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  1. Book ; Online ; E-Book: Sleep and combat-related post traumatic stress disorder

    Vermetten, Eric / Germain, Anne / Neylan, Thomas C.

    2018  

    Author's details Eric Vermetten, Anne Germain, Thomas C. Neylan editors
    Keywords Medicine ; Neurosciences ; Critical care medicine ; Respiratory organs/Diseases ; Neurology ; Psychiatry
    Subject code 616.89
    Language English
    Size 1 Online-Ressource (XIV, 424 Seiten), Illustrationen
    Publisher Springer
    Publishing place New York
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019583632
    ISBN 978-1-4939-7148-0 ; 9781493971466 ; 1-4939-7148-4 ; 1493971468
    DOI 10.1007/978-1-4939-7148-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Wake, NREM, and REM sleep measures predict incident dementia.

    Neylan, Thomas C / Walsh, Christine M

    Sleep

    2023  Volume 47, Issue 3

    MeSH term(s) Humans ; Sleep, REM ; Sleep ; Sleep Stages ; Dementia/complications ; Dementia/epidemiology
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Nightmares and cardiovascular disease: an emerging risk factor?

    Neylan, Thomas C / Cohen, Beth E

    Sleep

    2023  Volume 46, Issue 6

    MeSH term(s) Humans ; Dreams ; Cardiovascular Diseases ; Risk Factors ; Suicide
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1475: Show issues Location:
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  4. Article ; Online: Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models.

    Son, Gowoon / Neylan, Thomas C / Grinberg, Lea T

    Molecular neurodegeneration

    2024  Volume 19, Issue 1, Page(s) 4

    Abstract: Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, ...

    Abstract Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) and endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given to investigating tauopathy-driven neuropathology in the SCN and the repercussions of SCN and circadian gene dysfunction in the human brain affected by tauopathies. This review aims to provide an overview of the current literature on the vulnerability of the SCN in tauopathies in humans. Emphasis is placed on elucidating the neuronal and glial changes contributing to the widespread disruption of the molecular circadian clock. Furthermore, this review identifies areas of knowledge requiring further investigation.
    MeSH term(s) Animals ; Humans ; Neuroglia ; Tauopathies ; Suprachiasmatic Nucleus ; Alzheimer Disease ; Models, Animal
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-023-00695-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sleep spindles, tau, and neurodegeneration.

    Neylan, Thomas C / Walsh, Christine M

    Sleep

    2022  Volume 45, Issue 9

    MeSH term(s) Electroencephalography ; Polysomnography ; Sleep
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsac161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Post-traumatic Stress Disorder and Neurodegeneration.

    Neylan, Thomas C

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2019  Volume 28, Issue 1, Page(s) 61–63

    MeSH term(s) Dementia ; Humans ; Stress Disorders, Post-Traumatic
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2019.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4443: Show issues Location:
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  7. Article: The lipidome of posttraumatic stress disorder.

    Bhargava, Aditi / Knapp, Johannes D / Fiehn, Oliver / Neylan, Thomas C / Inslicht, Sabra S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Posttraumatic stress disorder (PTSD) can develop after trauma exposure. Some studies report that women develop PTSD at twice the rate of men, despite greater trauma exposure in men. Lipids and their metabolites (lipidome) regulate a myriad of key ... ...

    Abstract Posttraumatic stress disorder (PTSD) can develop after trauma exposure. Some studies report that women develop PTSD at twice the rate of men, despite greater trauma exposure in men. Lipids and their metabolites (lipidome) regulate a myriad of key biological processes and pathways such as membrane integrity, oxidative stress, and neuroinflammation in the brain by maintaining neuronal connectivity and homeostasis. In this study, we analyzed the lipidome of 40 individuals with PTSD and 40 trauma-exposed non-PTSD individuals. Plasma samples were analyzed for lipidomics using Quadrupole Time-of-Flight (QToF) mass spectrometry. Additionally, ~ 90 measures were collected, on sleep, mental and physical health indices. Sleep quality worsened as PTSD severity increased in both sexes. The lipidomics analysis identified a total of 348 quantifiable known lipid metabolites and 1951 lipid metabolites that are yet unknown; known metabolites were part of 13 classes of lipids. After adjusting for sleep quality, in women with PTSD, only one lipid subclass, phosphatidylethanolamine (PE) was altered, whereas, in men with PTSD, 9 out of 13 subclasses were altered compared to non-PTSD women and men, respectively. Severe PTSD was associated with 22% and 5% of altered lipid metabolites in men and women, respectively. Of the changed metabolites, only 0.5% measures (2 PEs and cholesterol) were common between women and men with PTSD. Several sphingomyelins, PEs, ceramides, and triglycerides were increased in men with severe PTSD. The triglycerides and ceramide metabolites that were most highly increased were correlated with cholesterol metabolites and systolic blood pressure in men but not always in women with PTSD. Alterations in triglycerides and ceramides are linked with cardiac health and metabolic function in humans. Thus, disturbed sleep and higher weight may have contributed to changes in the lipidome found in PTSD.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.23.581833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of psychiatric disorders with clinical diagnosis of long COVID in US veterans.

    Nishimi, Kristen / Neylan, Thomas C / Bertenthal, Daniel / Seal, Karen H / O'Donovan, Aoife

    Psychological medicine

    2024  , Page(s) 1–9

    Abstract: Background: Psychiatric disorders may be a risk factor for long COVID, broadly defined as COVID-19 conditions continuing three months post-acute infection. In US Veterans with high psychiatric burden, we examined associations between psychiatric ... ...

    Abstract Background: Psychiatric disorders may be a risk factor for long COVID, broadly defined as COVID-19 conditions continuing three months post-acute infection. In US Veterans with high psychiatric burden, we examined associations between psychiatric disorders and clinical diagnosis of long COVID.
    Methods: We conducted a retrospective cohort study using health records from VA patients with a positive SARS-CoV-2 test from February 2020 to February 2023. Generalized linear models estimated associations between any psychiatric disorder and likelihood of subsequent diagnosis with long COVID (i.e. two or more long COVID clinical codes). Models were adjusted for socio-demographic, medical, and behavioral factors. Secondary models examined individual psychiatric disorders and age-stratified associations.
    Results: Among 660 217 VA patients with positive SARS-CoV-2 tests, 56.3% had at least one psychiatric disorder diagnosis and 1.4% were diagnosed with long COVID. Individuals with any psychiatric disorder had higher risk for long COVID diagnosis in models adjusted for socio-demographic factors, vaccination status, smoking, and medical comorbidities (relative risk, RR = 1.28, 95% CI 1.21-1.35), with the strongest associations in younger individuals. Considering specific disorders, depressive, anxiety, and stress-related disorders were associated with increased risk for long COVID diagnoses (RRs = 1.36-1.48), but associations were in the opposite direction for substance use and psychotic disorders (RRs = 0.78-0.88).
    Conclusions: Psychiatric disorder diagnoses were associated with increased long COVID diagnosis risk in VA patients, with the strongest associations observed in younger individuals. Improved surveillance, treatment, and prevention for COVID-19 and its long-term sequelae should be considered for individuals with psychiatric conditions.
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291724000114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1003: Show issues Location:
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  9. Article ; Online: Potential Limitations for Assessing Adverse Posttraumatic Neuropsychiatric Sequelae With Wrist-Wearable Device and Self-report Survey-Reply.

    Straus, Laura D / Neylan, Thomas C / McLean, Samuel A

    JAMA psychiatry

    2023  Volume 80, Issue 7, Page(s) 752

    MeSH term(s) Humans ; Wrist ; Self Report ; Wearable Electronic Devices ; Surveys and Questionnaires
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.1147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.235: Show issues Location:
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  10. Article ; Online: Frontal Lobe Moderators and Mediators of Response to Exposure Therapy in PTSD.

    Neylan, Thomas C

    The American journal of psychiatry

    2017  Volume 174, Issue 12, Page(s) 1131–1133

    MeSH term(s) Frontal Lobe ; Humans ; Implosive Therapy ; Magnetic Resonance Imaging ; Stress Disorders, Post-Traumatic ; Veterans
    Language English
    Publishing date 2017--01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2017.17091056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.30: Show issues Location:
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