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  1. Book ; Online: Modernizing George Eliot

    Newton, K.M.

    The Writer as Artist, Intellectual, Proto-Modernist, Cultural Critic

    2011  

    Keywords Literary studies: c 1800 to c 1900 ; Literary theory ; Literary studies: fiction, novelists & prose writers ; Literary studies: from c 1900 ; Literature: history and criticism
    Language 0|e
    Size 1 electronic resource (240 pages)
    Publisher Bloomsbury Academic
    Publishing place London
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620803
    ISBN 9781849664981 ; 1849664986
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation.

    Newton, Kim

    Cold Spring Harbor perspectives in biology

    2020  Volume 12, Issue 3

    Abstract: Receptor-interacting serine threonine kinase 1 (RIPK1) is a widely expressed kinase that is essential for limiting inflammation in both mice and humans. Mice lacking RIPK1 die at birth from multiorgan inflammation and aberrant cell death, whereas humans ... ...

    Abstract Receptor-interacting serine threonine kinase 1 (RIPK1) is a widely expressed kinase that is essential for limiting inflammation in both mice and humans. Mice lacking RIPK1 die at birth from multiorgan inflammation and aberrant cell death, whereas humans lacking RIPK1 are immunodeficient and develop very early-onset inflammatory bowel disease. In contrast to complete loss of RIPK1, inhibiting the kinase activity of RIPK1 genetically or pharmacologically prevents cell death and inflammation in several mouse disease models. Indeed, small molecule inhibitors of RIPK1 are in phase I clinical trials for amyotrophic lateral sclerosis, and phase II clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. This review focuses on which signaling pathways use RIPK1, how activation of RIPK1 is regulated, and when activation of RIPK1 appears to be an important driver of inflammation.
    MeSH term(s) Animals ; Apoptosis ; Caspase 8/metabolism ; Cell Death ; Cell Survival ; Clinical Trials as Topic ; Gene Expression Regulation ; Gene Expression Regulation, Enzymologic ; Humans ; Inflammation/enzymology ; Intestines ; Mice ; Neoplasms/metabolism ; Phosphorylation ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Toll-Like Receptor 3/metabolism ; Toll-Like Receptor 4/metabolism
    Chemical Substances Toll-Like Receptor 3 ; Toll-Like Receptor 4 ; RIPK1 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Caspase 8 (EC 3.4.22.-)
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a036368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Government Communications, Political Trust and Compliant Social Behaviour: The Politics of Covid-19 in Britain.

    Newton, Kenneth

    The Political quarterly

    2020  Volume 91, Issue 3, Page(s) 502–513

    Abstract: It is commonly said that the lockdowns and social distancing necessary to control coronavirus pandemics will only work if the general population trusts its government, believes the information it provides, and has confidence in its policies. This article ...

    Abstract It is commonly said that the lockdowns and social distancing necessary to control coronavirus pandemics will only work if the general population trusts its government, believes the information it provides, and has confidence in its policies. This article traces the British government's record in providing information about its policies and performance, and compares this with the public's use of the mainstream news media. It then considers how these two sources of information affected trust in government and public compliance with social distancing and lockdown rules. Lastly, it compares Covid-19 with Brexit and draws conclusions about how beliefs and behaviour are formed when individuals are personally faced with a serious threat.
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1481296-4
    ISSN 1467-923X ; 0032-3179
    ISSN (online) 1467-923X
    ISSN 0032-3179
    DOI 10.1111/1467-923X.12901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Deubiquitinases in cell death and inflammation.

    Newton, Kim / Gitlin, Alexander D

    The Biochemical journal

    2022  Volume 479, Issue 10, Page(s) 1103–1119

    Abstract: Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational ... ...

    Abstract Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification made by ubiquitin ligases that modulates protein abundance, localization, and/or activity. For example, some ubiquitin chains target proteins for degradation, while others function as scaffolds for the assembly of signaling complexes. Deubiquitinases (DUBs) are the proteases that counteract ubiquitin ligases by cleaving ubiquitin from their protein substrates. Here, we review the DUBs that have been found to suppress or promote apoptosis, pyroptosis, or necroptosis.
    MeSH term(s) Cell Death ; Deubiquitinating Enzymes/metabolism ; Humans ; Inflammation ; Ligases/metabolism ; Ubiquitin/metabolism ; Ubiquitination
    Chemical Substances Ubiquitin ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Ligases (EC 6.-)
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20210735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Government Communications, Political Trust and Compliant Social Behaviour

    Newton, Kenneth

    The Political Quarterly

    The Politics of Covid‐19 in Britain

    2020  Volume 91, Issue 3, Page(s) 502–513

    Keywords Sociology and Political Science ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1481296-4
    ISSN 1467-923X ; 0032-3179
    ISSN (online) 1467-923X
    ISSN 0032-3179
    DOI 10.1111/1467-923x.12901
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

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  6. Article: Government Communications, Political Trust and Compliant Social Behaviour: The Politics of Covid-19 in Britain

    Newton, Kenneth

    Political quarterly

    Abstract: It is commonly said that the lockdowns and social distancing necessary to control coronavirus pandemics will only work if the general population trusts its government, believes the information it provides, and has confidence in its policies. This article ...

    Abstract It is commonly said that the lockdowns and social distancing necessary to control coronavirus pandemics will only work if the general population trusts its government, believes the information it provides, and has confidence in its policies. This article traces the British government's record in providing information about its policies and performance, and compares this with the public's use of the mainstream news media. It then considers how these two sources of information affected trust in government and public compliance with social distancing and lockdown rules. Lastly, it compares Covid-19 with Brexit and draws conclusions about how beliefs and behaviour are formed when individuals are personally faced with a serious threat.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #732083
    Database COVID19

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  7. Audio / Video ; Online: [Kelly Newton wearing a cloth face mask] ; COVID-19 Response

    Newton, Kelly

    2020  

    Abstract: Selfie of Kelly Newton in a car wearing a cloth face mask. ...

    Abstract Selfie of Kelly Newton in a car wearing a cloth face mask.
    Keywords Education - Colleges and Universities - University of North Texas ; COVID-19 ; Coronavirus ; pandemics ; quarantine ; social distancing ; selfies ; face masks ; covid19
    Language English
    Publishing date 2020-04-22
    Publishing country us
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Audio / Video ; Online: [Kelly Newton and Travis Hayne at Lake Cleburne] ; COVID-19 Response

    Newton, Kelly

    2020  

    Abstract: Selfie of Kelly Newton (left) and Travis Hayne smiling in front of the water at Lake Cleburne in Cleburne, TX. ...

    Abstract Selfie of Kelly Newton (left) and Travis Hayne smiling in front of the water at Lake Cleburne in Cleburne, TX.
    Keywords Education - Colleges and Universities - University of North Texas ; COVID-19 ; Coronavirus ; pandemics ; quarantine ; social distancing ; Lake Pat Cleburne ; selfies ; covid19
    Language English
    Publishing date 2020-05-22
    Publishing country us
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Audio / Video ; Online: [San Antonio River Walk] ; COVID-19 Response

    Newton, Kelly

    2020  

    Abstract: Photograph of the San Antonio River Walk. ...

    Abstract Photograph of the San Antonio River Walk.
    Keywords Education - Colleges and Universities - University of North Texas ; COVID-19 ; Coronavirus ; pandemics ; quarantine ; social distancing ; San Antonio River Walk ; covid19
    Language English
    Publishing date 2020-06-22
    Publishing country us
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Audio / Video ; Online: [Jessie and Kimberly Newton wearing cloth face masks with Buc-ee's statue] ; COVID-19 Response

    Newton, Kelly

    2020  

    Abstract: Photograph of Jessie and Kimberly Newton posing with the statue of Buc-ee's convenience store mascot outside the Temple, TX location. Both children are wearing cloth face masks, and the statue also has a t-shirt covering its mouth and nose like a face ... ...

    Abstract Photograph of Jessie and Kimberly Newton posing with the statue of Buc-ee's convenience store mascot outside the Temple, TX location. Both children are wearing cloth face masks, and the statue also has a t-shirt covering its mouth and nose like a face mask.
    Keywords Education - Colleges and Universities - University of North Texas ; COVID-19 ; Coronavirus ; pandemics ; quarantine ; social distancing ; Buc-ee's ; convenience stores ; children ; face masks ; covid19
    Language English
    Publishing date 2020-06-15
    Publishing country us
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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