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Article ; Online: Haber-independent, asymmetric synthesis of the marine alkaloid

Neville, Jessica C / Lau, Michelle Y / Söhnel, Tilo / Sperry, Jonathan

Organic & biomolecular chemistry

2022  Volume 20, Issue 33, Page(s) 6562–6565

Abstract: Chitin-derived platforms are emerging as valuable chemical entities for the construction of nitrogenous fine chemicals in processes independent of Haber ammonia. However, much of the work in this area has focused on achiral platforms that limit routine ... ...

Abstract Chitin-derived platforms are emerging as valuable chemical entities for the construction of nitrogenous fine chemicals in processes independent of Haber ammonia. However, much of the work in this area has focused on achiral platforms that limit routine entry into enantiopure, bio-based N-chemical space. Herein, dihydroxyethyl acetamidofuran (Di-HAF), a chiral synthon readily available from chitin, has been transformed into the marine alkaloid
MeSH term(s) Alkaloids ; Antineoplastic Agents ; Chitin ; Nitrogen ; Stereoisomerism
Chemical Substances Alkaloids ; Antineoplastic Agents ; Chitin (1398-61-4) ; Nitrogen (N762921K75)
Language English
Publishing date 2022-08-24
Publishing country England
Document type Journal Article
ZDB-ID 2097583-1
ISSN 1477-0539 ; 1477-0520
ISSN (online) 1477-0539
ISSN 1477-0520
DOI 10.1039/d2ob01251k
Database MEDical Literature Analysis and Retrieval System OnLINE

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