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  1. Article ; Online: Disentangling the influence of entanglement on recruitment in North Atlantic right whales.

    Reed, Joshua / New, Leslie / Corkeron, Peter / Harcourt, Robert

    Proceedings. Biological sciences

    2024  Volume 291, Issue 2018, Page(s) 20240314

    Abstract: North Atlantic right whales are Critically Endangered and declining, with entanglements in fishing gear a key contributor to their decline. Entanglement events can result in lethal and sub-lethal (i.e. increased energetic demands and reduced foraging ... ...

    Abstract North Atlantic right whales are Critically Endangered and declining, with entanglements in fishing gear a key contributor to their decline. Entanglement events can result in lethal and sub-lethal (i.e. increased energetic demands and reduced foraging ability) impacts, with the latter influencing critical life-history states, such as reproduction. Using a multi-event framework, we developed a Bayesian mark-recapture model to investigate the influence of entanglement severity on survival and recruitment for female right whales. We used information from 199 known-aged females sighted between 1977 and 2018, combined with known entanglements of varying severity that were classified as minor, moderate or severe. Severe entanglements resulted in an average decline in survival of 27% for experienced non-breeders, 9% for breeders and 26% for pre-breeding females compared with other entanglements and unentangled individuals. Surviving individuals with severe entanglements had low transitional probabilities to breeders, but surprisingly, individuals with minor entanglements had the lowest transitional probabilities, contrary to expectations underpinning current management actions. Management actions are needed to address the lethal and sub-lethal impacts of entanglements, regardless of severity classification.
    MeSH term(s) Humans ; Animals ; Female ; Aged ; Whales ; Bayes Theorem ; Reproduction ; Breeding ; Atlantic Ocean
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2024.0314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bioenergetic modelling of a marine top predator's responses to changes in prey structure.

    Silva, Mariana P / Oliveira, Cláudia / Prieto, Rui / Silva, Mónica A / New, Leslie / Pérez-Jorge, Sergi

    Ecology and evolution

    2024  Volume 14, Issue 3, Page(s) e11135

    Abstract: Determining how animals allocate energy, and how external factors influence this allocation, is crucial to understand species' life history requirements and response to disturbance. This response is driven in part by individuals' energy balance, prey ... ...

    Abstract Determining how animals allocate energy, and how external factors influence this allocation, is crucial to understand species' life history requirements and response to disturbance. This response is driven in part by individuals' energy balance, prey characteristics, foraging behaviour and energy required for essential functions. We developed a bioenergetic model to estimate minimum foraging success rate (FSR), that is, the lowest possible prey capture rate for individuals to obtain the minimum energy intake needed to meet daily metabolic requirements, for female sperm whale (
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.11135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Microbial mutualist distribution limits spread of the invasive legume Medicago polymorpha

    Lopez, Zoie C / Friesen, Maren L / Von Wettberg, Eric / New, Leslie / Porter, Stephanie

    Biological invasions. 2021 Mar., v. 23, no. 3

    2021  

    Abstract: The spread of invasive species can be limited or promoted by the distributions of mutualists, which presents an opportunity for managing biological invasions. However, the ways in which the geographical distributions of mutualists shape the range limits ... ...

    Abstract The spread of invasive species can be limited or promoted by the distributions of mutualists, which presents an opportunity for managing biological invasions. However, the ways in which the geographical distributions of mutualists shape the range limits and invasion dynamics of introduced species remains unclear. Legumes include noxious invaders whose success is tied to their mutualism with nitrogen-fixing rhizobium bacteria. We examine whether the availability of compatible rhizobia limits the spread of an invasive legume at both small (50 m) and large (United States) spatial scales across natural invasion fronts. Using greenhouse experiments we simulated the dispersal of Medicago polymorpha into soils at increasing distances from a host patch. We find that rhizobial mutualist availability rapidly declines to almost zero within 20 m of established legume patches and legume fitness and the percentage of leaf nitrogen derived from symbiotic nitrogen fixation show a concomitant decline. The decline of fitness due to the lack of rhizobium mutualists differs among M. polymorpha genotypes. Our findings support the missed mutualist hypothesis whereby mutualist limitation reduces invasiveness. As M. polymorpha colonizes novel areas, seeds following either short- (50 m) or long-range seed dispersal will be mutualist-limited and exhibit low fitness and nitrogen fixation. Without co-introduction via transport of soil containing both mutualists, the patchy distribution of E. medicae may limit M. polymorpha invasion. Plant lineages exhibit genetic variation upon which selection could act to reduce dependence on rhizobia, thus a scarcity of symbionts could cause plant symbiosis traits to evolve during invasion.
    Keywords Medicago polymorpha ; decline ; genetic variation ; greenhouses ; introduced species ; invasive species ; leaves ; legumes ; mutualism ; nitrogen ; nitrogen fixation ; seed dispersal ; soil ; symbionts
    Language English
    Dates of publication 2021-03
    Size p. 843-856.
    Publishing place Springer International Publishing
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1438729-3
    ISSN 1573-1464 ; 1387-3547
    ISSN (online) 1573-1464
    ISSN 1387-3547
    DOI 10.1007/s10530-020-02404-4
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: AP-3 complex subunit delta gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio).

    Neuffer, Sam J / Beltran-Cardona, David / Jimenez-Perez, Kevin / Clancey, Lauren F / Brown, Alexander / New, Leslie / Cooper, Cynthia D

    Pigment cell & melanoma research

    2022  Volume 35, Issue 5, Page(s) 495–505

    Abstract: Zebrafish are an emerging model organism to study the syndromic albinism disorder, Hermansky-Pudlak syndrome (HPS), due to visible pigment development at 24 hours postfertilization, and conserved melanogenesis mechanisms. We describe crasher, a novel HPS ...

    Abstract Zebrafish are an emerging model organism to study the syndromic albinism disorder, Hermansky-Pudlak syndrome (HPS), due to visible pigment development at 24 hours postfertilization, and conserved melanogenesis mechanisms. We describe crasher, a novel HPS type 10 (HPS10) zebrafish model, with a mutation in AP-3 complex subunit delta gene, ap3d1. Exon 14 of ap3d1 is overexpressed in crasher mutants, while the expression of ap3d1 as a whole is reduced. ap3d1 knockout in *AB zebrafish recapitulates the mutant crasher phenotype. We show ap3d1 loss-of-function mutations cause significant expression changes in the melanogenesis genes, dopachrome tautomerase (dct) and tyrosinase-related protein 1b (tyrp1b), but not tyrosinase (tyr). Last, Generally Applicable Gene-set Enrichment (GAGE) analysis suggests autophagy pathway genes are upregulated together in crasher. Treatment with autophagy-inhibitor, bafilomycin A1, significantly decreases melanophore number in crasher, suggesting ap3d1 promotes melanophore survival by limiting excessive autophagy. crasher is a valuable model to explore the regulation of melanogenesis gene expression and pigmentation disease.
    MeSH term(s) Animals ; Autophagy/genetics ; Carrier Proteins/genetics ; Hermanski-Pudlak Syndrome/genetics ; Melanophores/metabolism ; Mutation ; Pigmentation/genetics ; Zebrafish/genetics ; Zebrafish/metabolism
    Chemical Substances Carrier Proteins
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.13055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assessing variation in faecal glucocorticoid concentrations in gray whales exposed to anthropogenic stressors.

    Pirotta, Enrico / Fernandez Ajó, Alejandro / Bierlich, K C / Bird, Clara N / Buck, C Loren / Haver, Samara M / Haxel, Joseph H / Hildebrand, Lisa / Hunt, Kathleen E / Lemos, Leila S / New, Leslie / Torres, Leigh G

    Conservation physiology

    2023  Volume 11, Issue 1, Page(s) coad082

    Abstract: Understanding how individual animals respond to stressors behaviourally and physiologically is a critical step towards quantifying long-term population consequences and informing management efforts. Glucocorticoid (GC) metabolite accumulation in various ... ...

    Abstract Understanding how individual animals respond to stressors behaviourally and physiologically is a critical step towards quantifying long-term population consequences and informing management efforts. Glucocorticoid (GC) metabolite accumulation in various matrices provides an integrated measure of adrenal activation in baleen whales and could thus be used to investigate physiological changes following exposure to stressors. In this study, we measured GC concentrations in faecal samples of Pacific Coast Feeding Group (PCFG) gray whales (
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2721508-8
    ISSN 2051-1434
    ISSN 2051-1434
    DOI 10.1093/conphys/coad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: (with research data) Central place foragers and moving stimuli: A hidden-state model to discriminate the processes affecting movement.

    Pirotta, Enrico / Edwards, Ewan W J / New, Leslie / Thompson, Paul M

    The Journal of animal ecology

    2018  Volume 87, Issue 4, Page(s) 1116–1125

    Abstract: Human activities can influence the movement of organisms, either repelling or attracting individuals depending on whether they interfere with natural behavioural patterns or enhance access to food. To discern the processes affecting such interactions, an ...

    Abstract Human activities can influence the movement of organisms, either repelling or attracting individuals depending on whether they interfere with natural behavioural patterns or enhance access to food. To discern the processes affecting such interactions, an appropriate analytical approach must reflect the motivations driving behavioural decisions at multiple scales. In this study, we developed a modelling framework for the analysis of foraging trips by central place foragers. By recognising the distinction between movement phases at a larger scale and movement steps at a finer scale, our model can identify periods when animals are actively following moving attractors in their landscape. We applied the framework to GPS tracking data of northern fulmars Fulmarus glacialis, paired with contemporaneous fishing boat locations, to quantify the putative scavenging activity of these seabirds on discarded fish and offal. We estimated the rate and scale of interaction between individual birds and fishing boats and the interplay with other aspects of a foraging trip. The model classified periods when birds were heading out to sea, returning towards the colony or following the closest boat. The probability of switching towards a boat declined with distance and varied depending on the phase of the trip. The maximum distance at which a bird switched towards the closest boat was estimated around 35 km, suggesting the use of olfactory information to locate food. Individuals spent a quarter of a foraging trip, on average, following fishing boats, with marked heterogeneity among trips and individuals. Our approach can be used to characterise interactions between central place foragers and different anthropogenic or natural stimuli. The model identifies the processes influencing central place foraging at multiple scales, which can improve our understanding of the mechanisms underlying movement behaviour and characterise individual variation in interactions with a range of human activities that may attract or repel these species. Therefore, it can be adapted to explore the movement of other species that are subject to multiple dynamic drivers.
    MeSH term(s) Animals ; Birds/physiology ; Ecosystem ; Feeding Behavior ; Models, Biological ; Movement ; Olfactory Perception
    Language English
    Publishing date 2018-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.12830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes.

    Peterson, Kersten A / Neuffer, Samantha / Bean, Miranda E / New, Leslie / Coffin, Allison B / Cooper, Cynthia D

    Experimental dermatology

    2019  Volume 28, Issue 7, Page(s) 795–800

    Abstract: Melanoma is the deadliest form of skin cancer, partially due to its inherent resistance to therapy. Here, we test in live larvae the hypothesis that mature melanosomes contribute to resistance to chemotherapeutic drug, cisplatin, via drug sequestration. ... ...

    Abstract Melanoma is the deadliest form of skin cancer, partially due to its inherent resistance to therapy. Here, we test in live larvae the hypothesis that mature melanosomes contribute to resistance to chemotherapeutic drug, cisplatin, via drug sequestration. We also compare three melanosome biogenesis proteins-microphthalmia-associated transcription factor (Mitfa), vacuolar protein sorting 11 (Vps11) and oculocutaneous albinism 2 (Oca2) to determine their respective contributions to chemoresistance. Melanocytes in zebrafish larvae harbouring loss-of-function mutations in the mitfa, vps11 or oca2 genes are more sensitive to cisplatin damage than wild-type larvae. As a comparison, we examined sensory hair cells of the lateral line, which are sensitive to cisplatin. Hair cells in oca2 and mitfa mutants do not show increased cisplatin sensitivity when compared to wild-type larvae, suggesting the increase in cisplatin sensitivity could be melanocyte specific. However, hair cells in vps11 mutants are more sensitive to cisplatin than their wild-type counterparts, suggesting that this mutation increases cisplatin susceptibility in multiple cell types. This is the first in vivo study to show an increase in chemotherapeutic drug sensitivity when melanosome maturation mutations are present. The proteins tested, especially Oca2, represent novel drug targets for increasing the efficiency of melanoma chemotherapy treatment.
    MeSH term(s) Animals ; Cisplatin/pharmacology ; Disease Models, Animal ; Drug Resistance, Neoplasm ; In Situ Hybridization ; Melanocytes/cytology ; Melanosomes/physiology ; Membrane Transport Proteins/physiology ; Microphthalmia-Associated Transcription Factor/physiology ; Mutation ; Vesicular Transport Proteins/physiology ; Zebrafish ; Zebrafish Proteins/physiology
    Chemical Substances Membrane Transport Proteins ; Microphthalmia-Associated Transcription Factor ; OCA2 protein, zebrafish ; Vesicular Transport Proteins ; Zebrafish Proteins ; mitfa protein, zebrafish ; vacuolar protein sorting 11, zebrafish ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-05-15
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.13937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Propensity for Risk in Reproductive Strategy Affects Susceptibility to Anthropogenic Disturbance.

    Pirotta, Enrico / Hin, Vincent / Mangel, Marc / New, Leslie / Costa, Daniel P / de Roos, André M / Harwood, John

    The American naturalist

    2020  Volume 196, Issue 4, Page(s) E71–E87

    Abstract: AbstractAnimals initiate, interrupt, or invest resources in reproduction in light of their physiology and the environment. The energetic risks entailed in an individual's reproductive strategy can influence the ability to cope with additional stressors, ... ...

    Abstract AbstractAnimals initiate, interrupt, or invest resources in reproduction in light of their physiology and the environment. The energetic risks entailed in an individual's reproductive strategy can influence the ability to cope with additional stressors, such as anthropogenic climate change and disturbance. To explore the trade-offs between internal state, external resource availability, and reproduction, we applied state-dependent life-history theory (SDLHT) to a dynamic energy budget (DEB) model for long-finned pilot whales (
    MeSH term(s) Animals ; Energy Metabolism ; Female ; Human Activities ; Life History Traits ; Reproduction/physiology ; Whales, Pilot/physiology
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 207092-3
    ISSN 1537-5323 ; 0003-0147
    ISSN (online) 1537-5323
    ISSN 0003-0147
    DOI 10.1086/710150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Indirect effects of primary prey population dynamics on alternative prey.

    Barraquand, Frédéric / New, Leslie F / Redpath, Stephen / Matthiopoulos, Jason

    Theoretical population biology

    2015  Volume 103, Page(s) 44–59

    Abstract: We develop a theory of generalist predation showing how alternative prey species are affected by changes in both mean abundance and variability (coefficient of variation) of their predator's primary prey. The theory is motivated by the indirect effects ... ...

    Abstract We develop a theory of generalist predation showing how alternative prey species are affected by changes in both mean abundance and variability (coefficient of variation) of their predator's primary prey. The theory is motivated by the indirect effects of cyclic rodent populations on ground-breeding birds, and developed through progressive analytic simplifications of an empirically-based model. It applies nonetheless to many other systems where primary prey have fast life-histories and can become superabundant, thus facilitating impact on alternative prey species and generating highly asymmetric interactions. Our results suggest that predator effects on alternative prey should generally decrease with mean primary prey abundance, and increase with primary prey variability (low to high CV)-unless predators have strong aggregative responses, in which case these results can be reversed. Approximations of models including predator dynamics (general numerical response with possible delays) confirm these results but further suggest that negative temporal correlation between predator and primary prey is harmful to alternative prey. Finally, we find that measurements of predator numerical responses are crucial to predict-even qualitatively-the response of ecosystems to changes in the dynamics of outbreaking prey species.
    MeSH term(s) Animals ; Models, Theoretical ; Predatory Behavior ; Rodentia
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3948-2
    ISSN 1096-0325 ; 0040-5809
    ISSN (online) 1096-0325
    ISSN 0040-5809
    DOI 10.1016/j.tpb.2015.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Context-dependent variability in the predicted daily energetic costs of disturbance for blue whales.

    Pirotta, Enrico / Booth, Cormac G / Cade, David E / Calambokidis, John / Costa, Daniel P / Fahlbusch, James A / Friedlaender, Ari S / Goldbogen, Jeremy A / Harwood, John / Hazen, Elliott L / New, Leslie / Southall, Brandon L

    Conservation physiology

    2021  Volume 9, Issue 1, Page(s) coaa137

    Abstract: Assessing the long-term consequences of sub-lethal anthropogenic disturbance on wildlife populations requires integrating data on fine-scale individual behavior and physiology into spatially and temporally broader, population-level inference. A typical ... ...

    Abstract Assessing the long-term consequences of sub-lethal anthropogenic disturbance on wildlife populations requires integrating data on fine-scale individual behavior and physiology into spatially and temporally broader, population-level inference. A typical behavioral response to disturbance is the cessation of foraging, which can be translated into a common metric of energetic cost. However, this necessitates detailed empirical information on baseline movements, activity budgets, feeding rates and energy intake, as well as the probability of an individual responding to the disturbance-inducing stressor within different exposure contexts. Here, we integrated data from blue whales (
    Language English
    Publishing date 2021-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2721508-8
    ISSN 2051-1434
    ISSN 2051-1434
    DOI 10.1093/conphys/coaa137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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