / Proestler, Eva / Riedel, Anna / Nevermann, Sheila / Hertel, Brigitte / Guenther, Andreas / Gattenlöhner, Stefan / Savai, Rajkumar / Larsson, Karin / Saul, Meike J

    Journal of extracellular vesicles

    2021  Volume 10, Issue 12, Page(s) e12143

    Abstract: Intercellular communication plays an essential role in lung cancer (LC). One of the major players in cell-cell-communication is small extracellular vesicles (sEV). SEV trigger various biological responses by transporting cellular cargo to target cells. ... ...

    Abstract Intercellular communication plays an essential role in lung cancer (LC). One of the major players in cell-cell-communication is small extracellular vesicles (sEV). SEV trigger various biological responses by transporting cellular cargo to target cells. One essential sEV component are microRNAs (miRs), whose transport has recently attracted increasing research interest. We report that prostaglandin E
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Extracellular Vesicles/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Toll-Like Receptor 7/metabolism ; Transfection
    Chemical Substances TLR7 protein, human ; Toll-Like Receptor 7
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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